New doxorubicin-loaded phospholipid microbubbles for targeted tumor therapy: In-vivo characterization

Journal of Controlled Release

Volumn 148, Issue 3, 2010, Pages 368-372

  Tinkov, Steliyan ^a   Coester, Conrad ^a   Serba, Susanne ^b   Geis, Nicolas A ^b   Katus, Hugo A ^b   Winter, Gerhard ^a   Bekeredjian, Raffi ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Contrast agents; Drug targeting; Microbubbles; Tumor therapy; Ultrasound

Indexed keywords

CONTRAST AGENT; DRUG-TARGETING; MICROBUBBLES; TUMOR THERAPY; ULTRASOUND;

CHEMOTHERAPY; CONCENTRATION (PROCESS); DRUG DELIVERY; PHOSPHOLIPIDS; RATS; TOXICITY; ULTRASONICS;

TUMORS;

DIPALMITOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; DIPALMITOYLPHOSPHATIDYLGLYCEROL; DOXORUBICIN; EDETIC ACID; LIPOSOME; MACROGOL 2000; PHOSPHOLIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMOEMBOLIZATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; DRUG TARGETING; DRUG TISSUE LEVEL; LUNG BLOOD VESSEL; MALE; MICROBUBBLE; NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; RAT; ULTRASOUND;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CARCINOMA; CONTRAST MEDIA; DOXORUBICIN; DRUG DELIVERY SYSTEMS; MICROBUBBLES; PANCREATIC NEOPLASMS; RATS; RATS, INBRED LEW; ULTRASONICS;

EID: 78649783863     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.09.004     Document Type: Article

References (14)

1. N.Y. Rapoport, A.M. Kennedy, J.E. Shea, C.L. Scaife, and K.-H. Nam Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles J. Control. Release 138 3 2009 268 276
2. R. Bekeredjian, H.A. Katus, and H.F. Kuecherer Therapeutic use of ultrasound targeted microbubble destruction: a review of non-cardiac applications Ultraschall Med. 27 2 2006 134 140
3. R. Bekeredjian, R. Kroll, D.E. Fein, S. Tinkov, C. Coester, G. Winter, H. Katus, and A.H. Kulaksiz Ultrasound targeted microbubble destruction increases capillary permeability in hepatomas Ultrasound Med. Biol. 33 10 2007 1592 1598
4. R. Karshafian, P. Bevan, D.R. Williams, S. Samac, and P.N. Burns Sonoporation by ultrasound-activated microbubble contrast agents: effect of acoustic exposure parameters on cell membrane permeability and cell viability Ultrasound Med. Biol. 35 5 2009 847 860
5. R. Karshafian, S. Samac, P.D. Bevan, and P.N. Burns Microbubble mediated sonoporation of cells in suspension: clonogenic viability and influence of molecular size on uptake Ultrasonics 50 7 2010 691 697
6. S. Tinkov, G. Winter, C. Coester, and R. Bekeredjian New doxorubicin-loaded phospholipid microbubbles for targeted tumor therapy: Part I - formulation development and in-vitro characterization J. Control. Release 143 1 2010 143 150
7. O.S. Pettengill, R.A. Faris, R.H. Bell Jr., E.T. Kuhlmann, and D.S. Longnecker Derivation of ductlike cell lines from a transplantable acinar cell carcinoma of the rat pancreas Am. J. Pathol. 143 1 1993 292 303
8. N.A. Geis, C.R. Mayer, R.D. Kroll, S.E. Hardt, H.A. Katus, and R. Bekeredjian Spatial distribution of ultrasound targeted microbubble destruction increases cardiac transgene expression but not capillary permeability Ultrasound Med. Biol. 35 7 2009 1119 1126
9. European Pharmacopoeia 5.00, Allgemeine Vorschriften, Doxorubicini hydrochloridum. Vol. Grundwerk 5.00, 2005, pp. 2009-2010.
10. A.C. Borges, T. Walde, R.K. Reibis, A. Grohmann, R. Ziebig, W. Rutsch, I. Schimke, and G. Baumann Does contrast echocardiography with optison induce myocardial necrosis in humans? J. Am. Soc. Echocardiogr. 15 10 2002 1080 1086
11. S. Chen, M.H. Kroll, R.V. Shohet, P. Frenkel, S.A. Mayer, and P.A. Grayburn Bioeffects of myocardial contrast microbubble destruction by echocardiography Echocardiography 19 6 2002 495 500
12. R. Bekeredjian, S. Chen, W. Pan, P.A. Grayburn, and R.V. Shohet Effects of ultrasound-targeted microbubble destruction on cardiac gene expression Ultrasound Med. Biol. 30 4 2004 539 543
13. V. Rouffiac, J.-S. Duret, P. Péronneau, N. Dehez, P. Opolon, A. Roche, and N. Lassau Combination of HIFU therapy with contrast-enhanced sonography for quantitative assessment of therapeutic efficiency on tumor grafted mice Ultrasound Med. Biol. 32 5 2006 729 740
14. D.L. Miller, and C. Dou The potential for enhancement of mouse melanoma metastasis by diagnostic and high-amplitude ultrasound Ultrasound Med. Biol. 32 7 2006 1097 1101