-
1
-
-
84934946412
-
Do we understand the personalized medicine paradigm?
-
Pavelić K., Martinović T., Pavelić S.K. Do we understand the personalized medicine paradigm?. EMBO reports 2014, e201439609.
-
(2014)
EMBO reports
, pp. e201439609
-
-
Pavelić, K.1
Martinović, T.2
Pavelić, S.K.3
-
2
-
-
84896714827
-
Safety and efficacy of vemurafenib in BRAF V600E and BRAF V600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study
-
McArthur G.A., Chapman P.B., Robert C., Larkin J., Haanen J.B., Dummer R., Ribas A., Hogg D., Hamid O., Ascierto P.A. Safety and efficacy of vemurafenib in BRAF V600E and BRAF V600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol 2014, 15:323-332.
-
(2014)
Lancet Oncol
, vol.15
, pp. 323-332
-
-
McArthur, G.A.1
Chapman, P.B.2
Robert, C.3
Larkin, J.4
Haanen, J.B.5
Dummer, R.6
Ribas, A.7
Hogg, D.8
Hamid, O.9
Ascierto, P.A.10
-
3
-
-
84877018587
-
How smart do biomaterials need to be? A translational science and clinical point of view
-
Holzapfel B.M., Reichert J.C., Schantz J.-T., Gbureck U., Rackwitz L., Noeth U., Jakob F., Rudert M., Groll J., Hutmacher D.W. How smart do biomaterials need to be? A translational science and clinical point of view. Adv Drug Deliv Rev 2013, 65:581-603.
-
(2013)
Adv Drug Deliv Rev
, vol.65
, pp. 581-603
-
-
Holzapfel, B.M.1
Reichert, J.C.2
Schantz, J.-T.3
Gbureck, U.4
Rackwitz, L.5
Noeth, U.6
Jakob, F.7
Rudert, M.8
Groll, J.9
Hutmacher, D.W.10
-
4
-
-
39149124477
-
State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective
-
Hutmacher D.W., Schantz J.T., Lam C.X.F., Tan K.C., Lim T.C. State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective. J Tissue Eng Regenerative Med 2007, 1:245-260.
-
(2007)
J Tissue Eng Regenerative Med
, vol.1
, pp. 245-260
-
-
Hutmacher, D.W.1
Schantz, J.T.2
Lam, C.X.F.3
Tan, K.C.4
Lim, T.C.5
-
5
-
-
70449643153
-
Engineering organs
-
Atala A. Engineering organs. Curr Opin Biotechnol 2009, 20:575-592.
-
(2009)
Curr Opin Biotechnol
, vol.20
, pp. 575-592
-
-
Atala, A.1
-
6
-
-
84884415227
-
Engineering the matrix microenvironment for cell delivery and engraftment for tissue repair
-
Cheng A.Y., García A.J. Engineering the matrix microenvironment for cell delivery and engraftment for tissue repair. Curr Opin Biotechnol 2013, 24:864-871.
-
(2013)
Curr Opin Biotechnol
, vol.24
, pp. 864-871
-
-
Cheng, A.Y.1
García, A.J.2
-
7
-
-
75749158184
-
Biomaterials offer cancer research the third dimension
-
Hutmacher D.W. Biomaterials offer cancer research the third dimension. Nat Mater 2010, 9:90-93.
-
(2010)
Nat Mater
, vol.9
, pp. 90-93
-
-
Hutmacher, D.W.1
-
8
-
-
84880531962
-
Engineered culture models for studies of tumor-microenvironment interactions
-
Infanger D.W., Lynch M.E., Fischbach C. Engineered culture models for studies of tumor-microenvironment interactions. Annual Rev Biomed Eng 2013, 15:29-53.
-
(2013)
Annual Rev Biomed Eng
, vol.15
, pp. 29-53
-
-
Infanger, D.W.1
Lynch, M.E.2
Fischbach, C.3
-
9
-
-
84897425769
-
Preclinical research: make mouse studies work
-
Perrin S. Preclinical research: make mouse studies work. Nature 2014, 507:423-425.
-
(2014)
Nature
, vol.507
, pp. 423-425
-
-
Perrin, S.1
-
10
-
-
77649234756
-
How to improve R&D productivity: the pharmaceutical industry's grand challenge
-
Paul S.M., Mytelka D.S., Dunwiddie C.T., Persinger C.C., Munos B.H., Lindborg S.R., Schacht A.L. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat Rev Drug Discov 2010, 9:203-214.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
Persinger, C.C.4
Munos, B.H.5
Lindborg, S.R.6
Schacht, A.L.7
-
11
-
-
84907662103
-
Advances in individualized and regenerative medicine
-
Blum H.E. Advances in individualized and regenerative medicine. Adv Med Sci 2014, 59:7-12.
-
(2014)
Adv Med Sci
, vol.59
, pp. 7-12
-
-
Blum, H.E.1
-
12
-
-
66249088017
-
The second wave of synthetic biology: from modules to systems
-
Purnick P.E., Weiss R. The second wave of synthetic biology: from modules to systems. Nat Rev Mol Cell Biol 2009, 10:410-422.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 410-422
-
-
Purnick, P.E.1
Weiss, R.2
-
13
-
-
84890170191
-
Synthetic biology: evolution or revolution? A co-founder's perspective
-
Gardner T.S., Hawkins K. Synthetic biology: evolution or revolution? A co-founder's perspective. Curr Opin Chem Biol 2013, 17:871-877.
-
(2013)
Curr Opin Chem Biol
, vol.17
, pp. 871-877
-
-
Gardner, T.S.1
Hawkins, K.2
-
14
-
-
77952300112
-
Can tissue engineering concepts advance tumor biology research?
-
Hutmacher D.W., Loessner D., Rizzi S., Kaplan D.L., Mooney D.J., Clements J.A. Can tissue engineering concepts advance tumor biology research?. Trends Biotechnol 2010, 28:125-133.
-
(2010)
Trends Biotechnol
, vol.28
, pp. 125-133
-
-
Hutmacher, D.W.1
Loessner, D.2
Rizzi, S.3
Kaplan, D.L.4
Mooney, D.J.5
Clements, J.A.6
-
15
-
-
84901823942
-
Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro
-
Torisawa Y.-s., Spina C.S., Mammoto T., Mammoto A., Weaver J.C., Tat T., Collins J.J., Ingber D.E. Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro. Nat Methods 2014, 11:663-669.
-
(2014)
Nat Methods
, vol.11
, pp. 663-669
-
-
Torisawa, Y.-S.1
Spina, C.S.2
Mammoto, T.3
Mammoto, A.4
Weaver, J.C.5
Tat, T.6
Collins, J.J.7
Ingber, D.E.8
-
16
-
-
84919660539
-
Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses
-
Loessner D., Holzapfel B.M., Clements J.A. Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses. Adv Drug Deliv Rev 2014, 79:193-213.
-
(2014)
Adv Drug Deliv Rev
, vol.79
, pp. 193-213
-
-
Loessner, D.1
Holzapfel, B.M.2
Clements, J.A.3
-
17
-
-
84878114431
-
Humanised xenograft models of bone metastasis revisited: novel insights into species-specific mechanisms of cancer cell osteotropism
-
Holzapfel B.M., Thibaudeau L., Hesami P., Taubenberger A., Holzapfel N.P., Mayer-Wagner S., Power C., Clements J., Russell P., Hutmacher D.W. Humanised xenograft models of bone metastasis revisited: novel insights into species-specific mechanisms of cancer cell osteotropism. Cancer Metastasis Rev 2013, 32:129-145.
-
(2013)
Cancer Metastasis Rev
, vol.32
, pp. 129-145
-
-
Holzapfel, B.M.1
Thibaudeau, L.2
Hesami, P.3
Taubenberger, A.4
Holzapfel, N.P.5
Mayer-Wagner, S.6
Power, C.7
Clements, J.8
Russell, P.9
Hutmacher, D.W.10
-
18
-
-
84896728350
-
Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone
-
Holzapfel B.M., Wagner F., Loessner D., Holzapfel N.P., Thibaudeau L., Crawford R., Ling M.-T., Clements J.A., Russell P.J., Hutmacher D.W. Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone. Biomaterials 2014, 35:4108-4115.
-
(2014)
Biomaterials
, vol.35
, pp. 4108-4115
-
-
Holzapfel, B.M.1
Wagner, F.2
Loessner, D.3
Holzapfel, N.P.4
Thibaudeau, L.5
Crawford, R.6
Ling, M.-T.7
Clements, J.A.8
Russell, P.J.9
Hutmacher, D.W.10
-
19
-
-
84894292115
-
A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone
-
Thibaudeau L., Taubenberger A.V., Holzapfel B.M., Quent V.M., Fuehrmann T., Hesami P., Brown T.D., Dalton P.D., Power C.A., Hollier B.G. A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone. Disease Models Mech 2014, 7:299-309.
-
(2014)
Disease Models Mech
, vol.7
, pp. 299-309
-
-
Thibaudeau, L.1
Taubenberger, A.V.2
Holzapfel, B.M.3
Quent, V.M.4
Fuehrmann, T.5
Hesami, P.6
Brown, T.D.7
Dalton, P.D.8
Power, C.A.9
Hollier, B.G.10
-
20
-
-
84896705997
-
Cancer Systems Biology: a peek into the future of patient care?
-
Werner H.M., Mills G.B., Ram P.T. Cancer Systems Biology: a peek into the future of patient care?. Nat Rev Clin Oncol 2014, 11:167-176.
-
(2014)
Nat Rev Clin Oncol
, vol.11
, pp. 167-176
-
-
Werner, H.M.1
Mills, G.B.2
Ram, P.T.3
-
21
-
-
84880252884
-
Eyes on 3D-current 3D biomimetic disease concept models and potential applications in age-related macular degeneration
-
Feigl B., Hutmacher D. Eyes on 3D-current 3D biomimetic disease concept models and potential applications in age-related macular degeneration. Adv Healthcare Mater 2013, 2:1056-1062.
-
(2013)
Adv Healthcare Mater
, vol.2
, pp. 1056-1062
-
-
Feigl, B.1
Hutmacher, D.2
-
22
-
-
48149100933
-
New dimensions in tumor immunology: what does 3D culture reveal?
-
Feder-Mengus C., Ghosh S., Reschner A., Martin I., Spagnoli G.C. New dimensions in tumor immunology: what does 3D culture reveal?. Trends Mol Med 2008, 14:333-340.
-
(2008)
Trends Mol Med
, vol.14
, pp. 333-340
-
-
Feder-Mengus, C.1
Ghosh, S.2
Reschner, A.3
Martin, I.4
Spagnoli, G.C.5
-
24
-
-
77956187576
-
Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells
-
Loessner D., Stok K.S., Lutolf M.P., Hutmacher D.W., Clements J.A., Rizzi S.C. Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. Biomaterials 2010, 31:8494-8506.
-
(2010)
Biomaterials
, vol.31
, pp. 8494-8506
-
-
Loessner, D.1
Stok, K.S.2
Lutolf, M.P.3
Hutmacher, D.W.4
Clements, J.A.5
Rizzi, S.C.6
-
25
-
-
33748980058
-
Engineering tissues for in vitro applications
-
Khetani S.R., Bhatia S.N. Engineering tissues for in vitro applications. Curr Opin Biotechnol 2006, 17:524-531.
-
(2006)
Curr Opin Biotechnol
, vol.17
, pp. 524-531
-
-
Khetani, S.R.1
Bhatia, S.N.2
-
27
-
-
84884416974
-
Engineering synthetic hydrogel microenvironments to instruct stem cells
-
Guvendiren M., Burdick J.A. Engineering synthetic hydrogel microenvironments to instruct stem cells. Curr Opin Biotechnol 2013, 24:841-846.
-
(2013)
Curr Opin Biotechnol
, vol.24
, pp. 841-846
-
-
Guvendiren, M.1
Burdick, J.A.2
-
28
-
-
79957684206
-
In vitro human tissue models-moving towards personalized regenerative medicine
-
Schenke-Layland K., Nerem R.M. In vitro human tissue models-moving towards personalized regenerative medicine. Adv Drug Deliv Rev 2011, 63:195-196.
-
(2011)
Adv Drug Deliv Rev
, vol.63
, pp. 195-196
-
-
Schenke-Layland, K.1
Nerem, R.M.2
-
29
-
-
33644529130
-
Capturing complex 3D tissue physiology in vitro
-
Griffith L.G., Swartz M.A. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 2006, 7:211-224.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 211-224
-
-
Griffith, L.G.1
Swartz, M.A.2
-
30
-
-
79952700142
-
Cell patterning technologies for organotypic tissue fabrication
-
Guillotin B., Guillemot F. Cell patterning technologies for organotypic tissue fabrication. Trends Biotechnol 2011, 29:183-190.
-
(2011)
Trends Biotechnol
, vol.29
, pp. 183-190
-
-
Guillotin, B.1
Guillemot, F.2
-
31
-
-
66249146049
-
Complexity in biomaterials for tissue engineering
-
Place E.S., Evans N.D., Stevens M.M. Complexity in biomaterials for tissue engineering. Nat Mater 2009, 8:457-470.
-
(2009)
Nat Mater
, vol.8
, pp. 457-470
-
-
Place, E.S.1
Evans, N.D.2
Stevens, M.M.3
-
32
-
-
84902744027
-
In vitro pre-vascularisation of tissue-engineered constructs A co-culture perspective
-
Baldwin J., Antille M., Bonda U., De-Juan-Pardo E.M., Khosrotehrani K., Ivanovski S., Petcu E.B., Hutmacher D.W. In vitro pre-vascularisation of tissue-engineered constructs A co-culture perspective. Vascular Cell 2014, 6:13.
-
(2014)
Vascular Cell
, vol.6
, pp. 13
-
-
Baldwin, J.1
Antille, M.2
Bonda, U.3
De-Juan-Pardo, E.M.4
Khosrotehrani, K.5
Ivanovski, S.6
Petcu, E.B.7
Hutmacher, D.W.8
-
33
-
-
84875806444
-
How induced pluripotent stem cells are redefining personalized medicine
-
Ferreira L.M., Mostajo-Radji M.A. How induced pluripotent stem cells are redefining personalized medicine. Gene 2013, 520:1-6.
-
(2013)
Gene
, vol.520
, pp. 1-6
-
-
Ferreira, L.M.1
Mostajo-Radji, M.A.2
-
34
-
-
84891930814
-
Physiologically relevant organs on chips
-
Yum K., Hong S.G., Healy K.E., Lee L.P. Physiologically relevant organs on chips. Biotechnol J 2014, 9:16-27.
-
(2014)
Biotechnol J
, vol.9
, pp. 16-27
-
-
Yum, K.1
Hong, S.G.2
Healy, K.E.3
Lee, L.P.4
-
35
-
-
84862811634
-
Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system
-
Ma L., Barker J., Zhou C., Li W., Zhang J., Lin B., Foltz G., Küblbeck J., Honkakoski P. Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system. Biomaterials 2012, 33:4353-4361.
-
(2012)
Biomaterials
, vol.33
, pp. 4353-4361
-
-
Ma, L.1
Barker, J.2
Zhou, C.3
Li, W.4
Zhang, J.5
Lin, B.6
Foltz, G.7
Küblbeck, J.8
Honkakoski, P.9
-
36
-
-
80054857419
-
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
-
Sato T., Stange D.E., Ferrante M., Vries R.G., Van Es J.H., Van den Brink S., Van Houdt W.J., Pronk A., Van Gorp J., Siersema P.D. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology 2011, 141:1762-1772.
-
(2011)
Gastroenterology
, vol.141
, pp. 1762-1772
-
-
Sato, T.1
Stange, D.E.2
Ferrante, M.3
Vries, R.G.4
Van Es, J.H.5
Van den Brink, S.6
Van Houdt, W.J.7
Pronk, A.8
Van Gorp, J.9
Siersema, P.D.10
-
37
-
-
84894581126
-
Collective invasion in breast cancer requires a conserved basal epithelial program
-
Cheung K.J., Gabrielson E., Werb Z., Ewald A.J. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell 2013, 155:1639-1651.
-
(2013)
Cell
, vol.155
, pp. 1639-1651
-
-
Cheung, K.J.1
Gabrielson, E.2
Werb, Z.3
Ewald, A.J.4
-
38
-
-
84910682457
-
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
-
Alépée N., Bahinski T., Daneshian M., De Wever B., Fritsche E., Goldberg A., Hansmann J., Hartung T., Haycock J., Hogberg H., et al. State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX 2014, 31:441-477.
-
(2014)
ALTEX
, vol.31
, pp. 441-477
-
-
Alépée, N.1
Bahinski, T.2
Daneshian, M.3
De Wever, B.4
Fritsche, E.5
Goldberg, A.6
Hansmann, J.7
Hartung, T.8
Haycock, J.9
Hogberg, H.10
-
39
-
-
84899640651
-
Bioengineering approaches to guide stem cell-based organogenesis
-
Gjorevski N., Ranga A., Lutolf M.P. Bioengineering approaches to guide stem cell-based organogenesis. Development 2014, 141:1794-1804.
-
(2014)
Development
, vol.141
, pp. 1794-1804
-
-
Gjorevski, N.1
Ranga, A.2
Lutolf, M.P.3
-
40
-
-
84929774215
-
Concise review: humanized models of tumor immunology in the 21st century: convergence of cancer research and tissue engineering
-
Holzapfel B.M., Wagner F., Thibaudeau L., Levesque J.-P., Hutmacher D.W. Concise review: humanized models of tumor immunology in the 21st century: convergence of cancer research and tissue engineering. Stem Cells 2015, 33:1696-1704.
-
(2015)
Stem Cells
, vol.33
, pp. 1696-1704
-
-
Holzapfel, B.M.1
Wagner, F.2
Thibaudeau, L.3
Levesque, J.-P.4
Hutmacher, D.W.5
-
41
-
-
84910136913
-
Three-dimensional organotypic culture: experimental models of mammalian biology and disease
-
Shamir E.R., Ewald A.J. Three-dimensional organotypic culture: experimental models of mammalian biology and disease. Nat Rev Mol Cell Biol 2014, 15:647-664.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, pp. 647-664
-
-
Shamir, E.R.1
Ewald, A.J.2
-
42
-
-
84882247304
-
The future of the patient-specific body-on-a-chip
-
Williamson A., Singh S., Fernekorn U., Schober A. The future of the patient-specific body-on-a-chip. Lab on a Chip 2013, 13:3471-3480.
-
(2013)
Lab on a Chip
, vol.13
, pp. 3471-3480
-
-
Williamson, A.1
Singh, S.2
Fernekorn, U.3
Schober, A.4
-
43
-
-
84921957467
-
Three-dimensional in vitro tumor models for cancer research and drug evaluation
-
Xu X., Farach-Carson M.C., Jia X. Three-dimensional in vitro tumor models for cancer research and drug evaluation. Biotechnol Adv 2014, 32:1256-1268.
-
(2014)
Biotechnol Adv
, vol.32
, pp. 1256-1268
-
-
Xu, X.1
Farach-Carson, M.C.2
Jia, X.3
-
44
-
-
84907954023
-
The littlest patient
-
Couzin-Frankel J. The littlest patient. Science 2014, 346:24-27.
-
(2014)
Science
, vol.346
, pp. 24-27
-
-
Couzin-Frankel, J.1
-
46
-
-
84867898654
-
Humanized mice for immune system investigation: progress, promise and challenges
-
Shultz L.D., Brehm M.A., Garcia-Martinez J.V., Greiner D.L. Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol 2012, 12:786-798.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 786-798
-
-
Shultz, L.D.1
Brehm, M.A.2
Garcia-Martinez, J.V.3
Greiner, D.L.4
-
47
-
-
33846630040
-
Humanized mice in translational biomedical research
-
Shultz L.D., Ishikawa F., Greiner D.L. Humanized mice in translational biomedical research. Nat Rev Immunol 2007, 7:118-130.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 118-130
-
-
Shultz, L.D.1
Ishikawa, F.2
Greiner, D.L.3
-
48
-
-
84905815023
-
Kit regulates HSC engraftment across the human-mouse species barrier
-
Cosgun K.N., Rahmig S., Mende N., Reinke S., Hauber I., Schäfer C., Petzold A., Weisbach H., Heidkamp G., Purbojo A. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell 2014, 15:227-238.
-
(2014)
Cell Stem Cell
, vol.15
, pp. 227-238
-
-
Cosgun, K.N.1
Rahmig, S.2
Mende, N.3
Reinke, S.4
Hauber, I.5
Schäfer, C.6
Petzold, A.7
Weisbach, H.8
Heidkamp, G.9
Purbojo, A.10
-
49
-
-
84875548150
-
Human hemato-lymphoid system mice: current use and future potential for medicine
-
Rongvaux A., Takizawa H., Strowig T., Willinger T., Eynon E.E., Flavell R.A., Manz M.G. Human hemato-lymphoid system mice: current use and future potential for medicine. Annual Rev Immunol 2013, 31:635.
-
(2013)
Annual Rev Immunol
, vol.31
, pp. 635
-
-
Rongvaux, A.1
Takizawa, H.2
Strowig, T.3
Willinger, T.4
Eynon, E.E.5
Flavell, R.A.6
Manz, M.G.7
|