Novel thiourea-based sirtuin inhibitory warheads

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 16, 2015, Pages 3319-3324

  Zang, Wenwen ^a   Hao, Yujun ^b   Wang, Zhenghe ^b   Zheng, Weiping ^a  

^a JIANGSU UNIVERSITY   (China)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 O AADPR 2 O acyl ADP ribose; Abbreviations NAD+ nicotinamide adenine dinucleotide; HRMS high resolution mass spectrometry; IC50 the inhibitor concentration at which an enzymatic reaction velocity is reduced by 50 ; RP HPLC reversed phase high pressure liquid chromatography; SPPS solid phase peptide synthesis

Indexed keywords

ALKYL GROUP; HYDROLASE INHIBITOR; N CARBOXYETHYL THIOCARBAMOYL LYSINE; N METHYL THIOCARBAMOYL LYSINE; N THIOCARBAMOYL LYSINE; SIRTUIN 1 INHIBITOR; SIRTUIN 2 INHIBITOR; SIRTUIN 3 INHIBITOR; SIRTUIN 5 INHIBITOR; THIOUREA BASED SIRTUIN INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; SIRTUIN 1; SIRTUIN 2; THIOUREA;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION;

ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; SIRTUIN 1; SIRTUIN 2; THIOUREA;

EID: 84934807944     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.05.058     Document Type: Article

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