Distinct phenotypes caused by mutation of MSH2 in trypanosome insect and mammalian life cycle forms are associated with parasite adaptation to oxidative stress

PLoS Neglected Tropical Diseases

Volumn 9, Issue 6, 2015, Pages

  Grazielle Silva, Viviane ^a,b   Zeb, Tehseen Fatima ^b   Bolderson, Jason ^b   Campos, Priscila C ^a   Miranda, Julia B ^a   Alves, Ceres L ^a   Machado, Carlos R ^a   McCulloch, Richard ^b   Teixeira, Santuza M R ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; METHYLNITRONITROSOGUANIDINE; PROTEIN MSH2; 8-HYDROXYGUANINE; GUANINE; MICROSATELLITE DNA; PROTOZOAL DNA;

ADAPTATION; ALKYLATION; ANIMAL CELL; ARTICLE; CELL COUNT; CELLULAR DISTRIBUTION; GENE AMPLIFICATION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MOUSE; NONHUMAN; NORTHERN BLOTTING; OXIDATIVE STRESS; PARASITE SURVIVAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; ANALOGS AND DERIVATIVES; ANIMAL; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; RNA INTERFERENCE; TRYPANOSOMA BRUCEI BRUCEI;

ANIMALS; DNA, PROTOZOAN; GENE DELETION; GENE EXPRESSION REGULATION; GUANINE; MICROSATELLITE REPEATS; MUTS HOMOLOG 2 PROTEIN; OXIDATIVE STRESS; PROTEIN TRANSPORT; RNA INTERFERENCE; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 84934779951     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003870     Document Type: Article

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