The Hepatic Raldh1 Expression Is elevated in Zucker Fatty Rats and Its Over-Expression Introduced the Retinal-Induced Srebp-1c Expression in INS-1 Cells

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Li, Yang ^a   Zhang, Yan ^a   Li, Rui ^a   Chen, Wei ^a   Howell, Meredith ^a   Zhang, Rui ^a   Chen, Guoxun ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450 26A1; MESSENGER RNA; RETINAL; RETINAL DEHYDROGENASE; RETINALDEHYDE DEHYDROGENASE 1; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; RETINOL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYP26A1 GENE; EMBRYO; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIPOGENESIS; LIVER CELL CULTURE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN INDUCTION; RALDH1 GENE; RAT; RECEPTOR BLOCKING; SREBP 1C GENE; VIRUS RECOMBINANT; VITAMIN METABOLISM; ZUCKER RAT;

ANIMALS; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; HEPATOCYTES; LIPOGENESIS; LIVER; MALE; OBESITY; RATS; RATS, ZUCKER; RETINAL DEHYDROGENASE; RETINALDEHYDE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRETINOIN; VITAMIN A;

ADENOVIRIDAE; RATTUS;

EID: 84866419847     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045210     Document Type: Article

References (46)

1. Yanovski SZ, Yanovski JA, (2011) Obesity prevalence in the United States - up, down, or sideways? N Engl J Med 364: 987-989.
2. Schulze MB, Hu FB, (2005) Primary prevention of diabetes: what can be done and how much can be prevented? Annu Rev of Public Health 26: 445-467.
3. Haslam DW, James WP, (2005) Obesity. Lancet 366: 1197-1209.
4. Friedman JM, (2009) Leptin at 14 y of age: an ongoing story. Am J Clin Nutr 89: 973S-979S.
5. Gaulton KJ, Willer CJ, Li Y, Scott LJ, Conneely KN, et al. (2008) Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes 57: 3136-3144.
6. O'Rahilly S, Farooqi IS, (2008) Human obesity as a heritable disorder of the central control of energy balance. Int J Obes 32: S55-S61.
7. McGarry JD, (2002) Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51: 7-18.
8. Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, et al. (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6: 77-86.
9. Spiegelman BM, Flier JS, (2001) Obesity and the regulation of energy balance. Cell 104: 531-543.
10. Bray GA, Nielsen SJ, Popkin BM, (2004) Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79: 537-543.
11. Sporn MB, Robers AB, Goodman DS (1994) The Retinoids, Biology, Chemistry, and Medicine. New York: Raven Press.
12. Ross AC, (2003) Retinoid production and catabolism: role of diet in regulating retinol esterification and retinoic acid oxidation. J Nutr 133: 291S-296.
13. Napoli JL, (2011) Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta 1821: 152-167.
14. Zhang Y, Li R, Chen W, Li Y, Chen G, (2011) Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic acid receptor in primary rat hepatocytes. Mol Cell Biochem 355: 1-8.
15. Chen G, Zhang Y, Lu D, Li N, Ross AC, (2009) Retinoids synergize with insulin to induce hepatic Gck expression. Biochem J 419: 645-653.
16. Li R, Chen W, Li Y, Zhang Y, Chen G, (2011) Retinoids synergized with insulin to induce Srebp-1c expression and activated its promoter via the two liver X receptor binding sites that mediate insulin action. Biochem Biophys Res Commun 406: 268-272.
17. Lucas PC, Forman BM, Samuels HH, Granner DK, (1991) Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding. Mol Cell Biol 11: 5164-5170.
18. Lucas PC, O'Brien RM, Mitchell JA, Davis CM, Imai E, et al. (1991) A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene. Proc Natl Acad Sci U S A 88: 2184-2188.
19. Scott DK, Mitchell JA, Granner DK, (1996) Identification and characterization of a second retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter. J Biol Chem 271: 6260-6264.
20. Chen G, Liang G, Ou J, Goldstein JL, Brown MS, (2004) Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A 101: 11245-11250.
21. Jones D, (2008) End of the line for cannabinoid receptor 1 as an anti-obesity target? Nat Rev Drug Discov 7: 961-962.
22. Mukhopadhyay B, Liu J, Osei-Hyiaman D, Godlewski G, Mukhopadhyay P, et al. (2010) Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-γ. J Biol Chem 285: 19002-19011.
23. Zhao S, Li R, Li Y, Chen W, Zhang Y, et al. (2012) Roles of vitamin A status and retinoids in glucose and fatty acid metabolism. Biochem Cell Biol 90: 1-11.
24. Duester G, (2000) Families of retinoid dehydrogenases regulating vitamin A function. Eur J Biochem 267: 4315-4324.
25. Wolf G, (2010) Tissue-specific increases in endogenous all-trans retinoic acid: possible contributing factor in ethanol toxicity. Nutr Rev 68: 689-692.
26. Bhat PV, Labrecque J, Boutin JM, Lacroix A, Yoshida A, (1995) Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation. Gene 166: 303-306.
27. Lin M, Zhang M, Abraham M, Smith SM, Napoli JL, (2003) Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells. J Biol Chem 278: 9856-9861.
28. Mic FA, Molotkov A, Fan X, Cuenca AE, Duester G, (2000) RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development. Mech Dev 97: 227-230.
29. Wang X, Penzes P, Napoli JL, (1996) Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. J Biol Chem 271: 16288-16293.
30. Fan X, Molotkov A, Manabe SI, Donmoyer CM, Deltour L, et al. (2003) Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol 23: 4637-4648.
31. Ziouzenkova O, Orasanu G, Sharlach M, Akiyama TE, Berger JP, et al. (2007) Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med 13: 695-702.
32. Huq MM, Tsai NP, Gupta P, Wei LN, (2006) Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites. EMBO J 25: 3203-3213.
33. Theodosiou M, Laudet V, Schubert M, (2010) From carrot to clinic: an overview of the retinoic acid signaling pathway. Cell Mol Life Sci 67: 1423-1445.
34. Keidel S, LeMotte P, Apfel C, (1994) Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. Mol Cell Biol 14: 287-298.
35. Forest CD, O'Brien RM, Lucas PC, Magnuson MA, Granner DK, (1990) Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Mol Endocrinol 4: 1302-1310.
36. Chen G, Hohmeier HE, Gasa R, Tran VV, Newgard CB, (2000) Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. Diabetes 49: 562-570.
37. Brown MS, Goldstein JL, (2008) Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 7: 95-96.
38. Wang Y, Zolfaghari R, Ross AC, (2002) Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch Biochem Biophys 401: 235-243.
39. Starkey JM, Zhao Y, Sadygov RG, Haidacher SJ, LeJeune WS, et al. (2010) Altered retinoic acid metabolism in diabetic mouse kidney identified by O isotopic labeling and 2D mass spectrometry. PLoS One 5: e11095.
40. Shimomura I, Bashmakov Y, Ikemoto S, Horton JD, Brown MS, et al. (1999) Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci U S A 96: 13656-13661.
41. Aleixandre de Artiñano A, Miguel Castro M, (2009) Experimental rat models to study the metabolic syndrome. Br J Nutr 102: 1246-1253.
42. Unger RH, (1997) How obesity causes diabetes in Zucker diabetic fatty rats. Trends Endocrinol Metab 8: 276-282.
43. Zhang Y, Chen W, Li R, Li Y, Ge Y, et al. (2011) Insulin-regulated Srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats Is affected by feeding conditions. PLoS One 6: e21342.
44. Chen G, (2007) Liver lipid molecules induce PEPCK-C gene transcription and attenuate insulin action. Biochem Biophys Res Commun 361: 805-810.
45. Wang Y, Zolfaghari R, Ross AC, (2002) Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch Biochem Biophys 401: 235-243.
46. Fujiwara K, Kikuchi M, Horiguchi K, Kusumoto K, Kouki T, et al. (2009) Estrogen receptor alpha regulates retinaldehyde dehydrogenase 1 expression in rat anterior pituitary cells. Endocr J 56: 963-973.