Simvastatin prevents β-amyloid25-35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate

Neuropharmacology

Volumn 97, Issue , 2015, Pages 122-132

  Wang, Conghui ^a   Chen, Tingting ^a   Li, Guoxi ^a   Zhou, Libin ^a   Sha, Sha ^a   Chen, Ling ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Farnesyl pyrophosphate (FPP); Neurogenesis; Simvastatin (SV); 7 nicotinic acetylcholine receptor ( 7nAChR); Amyloid (A )

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; BRAIN DERIVED NEUROTROPHIC FACTOR; BUNGAROTOXIN RECEPTOR; FARNESYL DIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SIMVASTATIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (25-35); ISOPRENOID PHOSPHATE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; SESQUITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DOSE RESPONSE; DRUG EFFECT; ENZYME PHOSPHORYLATION; MALE; MORRIS WATER MAZE TEST; MOUSE; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; Y-MAZE TEST; ALZHEIMER DISEASE; ANIMAL; ANTAGONISTS AND INHIBITORS; COGNITION DISORDERS; DISEASE MODEL; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; MAZE TEST; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION DISORDERS; DENTATE GYRUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MAZE LEARNING; MICE, INBRED ICR; NEUROGENESIS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PHOSPHATIDYLINOSITOL 3-KINASES; POLYISOPRENYL PHOSPHATES; PROTO-ONCOGENE PROTEINS C-AKT; SESQUITERPENES; SIMVASTATIN;

EID: 84934982395     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.05.020     Document Type: Article

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