A pharmacokinetic PET study of NK1 receptor occupancy

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 39, Issue 2, 2012, Pages 226-235

  Zamuner, Stefano ^a   Rabiner, Eugenii A ^b   Fernandes, Sofia A ^c   Bani, Massimo ^c   Gunn, Roger N ^b,d   Gomeni, Roberto ^e   Ratti, Emilangelo ^c   Cunningham, Vincent J ^b,f  

^a GLAXOSMITHKLINE   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c GSK   (Italy)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e GLAXOSMITHKLINE   (United States)

^f UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Kinetic modelling; NK 1 receptors; Pharmacokinetics; Population approach; Positron emission tomography

Indexed keywords

CASOPITANT; VOFOPITANT;

AGED; ANXIETY DISORDER; ARTERIAL BLOOD; ARTICLE; CONTROLLED STUDY; DEPRESSION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; RECEPTOR BINDING; RECEPTOR OCCUPANCY; SINGLE DRUG DOSE; VENOUS BLOOD;

ADMINISTRATION, ORAL; ADULT; AGED; ANTIEMETICS; CARBON ISOTOPES; DEPRESSION; HUMANS; KINETICS; MALE; MIDDLE AGED; PIPERAZINES; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, NEUROKININ-1; TETRAZOLES; TIME FACTORS;

EID: 84859633178     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-011-1954-2     Document Type: Article

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