Intranasal delivery of progesterone after transient ischemic stroke decreases mortality and provides neuroprotection

Neuropharmacology

Volumn 97, Issue , 2015, Pages 394-403

  Fréchou, Magalie ^a   Zhang, Shaodong ^a   Liere, Philippe ^a   Delespierre, Brigitte ^a   Soyed, Nouha ^a   Pianos, Antoine ^a   Schumacher, Michael ^a   Mattern, Claudia ^b   Guennoun, Rachida ^a  

^a Bicetre Hospital   (France)

^b M et P Pharma AG   (Switzerland)

Author keywords

Corticosterone; Intranasal; Neuroprotection; Progesterone; Steroid; Stroke

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; CORTICOSTERONE; DEOXYCORTICOSTERONE; DRUG METABOLITE; EVANS BLUE; FLUORESCEIN SODIUM; PLACEBO; PROGESTERONE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BLOOD BRAIN BARRIER; BRAIN INFARCTION SIZE; BRAIN LEVEL; CELL LOSS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG METABOLISM; GEL; HISTOPATHOLOGY; MASS FRAGMENTOGRAPHY; MIDDLE CEREBRAL ARTERY OCCLUSION; MORTALITY; MOTOR PERFORMANCE; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; STROKE PATIENT; TRANSIENT ISCHEMIC ATTACK; ANIMAL; BRAIN; BRAIN ISCHEMIA; C57BL MOUSE; CAPILLARY PERMEABILITY; CEREBRAL ARTERY DISEASE; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; INTRANASAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; METABOLISM; PHYSIOLOGY; RANDOMIZATION; STROKE;

ADMINISTRATION, INTRANASAL; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN ISCHEMIA; CAPILLARY PERMEABILITY; CORTICOSTERONE; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRAPERITONEAL; MALE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PROGESTERONE; RANDOM ALLOCATION; STROKE;

EID: 84934774904     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.06.002     Document Type: Article

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