Metabolic modeling of synthesis gas fermentation in bubble column reactors

Biotechnology for Biofuels

Volumn 8, Issue 1, 2015, Pages

  Chen, Jin ^a   Gomez, Jose A ^b   Höffner, Kai ^b   Barton, Paul I ^b   Henson, Michael A ^a  

^a University of Massachusetts   (United States)

^b Massachusetts Institute of Technology   (United States)

Author keywords

Bioprocess engineering; Ethanol production; Metabolic modeling; Microbial fermentation

Indexed keywords

BUBBLE COLUMNS; DIFFERENTIAL EQUATIONS; ETHANOL; ETHANOL FUELS; FERMENTATION; LINEAR PROGRAMMING; MATLAB; METABOLISM; MOBILE SECURITY; ORDINARY DIFFERENTIAL EQUATIONS; SPACE TIME CODES;

BIOPROCESS ENGINEERING; BUBBLE COLUMN REACTORS; CLOSTRIDIUM LJUNGDAHLII; COMMERCIAL DEVELOPMENT; ETHANOL PRODUCTION; METABOLIC MODELING; MICROBIAL FERMENTATION; SYNTHESIS GASSES (SYNGAS);

SYNTHESIS GAS;

BIOENGINEERING; BIOREACTOR; CATALYST; ETHANOL; FERMENTATION; GAS; METABOLISM; MICROBIAL ACTIVITY; MODELING;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM LJUNGDAHLII;

EID: 84935015837     PISSN: 17546834     EISSN: None     Source Type: Journal    
DOI: 10.1186/s13068-015-0272-5     Document Type: Article

References (35)

1. Kirkels AF, Verbong GPJ. Biomass gasification: still promising? A 30-year global overview. Renew Sust Energ Rev. 2011;15(1):471-81.
2. McKendry P. Energy production from biomass (part 3): gasification technologies. Bioresour Technol. 2002;83(1):55-63.
3. Tanner RS, Miller LM, Yang D. Clostridium ljungdahlii sp. nov., an acetogenic species in clostridial rRNA homology group I. Int J Syst Bacteriol. 1993;43(2):232-6.
4. Tanner R.S. Production of ethanol from synthesis gas 2008 J. Wall C. Harwood A. Demain (eds)
5. Sim JH, Kamaruddin AH, Long WS, Najafpour G. Clostridium aceticum - a potential organism in catalyzing carbon monoxide to acetic acid: application of response surface methodology. Enzyme Microb Technol. 2007;40(5):1234-43.
6. Genthner BRS, Bryant MP. Additional characteristics of one-carbon-compound utilization by Eubacterium limosum and Acetobacterium woodii. Appl Environ Microbiol. 1987;53(3):471-6.
7. Liou JSC, Balkwill DL, Drake GR, Tanner RS. Clostridium carboxidivorans sp. nov., a solvent-producing clostridium isolated from an agricultural settling lagoon, and reclassification of the acetogen Clostridium scatologenes strain SL1 as Clostridium drakei sp. nov. Int J Syst Evol Microbiol. 2005;55:2085-91.
8. Daniell J, Kopke M, Simpson SD. Commercial biomass syngas fermentation. Energies. 2012;5(12):5372-417.
9. Munasinghe PC, Khanal SK. Biomass-derived syngas fermentation into biofuels: opportunities and challenges. Bioresour Technol. 2010;101(13):5013-22.
10. Abubackar HN, Veiga MC, Kennes C. Biological conversion of carbon monoxide: rich syngas or waste gases to bioethanol. Biofuel Bioprod Bior. 2011;5(1):93-114.
11. Riggs SS, Heindel TJ. Measuring carbon monoxide gas-liquid mass transfer in a stirred tank reactor for syngas fermentation. Biotechnol Prog. 2006;22(3):903-6.
12. Hurst KM, Lewis RS. Carbon monoxide partial pressure effects on the metabolic process of syngas fermentation. Biochem Eng J. 2010;48(2):159-65.
13. Mohammadi M, Mohamed AR, Najafpour GD, Younesi H, Uzir MH. Kinetic studies on fermentative production of biofuel from synthesis gas using Clostridium ljungdahlii. Sci World J. 2014;2014:910590.
14. Datar RP, Shenkman RM, Cateni BG, Huhnke RL, Lewis RS. Fermentation of biomass-generated producer gas to ethanol. Biotechnol Bioeng. 2004;86(5):587-94.
15. Henstra AM, Sipma J, Rinzema A, Stams AJM. Microbiology of synthesis gas fermentation for biofuel production. Curr Opin Biotechnol. 2007;18(3):200-6.
16. Papin JA, Price ND, Wiback SJ, Fell DA, Palsson BO. Metabolic pathways in the post-genome era. Trends Biochem Sci. 2003;28(5):250-8.
17. Hanly TJ, Henson MA. Dynamic flux balance modeling of microbial co-cultures for efficient batch fermentation of glucose and xylose mixtures. Biotechnol Bioeng. 2011;108(2):376-85.
18. Hjersted JL, Henson MA, Mahadevan R. Genome-scale analysis of Saccharomyces cerevisiae metabolism and ethanol production in fed-batch culture. Biotechnol Bioeng. 2007;97(5):1190-204.
19. Varma A, Palsson BO. Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. Appl Environ Microbiol. 1994;60(10):3724-31.
20. Mahadevan R, Edwards JS, Doyle FJ. Dynamic flux balance analysis of diauxic growth in Escherichia coli. Biophys J. 2002;83(3):1331-40.
21. Nagarajan H, Sahin M, Nogales J, Latif H, Lovley DR, Ebrahim A, et al. Characterizing acetogenic metabolism using a genome-scale metabolic reconstruction of Clostridium ljungdahlii. Microb Cell Fact. 2013;12:118.
22. Younesi H, Najafpour G, Mohamed AR. Ethanol and acetate production from synthesis gas via fermentation processes using anaerobic bacterium, Clostridium ljungdahlii. Biochem Eng J. 2005;27(2):110-9.
23. Harcombe WR, Riehl WJ, Dukovski I, Granger BR, Betts A, Lang AH, et al. Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamics. Cell Rep. 2014;7(4):1104-15.
24. Fang Y, Scheibe TD, Mahadevan R, Garg S, Long PE, Lovley DR. Direct coupling of a genome-scale microbial in silico model and a groundwater reactive transport model. J Contam Hydrol. 2011;122(1-4):96-103.
25. Jayasinghe N, Franks A, Nevin KP, Mahadevan R. Metabolic modeling of spatial heterogeneity of biofilms in microbial fuel cells reveals substrate limitations in electrical current generation. Biotechnol J. 2014;9(10):1350-61.
26. Gomez JA, Höffner K, Barton PI. DFBAlab: a fast and reliable MATLAB code for dynamic flux balance analysis. BMC Bioinformatics. 2014;15:409.
27. Gaddy JL, Arora DK, Ko CW, Philip JR, Basu R. Methods for increasing the production of ethanol from microbial fermentation. US Patent Application 7285402 B2.
28. Munasinghe PC, Khanal SK. Syngas fermentation to biofuel: evaluation of carbon monoxide mass transfer coefficient (k (L) a) in different reactor configurations. Biotechnol Prog. 2010;26(6):1616-21.
29. Kantarci N, Borak F, Ulgen KO. Bubble column reactors. Process Biochem. 2005;40(7):2263-83.
30. Drake HL, Gossner AS, Daniel SL. Old acetogens, new light. Ann Ny Acad Sci. 2008;1125:100-28.
31. Bouaifi M, Hebrard G, Bastoul D, Roustan M. A comparative study of gas hold-up, bubble size, interfacial area and mass transfer coefficients in stirred gas-liquid reactors and bubble columns. Chem Eng Process. 2001;40(2):97-111.
32. Prakash A, Margaritis A, Li H, Bergougnou MA. Hydrodynamics and local heat transfer measurements in a bubble column with suspension of yeast. Biochem Eng J. 2001;9(2):155-63.
33. Joshi JB, Sharma MM. Circulation cell model for bubble-columns. T I Chem Eng-Lond. 1979;57(4):244-51.
34. Bredwell MD, Srivastava P, Worden RM. Reactor design issues for synthesis-gas fermentations. Biotechnol Prog. 1999;15(5):834-44.
35. Linstrom P.J., Mallard W.G. 2015