Effects of the microbubble shell physicochemical properties on ultrasound-mediated drug delivery to the brain

Journal of Controlled Release

Volumn 212, Issue , 2015, Pages 30-40

  Wu, Shih Ying ^a   Chen, Cherry C ^a   Tung, Yao Sheng ^a   Olumolade, Oluyemi O ^a   Konofagou, Elisa E ^a,b  

^a Fu Foundation School of Engineering and Applied Science   (United States)

^b Howard Hughes Medical Institute   (United States)

Author keywords

Blood brain barrier; Drug delivery; Microbubble; Passive cavitation detection; Shell; Ultrasound

Indexed keywords

BLOOD; CAVITATION; CHAIN LENGTH; CHAINS; DEXTRAN; DRUG DELIVERY; ENERGY EFFICIENCY; HYDROPHOBICITY; MONOLAYERS; PHOSPHOLIPIDS; ULTRASONIC APPLICATIONS; ULTRASONICS;

ACOUSTIC CAVITATIONS; BLOOD-BRAIN BARRIER; DISSOLUTION BEHAVIOR; HYDROPHOBIC CHAIN LENGTHS; MICRO-BUBBLE; PASSIVE CAVITATION DETECTION; PHYSICOCHEMICAL PROPERTY; SHELL;

SHELLS (STRUCTURES);

DEXTRAN; DRUG CARRIER; PHOSPHOLIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG SYNTHESIS; FLUORESCENCE IMAGING; IN VIVO STUDY; INVESTIGATIVE PROCEDURES; LIPID MONOLAYER; MALE; MICROBUBBLE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RIGIDITY; RISK ASSESSMENT; SHEAR STRESS; TISSUE INJURY; ULTRASOUND; ANIMAL; C57BL MOUSE; CHEMISTRY; METABOLISM; PATHOLOGY;

ANIMALS; BRAIN; DEXTRANS; DRUG DELIVERY SYSTEMS; MALE; MICE, INBRED C57BL; MICROBUBBLES; PHOSPHOLIPIDS; SONICATION; ULTRASONIC WAVES;

EID: 84935004907     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.06.007     Document Type: Article

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