Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus

Phytotherapy Research

Volumn 22, Issue 2, 2008, Pages 228-237

  Xi, Miaomiao ^a   Hai, Chunxu ^a   Tang, Haifeng ^b   Chen, Mingsheng ^b   Fang, Kunquan ^b   Liang, Xin ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antidiabetes; Antiglycation; Antioxidant; Free radical scavenger; Total saponins; Traditional Chinese medicine

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACANTHOPANAX SENTICOSUS EXTRACT; ADVANCED GLYCATION END PRODUCT; ARALIA TAIBAIENSIS EXTRACT; ASCORBIC ACID; BOVINE SERUM ALBUMIN; CARBON TETRACHLORIDE; FERROUS ION; FREE RADICAL; GLUCOSE; HEMOGLOBIN DELTA GLUCONOLACTONE; LACTONE DERIVATIVE; N ACETYLGLYCYLLYSINE METHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PEPTIDE; PLANT EXTRACT; RIBOSE; SAPONIN; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARALIA TAIBAIENSIS; ARTICLE; ASSAY; CHINESE MEDICINE; DIABETES MELLITUS; DRUG SCREENING; ELEUTHEROCOCCUS SENTICOSUS; LIPID PEROXIDATION; LIVER MICROSOME; MALE; MEDICINAL PLANT; NONHUMAN; RAT;

ARALIA; BOVINAE; ELEUTHEROCOCCUS SENTICOSUS; RATTUS;

EID: 40549131630     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2297     Document Type: Article

References (34)

1. Abdel‐Zaher AO, Salim SY, Assaf MH, Abdel‐Hady RH. 2005. Antidiabetic activity and toxicity of Zizyphus spina ‐ christi leaves. J Ethnopharmacol 101: 129–138.
2. Aruoma OI. 1998. Free radicals, oxidative stress, and antioxidants in human health and disease. J Am Oil Chem Soc 75: 199–212.
3. Baynes JW. 1991. Role of oxidative stress in development of complications in diabetes. Diabetes 40: 405–412.
4. Ceriello A, Giugliano D, Quatraro A, Donzella C, Dipalo G, Lefebvre PJ. 1991. Vitamin E reduction of protein glycosylation in diabetes. New prospect for prevention of diabetic complications? Diabetes Care 14: 68–72.
5. Duraisamy Y, Gaffney J, Slevin M, Smith CA, Williamson K, Ahmed N. 2003. Aminosalicylic acid reduces the antiproliferative effect of hyperglycaemia, advanced glycation endproducts and glycated basic fibroblast growth factor in cultured bovine aortic endothelial cells: comparison with aminoguanidine. Mol Cell Biochem 246: 143–153.
6. Fogliano V, Verde V, Randazzo G, Ritieni X. 1999. A method for measuring antioxidant activity and its application to monitoring the antioxidant capacity of wines. J Agric Food Chem 47: 1035–1040.
7. Gao XQ, Ohlander M, Jeppsson N, Bjork L, Trajkovski V. 2000. Changes in antioxidant effects and their relationship to phytonutrients in fruits of Sea Buckthorn (Hippophae rhamnoides L.) during maturation. J Agric Food Chem 48: 1485–1490.
8. Gutteridge JMC, Halliwell B. 1990. The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci 15: 129–135.
9. Halliwell B. 2001. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 18: 685–716.
10. Hiai S, Oura H, Nakajima T. 1976. Color reaction of some sapogenins and saponins with vanillin sulphuric acid. Planta Med 29: 116–122.
11. Ikeda K, Higashi T, Sano H et al. 1996. N(epsilon)‐(carboxymethyl)‐lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction. Biochemistry 35: 8075–8083.
12. Jakus V, Rietbrock N. 2004. Advanced glycation end‐products and the progress of diabetic vascular complications. Physiol Res 53: 131–142.
13. Jang YJ, Kim JK, Lee MS et al. 2001. Hypoglycemic and hypolipidemic effects of crude saponin fractions from Panax ginseng and Gynostemma pentaphyllum. Yakhak Hoechi 45: 545–556.
14. Jia W, Gao W, Tang L. 2003. Antidiabetic herbal drugs officially approved in China. Phytother Res 17: 1127–1134.
15. Khalifa RG, Baynes JW, Hudson BG. 1999. Amadorins: novel post‐Amadori inhibitors of advanced glycation end product. Biochem Biophys Res Commun 257: 251–258.
16. Lee KT, Sohn IC, Kim DH, Choi JW, Kwon SH, Park HJ. 2000. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin‐induced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 23: 461–466.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265–275.
18. Nagaraj RH, Shipanova IN, Faust FM. 1996. Protein crosslinking by the Maillard reaction. Isolation, characterization, and in vivo detection of a lysine‐lysine cross‐link derived from methylglyoxal. J Biol Chem 271: 19338–19345.
19. Nakagawa T, Yokozawa T, Terasawa K, Shu S, Juneja LR. 2002. Protective activity of green tea against free radical‐ and glucose‐mediated protein damage. J Agric Food Chem 50: 2418–2422.
20. Nawroth PP, Bierhaus A, Vogel GE et al. 1999. Non‐enzymatic glycation and oxidative stress in chronic illnesses and diabetes mellitus. Med Klin 94: 29–38.
21. Oishi Y, Sakamoto T, Udagawa Hn et al. 2007. Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction. Biosci Biotechnol Biochem 71: 735–740.
22. Pompella A, Maellaro E, Casini A, Ferrali M, Ciccoli L, Comporti M. 1987. Measurement of lipid peroxidation in vivo: a comparison of different procedures. Lipids 22: 206–211.
23. Rahbar S, Nadler JL. 1999. A new rapid method to detect inhibition of Amadori product generated by δ ‐gluconolactone. Clin Chim Acta 287: 123–130.
24. Satav JG, Katyare SS. 1982. Effect of experimental thyrotoxicosis on oxidative phosphorylation in rat liver, kidney and brain. Mol Cell Endocrinol 28: 178–189.
25. Slater TF, Sawyer BC. 1971. The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reaction in rat liver fractions in vitro. Biochem J 123: 805–814.
26. Tang HF, Wang ZZ, Yi YH, Jiang YP, Hu WJ, Li YQ. 1997. Triterpenoid saponins from the root bark of Aralia taibaiensis. J Chin Pharm Sci 6: 75–81.
27. Ulrich P, Cerami A. 2001. Protein glycation, diabetes, and aging. Recent Prog Horm Res 56: 1–21.
28. Vlassara H. 1996. Advanced glycation endproducts and atherosclerosis. Annal Med 28: 419–426.
29. Vlassara H, Palace MR. 2002. Diabetes and advanced glycation endproducts. J Intern Med 251: 87–101.
30. Wu Z. 1998. Progress in the study of hypoglycemic action of the active constituents of Chinese herbal drugs and their therapy of type 2 diabetes mellitus. Zhongguo Zhong Yao Za Zhi 23: 118–120.
31. Xu R, Zhao W, Xu J, Shao B, Qin G. 1996. Studies on bioactive saponins from Chinese medicinal plants. Adv Exp Med Biol 404: 371–382.
32. Xu XD, Yang JS, Zhu ZY. 1997. Advances in the studies of saponins from Aralia. Yao Xue Xue Bao 32: 711–720.
33. Yokozawa T, Chen CP, Dong E, Tanaka T, Nonaka GI, Nishioka I. 1998. Study on the inhibitory effect of tannins and flavonoids against DPPH radical. Biochem Pharmacol 56: 213–222.
34. Zhang LH, Xiao PG. 1993. Recent advances in studies of antihyperlipaemic and antihyperglycaemic compounds from Chinese traditional and herbal medicines. Phytother Res 7: 217–226.