Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: Implications in antihyperglycemic and hypolipidemic effects

Journal of Pharmacy and Pharmacology

Volumn 67, Issue 7, 2015, Pages 997-1007

  Li, Yuwen ^a   Zhang, Tiejun ^b   Cui, Jia ^a   Jia, Na ^a   Wu, Yin ^a   Xi, Miaomiao ^a   Wen, Aidong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Chungnam National University   (South Korea)

Author keywords

Adenosine monophosphate activated protein kinase; carnitine palmitoyl transferase 1; Chikusetsu saponin IVa; glucose and lipid metabolism; Glucose transporter 4

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; CARNITINE PALMITOYLTRANSFERASE I; CHIKUSETSU SAPONIN IVA; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINAMIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; OLEANOLIC ACID; SAPONIN; STREPTOZOCIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARALIA; ARALIA TAIBAIENSIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HYPERGLYCEMIA; IMMUNOBLOTTING; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MUSCLE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PLANT ROOT; RAT; REGULATORY MECHANISM; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TOXICITY TESTING; ANALOGS AND DERIVATIVES; ANIMAL; BARK; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ARALIA; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; GLUCOSE; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; OLEANOLIC ACID; OXIDATION-REDUCTION; PLANT BARK; PLANT ROOTS; RATS; RATS, WISTAR; SAPONINS; STREPTOZOCIN; TRIGLYCERIDES;

EID: 84935015682     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12392     Document Type: Article

References (28)

1. Saltiel AR, Kahn CR,. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 414: 799-806.
2. Palitzsch D, Buhrlen M,. Prevention of type 2 diabetes mellitus. MMW Fortschr Med 2012; 154: 45-48.
3. Wong AK, et al. The effect of metformin on insulin resistance and exercise parameters in patients with heart failure. Eur J Heart Fail 2012; 14: 1303-1310.
4. Jia W, et al. Antidiabetic herbal drugs officially approved in China. Phytother Res 2003; 17: 1127-1134.
5. Viollet B, et al. Targeting the AMPK pathway for the treatment of type 2 diabetes. Front Biosci 2009; 14: 3380-3400.
6. Adachi Y, et al. Petasin activates AMP-activated protein kinase and modulates glucose metabolism. J Nat Prod 2014; 77: 1262-1269.
7. Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 444: 337-342.
8. Winder WW, Hardie DG,. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 1999; 277: E1-E10.
9. Abu-Elheiga L, et al. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 2001; 291: 2613-2616.
10. Saha AK, Ruderman NB,. Malonyl-CoA and AMP-activated protein kinase: an expanding partnership. Mol Cell Biochem 2003; 253: 65-70.
11. Misra P, Chakrabarti R,. The role of AMP kinase in diabetes. Indian J Med Res 2007; 125: 389-398.
12. Kirwan JP,. Insulin sensitivity in skeletal muscle: 'use it or lose it, fast'. J Appl Physiol 2010; 108: 1023-1024.
13. Hardie DG,. The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci 2004; 117: 5479-5487.
14. Abdel-Zaher AO, et al. Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J Ethnopharmacol 2005; 101: 129-138.
15. Oishi Y, et al. Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction. Biosci Biotechnol Biochem 2007; 71: 735-740.
16. Lee KT, et al. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 2000; 23: 461-466.
17. Xi M, et al. Antioxidant and antiglycation properties of triterpenoid saponins from Aralia taibaiensis traditionally used for treating diabetes mellitus. Redox Rep 2010; 15: 20-28.
18. Xi M, et al. Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytother Res 2008; 22: 228-237.
19. Weng Y, et al. Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats. J Ethnopharmacol 2014; 152: 553-560.
20. Cui J, et al. Insulin-secretagogue activity of eleven plant extracts and twelve pure compounds isolated from Aralia taibaiensis. Life Sci 2013; 92: 131-136.
21. Tang HF, et al. Studies on the triterpenoid saponins of the root bark of Aralia taibaiensis. Yao Xue Xue Bao 1996; 31: 517-523.
22. Diabetes Research and Clinical Practice 2000; 49: 181-186.
23. Organisation for Economic Co-operation and Development (OECD). Guideline for Testing of Chemicals 423: Acute Oral Toxicity acute Toxic Class Method.
24. Koistinen HA, et al. 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes 2003; 52: 1066-1072.
25. Kasuga M, et al. Insulin stimulates the phosphorylation of the 95 000-dalton subunit of its own receptor. Science 1982; 215: 185-187.
26. Kapeller R, Cantley LC,. Phosphatidylinositol 3-kinase. Bioessays 1994; 16: 565-576.
27. Mackenzie RW, Elliott BT,. Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes. Diabetes Metab Syndr Obes 2014; 7: 55-64.
28. Berdichevsky A, et al. Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK. J Biol Chem 2010; 285: 21581-21589.