Intranasal pyrrolidine dithiocarbamate decreases brain inflammatory mediators and provides neuroprotection after brain hypoxia-ischemia in neonatal rats

Experimental Neurology

Volumn 249, Issue , 2013, Pages 74-82

  Wang, Zhi ^a,b   Zhao, Huijuan ^a,b   Peng, Shuling ^b   Zuo, Zhiyi ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Brain hypoxia ischemia; Inflammation; Neonates; Neuroprotection; Pyrrolidine dithiocarbamate

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; NUCLEAR FACTOR; PYRROLIDINE DITHIOCARBAMATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE ACTIVATION; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN TISSUE; CELL NUCLEUS; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; ENCEPHALITIS; FEMALE; HISTOPATHOLOGY; INTRACELLULAR TRANSPORT; LIPID OXIDATION; MALE; NEUROPROTECTION; NEWBORN; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; TREATMENT RESPONSE;

BRAIN HYPOXIA-ISCHEMIA; INFLAMMATION; NEONATES; NEUROPROTECTION; PYRROLIDINE DITHIOCARBAMATE;

ADMINISTRATION, INTRANASAL; ANIMALS; ANIMALS, NEWBORN; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPOXIA-ISCHEMIA, BRAIN; INFLAMMATION MEDIATORS; MALE; NEUROPROTECTIVE AGENTS; PYRROLIDINES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; THIOCARBAMATES;

EID: 84884159849     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.08.006     Document Type: Article

References (33)

1. Allen C.L., Bayraktutan U. Oxidative stress and its role in the pathogenesis of ischaemic stroke. Int. J. Stroke 2009, 4:461-470.
2. Bagger M.A., Bechgaard E. The potential of nasal application for delivery to the central brain-a microdialysis study of fluorescein in rats. Eur. J. Pharm. Sci. 2004, 21:235-242.
3. Bang A.T., Bang R.A., Baitule S.B., Reddy H.M., Deshmukh M.D. Management of birth asphyxia in home deliveries in rural Gadchiroli: the effect of two types of birth attendants and of resuscitating with mouth-to-mouth, tube-mask or bag-mask. J. Perinatol. 2005, 25(Suppl. 1):S82-S91.
4. Chabicovsky M., Prieschl-Grassauer E., Seipelt J., Muster T., Szolar O.H., Hebar A., Doblhoff-Dier O. Pre-clinical safety evaluation of pyrrolidine dithiocarbamate. Basic Clin. Pharmacol. Toxicol. 2010, 107:758-767.
5. Fisher M., Feuerstein G., Howells D.W., Hurn P.D., Kent T.A., Savitz S.I., Lo E.H. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 2009, 40:2244-2250.
6. Giacomini E., Remoli M.E., Scandurra M., Gafa V., Pardini M., Fattorini L., Coccia E.M. Expression of proinflammatory and regulatory cytokines via NF-kappaB and MAPK-dependent and IFN regulatory factor-3-independent mechanisms in human primary monocytes infected by Mycobacterium tuberculosis. Clin. Dev. Immunol. 2011, 2011:841346.
7. Iadecola C., Anrather J. The immunology of stroke: from mechanisms to translation. Nat. Med. 2011, 17:796-808.
8. Kim J.J., Fanselow M.S. Modality-specific retrograde amnesia of fear. Science 1992, 256:675-677.
9. Lakhan S.E., Kirchgessner A., Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J. Transl. Med. 2009, 7:97.
10. Lampl Y., Boaz M., Gilad R., Lorberboym M., Dabby R., Rapoport A., Anca-Hershkowitz M., Sadeh M. Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology 2007, 69:1404-1410.
11. Li L., Zuo Z. Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats. Neurosci. 2009, 164:497-506.
12. Li L., Zuo Z. Glutamate transporter type 3 knockout reduces brain tolerance to focal brain ischemia in mice. J. Cereb. Blood Flow Metab. 2011, 31:1283-1292.
13. Li J., Sheng W., Feng C., Zuo Z. Pyrrolidine dithiocarbamate attenuates brain Abeta increase and improves long-term neurological outcome in rats after transient focal brain ischemia. Neurobiol. Dis. 2012, 45:564-572.
14. Lin D., Zuo Z. Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats. Neuropharmacology 2011, 61:1354-1359.
15. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 1999, 79:1431-1568.
16. Liu S.F., Ye X., Malik A.B.. Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes. Circulation 1999, 100:1330-1337.
17. Lynch J.K., Nelson K.B. Epidemiology of perinatal stroke. Curr. Opin. Pediatr. 2001, 13:499-505.
18. Minino A.M., Heron M.P., Murphy S.L., Kochanek K.D. Deaths: final data for 2004. Natl. Vital Stat. Rep. 2007, 55:1-119.
19. Mongiat L.A., Schinder A.F. Adult neurogenesis and the plasticity of the dentate gyrus network. Eur. J. Neurosci. 2011, 33:1055-1061.
20. Nurmi A., Lindsberg P.J., Koistinaho M., Zhang W., Juettler E., Karjalainen-Lindsberg M.L., Weih F., Frank N., Schwaninger M., Koistinaho J. Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke 2004, 35:987-991.
21. Nurmi A., Vartiainen N., Pihlaja R., Goldsteins G., Yrjanheikki J., Koistinaho J. Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window. J. Neurochem. 2004, 91:755-765.
22. Nurmi A., Goldsteins G., Narvainen J., Pihlaja R., Ahtoniemi T., Grohn O., Koistinaho J. Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia. Free Radic. Biol. Med. 2006, 40:1776-1784.
23. Rota C., Bergamini S., Daneri F., Tomasi A., Virgili F., Iannone A. N-Acetylcysteine negatively modulates nitric oxide production in endotoxin-treated rats through inhibition of NF-kappaB activation. Antioxid. Redox Signal. 2002, 4:221-226.
24. Si X., McManus B.M., Zhang J., Yuan J., Cheung C., Esfandiarei M., Suarez A., Morgan A., Luo H. Pyrrolidine dithiocarbamate reduces coxsackievirus B3 replication through inhibition of the ubiquitin-proteasome pathway. J. Virol. 2005, 79:8014-8023.
25. Sran S.K., Baumann R.J. Outcome of neonatal strokes. Am. J. Dis. Child. 1988, 142:1086-1088.
26. Sreenan C., Bhargave R., Robertson C.M. Cerebral infarction in the term new-born: clinical presentation and long-term outcome. J. Pediatr. 2000, 137:351-355.
27. Tsuji M., Aoo N., Harada K., Sakamoto Y., Akitake Y., Irie K., Mishima K., Ikeda T., Fujiwara M. Sex differences in the benefits of rehabilitative training during adolescence following neonatal hypoxia-ischemia in rats. Exp. Neurol. 2010, 226:285-292.
28. Valentine H.L., Amarnath K., Amarnath V., Valentine W.M. Dietary copper enhances the peripheral myelinopathy produced by oral pyrrolidine dithiocarbamate. Toxicol. Sci. 2006, 89:485-494.
29. World-Health The World Health Report Shaping the Future 2003, World Health Organization.
30. Yamaguchi T., Sano K., Takakura K., Saito I., Shinohara Y., Asano T., Yasuhara H. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group. Stroke 1998, 29:12-17.
31. Zhao P., Zuo Z. Isoflurane preconditioning induces neuroprotection that is inducible nitric oxide synthase-dependent in the neonatal rats. Anesthesiology 2004, 101:695-702.
32. Zhao P., Peng L., Li L., Xu X., Zuo Z. Isoflurane preconditioning improves long-term neurologic outcome after hypoxic-ischemic brain injury in neonatal rats. Anesthesiology 2007, 107:963-970.
33. Zhu C., Xu F., Wang X., Shibata M., Uchiyama Y., Blomgren K., Hagberg H. Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J. Neurochem. 2006, 96:1016-1027.