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Volumn 127, Issue 4, 2015, Pages 430-438

High-fat diet enhanced retinal dehydrogenase activity, but suppressed retinol dehydrogenase activity in liver of rats

Author keywords

Alcohol dehydrogenases; Hyperlipidemia; Retinaldehyde dehydrogenases; Retinoid; Retinol dehydrogenases

Indexed keywords

ALCOHOL DEHYDROGENASE; CHOLESTEROL; MESSENGER RNA; PRAVASTATIN; RETINAL DEHYDROGENASE; RETINOL; RETINOL DEHYDROGENASE; OXIDOREDUCTASE; RETINAL; RETINOIC ACID; RETINOID;

EID: 84935007292     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2015.03.001     Document Type: Article
Times cited : (19)

References (48)
  • 1
    • 80054883942 scopus 로고    scopus 로고
    • Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
    • Vendrell J, El Bekay R, Peral B, García-Fuentes E, Megia A, Macias-Gonzalez M, et al. Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance. Endocrinology. 2011;152:4072-4079.
    • (2011) Endocrinology , vol.152 , pp. 4072-4079
    • Vendrell, J.1    El Bekay, R.2    Peral, B.3    García-Fuentes, E.4    Megia, A.5    Macias-Gonzalez, M.6
  • 2
    • 2642568613 scopus 로고    scopus 로고
    • Obesity: An overview on its current perspectives and treatment options
    • Nammi S, Koka S, Chinnala KM, Boini KM. Obesity: an overview on its current perspectives and treatment options. Nutr J. 2004;3:1-8.
    • (2004) Nutr J. , vol.3 , pp. 1-8
    • Nammi, S.1    Koka, S.2    Chinnala, K.M.3    Boini, K.M.4
  • 3
    • 37549038650 scopus 로고    scopus 로고
    • Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex
    • Ziouzenkova O, Plutzky J. Retinoid metabolism and nuclear receptor responses: new insights into coordinated regulation of the PPAR-RXR complex. FEBS Lett. 2008;582:32-38.
    • (2008) FEBS Lett. , vol.582 , pp. 32-38
    • Ziouzenkova, O.1    Plutzky, J.2
  • 4
    • 33144488245 scopus 로고    scopus 로고
    • Function of retinoid nuclear receptors: Lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
    • Mark M, Ghyselinck NB, Chambon P. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol. 2006;46:451-480.
    • (2006) Annu Rev Pharmacol Toxicol. , vol.46 , pp. 451-480
    • Mark, M.1    Ghyselinck, N.B.2    Chambon, P.3
  • 5
    • 45549091674 scopus 로고    scopus 로고
    • Retinoic acid in development: Towards an integrated view
    • Niederreither K, Dolle P. Retinoic acid in development: towards an integrated view. Nat Rev Genet. 2008;9:541-553.
    • (2008) Nat Rev Genet. , vol.9 , pp. 541-553
    • Niederreither, K.1    Dolle, P.2
  • 6
    • 15744386871 scopus 로고    scopus 로고
    • Nuclear receptors as targets for drug development: Regulation of cholesterol and bile acid metabolism by nuclear receptors
    • Makishima M. Nuclear receptors as targets for drug development: regulation of cholesterol and bile acid metabolism by nuclear receptors. J Pharmacol Sci. 2005;97:177-183.
    • (2005) J Pharmacol Sci. , vol.97 , pp. 177-183
    • Makishima, M.1
  • 7
    • 84905665415 scopus 로고    scopus 로고
    • Roles of vitamin A metabolism in the development of hepatic insulin resistance
    • 2013
    • Chen G. Roles of vitamin A metabolism in the development of hepatic insulin resistance. ISRN Hepatol. 2013;2013.
    • (2013) ISRN Hepatol.
    • Chen, G.1
  • 8
    • 0031037988 scopus 로고    scopus 로고
    • Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription
    • Schwarz EJ, Reginato MJ, Shao D, Krakow SL, Lazar MA. Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription. Mol Cell Biol. 1997;17:1552-1561.
    • (1997) Mol Cell Biol. , vol.17 , pp. 1552-1561
    • Schwarz, E.J.1    Reginato, M.J.2    Shao, D.3    Krakow, S.L.4    Lazar, M.A.5
  • 9
    • 84862744699 scopus 로고    scopus 로고
    • Roles of vitamin A status and retinoids in glucose and fatty acid metabolism
    • Zhao S, Li R, Li Y, Chen W, Zhang Y, Chen G. Roles of vitamin A status and retinoids in glucose and fatty acid metabolism. Biochem Cell Biol. 2012;90:142-152.
    • (2012) Biochem Cell Biol. , vol.90 , pp. 142-152
    • Zhao, S.1    Li, R.2    Li, Y.3    Chen, W.4    Zhang, Y.5    Chen, G.6
  • 11
    • 83255187847 scopus 로고    scopus 로고
    • Physiological insights into all-trans-retinoic acid biosynthesis
    • Napoli JL. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta. 2012;1821:152-167.
    • (2012) Biochim Biophys Acta. , vol.1821 , pp. 152-167
    • Napoli, J.L.1
  • 12
    • 0037325448 scopus 로고    scopus 로고
    • Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid
    • Duester G, Mic FA, Molotkov A. Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid. Chem Biol Interact. 2003;143:201-210.
    • (2003) Chem Biol Interact. , vol.143 , pp. 201-210
    • Duester, G.1    Mic, F.A.2    Molotkov, A.3
  • 13
    • 0027537924 scopus 로고
    • Overview of retinoid metabolism
    • Ross AC. Overview of retinoid metabolism. J Nutr. 1993;123:346-350.
    • (1993) J Nutr. , vol.123 , pp. 346-350
    • Ross, A.C.1
  • 14
    • 34548506744 scopus 로고    scopus 로고
    • Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse
    • Zhang M, Hu P, Krois CR, Kane MA, Napoli JL. Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. FASEB J. 2007;21:2886-2896.
    • (2007) FASEB J. , vol.21 , pp. 2886-2896
    • Zhang, M.1    Hu, P.2    Krois, C.R.3    Kane, M.A.4    Napoli, J.L.5
  • 15
    • 7444257882 scopus 로고    scopus 로고
    • Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation
    • Molotkov A, Ghyselinck N, Chambon P, Duester G. Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation. Biochem J. 2004;383:295-302.
    • (2004) Biochem J. , vol.383 , pp. 295-302
    • Molotkov, A.1    Ghyselinck, N.2    Chambon, P.3    Duester, G.4
  • 16
    • 0037706864 scopus 로고    scopus 로고
    • Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina
    • Fan X, Molotkov A, Manabe S-I, Donmoyer CM, Deltour L, Foglio MH, et al. Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol. 2003;23:4637-4648.
    • (2003) Mol Cell Biol. , vol.23 , pp. 4637-4648
    • Fan, X.1    Molotkov, A.2    Manabe, S.-I.3    Donmoyer, C.M.4    Deltour, L.5    Foglio, M.H.6
  • 18
    • 84862736649 scopus 로고    scopus 로고
    • Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism
    • Kiefer FW, Orasanu G, Nallamshetty S, Brown JD, Wang H, Luger P, et al. Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism. Endocrinology. 2012;153:3089-3099.
    • (2012) Endocrinology , vol.153 , pp. 3089-3099
    • Kiefer, F.W.1    Orasanu, G.2    Nallamshetty, S.3    Brown, J.D.4    Wang, H.5    Luger, P.6
  • 21
    • 84905909398 scopus 로고    scopus 로고
    • Plasma adipocytokines and antioxidantsstatus in Korean overweight and obese females with dyslipidemia
    • Ha AW, Jeong SY, Kang NE, Kim WK. Plasma adipocytokines and antioxidantsstatus in Korean overweight and obese females with dyslipidemia. Nutr Res Pract. 2014;8:417-424.
    • (2014) Nutr Res Pract. , vol.8 , pp. 417-424
    • Ha, A.W.1    Jeong, S.Y.2    Kang, N.E.3    Kim, W.K.4
  • 22
    • 0037545571 scopus 로고    scopus 로고
    • The relationships between anthropometric measurements, serum vitamin A and E concentrations and lipid profiles in overweight and obese subjects
    • Tungtrongchitr R, Changbumrung S, Tungtrongchitr A, Schelp FP. The relationships between anthropometric measurements, serum vitamin A and E concentrations and lipid profiles in overweight and obese subjects. Asia Pac J Clin Nutr. 2003;12:73-79.
    • (2003) Asia Pac J Clin Nutr. , vol.12 , pp. 73-79
    • Tungtrongchitr, R.1    Changbumrung, S.2    Tungtrongchitr, A.3    Schelp, F.P.4
  • 23
    • 43349095485 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and its relationship with the nutritional status of vitamin A in individuals with class III obesity
    • Chaves GV, Pereira SE, Saboya CJ, Ramalho A. Non-alcoholic fatty liver disease and its relationship with the nutritional status of vitamin A in individuals with class III obesity. Obes Surg. 2008;18:378-385.
    • (2008) Obes Surg. , vol.18 , pp. 378-385
    • Chaves, G.V.1    Pereira, S.E.2    Saboya, C.J.3    Ramalho, A.4
  • 24
    • 0033761823 scopus 로고    scopus 로고
    • A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat
    • Reed M, Meszaros K, Entes L, Claypool M, Pinkett J, Gadbois T, et al. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism. 2000;49:1390-1394.
    • (2000) Metabolism , vol.49 , pp. 1390-1394
    • Reed, M.1    Meszaros, K.2    Entes, L.3    Claypool, M.4    Pinkett, J.5    Gadbois, T.6
  • 25
    • 79956363660 scopus 로고    scopus 로고
    • Pharmacokinetics of verapamil in diabetic rats induced by combination of high-fat diet and streptozotocin injection
    • Chen G, Hu N, Liu L, Xie S, Wang P, Li J, et al. Pharmacokinetics of verapamil in diabetic rats induced by combination of high-fat diet and streptozotocin injection. Xenobiotica. 2011;41:494-500.
    • (2011) Xenobiotica , vol.41 , pp. 494-500
    • Chen, G.1    Hu, N.2    Liu, L.3    Xie, S.4    Wang, P.5    Li, J.6
  • 26
    • 84877319910 scopus 로고    scopus 로고
    • Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides
    • Liu C, Zhang M, Hu M-y, Guo H-f, Li J, Yu Y-l, et al. Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides. J Endocrinol. 2013;217:185-196.
    • (2013) J Endocrinol. , vol.217 , pp. 185-196
    • Liu, C.1    Zhang, M.2    Hu, M.-Y.3    Guo, H.-F.4    Li, J.5    Yu, Y.-L.6
  • 27
    • 84902282789 scopus 로고    scopus 로고
    • Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure
    • Li F, Zhang M, Xu D, Liu C, Zhong Z-y, Jia L-l, et al. Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure. Acta Pharmacol Sin. 2014;35:792-805.
    • (2014) Acta Pharmacol Sin. , vol.35 , pp. 792-805
    • Li, F.1    Zhang, M.2    Xu, D.3    Liu, C.4    Zhong, Z.-Y.5    Jia, L.-L.6
  • 28
    • 0034625573 scopus 로고    scopus 로고
    • High-performance liquid chromatographic determination of mono-, poly- and hydroxycarboxylic acids in foods and beverages as their 2-nitrophenylhydrazides
    • Miwa H. High-performance liquid chromatographic determination of mono-, poly- and hydroxycarboxylic acids in foods and beverages as their 2-nitrophenylhydrazides. J Chromatogr A. 2000;881:365-385.
    • (2000) J Chromatogr A. , vol.881 , pp. 365-385
    • Miwa, H.1
  • 29
    • 0021980642 scopus 로고
    • Comparative pharmacokinetics of vitamin A (retinol) in rats and hamsters
    • Willhite C, Chow F, Taylor M, Omaye S. Comparative pharmacokinetics of vitamin A (retinol) in rats and hamsters. Food Chem Toxicol. 1985;23:51-55.
    • (1985) Food Chem Toxicol. , vol.23 , pp. 51-55
    • Willhite, C.1    Chow, F.2    Taylor, M.3    Omaye, S.4
  • 30
    • 84899519932 scopus 로고    scopus 로고
    • The aggravation of clozapine-induced hepatotoxicity by glycyrrhetinic acid in rats
    • Jia L-l, Zhong Z-y, Li F, Ling Z-l, Chen Y, Zhao W-m, et al. The aggravation of clozapine-induced hepatotoxicity by glycyrrhetinic acid in rats. J Pharmacol Sci. 2014;124:468-479.
    • (2014) J Pharmacol Sci. , vol.124 , pp. 468-479
    • Jia, L.-L.1    Zhong, Z.-Y.2    Li, F.3    Ling, Z.-L.4    Chen, Y.5    Zhao, W.-M.6
  • 31
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
    • (1976) Anal Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 32
    • 0023601664 scopus 로고
    • NAD+-dependent retinol dehydrogenase in liver microsomes
    • Leo MA, Kim C-I, Lieber CS. NAD+-dependent retinol dehydrogenase in liver microsomes. Arch Biochem Biophys. 1987;259:241-249.
    • (1987) Arch Biochem Biophys. , vol.259 , pp. 241-249
    • Leo, M.A.1    Kim, C.-I.2    Lieber, C.S.3
  • 33
    • 0026030295 scopus 로고
    • Conversion of retinol to retinal by rat liver microsomes
    • Shih T, Hill D. Conversion of retinol to retinal by rat liver microsomes. Drug Metab Dispos. 1991;19:332-335.
    • (1991) Drug Metab Dispos. , vol.19 , pp. 332-335
    • Shih, T.1    Hill, D.2
  • 34
    • 33751194417 scopus 로고    scopus 로고
    • Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats
    • Liu H, Xu X, Yang Z, Deng Y, Liu X, Xie L Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats. Brain Res. 2006;1123:245-252.
    • (2006) Brain Res. , vol.1123 , pp. 245-252
    • Liu, H.1    Xu, X.2    Yang, Z.3    Deng, Y.4    Liu, X.5    Xie, L.6
  • 35
    • 0027170672 scopus 로고
    • Metabolic activation by a supernatant from human hepatoma cells: A possible alternative in mutagenic tests
    • Duverger-van Bogaert M, Dierickx P, Stecca C, Crutzen M-C. Metabolic activation by a supernatant from human hepatoma cells: a possible alternative in mutagenic tests. Mutat Res. 1993;292:199-204.
    • (1993) Mutat Res. , vol.292 , pp. 199-204
    • Duverger-Van Bogaert, M.1    Dierickx, P.2    Stecca, C.3    Crutzen, M.-C.4
  • 37
    • 33846864234 scopus 로고    scopus 로고
    • Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element
    • Uehara Y, Miura S-i, von Eckardstein A, Abe S, Fujii A, Matsuo Y, et al. Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. Atherosclerosis. 2007;191:11-21.
    • (2007) Atherosclerosis , vol.191 , pp. 11-21
    • Uehara, Y.1    Miura, S.-I.2    Von Eckardstein, A.3    Abe, S.4    Fujii, A.5    Matsuo, Y.6
  • 38
    • 27844480097 scopus 로고    scopus 로고
    • Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on vitamin A metabolism in mice
    • Yang YM, Huang DY, Liu GF, Zhong JC, Du K, Li YF, et al. Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on vitamin A metabolism in mice. J Biochem Mol Toxicol. 2005;19:327-335.
    • (2005) J Biochem Mol Toxicol. , vol.19 , pp. 327-335
    • Yang, Y.M.1    Huang, D.Y.2    Liu, G.F.3    Zhong, J.C.4    Du, K.5    Li, Y.F.6
  • 39
    • 43849100786 scopus 로고    scopus 로고
    • HPLC/UV quantitation of retinal, retinol, and retinyl esters in serum and tissues
    • Kane MA, Folias AE, Napoli JL. HPLC/UV quantitation of retinal, retinol, and retinyl esters in serum and tissues. Anal Biochem. 2008;378:71-79.
    • (2008) Anal Biochem. , vol.378 , pp. 71-79
    • Kane, M.A.1    Folias, A.E.2    Napoli, J.L.3
  • 40
    • 0034057188 scopus 로고    scopus 로고
    • Biosynthesis of all-trans-retinoic acid from all-trans-retinol: Catalysis of all-trans-retinol oxidation by human P-450 cytochromes
    • Chen H, Howald WN, Juchau MR. Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes. Drug Metab Dispos. 2000;28:315-322.
    • (2000) Drug Metab Dispos. , vol.28 , pp. 315-322
    • Chen, H.1    Howald, W.N.2    Juchau, M.R.3
  • 41
    • 0037134450 scopus 로고    scopus 로고
    • Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice
    • Molotkov A, Deltour L, Foglio MH, Cuenca AE, Duester G. Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice. J Biol Chem. 2002;277:13804-13811.
    • (2002) J Biol Chem. , vol.277 , pp. 13804-13811
    • Molotkov, A.1    Deltour, L.2    Foglio, M.H.3    Cuenca, A.E.4    Duester, G.5
  • 42
    • 0028354233 scopus 로고
    • Rat liver cytosolic retinal dehydrogenase: Comparison of 13-cis-, 9-cis-, and all-trans-retinal as substrates and effects of cellular retinoid-binding proteins and retinoic acid on activity
    • El Akawi Z, Napoli JL. Rat liver cytosolic retinal dehydrogenase: comparison of 13-cis-, 9-cis-, and all-trans-retinal as substrates and effects of cellular retinoid-binding proteins and retinoic acid on activity. Biochemistry. 1994;33:1938-1943.
    • (1994) Biochemistry , vol.33 , pp. 1938-1943
    • El Akawi, Z.1    Napoli, J.L.2
  • 43
    • 84886932409 scopus 로고    scopus 로고
    • Retinol-binding protein 4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and retinoic acid receptor a activity
    • Muenzner M, Tuvia N, Deutschmann C, Witte N, Tolkachov A, Valai A, et al. Retinol-binding protein 4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and retinoic acid receptor a activity. Mol Cell Biol. 2013;33:4068-4082.
    • (2013) Mol Cell Biol. , vol.33 , pp. 4068-4082
    • Muenzner, M.1    Tuvia, N.2    Deutschmann, C.3    Witte, N.4    Tolkachov, A.5    Valai, A.6
  • 44
    • 84866419847 scopus 로고    scopus 로고
    • The hepatic Raldh1 expression is elevated in zucker fatty rats and its over-expression introduced the retinal-induced Srebp-1c expression in INS-1 cells
    • Li Y, Zhang Y, Li R, Chen W, Howell M, Zhang R, et al. The hepatic Raldh1 expression is elevated in zucker fatty rats and its over-expression introduced the retinal-induced Srebp-1c expression in INS-1 cells. PLoS One. 2012;7:e45210.
    • (2012) PLoS One , vol.7 , pp. e45210
    • Li, Y.1    Zhang, Y.2    Li, R.3    Chen, W.4    Howell, M.5    Zhang, R.6
  • 45
    • 0028819996 scopus 로고
    • Effects on rat embryos of culture in serum of women with gestational diabetes
    • Ornoy A, Zaken V, Abir R, Yaffe P, Raz I. Effects on rat embryos of culture in serum of women with gestational diabetes. Toxicol In Vitro. 1995;9:643-651.
    • (1995) Toxicol in Vitro , vol.9 , pp. 643-651
    • Ornoy, A.1    Zaken, V.2    Abir, R.3    Yaffe, P.4    Raz, I.5
  • 46
    • 34548290827 scopus 로고    scopus 로고
    • Impact of diabetic serum on endothelial cells: An in-vitro-analysis of endothelial dysfunction in diabetes mellitus type 2
    • Münzel D, Lehle K, Haubner F, Schmid C, Birnbaum DE, Preuner JG. Impact of diabetic serum on endothelial cells: an in-vitro-analysis of endothelial dysfunction in diabetes mellitus type 2. Biochem Biophys Res Commun. 2007;362:238-244.
    • (2007) Biochem Biophys Res Commun. , vol.362 , pp. 238-244
    • Münzel, D.1    Lehle, K.2    Haubner, F.3    Schmid, C.4    Birnbaum, D.E.5    Preuner, J.G.6
  • 47
    • 79955930291 scopus 로고    scopus 로고
    • Insulin suppresses the expression and function of breast cancer resistance protein in primary cultures of rat brain microvessel endothelial cells
    • Liu X, Jing X, Jin S, Li Y, Liu L, Yu Y, et al. Insulin suppresses the expression and function of breast cancer resistance protein in primary cultures of rat brain microvessel endothelial cells. Pharmacol Rep. 2011;63:487-493.
    • (2011) Pharmacol Rep. , vol.63 , pp. 487-493
    • Liu, X.1    Jing, X.2    Jin, S.3    Li, Y.4    Liu, L.5    Yu, Y.6
  • 48
    • 84899511548 scopus 로고    scopus 로고
    • Increased levels of fatty acids contributed to induction of hepatic CYP3A4 activity induced by diabetes-in vitro evidence from HepG2 cell and Fa2N-4 cell lines
    • Hu N, Hu M, Duan R, Liu C, Guo H, Zhang M, et al. Increased levels of fatty acids contributed to induction of hepatic CYP3A4 activity induced by diabetes-in vitro evidence from HepG2 cell and Fa2N-4 cell lines. J Pharmacol Sci. 2014;124:433-444.
    • (2014) J Pharmacol Sci. , vol.124 , pp. 433-444
    • Hu, N.1    Hu, M.2    Duan, R.3    Liu, C.4    Guo, H.5    Zhang, M.6


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