Insulin suppresses the expression and function of breast cancer resistance protein in primary cultures of rat brain microvessel endothelial cells

Pharmacological Reports

Volumn 63, Issue 2, 2011, Pages 487-493

  Liu, Xiang ^a,b   Jing, Xin Yue ^a   Jin, Shi ^a   Li, Yang ^a   Liu, Li ^a   Yu, N Li ^a   Liu, Xiao Dong ^a   Xie, Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b DMPK Department   (China)

Author keywords

Breast cancer resistance protein; Diabetes; Insulin; Rat brain microvessel endothelial cells

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; IMATINIB; INSULIN; INSULIN RECEPTOR ANTIBODY; NOVOBIOCIN; PRAZOSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; DRUG EFFICACY; DRUG UPTAKE; ENDOTHELIUM CELL; INSULIN RESPONSE; MICROVASCULATURE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; VASCULAR ENDOTHELIUM;

EID: 79955930291     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/s1734-1140(11)70515-1     Document Type: Article

References (29)

1. Bark H, Xu HD, Kim SH, Yun J, Choi CH: P-glycoprotein down-regulates expression of breast cancer resistance protein in a drug-free state. FEBS Lett, 2008, 582, 2595-2600.
2. Bordow SB, Haber M, Madafiglio J, Cheung B, Marshall GM, Norris MD: Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Cancer Res, 1994, 54, 5036-5040. (Pubitemid 24313471)
3. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 1976, 72, 248-254.
4. Brendel C, Scharenberg C, Dohse M, Robey RW, Bates SE, Shukla S, Ambudkar SV et al.: Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells. Leukemia, 2007, 21, 1267-1275.
5. Brock I, Hipfner DR, Nielsen BS, Jensen PB, Deeley RG, Cole SP, Sehested M: Sequential coexpression of the multidrug resistance genes MRP and mdr1 and their products in VP-16 (etoposide)-selected H69 small cell lung cancer cells. Cancer Res, 1995, 55, 459-462.
6. Choi CH, Kim HS, Rha HS, Jeong JH, Park YH, Min YD, Kee KH, Lim DY: Drug concentration-dependent expression of multidrug resistance-associated protein and P-glycoprotein in the doxorubicin-resistant acute myelogenous leukemia sublines. Mol Cells, 1999, 9, 314-319.
7. Cisternino S, Mercier C, Bourasset F, Roux F, Scherrmann JM: Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier. Cancer Res, 2004, 64, 3296-3301. (Pubitemid 38581436)
8. Cooray HC, Blackmore CG, Maskell L, Barrand MA: Localisation of breast cancer resistance protein in microvessel endothelium of human brain. Neuroreport, 2002, 3, 2059-2063. (Pubitemid 36005925)
9. Eisenblätter T, Galla HJ: A new multidrug resistance protein at the blood-brain barrier. Biochem Biophys Res Commun, 2002, 293, 1273-1278. (Pubitemid 34681079)
10. Eisenblätter T, Hüwel S, Galla HJ: Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier. Brain Res, 2003, 971, 221-231. (Pubitemid 36423323)
11. Elahian F, Kalalinia F, Behravan J: Dexamethasone downregulates BCRP mRNA and protein expression in breast cancer cell lines. Oncol Res, 2009, 18, 9-15.
12. Friedrich RE, Punke C, Reymann A: Expression of multi-drug resistance genes (mdr1, mrp1, bcrp) in primary oral squamous cell carcinoma. In Vivo, 2004, 18, 133-147.
13. Hawkins BT, Ocheltree SM, Norwood KM, Egleton RD: Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats. Neurosci Lett, 2007, 411, 1-5. (Pubitemid 44751936)
14. Liu H, Liu X, Jia L, Liu Y, Yang H, Wang G, Xie L: Insulin therapy restores impaired function and expression of P-glycoprotein in blood-brain barrier of experimental diabetes. Biochem Pharmacol, 2008, 75, 1649-1658.
15. Liu H, Xu X, Yang Z, Deng Y, Liu X, Xie L: Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats. Brain Res, 2006, 1123 245-252.
16. Liu XD, Wang DW, Xie L: Correlation between quinolone uptakes by BCECs in vitro and brain-to-plasma concentration ratios in rats. Eur J Drug Metab Pharmacokinet, 2005, 30, 249-254. (Pubitemid 43099304)
17. Liu YC, Liu HY, Yang HW, Wen T, Shang Y, Liu XD, Xie L, Wang GJ: Impaired expression and function of breast cancer resistance protein (Bcrp) in brain cortex of streptozocin-induced diabetic rats. Biochem Pharmacol, 2007, 74, 1766-1772. (Pubitemid 350088680)
18. Milane A, Vautier S, Chacun H, Meininger V, Bensimon G, Farinotti R, Fernandez C: Interactions between riluzole and ABCG2/BCRP transporter. Neurosci Lett, 2009, 452, 12-16.
19. Nowicki MT, Aleksunes LM, Sawant SP, Dnyanmote AV, Mehendale HM, Manautou JE: Renal and hepatic transporter expression in type 2 diabetic rats. Drug Metab Lett, 2008, 2, 11-17. (Pubitemid 351411256)
20. Poller B, Drewe J, Krähenbühl S, Huwyler J, Gutmann H: Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human bloodbrain barrier. Cell Mol Neurobiol, 2010, 30, 63-70.
21. Qian ZY, Huang Q, Zhou LY, Sun ZF: Isolation and long-term cultivation of rat brain microvascular endothelial cells. Chin J Cell Biol, 1999, 21, 42-45.
22. Shiozawa K, Oka M, Soda H, Yoshikawa M, Ikegami Y, Tsurutani J, Nakatomi K et al.: Reversal of breast cancer resistance protein (BCRP/ABCG2)-mediated drug resistance by novobiocin, a coumermycin antibiotic. Int J Cancer, 2004, 108, 146-151. (Pubitemid 37444457)
23. Stein U, Walther W, Laurencot CM, Scheffer GL, Scheper RJ, Shoemaker RH: Tumor necrosis factor-α and expression of the multidrug resistance-associated genes LRP and MRP. J Natl Cancer Inst, 1997, 89, 807-813. (Pubitemid 27242283)
24. Sun JJ, Xie L, Liu XD: Transport of carbamazepine and drug interactions at blood-brain barrier. Acta Pharmacol Sin, 2006, 27, 249-253. (Pubitemid 43171166)
25. Van Waarde WM, Verkade HJ, Wolters H, Havinga R, Baller J, Bloks V, Müller M et al.: Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. Gastroenterology, 2002, 122, 1842-1852. (Pubitemid 34651429)
26. Warren MS, Zerangue N, Woodford K, Roberts LM, Tate EH, Feng B, Li C et al.: Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human. Pharmacol Res, 2009, 59, 404-413.
27. Zhang L, Liu XD, Xie L, Wang GJ: P-glycoprotein restricted transport of nimodipine across blood-brain barrier. Acta Pharmacol Sin, 2003, 24, 903-906.
28. Zhang W, Mojsilovic-Petrovic J, Andrade MF, Zhang H, Ball M, Stanimirovic DB: The expression and functional characterization of ABCG2 in brain endothelial cells and vessels. FASEB J, 2003, 17, 2085-2087.
29. Zhang Y, Laterra J, Pomper MG: Hedgehog pathway inhibitor Hh Antag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia, 2009, 11, 96-101.