The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: A human experimental study

Psychopharmacology

Volumn 232, Issue 1, 2015, Pages 295-304

  Kwako, Laura E ^a   George, David T ^a   Schwandt, Melanie L ^a   Spagnolo, Primavera A ^a   Momenan, Reza ^a   Hommer, Daniel W ^a   Diamond, Christine A ^a   Sinha, Rajita ^b   Shaham, Yavin ^c   Heilig, Markus ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Alcohol dependence; Anxiety; Craving; NK1; PTSD; Stress

Indexed keywords

APREPITANT; MORPHOLINE DERIVATIVE; NEUROKININ 1 RECEPTOR ANTAGONIST;

ADULT; ALCOHOLISM; BRAIN; COMORBIDITY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; EMOTION; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTOSTIMULATION; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL; STRESS DISORDERS, POST-TRAUMATIC;

ADULT; ALCOHOLISM; BRAIN; COMORBIDITY; DOUBLE-BLIND METHOD; EMOTIONS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MORPHOLINES; NEUROKININ-1 RECEPTOR ANTAGONISTS; PHOTIC STIMULATION; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84934768193     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3665-4     Document Type: Article

References (57)

1. Acheson DT, Gresack JE, Risbrough VB (2012) Hippocampal dysfunction effects on context memory: possible etiology for posttraumatic stress disorder. Neuropharmacology 62:674-685
2. Adinoff B, Junghanns K, Kiefer F, Krishnan-Sarin S (2005) Suppression of the HPA axis stress-response: implications for relapse. Alcohol Clin Exp Res 29:1351-1355
3. Bergstrom M, Hargreaves RJ, Burns HD et al (2004) Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant. Biol Psychiatry 55:1007-1012
4. Bernstein DP, Fink L, Handelsman L, Foote J, Lovejoy M, Wenzel K, Sapareto E, Ruggiero J (1994) Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am J Psychiatr 151:1132-1136
5. Bohn MJ, Krahn DD, Staehler BA (1995) Development and initial validation of a measure of drinking urges in abstinent alcoholics. Alcohol Clin Exp Res 19:600-606
6. Bossert JM, Marchant NJ, Calu DJ, Shaham Y (2013) The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research. Psychopharmacology (Berl)
7. Brady KT, Waldrop AE, McRae AL, Back SE, Saladin ME, Upadhyaya HP, Anton RF, Randall PK (2006) The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task response. J Stud Alcohol 67:700-706
8. Coffey SF, Stasiewicz PR, Hughes PM, Brimo ML (2006) Trauma-focused imaginal exposure for individuals with comorbid posttraumatic stress disorder and alcohol dependence: revealing mechanisms of alcohol craving in a cue reactivity paradigm. Psychol Addict Behav 20:425-435
9. Coffey SF, Schumacher JA, Stasiewicz PR, Henslee AM, Baillie LE, Landy N (2010) Craving and physiological reactivity to trauma and alcohol cues in posttraumatic stress disorder and alcohol dependence. Exp Clin Psychopharmacol 18:340-349
10. Cooney NL, Litt MD, Morse PA, Bauer LO, Gaupp L (1997) Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men. J Abnorm Psychol 106:243-250
11. Costa PT, McCrae RR (2002) NEO Personality Inventory-Revised (NEO PI-R). APA, Washington, DC
12. Cox RW (1996) AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29:162-173
13. de Kloet CS, Vermetten E, Geuze E, Kavelaars A, Heijnen CJ, Westenberg HG (2006) Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J Psychiatr Res 40:550-567
14. First MB, Spitzer RL, Gibbon M, Williams JBW (1995) Structured clinical interview for DSM-IV patient edition. Biometric Research, New York
15. Foa EB, Riggs DS, Dancu CV, Rothbaum BO (1993) Reliability and validity of a brief instrument for assessing post-traumatic stress disorder. J Trauma Stress 6:459-473
16. Fox HC, Bergquist KL, K-I H, Sinha R (2007) Stress-induced and alcohol cue-induced craving in recently-abstinent alcohol dependent individuals. Alcohol Clin Exp Res 31:395-403
17. Frank R, Hargreaves R (2003) Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov 2:566-580
18. George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt JE, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M (2008) Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science 319:1536-1539
19. Geracioti TD Jr, Carpenter LL, Owens MJ, Baker DG, Ekhator NN, Horn PS, Strawn JR, Sanacora G, Kinkead B, Price LH, Nemeroff CB (2006) Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression. Am J Psychiatry 163:637-643
20. Gillespie CF, Phifer J, Bradley B, Ressler KJ (2009) Risk and resilience: genetic and environmental influences on development of the stress response. Depress Anxiety 26:984-992
21. Higley AE, Crane NA, Spadoni AD, Quello SB, Goodell V, Mason BJ (2011) Craving in response to stress induction in a human laboratory paradigm predicts treatment outcome in alcohol-dependent individuals. Psychopharmacology (Berl) 218:121-129
22. Institute of Medicine. Committee on Treatment of Posttraumatic Stress Disorder (2008) Treatment of posttraumatic stress disorder: an assessment of the evidence. National Academies Press, Washington, DC
23. Keller M, Montgomery S, Ball W, Morrison M, Snavely D, Liu G, Hargreaves R, Hietala J, Lines C, Beebe K, Reines S (2006) Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder. Biol Psychiatry 59:216-223
24. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB (1995) Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 52:1048-1060
25. Kirschbaum C, Pirke KM, Hellhammer DH (1993) The 'Trier Social Stress Test' - a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28:76-81
26. Kramer MS et al (1998) Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281:1640-1645
27. Kwako LE, Schwandt ML, Sells JR, Ramchandani VA, Hommer DW, George DT, Sinha R, Heilig, M (2014) Methods for inducing alcohol craving in individuals with comorbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes. Addict Biol (e-publication ahead of print)
28. Lang PJ, Bradley MM, Cuthbert BN (1999) International affective picture system (IAPS): technical manual and affective ratings. In: The Center for Research in Psychophysiology, University of Florida, Gainesville, FL
29. Liberzon I, Sripada CS (2008) The functional neuroanatomy of PTSD: a critical review. Prog Brain Res 167:151-169
30. Likhtik E, Stujenske JM, Topiwala MA, Harris AZ, Gordon JA (2014) Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety. Nat Neurosci 17:106-113
31. Lovallo WR, Dickensheets SL, Myers DA, Thomas TL, Nixon SJ (2000) Blunted stress cortisol response in abstinent alcoholic and polysubstance-abusing men. Alcohol Clin Exp Res 24:651-658
32. Matsumoto D, Ekman P (1988) Japanese and Caucasian facial expressions of emotion and neutral faces (JACFEE and JACNeuF). Human Interaction Laboratory, University of California, San Francisco, 401
33. McRae AL, Saladin ME, Brady KT, Upadhyaya H, Back SE, Timmerman MA (2006) Stress reactivity: biological and subjective responses to the cold pressor and Trier Social stressors. Hum Psychopharmacol 21:377-385
34. Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL (2007) Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry 62:446-454
35. Mills KL, Teeson M, Back SE, Brady KT, Baker AL, Hopwood S, Sannibale C, Barrett EL, Merz S, Rosenfeld J, Ewer PL (2012) Integrated exposure-based therapy for co-occurring posttraumatic stress disorder and substance dependence: a randomized controlled trial. JAMA 308:690-699
36. Monti PM, Binkoff JA, Abrams DB, Zwick WR, Nirenberg TD, Liepman MR (1987) Reactivity of alcoholics and nonalcoholics to drinking cues. J Abnorm Psychol 96:122-126
37. Pickens CL, Golden SA, Adams-Deutsch T, Nair SG, Shaham Y (2009) Long-lasting incubation of conditioned fear in rats. Biol Psychiatry 65:881-886
38. Quirk GJ, Mueller D (2008) Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology 33:56-72
39. Ratti E, Bellew K, Bettica P, Bryson H, Zamuner S, Archer G, Squassante L, Bye A, Trist D, Krishnan KR, Fernandes S (2011) Results from 2 randomized, double-blind, placebo-controlled studies of the novel NK1 receptor antagonist casopitant in patients with major depressive disorder. J Clin Psychopharmacol 31:727-733
40. Rohsenow DJ, Monti PM, Rubonis AV, Sirota AD, Niaura RS, Colby SM, Wunschel SM, Abrams DB (1994) Cue reactivity as a predictor of drinking among male alcoholics. J Consult Clin Psychol 62:620-626
41. Santa Ana EJ, Saladin ME, Back SE, Waldrop AE, Spratt EG, McRae AL, LaRowe SD, Timmerman MA, Upadhyaya H, Brady KT (2006) PTSD and the HPA axis: differences in response to the cold pressor task among individuals with child vs. adult trauma. Psychoneuroendocrinology 31:501-509
42. Schank JR, Pickens CL, Rowe KE, Cheng K, Thorsell A, Rice KC, Shaham Y, Heilig M (2011) Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429. Psychopharmacology (Berl) 218:111-119
43. Schank JR, Ryabinin AE, Giardino WJ, Ciccocioppo R, Heilig M (2012) Stress-related neuropeptides and addictive behaviors: beyond the usual suspects. Neuron 76:192-208
44. Seo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R (2013) Disrupted ventromedial prefrontal function, alcohol craving, and subsequent relapse risk. JAMA Psychiatry 70:727-739
45. Shin LM, Orr SP, Carson MA, Rauch SL, Macklin ML, Lasko NB, Peters PM, Metzger LJ, Dougherty DD, Cannistraro PA, Alpert NM, Fischman AJ, Pitman RK (2004) Regional cerebral blood flow in the amygdala andmedial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Arch Gen Psychiatry 61:168-176
46. Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL (2005) A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry 62:273-281
47. Sinha R, Fox HC, Hong KA, Bergquist K, Bhagwagar Z, Siedlarz KM (2009) Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology 34:1198-1208
48. Sinha R, Shaham Y, Heilig M (2011a) Translational and reverse translational research on the role of stress in drug craving and relapse. Psychopharmacology (Berl) 218:69-82
49. Sinha R, Fox HC, Hong KI, Hansen J, Tuit K, Kreek MJ (2011b) Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes. Arch Gen Psychiatry 68:942-952
50. Skinner HA (1984) Assessing alcohol-use by patients in treatment. Res Adv Alcohol Drug 8:183-207
51. Sobell MB, Sobell LC, Klajner F, Pavan D, Basian E (1986) The reliability of a timeline method for assessing normal drinker college students' recent drinking history: utility for alcohol research. Addict Behav 11:149-161
52. Spielberger CD, Gorsuch RL, Lushene RE (1970) The state-trait anxiety inventory. Consulting Psychologists Press, Palo Alto
53. Stasiewicz PR, Gulliver SB, Bradizza CM, Rohsenow DJ, Torrisi R, Monti PM (1997) Exposure to negative emotional cues and alcohol cue reactivity with alcoholics: a preliminary investigation. Behav Res Ther 35:1143-1149
54. Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW Jr, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF (2012) Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. J Neurosci 32:7563-7571
55. Weathers FW, Keane TM, Davidson JR (2001) Clinician-administered PTSD scale: a review of the first ten years of research. Depress Anxiety 13:132-156
56. Woodward SH, Kaloupek DG, Streeter CC, Martinez C, Schaer M, Eliez S (2006) Decreased anterior cingulate volume in combat-related PTSD. Biol Psychiatry 59:582-587
57. Zamuner S, Rabiner EA, Fernandes SA, Bani M, Gunn RN, Gomeni R, Ratti E, Cunningham VJ (2012) A pharmacokinetic PET study of NK(1) receptor occupancy. Eur J Nucl Med Mol Imaging 39:226-235