The generation of insulin producing cells from human mesenchymal stem cells by miR-375 and anti-miR-9

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Jafarian, Arefeh ^a   Taghikani, Mohammad ^a   Abroun, Saeid ^a   Allahverdi, Amir ^a   Lamei, Maryam ^a   Lakpour, Niknam ^b   Soleimani, Masoud ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 3; INSULIN; LENTIVIRUS VECTOR; MICRORNA 375; MICRORNA 9; NEUROGENIN 3; PANCREAS POLYPEPTIDE; SOMATOMEDIN C; SOMATOSTATIN; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR ONECUT; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX17; C PEPTIDE; HOMEODOMAIN PROTEIN; MICRORNA; MIRN375 MICRORNA, HUMAN; MIRN92 MICRORNA, HUMAN; ONECUT2 PROTEIN, HUMAN; RECOMBINANT SOMATOMEDIN C; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL ASSAY; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RELEASE; INTRACELLULAR SPACE; LENTIVIRINAE; MARKER GENE; NONHUMAN; NORMAL HUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION; ANTAGONISTS AND INHIBITORS; BONE MARROW CELL; CELL CULTURE; CELL TRANSDIFFERENTIATION; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENE VECTOR; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION;

BONE MARROW CELLS; C-PEPTIDE; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC VECTORS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LENTIVIRUS; MESENCHYMAL STROMAL CELLS; MICRORNAS; MICROSCOPY, FLUORESCENCE; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 84935014568     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128650     Document Type: Article

References (45)

1. Chen L-B, Jiang X-B, Yang L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells. World Journal of Gastroenterology. 2004; 10(20):3016-20. PMID: 15378785
2. Shim J, Kim S, Woo D, Kim S, Oh C, McKay R, et al. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia. 2007; 50(6):1228-38. PMID: 17457565
3. Bang OY, Lee JS, Lee PH, Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Annals of neurology. 2005; 57(6):874-82. PMID: 15929052
4. Bobis S, Jarocha D, Majka M. Mesenchymal stem cells: characteristics and clinical applications. Folia Histochemica et Cytobiologica. 2007; 44(4):215-4.
5. Nussbaum J, Minami E, Laflamme MA, Virag JA, Ware CB, Masino A, et al. Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. The FASEB Journal. 2007; 21(7):1345-57. PMID: 17284483
6. Ambros V. The functions of animal microRNAs. Nature. 2004; 431(7006):350-5. PMID: 15372042
7. Petersen CP, Bordeleau M-E, Pelletier J, Sharp PA. Short RNAs repress translation after initiation in mammalian cells. Molecular cell. 2006; 21(4):533-42. PMID: 16483934
8. Zhang B, Farwell M. microRNAs: a new emerging class of players for disease diagnostics and gene therapy. Journal of cellular and molecular medicine. 2008; 12(1):3-21. PMID: 18088390
9. Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nature Reviews Genetics. 2008; 9(2):102-14. doi: 10.1038/nrg2290 PMID: 18197166
10. Miranda KC, Huynh T, Tay Y, Ang Y-S, Tam W-L, Thomson AM, et al. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell. 2006; 126 (6):1203-17. PMID: 16990141
11. Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs. Cell. 2009; 136 (4):642-55. doi: 10.1016/j.cell.2009.01.035 PMID: 19239886
12. Pandey AK, Agarwal P, Kaur K, Datta M. MicroRNAs in diabetes: tiny players in big disease. Cellular Physiology and Biochemistry. 2009; 23(4-6):221-32. doi: 10.1159/000218188 PMID: 19471109
13. Kantharidis P, Wang B, Carew RM, Lan HY. Diabetes complications: the microRNA perspective. Diabetes. 2011; 60(7):1832-7. doi: 10.2337/db11-0082 PMID: 21709278
14. Kloosterman WP, Lagendijk AK, Ketting RF, Moulton JD, Plasterk RH. Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS biology. 2007; 5(8):e203. PMID: 17676975
15. Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, MacDonald PE, et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 2004; 432(7014):226-30. PMID: 15538371
16. Plaisance V, Abderrahmani A, Perret-Menoud V, Jacquemin P, Lemaigre F, Regazzi R. MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. Journal of Biological Chemistry. 2006; 281(37):26932-42. PMID: 16831872
17. Li Y, Xu X, Liang Y, Liu S, Xiao H, Li F, et al. miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression. International journal of clinical and experimental pathology. 2010; 3(3):254. PMID: 20224724
18. Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, et al. Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell metabolism. 2006; 4 (2):143-54. PMID: 16890542
19. Marappagounder D, Somasundaram I, Dorairaj S, Sankaran R. Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro. Cellular & Molecular Biology Letters. 2013; 18(1):75-88. doi: 10.2478/s11658-012-0040-5
20. Shantikumar S, Caporali A, Emanueli C. Role of microRNAs in diabetes and its cardiovascular complications. Cardiovascular research. 2012; 93(4):583-93. doi: 10.1093/cvr/cvr300 PMID: 22065734
21. Colter DC, Class R, DiGirolamo CM, Prockop DJ. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proceedings of the National Academy of Sciences. 2000; 97(7):3213-8. PMID: 10725391
22. Shiroi A, Yoshikawa M, Yokota H, Fukui H, Ishizaka S, Tatsumi K, et al. Identification of Insulin-Producing Cells Derived from Embryonic Stem Cells by Zinc-Chelating Dithizone. Stem cells. 2002; 20 (4):284-92. PMID: 12110697
23. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of immunological methods. 1983; 65(1):55-63.
24. Li Y, Zhang R, Qiao H, Zhang H, Wang Y, Yuan H, et al. Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells. Journal of cellular physiology. 2007; 211 (1):36-44. PMID: 17226789
25. Barry F, Boynton RE, Liu B, Murphy JM. Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Experimental cell research. 2001; 268(2):189-200. PMID: 11478845
26. Caplan AI. Mesenchymal stem cells. Journal of orthopaedic research. 1991; 9(5):641-50. PMID: 1870029
27. Krampera M, Pizzolo G, Aprili G, Franchini M. Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair. Bone. 2006; 39(4):678-83. PMID: 16765663
28. Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circulation research. 2004; 95(1):9-20. PMID: 15242981
29. Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger MF. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. Journal of Biological Chemistry. 2000; 275(13):9645-52. PMID: 10734116
30. Mauck R, Yuan X, Tuan R. Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoarthritis and cartilage. 2006; 14(2):179-89. PMID: 16257243
31. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. science. 1999; 284(5411):143-7. PMID: 10102814
32. Abbott AL, Alvarez-Saavedra E, Miska EA, Lau NC, Bartel DP, Horvitz HR, et al. The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans. Developmental cell. 2005; 9(3):403-14. PMID: 16139228
33. Li M, Jones-Rhoades MW, Lau NC, Bartel DP, Rougvie AE. Regulatory Mutations of mir-48, a C. elegans let-7 Family MicroRNA, Cause Developmental Timing Defects. Developmental cell. 2005; 9 (3):415-22. PMID: 16139229
34. Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM. bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila. Cell. 2003; 113(1):25-36. PMID: 12679032
35. Sokol NS, Ambros V. Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth. Genes & development. 2005; 19(19):2343-54.
36. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2):281-97. PMID: 14744438
37. Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007; 129(2):303-17. PMID: 17397913
38. Hwang H, Mendell J. MicroRNAs in cell proliferation, cell death, and tumorigenesis. British journal of cancer. 2006; 94(6):776-80. PMID: 16495913
39. Gregory RI, Shiekhattar R. MicroRNA biogenesis and cancer. Cancer research. 2005; 65(9):3509-12. PMID: 15867338
40. Saba R, Goodman CD, Huzarewich RL, Robertson C, Booth SA. A miRNA signature of prion induced neurodegeneration. PloS one. 2008; 3(11):e3652. doi: 10.1371/journal.pone.0003652 PMID: 18987751
41. Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression. Proceedings of the National Academy of Sciences. 2008; 105(17):6415-20. doi: 10.1073/pnas.0710263105 PMID: 18434550
42. Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, et al. Allele-Specific Targeting of microRNAs to HLA-G and Risk of Asthma. The American Journal of Human Genetics. 2007; 81(4):829-34.
43. Tang X, Tang G, Özcan S. Role of microRNAs in diabetes. Biochimica Et Biophysica Acta (BBA)-Gene Regulatory Mechanisms. 2008; 1779(11):697-701.
44. Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang J-Y, Widmann C, et al. Alterations in microRNA expression contribute to fatty acid-induced pancreatic β-cell dysfunction. Diabetes. 2008; 57(10):2728-36. doi: 10.2337/db07-1252 PMID: 18633110
45. Poy MN, Hausser J, Trajkovski M, Braun M, Collins S, Rorsman P, et al. miR-375 maintains normal pancreatic α-and β-cell mass. Proceedings of the National Academy of Sciences. 2009; 106(14):5813-8. doi: 10.1073/pnas.0810550106 PMID: 19289822