-
3
-
-
40549129995
-
Clinical and economic impact of common multidrug-resistant gram-negative bacilli
-
C.G. Giske, D.L. Monnet, O. Cars, and Y. Carmeli Clinical and economic impact of common multidrug-resistant gram-negative bacilli Antimicrob Agents Chemother 52 2008 813 821
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 813-821
-
-
Giske, C.G.1
Monnet, D.L.2
Cars, O.3
Carmeli, Y.4
-
4
-
-
84881429633
-
The scourge of antibiotic resistance: The important role of the environment
-
R.L. Finley, P. Collignon, D.G. Larsson, S.A. McEwen, X.Z. Li, W.H. Gaze, R. Reid-Smith, M. Timinouni, D.W. Graham, and E. Topp The scourge of antibiotic resistance: the important role of the environment Clin Infect Dis 57 2013 704 710
-
(2013)
Clin Infect Dis
, vol.57
, pp. 704-710
-
-
Finley, R.L.1
Collignon, P.2
Larsson, D.G.3
McEwen, S.A.4
Li, X.Z.5
Gaze, W.H.6
Reid-Smith, R.7
Timinouni, M.8
Graham, D.W.9
Topp, E.10
-
5
-
-
84908577353
-
Antibiotic resistance-problems, progress, and prospects
-
C. Nathan, and O. Cars Antibiotic resistance-problems, progress, and prospects N Engl J Med 371 2014 1761 1763
-
(2014)
N Engl J Med
, vol.371
, pp. 1761-1763
-
-
Nathan, C.1
Cars, O.2
-
10
-
-
84901594817
-
A three-step plan for antibiotics
-
A three-step plan for antibiotics Nature 509 2014 533
-
(2014)
Nature
, vol.509
, pp. 533
-
-
-
11
-
-
84934909416
-
Federal officials, congress seek ways to stimulate antibiotic development
-
J.L. Fox Federal officials, congress seek ways to stimulate antibiotic development Microbe 10 2015 13 16
-
(2015)
Microbe
, vol.10
, pp. 13-16
-
-
Fox, J.L.1
-
12
-
-
84903766667
-
Policy: An intergovernmental panel on antimicrobial resistance
-
M. Woolhouse, and J. Farrar Policy: an intergovernmental panel on antimicrobial resistance Nature 509 2014 555 557
-
(2014)
Nature
, vol.509
, pp. 555-557
-
-
Woolhouse, M.1
Farrar, J.2
-
14
-
-
84934963503
-
New drugs way to avoid an antibiotic apocalypse
-
New drugs way to avoid an antibiotic apocalypse Financial Times 2015
-
(2015)
Financial Times
-
-
-
15
-
-
84867841679
-
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
-
L.A. McAllister, J.I. Montgomery, J.A. Abramite, U. Reilly, M.F. Brown, J.M. Chen, R.A. Barham, Y. Che, S.W. Chung, C.A. Menard, and et al. Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents Bioorg Med Chem Lett 22 2012 6832 6838
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 6832-6838
-
-
McAllister, L.A.1
Montgomery, J.I.2
Abramite, J.A.3
Reilly, U.4
Brown, M.F.5
Chen, J.M.6
Barham, R.A.7
Che, Y.8
Chung, S.W.9
Menard, C.A.10
-
16
-
-
34250649348
-
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
-
J. Wang, S. Kodali, S.H. Lee, A. Galgoci, R. Painter, K. Dorso, F. Racine, M. Motyl, L. Hernandez, E. Tinney, and et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties Proc Natl Acad Sci U S A 104 2007 7612 7616
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 7612-7616
-
-
Wang, J.1
Kodali, S.2
Lee, S.H.3
Galgoci, A.4
Painter, R.5
Dorso, K.6
Racine, F.7
Motyl, M.8
Hernandez, L.9
Tinney, E.10
-
17
-
-
79951634603
-
Control of lipopolysaccharide biosynthesis by FtsH-mediated proteolysis of LpxC is conserved in enterobacteria but not in all gram-negative bacteria
-
S. Langklotz, M. Schakermann, and F. Narberhaus Control of lipopolysaccharide biosynthesis by FtsH-mediated proteolysis of LpxC is conserved in enterobacteria but not in all gram-negative bacteria J Bacteriol 193 2011 1090 1097
-
(2011)
J Bacteriol
, vol.193
, pp. 1090-1097
-
-
Langklotz, S.1
Schakermann, M.2
Narberhaus, F.3
-
18
-
-
84255201077
-
Antibiotics in development targeting protein synthesis
-
J.A. Sutcliffe Antibiotics in development targeting protein synthesis Ann N Y Acad Sci 1241 2011 122 152
-
(2011)
Ann N y Acad Sci
, vol.1241
, pp. 122-152
-
-
Sutcliffe, J.A.1
-
19
-
-
72249086358
-
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections
-
T.V. Magee, S.L. Ripp, B. Li, R.A. Buzon, L. Chupak, T.J. Dougherty, S.M. Finegan, D. Girard, A.E. Hagen, M.J. Falcone, and et al. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections J Med Chem 52 2009 7446 7457
-
(2009)
J Med Chem
, vol.52
, pp. 7446-7457
-
-
Magee, T.V.1
Ripp, S.L.2
Li, B.3
Buzon, R.A.4
Chupak, L.5
Dougherty, T.J.6
Finegan, S.M.7
Girard, D.8
Hagen, A.E.9
Falcone, M.J.10
-
20
-
-
84878278251
-
10 x '20 Progress - Development of new drugs active against gram-negative bacilli: An update from the Infectious Diseases Society of America
-
H.W. Boucher, G.H. Talbot, D.K. Benjamin Jr., J. Bradley, R.J. Guidos, R.N. Jones, B.E. Murray, R.A. Bonomo, and D. Gilbert 10 x '20 Progress - development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America Clin Infect Dis 56 2013 1685 1694
-
(2013)
Clin Infect Dis
, vol.56
, pp. 1685-1694
-
-
Boucher, H.W.1
Talbot, G.H.2
Benjamin, D.K.3
Bradley, J.4
Guidos, R.J.5
Jones, R.N.6
Murray, B.E.7
Bonomo, R.A.8
Gilbert, D.9
-
21
-
-
77955351648
-
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides
-
D. Pavlovic, and S. Mutak Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides J Med Chem 53 2010 5868 5880
-
(2010)
J Med Chem
, vol.53
, pp. 5868-5880
-
-
Pavlovic, D.1
Mutak, S.2
-
22
-
-
84884276513
-
Improvement of the pharmacokinetics and in vivo antibacterial efficacy of a novel type IIa topoisomerase inhibitor by formulation in liposomes
-
A.B. Shapiro, J. Newman, K. Goteti, M.E. Beaudoin, R. Harrison, S. Hopkins, N. Agrawal, and O. Rivin Improvement of the pharmacokinetics and in vivo antibacterial efficacy of a novel type IIa topoisomerase inhibitor by formulation in liposomes Antimicrob Agents Chemother 57 2013 4816 4824
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 4816-4824
-
-
Shapiro, A.B.1
Newman, J.2
Goteti, K.3
Beaudoin, M.E.4
Harrison, R.5
Hopkins, S.6
Agrawal, N.7
Rivin, O.8
-
23
-
-
39749190058
-
Ceftobiprole: A new option for treatment of skin and soft-tissue infections due to methicillin-resistant Staphylococcus aureus
-
A.F. Widmer Ceftobiprole: a new option for treatment of skin and soft-tissue infections due to methicillin-resistant Staphylococcus aureus Clin Infect Dis 46 2008 656 658
-
(2008)
Clin Infect Dis
, vol.46
, pp. 656-658
-
-
Widmer, A.F.1
-
24
-
-
84934963984
-
Drug makers tiptoe back into antibiotic R&D
-
H. Plumridge Drug makers tiptoe back into antibiotic R&D Wall Street J 2014
-
(2014)
Wall Street J
-
-
Plumridge, H.1
-
25
-
-
33845719937
-
Antibacterial discovery and development - The failure of success?
-
P. Fernandes Antibacterial discovery and development - the failure of success? Nat Biotechnol 24 2006 1497 1503
-
(2006)
Nat Biotechnol
, vol.24
, pp. 1497-1503
-
-
Fernandes, P.1
-
26
-
-
84909645276
-
Antibiotic treatment failure in four common infections in UK primary care 1991-2012: Longitudinal analysis
-
C.J. Currie, E. Berni, S. Jenkins-Jones, C.D. Poole, M. Ouwens, S. Driessen, H. de Voogd, C.C. Butler, and C.L. Morgan Antibiotic treatment failure in four common infections in UK primary care 1991-2012: longitudinal analysis BMJ 349 2014 g5493
-
(2014)
BMJ
, vol.349
-
-
Currie, C.J.1
Berni, E.2
Jenkins-Jones, S.3
Poole, C.D.4
Ouwens, M.5
Driessen, S.6
De Voogd, H.7
Butler, C.C.8
Morgan, C.L.9
-
27
-
-
45249108011
-
Increasing hospital admissions for pneumonia, England
-
C.L. Trotter, J.M. Stuart, R. George, and E. Miller Increasing hospital admissions for pneumonia, England Emerg Infect Dis 14 2008 727 733
-
(2008)
Emerg Infect Dis
, vol.14
, pp. 727-733
-
-
Trotter, C.L.1
Stuart, J.M.2
George, R.3
Miller, E.4
-
29
-
-
84910670192
-
Attributable healthcare utilization and cost of pneumonia due to drug-resistant streptococcus pneumonia: A cost analysis
-
C.A. Reynolds, J.A. Finkelstein, G.T. Ray, M.R. Moore, and S.S. Huang Attributable healthcare utilization and cost of pneumonia due to drug-resistant streptococcus pneumonia: a cost analysis Antimicrob Resist Infect Control 3 2014 16
-
(2014)
Antimicrob Resist Infect Control
, vol.3
, pp. 16
-
-
Reynolds, C.A.1
Finkelstein, J.A.2
Ray, G.T.3
Moore, M.R.4
Huang, S.S.5
-
30
-
-
84922937832
-
A new antibiotic kills pathogens without detectable resistance
-
L.L. Ling, T. Schneider, A.J. Peoples, A.L. Spoering, I. Engels, B.P. Conlon, A. Mueller, T.F. Schaberle, D.E. Hughes, S. Epstein, and et al. A new antibiotic kills pathogens without detectable resistance Nature 517 2015 455 459
-
(2015)
Nature
, vol.517
, pp. 455-459
-
-
Ling, L.L.1
Schneider, T.2
Peoples, A.J.3
Spoering, A.L.4
Engels, I.5
Conlon, B.P.6
Mueller, A.7
Schaberle, T.F.8
Hughes, D.E.9
Epstein, S.10
-
31
-
-
79958139104
-
Synthesis and antibacterial activity of pentacyclines: A novel class of tetracycline analogs
-
C. Sun, D.K. Hunt, R.B. Clark, D. Lofland, W.J. O'Brien, L. Plamondon, and X.Y. Xiao Synthesis and antibacterial activity of pentacyclines: a novel class of tetracycline analogs J Med Chem 54 2011 3704 3731
-
(2011)
J Med Chem
, vol.54
, pp. 3704-3731
-
-
Sun, C.1
Hunt, D.K.2
Clark, R.B.3
Lofland, D.4
O'Brien, W.J.5
Plamondon, L.6
Xiao, X.Y.7
-
32
-
-
58249107405
-
A robust platform for the synthesis of new tetracycline antibiotics
-
C. Sun, Q. Wang, J.D. Brubaker, P.M. Wright, C.D. Lerner, K. Noson, M. Charest, D.R. Siegel, Y.M. Wang, and A.G. Myers A robust platform for the synthesis of new tetracycline antibiotics J Am Chem Soc 130 2008 17913 17927
-
(2008)
J Am Chem Soc
, vol.130
, pp. 17913-17927
-
-
Sun, C.1
Wang, Q.2
Brubaker, J.D.3
Wright, P.M.4
Lerner, C.D.5
Noson, K.6
Charest, M.7
Siegel, D.R.8
Wang, Y.M.9
Myers, A.G.10
-
33
-
-
84905994821
-
The evolving role of chemical synthesis in antibacterial drug discovery
-
P.M. Wright, I.B. Seiple, and A.G. Myers The evolving role of chemical synthesis in antibacterial drug discovery Angew Chem Int Ed Engl 53 2014 8840 8869
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, pp. 8840-8869
-
-
Wright, P.M.1
Seiple, I.B.2
Myers, A.G.3
-
34
-
-
33645030241
-
Robust Salmonella metabolism limits possibilities for new antimicrobials
-
D. Becker, M. Selbach, C. Rollenhagen, M. Ballmaier, T.F. Meyer, M. Mann, and D. Bumann Robust Salmonella metabolism limits possibilities for new antimicrobials Nature 440 2006 303 307
-
(2006)
Nature
, vol.440
, pp. 303-307
-
-
Becker, D.1
Selbach, M.2
Rollenhagen, C.3
Ballmaier, M.4
Meyer, T.F.5
Mann, M.6
Bumann, D.7
-
35
-
-
84876223355
-
Single-dose safety, tolerability, and pharmacokinetics of the antibiotic GSK1322322, a novel peptide deformylase inhibitor
-
O.J. Naderer, E. Dumont, J. Zhu, M. Kurtinecz, and L.S. Jones Single-dose safety, tolerability, and pharmacokinetics of the antibiotic GSK1322322, a novel peptide deformylase inhibitor Antimicrob Agents Chemother 57 2013 2005 2009
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 2005-2009
-
-
Naderer, O.J.1
Dumont, E.2
Zhu, J.3
Kurtinecz, M.4
Jones, L.S.5
-
36
-
-
84876204256
-
Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322
-
K. O'Dwyer, M. Hackel, S. Hightower, D. Hoban, S. Bouchillon, D. Qin, K. Aubart, M. Zalacain, and D. Butler Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322 Antimicrob Agents Chemother 57 2013 2333 2342
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 2333-2342
-
-
O'Dwyer, K.1
Hackel, M.2
Hightower, S.3
Hoban, D.4
Bouchillon, S.5
Qin, D.6
Aubart, K.7
Zalacain, M.8
Butler, D.9
-
37
-
-
84923775846
-
Burden of Clostridium difficile infection in the United States
-
F.C. Lessa, Y. Mu, W.M. Bamberg, Z.G. Beldavs, G.K. Dumyati, J.R. Dunn, M.M. Farley, S.M. Holzbauer, J.I. Meek, E.C. Phipps, and et al. Burden of Clostridium difficile infection in the United States N Engl J Med 372 2015 825 834
-
(2015)
N Engl J Med
, vol.372
, pp. 825-834
-
-
Lessa, F.C.1
Mu, Y.2
Bamberg, W.M.3
Beldavs, Z.G.4
Dumyati, G.K.5
Dunn, J.R.6
Farley, M.M.7
Holzbauer, S.M.8
Meek, J.I.9
Phipps, E.C.10
-
38
-
-
79957789430
-
Pharmaceutical technologies for enhancing oral bioavailability of poorly soluble drugs
-
Y.S. Krishnaiah Pharmaceutical technologies for enhancing oral bioavailability of poorly soluble drugs J Bioequiv Availab 2 2010 28 36
-
(2010)
J Bioequiv Availab
, vol.2
, pp. 28-36
-
-
Krishnaiah, Y.S.1
-
39
-
-
77955957827
-
Integrated analysis of CANVAS 1 and 2: Phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection
-
G.R. Corey, M. Wilcox, G.H. Talbot, H.D. Friedland, T. Baculik, G.W. Witherell, I. Critchley, A.F. Das, and D. Thye Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection Clin Infect Dis 51 2010 641 650
-
(2010)
Clin Infect Dis
, vol.51
, pp. 641-650
-
-
Corey, G.R.1
Wilcox, M.2
Talbot, G.H.3
Friedland, H.D.4
Baculik, T.5
Witherell, G.W.6
Critchley, I.7
Das, A.F.8
Thye, D.9
-
40
-
-
84901948706
-
Phage therapy gets revitalized
-
S. Reardon Phage therapy gets revitalized Nature 510 2014 15 16
-
(2014)
Nature
, vol.510
, pp. 15-16
-
-
Reardon, S.1
-
41
-
-
84865690747
-
Anti-bacterial monoclonal antibodies: Back to the future?
-
M.B. Oleksiewicz, G. Nagy, and E. Nagy Anti-bacterial monoclonal antibodies: back to the future? Arch Biochem Biophys 526 2012 124 131
-
(2012)
Arch Biochem Biophys
, vol.526
, pp. 124-131
-
-
Oleksiewicz, M.B.1
Nagy, G.2
Nagy, E.3
-
42
-
-
84858381864
-
Modulating immunity as a therapy for bacterial infections
-
R.E. Hancock, A. Nijnik, and D.J. Philpott Modulating immunity as a therapy for bacterial infections Nat Rev Microbiol 10 2012 243 254
-
(2012)
Nat Rev Microbiol
, vol.10
, pp. 243-254
-
-
Hancock, R.E.1
Nijnik, A.2
Philpott, D.J.3
-
43
-
-
84928212486
-
Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: An observational cohort study
-
P.A. Waight, N.J. Andrews, S.N. Ladhani, C.L. Sheppard, M.P.E. Slack, and E. Miller Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: an observational cohort study Lancet Infect Dis 15 2015 535 543
-
(2015)
Lancet Infect Dis
, vol.15
, pp. 535-543
-
-
Waight, P.A.1
Andrews, N.J.2
Ladhani, S.N.3
Sheppard, C.L.4
Slack, M.P.E.5
Miller, E.6
-
44
-
-
29244437540
-
Vancomycin: A history
-
D.P. Levine Vancomycin: a history Clin Infect Dis 42 Suppl 1 2006 S5 S12
-
(2006)
Clin Infect Dis
, vol.42
, pp. S5-S12
-
-
Levine, D.P.1
-
45
-
-
34247192001
-
The FDA and the case of Ketek
-
D.B. Ross The FDA and the case of Ketek N Engl J Med 356 2007 1601 1604
-
(2007)
N Engl J Med
, vol.356
, pp. 1601-1604
-
-
Ross, D.B.1
-
46
-
-
78649638491
-
Molecular characterization of off-target activities of telithromycin: A potential role for nicotinic acetylcholine receptors
-
D. Bertrand, S. Bertrand, E. Neveu, and P. Fernandes Molecular characterization of off-target activities of telithromycin: a potential role for nicotinic acetylcholine receptors Antimicrob Agents Chemother 54 2010 5399 5402
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 5399-5402
-
-
Bertrand, D.1
Bertrand, S.2
Neveu, E.3
Fernandes, P.4
-
47
-
-
84882620294
-
Decreased susceptibility to cephalosporins among gonococci: Data from the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) in England and Wales, 2007-2011
-
C.A. Ison, K. Town, C. Obi, S. Chisholm, G. Hughes, D.M. Livermore, and C.M. Lowndes Decreased susceptibility to cephalosporins among gonococci: data from the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) in England and Wales, 2007-2011 Lancet Infect Dis 13 2013 762 768
-
(2013)
Lancet Infect Dis
, vol.13
, pp. 762-768
-
-
Ison, C.A.1
Town, K.2
Obi, C.3
Chisholm, S.4
Hughes, G.5
Livermore, D.M.6
Lowndes, C.M.7
-
48
-
-
84894059217
-
Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance
-
N. Goire, M.M. Lahra, M. Chen, B. Donovan, C.K. Fairley, R. Guy, J. Kaldor, D. Regan, J. Ward, M.D. Nissen, and et al. Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance Nat Rev Microbiol 12 2014 223 229
-
(2014)
Nat Rev Microbiol
, vol.12
, pp. 223-229
-
-
Goire, N.1
Lahra, M.M.2
Chen, M.3
Donovan, B.4
Fairley, C.K.5
Guy, R.6
Kaldor, J.7
Regan, D.8
Ward, J.9
Nissen, M.D.10
-
49
-
-
84929430297
-
Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes
-
A.R. Flores, J. Galloway-Pena, P. Sahasrabhojane, M. Saldana, H. Yao, X. Su, N.J. Ajami, M.E. Holder, J.F. Petrosino, E. Thompson, and et al. Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes Proc Natl Acad Sci USA 112 2015 6431 6436
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 6431-6436
-
-
Flores, A.R.1
Galloway-Pena, J.2
Sahasrabhojane, P.3
Saldana, M.4
Yao, H.5
Su, X.6
Ajami, N.J.7
Holder, M.E.8
Petrosino, J.F.9
Thompson, E.10
|