Salt-sensitive hypertension: Perspectives on intrarenal mechanisms

Current Hypertension Reviews

Volumn 11, Issue 1, 2015, Pages 38-48

  Majid, Dewan S A ^a   Prieto, Minolfa C ^a   Navar, Luis Gabriel ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin II; Angiotensinogen; Inflammatory cytokines; Intrarenal renin angiotensin system; Oxidative stress; Peroxynitrite; Tumor necrosis factor alpha

Indexed keywords

ANGIOTENSIN II; INTERLEUKIN 10; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; ANGIOTENSIN DERIVATIVE; SODIUM INTAKE;

ARTICLE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CELL PROLIFERATION; DOWN REGULATION; HUMAN; HYPERTENSION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SALT INTAKE; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR RESISTANCE; ANIMAL; BIOLOGICAL MODEL; BLOOD PRESSURE; DRUG EFFECTS; KIDNEY; KIDNEY PROXIMAL TUBULE; PATHOPHYSIOLOGY; PHARMACOLOGY; PHYSIOLOGY; SODIUM INTAKE; URINE;

ANGIOTENSIN II; ANGIOTENSINS; ANIMALS; BLOOD PRESSURE; HUMANS; HYPERTENSION; KIDNEY; KIDNEY TUBULES, PROXIMAL; MODELS, BIOLOGICAL; OXIDATIVE STRESS; RENIN-ANGIOTENSIN SYSTEM; SODIUM, DIETARY;

EID: 84934757499     PISSN: 15734021     EISSN: 18756506     Source Type: Journal    
DOI: 10.2174/1573402111666150530203858     Document Type: Article

References (156)

1. Ando K, Fujita T. Pathophysiology of salt sensitivity hypertension. Ann Med 2012; 44(Suppl 1): S119-26.
2. Frisoli TM, Schmieder RE, Grodzicki T, Messerli FH. Salt and hypertension: is salt dietary reduction worth the effort? Am J Med 2012; 125: 433-9.
3. Ha SK. Dietary salt intake and hypertension. Electrolyte Blood Pressure 2014; 12: 7-18.
4. Whelton PK, Appel LJ, Sacco RL, et al. Sodium, blood pressure, and cardiovascular disease: further evidence supporting the American Heart Association sodium reduction recommendations. Circulation 2012; 126: 2880-9.
5. de Wardener HE, He FJ, MacGregor GA. Plasma sodium and hypertension. Kidney Int 2004; 66: 2454-66.
6. Katori M, Majima M. A missing link between a high salt intake and blood pressure increase. J Pharmacol Sci 2006; 100: 370-90.
7. O'Donnell MJ, Mente A, Smyth A, Yusuf S. Salt intake and cardiovascular disease: why are the data inconsistent? Eur Heart J 2013; 34: 1034-40.
8. Kopkan L, Hess A, Huskova Z, Cervenka L, Navar LG, Majid DS. High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity. Am J Physiol Renal Physiol 2010; 299: F656-F63.
9. Hauck C, Frishman WH. Systemic hypertension: the roles of salt, vascular Na+/K+ ATPase and the endogenous glycosides, ouabain and marinobufagenin. Cardiol Rev 2012; 20: 130-8.
10. Blaustein MP, Leenen FH, Chen L, et al. How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol 2012; 302: H1031-H49.
11. Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 2007; 59: 251-87.
12. Luke RG. Essential Hypertension: A renal disease? A review and update of the evidence. Hypertension 1993; 21: 380-90.
13. Navar LG. The kidney in blood pressure regulation and development of hypertension. Med Clin North Am 1997; 81: 1165-98.
14. Gross V, Roman RJ, Cowley Jr AW. Abnormal pressure-natriuresis in transgenic renin gene rats. J Hypertens 1994; 12: 1029-34.
15. Navar LG, Hamm LL. The kidney in blood pressure regulation. In: Wilcox CS, editor. Atlas of Diseases of the Kidney Hypertension and the Kidney. Philadelphia: Current Medicine, Inc.; 1999. p. 1-22.
16. Greene AS, Yu ZY, Roman RJ, Cowley AW. Role of blood volume expansion in Dahl rat model of hypertension. Am J Physiol 1990; 258: H508-H14.
17. Rettig R, Folberth C, Stauss H, Kopf D, Waldherr R, Unger T. Role of the kidney in primary hypertension: a renal transplantation study in rats. Am J Physiol 1990; 258: F606-F11.
18. Roman RJ, Cowley AW. Abnormal pressure-diuresis-natriuresis response in spontaneously hypertensive rats. Am J Physiol 1985; 248: F199-F205.
19. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104: 545-56.
20. Mune T, Rogerson FM, Nikkila H, Agarwal AK, White PC. Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet 1995; 10: 394-9.
21. Shimkets RA, Warnock DG, Bositis CM, et al. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 1994; 79: 407-14.
22. Cowley Jr AW. Long-term control of arterial blood pressure. Physiol Rev 1992; 72: 231-300.
23. Guyton AC, Hall JE, Coleman TG, Manning Jr RD, Norman Jr RA. The dominant role of the kidneys in long-term arterial pressure regulation in normal and hypertensive states. In: Laragh JH, Brenner BM, editors. Hypertension: Pathophysiology, Diagnosis, and Management. New York: Raven Press, Ltd.; 1995. p. 1311-26.
24. Ritz E, Fliser D, Siebels M. Pathophysiology of hypertensive renal damage. Am J Hypertens 1993; 6: 241S-4S.
25. Navar LG. The role of the kidneys in hypertension. J Clin Hypertens 2005; 7: 542-9.
26. Sigmon DH, Beierwaltes WH. Renal nitric oxide and angiotensin II interaction in renovascular hypertension. Hypertension 1993; 22: 237-42.
27. Navar LG, Zou L, Von Thun AM, Wang CT, Imig JD, Mitchell KD. Unraveling the mystery of Goldblatt Hypertension. News Physiol Sci 1998; 13: 170-6.
28. Inscho EW, Cook AK, Clarke A, Zhang S, Guan Z. P2X1 receptormediated vasoconstriction of afferent arterioles in angiotensin IIinfused hypertensive rats fed a high-salt diet. Hypertension 2011; 57: 780-7.
29. Franco M, Tapia E, Bautista R, et al. Impaired pressure natriuresis resulting in salt-sensitive hypertension is caused by tubulointerstitial immune cell infiltration in the kidney. Am J Physiol Renal Physiol 2013; 304: F982-F90.
30. Nonaka-Sarukawa M, Okada T, Ito T, et al. Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats. J Gene Med 2008; 10: 368-74.
31. Numanami H, Nelson DK, Hoyt JC, et al. Peroxynitrite enhances interleukin-10 reduction in the release of neutrophil chemotactic activity. Am J Respir Cell Mol Biol 2003; 29: 239-44.
32. Rodriguez-Iturbe B, Vaziri ND, Herrera-Acosta J, Johnson RJ. Oxidative stress, renal infiltration of immune cells, and saltsensitive hypertension: all for one and one for all. Am J Physiol Renal Physiol 2004; 286: F606-F16.
33. Navar LG. The intrarenal renin-angiotensin system in hypertension. Kidney Int 2004; 65: 1522-32.
34. Navar LG, Kobori H, Prieto MC, Gonzalez-Villalobos RA. Intratubular renin-angiotensin system in hypertension. Hypertension 2011; 57: 355-62.
35. Lalouel JM, Rohrwasser A, Terreros D, Morgan T, Ward K. Angiotensinogen in essential hypertension: From genetics to nephrology. J Am Soc Nephrol 2001; 12: 606-15.
36. Graciano ML, Mouton CR, Patterson ME, Seth DM, Mullins JJ, Mitchell KD. Renal vascular and tubulointerstitial inflammation and proliferation in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension. Am J Physiol Renal Physiol 2007; 292: F1858-F66.
37. Makhanova N, Hagaman J, Kim HS, Smithies O. Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension 2008; 51: 134-40.
38. Milani CJ, Kobori H, Mullins JJ, Mitchell KD. Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension. Am J Med Sci 2010; 340: 389-94.
39. Howard CG, Mitchell KD. Renal functional responses to selective intrarenal renin inhibition in Cyp1a1-Ren2 transgenic rats with ANG II-dependent malignant hypertension. Am J Physiol Renal Physiol 2012; 302: F52-F9.
40. Mitchell KD, Mullins JJ. ANG II dependence of tubuloglomerular feedback responsiveness in hypertensive ren-2 transgenic rats. Am J Physiol Renal Physiol 1995; 268: F821-F8.
41. Sigmund CD, Jones CA, Kane CM, Wu C, Lang JA, Gross KW. Regulated tissue-and cell-specific expression of the human renin gene in transgenic mice. Circulation Res 1992; 70: 1070-9.
42. Yang G, Sigmund CD. Developmental expression of human angiotensinogen in transgenic mice. Am J Physiol Renal Physiol 1998; 274: F932-F9.
43. Caron KM, James LR, Kim HS, et al. A genetically clamped renin transgene for the induction of hypertension. Proc Natl Acad Sci USA 2002; 99: 8248-52.
44. Kobori H, Ozawa Y, Satou R, et al. Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in genetargeted mice. Am J Physiol Renal Physiol 2007; 293: F938-F45.
45. Ding Y, Davisson RL, Hardy DO, et al. The kidney androgenregulated protein promoter confers renal proximal tubule cellspecific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem 1997; 272: 28142-8.
46. Friis UG, Madsen K, Stubbe J, et al. Regulation of renin secretion by renal juxtaglomerular cells. Pflugers Arch 2013; 465: 25-37.
47. Peti-Peterdi J, Gevorgyan H, Lam L, Riquier-Brison A. Metabolic control of renin secretion. Pflugers Arch 2013; 465: 53-8.
48. Schnermann J, Briggs JP. Tubular control of renin synthesis and secretion. Pflugers Arch 2013; 465: 39-51.
49. Peti-Peterdi J, Harris RC. Macula densa sensing and signaling mechanisms of renin release. J Am Soc Nephrol 2010; 21: 1093-6.
50. Fox J, Guan S, Hymel AA, Navar LG. Dietary Na and ACE inhibition effects on renal tissue angiotensin I and II and ACE activity in rats. Am J Physiol Renal Physiol 1992; 262: F902-F9.
51. Imig JD, Navar GL, Zou LX, et al. Renal endosomes contain angiotensin peptides, converting enzyme, and AT 1A receptors. Am J Physiol Renal Physiol 1999; 277: F303-F11.
52. Ingert C, Grima M, Coquard C, Barthelmebs M, Imbs JL. Effects of dietary salt changes on renal renin-angiotensin system in rats. Am J Physiol Renal Physiol 2002; 283: F995-F1002.
53. Shao W, Seth DM, Prieto MC, Kobori H, Navar LG. Activation of the renin-angiotensin system by a low-salt diet does not augment intratubular angiotensinogen and angiotensin II in rats. Am J Physiol Renal Physiol 2013; 304: F505-F14.
54. Heer M, Baisch F, Kropp J, Gerzer R, Drummer C. High dietary sodium chloride consumption may not induce body fluid retention in humans. Am J Physiol Renal Physiol 2000; 278: F585-F95.
55. Fujita T. Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systems. J Am Soc Nephrol 2014; 25: 1148-55.
56. Singh I, Grams M, Wang WH, et al. Coordinate regulation of renal expression of nitric oxide synthase, renin, and angiotensinogen mRNA by dietary salt. Am J Physiol Renal Physiol 1996; 270: F1027-F37.
57. Cannon WB. The wisdom of the body. New York,: W. W. Norton & company; 1932. p. 217-29.
58. Kobori H, Nishiyama A, Abe Y, Navar LG. Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet. Hypertension 2003; 41: 592-7.
59. Susic D, Frohlich ED, Kobori H, Shao W, Seth D, Navar LG. Saltinduced renal injury in SHRs is mediated by AT1 receptor activation. J Hypertens 2011; 29: 716-23.
60. Weinberger MH. Salt sensitivity of blood pressure in humans. Hypertension 1996; 27: 481-90.
61. Titze J, Machnik A. Sodium sensing in the interstitium and relationship to hypertension. Curr Opin Nephrol Hypertens 2010; 19: 385-92.
62. Schmidlin O, Forman A, Leone A, Sebastian A, Morris RC, Jr. Salt sensitivity in blacks: evidence that the initial pressor effect of NaCl involves inhibition of vasodilatation by asymmetrical dimethylarginine. Hypertension 2011; 58: 380-5.
63. Ying WZ, Sanders PW. Dietary salt intake activates MAP kinases in the rat kidney. FASEB J 2002; 16: 1683-4.
64. Chandramohan G, Bai Y, Norris K, Rodriguez-Iturbe B, Vaziri ND. Effects of dietary salt on intrarenal angiotensin system, NAD(P)H oxidase, COX-2, MCP-1 and PAI-1 expressions and NFkappaB activity in salt-sensitive and-resistant rat kidneys. Am J Nephrol 2008; 28: 158-67.
65. Ingelfinger JR, Pratt RE, Ellison K, Dzau VJ. Sodium regulation of angiotensinogen mRNA expression in rat kidney cortex and medulla. J Clin Invest 1986; 78: 1311-5.
66. Maitland K, Bridges L, Davis WP, Loscalzo J, Pointer MA. Different effects of angiotensin receptor blockade on end-organ damage in salt-dependent and salt-independent hypertension. Circulation 2006; 114: 905-11.
67. Matavelli LC, Zhou X, Varagic J, Susic D, Frohlich ED. Salt loading produces severe renal hemodynamic dysfunction independent of arterial pressure in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2007; 292: H814-H9.
68. Susic D, Zhou X, Frohlich ED. Angiotensin blockade prevents saltinduced injury of the renal circulation in spontaneously hypertensive rats. Am J Nephrol 2009; 29: 639-45.
69. Varagic J, Frohlich ED, Susic D, et al. AT1 receptor antagonism attenuates target organ effects of salt excess in SHRs without affecting pressure. Am J Physiol Heart Circ Physiol 2008; 294: H853-8.
70. Lara LS, McCormack M, Semprum-Prieto LC, et al. AT1 receptormediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG II-salt hypertension. Am J Physiol Renal Physiol 2012; 302: F85-F94.
71. Franco M, Martinez F, Quiroz Y, et al. Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol 2007; 293: R251-6.
72. Mattson DL. Infiltrating immune cells in the kidney in saltsensitive hypertension and renal injury. Am J Physiol Renal Physiol 2014; 307: F499-F508.
73. Kobori H, Harrison-Bernard LM, Navar LG. Enhancement of angiotensinogen expression in angiotensin II-dependent hypertension. Hypertension 2001; 37: 1329-35.
74. Wang CT, Chin SY, Navar LG. Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats. Am J Physiol Renal Physiol 2000; 279: F319-F25.
75. Zou LX, Imig JD, Von Thun AM, Hymel A, Ono H, Navar LG. Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats. Hypertension 1996; 28: 669-77.
76. Border WA, Noble N. Maximizing hemodynamic-independent effects of angiotensin II antagonists in fibrotic diseases. Semin Nephrol 2001; 21: 563-72.
77. Ozawa Y, Kobori H, Suzaki Y, Navar LG. Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions. Am J Physiol Renal Physiol 2007; 292: F330-F9.
78. Franco M, Tapia E, Santamaria J, et al. Renal cortical vasoconstriction contributes to development of salt-sensitive hypertension after angiotensin II exposure. J Am Soc Nephrol 2001; 12: 2263-71.
79. Howard LL, Patterson ME, Mullins JJ, Mitchell KD. Salt-sensitive hypertension develops after transient induction of ANG IIdependent hypertension in Cyp1a1-Ren2 transgenic rats. Am J Physiol Renal Physiol 2005; 288: F810-F5.
80. Lombardi D, Gordon KL, Polinsky P, Suga S, Schwartz SM, Johnson RJ. Salt-sensitive hypertension develops after short-term exposure to angiotensin II. Hypertension 1999; 33: 1013-9.
81. Rodriguez-Iturbe B, Pons H, Quiroz Y, et al. Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure. Kidney Int 2001; 59: 2222-32.
82. Kobori H, Nishiyama A, Harrison-Bernard LM, Navar LG. Urinary angiotensinogen as an indicator of intrarenal Angiotensin status in hypertension. Hypertension 2003; 41: 42-9.
83. Kobori H, Urushihara M, Xu JH, Berenson GS, Navar LG. Urinary angiotensinogen is correlated with blood pressure in men (Bogalusa Heart Study). J Hypertens 2010; 28: 1422-8.
84. Williams DE, Prieto MC, Mullins JJ, Navar LG, Mitchell KD. AT1 receptor blockade prevents the increase in blood pressure and the augmentation of intrarenal ANG II levels in hypertensive Cyp1a1-Ren2 transgenic rats fed with a high-salt diet. Am J Med Sci 2010; 339: 356-61.
85. Kobori H, Harrison-Bernard LM, Navar LG. Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production. Kidney Int 2002; 61: 579-85.
86. Mills KT, Kobori H, Hamm LL, et al. Increased urinary excretion of angiotensinogen is associated with risk of chronic kidney disease. Nephrol Dial Transplant 2012; 27: 3176-81.
87. Navar LG. Translational studies on augmentation of intratubular renin-angiotensin system in hypertension. Kidney Int Suppl 2013; 3: 321-5.
88. Michel FS, Norton GR, Maseko MJ, Majane OH, Sareli P, Woodiwiss AJ. Urinary angiotensinogen excretion is associated with blood pressure independent of the circulating renin-angiotensin system in a group of african ancestry. Hypertension 2014; 64: 149-56.
89. Kobori H, Ohashi N, Katsurada A, et al. Urinary angiotensinogen as a potential biomarker of severity of chronic kidney diseases. J Am Soc Hypertens 2008; 2: 349-54.
90. Rebholz CM, Chen J, Zhao Q, et al. Urine angiotensinogen and salt-sensitivity and potassium-sensitivity of blood pressure. J Hypertens 2015.
91. Kobori H, Alper AB, Jr., Shenava R, et al. Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients. Hypertension 2009; 53: 344-50.
92. Prieto-Carrasquero MC, Harrison-Bernard LM, Kobori H, et al. Enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. Hypertension 2004; 44: 223-9.
93. Prieto-Carrasquero MC, Kobori H, Ozawa Y, Gutierrez A, Seth D, Navar LG. AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats Am J Physiol Renal Physiol 2005; 289: F632-F7.
94. Rohrwasser A, Ishigami T, Gociman B, et al. Renin and kallikrein in connecting tubule of mouse. Kidney Int 2003; 64: 2155-62.
95. Navar LG, Prieto-Carrasquero MC, Kobori H. Molecular aspects of the renal renin-angiotensin system. In: Re R, DiPette DJ, Schiffrin EL, Sowers JR, editors. Molecular Mechanisms in Hypertension: Taylor & Francis Group; 2006. p. 3-14.
96. Prieto MC, Gonzalez AA, Satou R, Kobori H, Navar LG. Renin-Angiotensin System. In: Kastin AJ, editor. Handbook of Biologically Active Peptides: Elsevier, Inc; 2013. p. 1499-506.
97. Prieto MC, Gonzalez AA, Navar LG. Evolving concepts on regulation and function of renin in distal nephron. Pflugers Arch 2013; 465: 121-32.
98. Wilcox CS, Welch WJ, Snellen H. Thromboxane mediates renal hemodynamic response to infused angiotensin II. Kidney Int 1991; 40: 1090-997.
99. Laursen JB, Rajagopalan S, Galis Z, Tarpey M, Freeman BA, Harrison DG. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Hypertension 1997; 95: 588-93.
100. Pollock DM. Renal endothelin in hypertension. Curr Opin Nephrol Hypertens 2000; 9: 157-64.
101. Navar LG, Harrison-Bernard LM, Nishiyama A, Kobori H. Regulation of intrarenal angiotensin II in hypertension. Hypertension 2002; 39: 316-22.
102. Graciano ML, Mitchell KD. Imatinib ameliorates renal morphological changes in Cyp1a1-Ren2 transgenic rats with inducible ANG IIdependent malignant hypertension. Am J Physiol Renal Physiol 2012; 302: F60-F9.
103. Peters H, Border WA, Noble NA. Targeting TGF-á overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade. Kidney Int 1998; 54: 1570-80.
104. Chua CC, Hamdy RC, Chua BH. Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells. Biochim Biophys Acta 1998; 1401: 187-94.
105. Dahlfors G, Chen Y, Wasteson M, Arnqvist HJ. PDGF-BB-induced DNA synthesis is delayed by angiotensin II in vascular smooth muscle cells. Am J Physiol 1998; 274: H1742-H8.
106. Wolf G. The renin-angiotensin system and progression of renal diseases. Hamburg: Karger; 2002.
107. Harrison DG, Guzik TJ, Lob HE, et al. Inflammation, immunity, and hypertension. Hypertension 2011; 57: 132-40.
108. Heitzer T, Wenzel U, Hink U, et al. Increased NAD(P)H oxidasemediated superoxide production in renovascular hypertension: evidence for an involvement of protein kinase C. Kidney Int 1999; 55: 252-60.
109. Cosentino F, Patton S, d'Uscio LV, et al. Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. J Clin Invest 1998; 101: 1530-7.
110. Fukui T, Ishizaka N, Rajagopalan S, et al. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circulation Res 1997; 80: 45-51.
111. Patterson ME, Mouton CR, Mullins JJ, Mitchell KD. Interactive effects of superoxide anion and nitric oxide on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertension. Am J Physiol Renal Physiol 2005; 289: F754-F9.
112. Kopkan L, Castillo A, Navar LG, Majid DS. Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats. Am J Physiol Renal Physiol 2006; 290: F80-F6.
113. Kranzhofer R, Browatzki M, Schmidt J, Kubler W. Angiotensin II activates the proinflammatory transcription factor nuclear factorkappaB in human monocytes. Biochem Biophys Res Commun 1999; 257: 826-8.
114. Tayeh MA, Scicli AG. Angiotensin II and bradykinin regulate the expression of P-selectin on the surface of endothelial cells in culture. Proc Assoc Am Physicians 1998; 110: 412-21.
115. Braun-Dullaeus RC, Mann MJ, Ziegler A, von der Leyen HE, Dzau VJ. A novel role for the cyclin-dependent kinase inhibitor p27 (Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. J Clin Invest 1999; 104: 815-23.
116. Fukai T, Siegfried MR, Ushio-Fukai M, Griendling KK, Harrison DG. Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension. Circulation Res 1999; 85: 23-8.
117. Satou R, Gonzalez-Villalobos RA, Miyata K, et al. Costimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells. Am J Physiol Renal Physiol 2008; 295: F283-F9.
118. Satou R, Gonzalez-Villalobos RA, Miyata K, et al. IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells. Mol Cell Endocrinol 2009; 311: 24-31.
119. Brands MW, Banes-Berceli AK, Inscho EW, Al Azawi H, Allen AJ, Labazi H. Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation. Hypertension 2010; 56: 879-84.
120. Kobori H, Urushihara M. Augmented intrarenal and urinary angiotensinogen in hypertension and chronic kidney disease. Pflugers Arch 2013; 465: 3-12.
121. Urushihara M, Kobori H. Angiotensinogen Expression Is Enhanced in the Progression of Glomerular Disease. Int J Clin Med 2011; 2: 378-87.
122. Ferreri NR, Zhao Y, Takizawa H, McGiff JC. Tumor necrosis factor-à-angiotensin interactions and regulation of blood pressure. J Hypertension 1997; 15: 1481-4.
123. Guzik TJ, Hoch NE, Brown KA, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 2007; 204: 2449-60.
124. Sriramula S, Haque M, Majid DS, Francis J. Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy. Hypertension 2008; 51: 1345-51.
125. Majid DS, Kopkan L. Nitric oxide and superoxide interactions in the kidney and their implication in the development of salt-sensitive hypertension. Clin Exp Pharmacol Physiol 2007; 34: 946-52.
126. Majid DS, Nishiyama A. Nitric oxide blockade enhances renal responses to superoxide dismutase inhibition in dogs. Hypertension 2002; 39: 293-7.
127. Majid DS, Nishiyama A, Jackson KE, Castillo A. Inhibition of nitric oxide synthase enhances superoxide activity in canine kidney. Am J Physiol Regul Integr Comp Physiol 2004; 287: R27-R32.
128. Majid DS, Nishiyama A, Jackson KE, Castillo A. Superoxide scavenging attenuates renal responses to ANG II during nitric oxide synthase inhibition in anesthetized dogs. Am J Physiol Renal Physiol 2005; 288: F412-F9.
129. Haque MZ, Majid DS. Assessment of Renal Functional Phenotype in Mice Lacking gp91PHOX Subunit of NAD(P)H Oxidase. Hypertension 2004; 43: 335-40.
130. Haque MZ, Majid DS. Reduced renal responses to nitric oxide synthase inhibition in mice lacking the gene for gp91phox subunit of NAD(P)H oxidase. Am J Physiol Renal Physiol 2008; 295: F758-64.
131. Kopkan L, Majid DS. Superoxide contributes to development of salt sensitivity and hypertension induced by nitric oxide deficiency. Hypertension 2005; 46: 1026-31.
132. Kopkan L, Majid DS. Enhanced superoxide activity modulates renal function in NO-deficient hypertensive rats. Hypertension 2006; 47: 568-72.
133. Welch WJ, Tojo A, Wilcox CS. Roles of NO and oxygen radicals in tubuloglomerular feedback in SHR. Am J Physiol Renal Physiol 2000; 278: F769-76.
134. Nakamura T, Kataoka K, Tokutomi Y, et al. Novel mechanism of salt-induced glomerular injury: critical role of eNOS and angiotensin II. J Hypertens 2011; 29: 1528-35.
135. Whiting C, Castillo A, Haque MZ, Majid DS. Protective role of the endothelial isoform of nitric oxide synthase in ANG II-induced inflammatory responses in the kidney. Am J Physiol Renal Physiol 2013; 305: F1031-F41.
136. Castillo A, Islam MT, Prieto MC, Majid DS. Tumor necrosis factoralpha receptor type 1, not type 2, mediates its acute responses in the kidney. Am J Physiol Renal Physiol 2012; 302: F1650-F7.
137. Herrera M, Ortiz PA, Garvin JL. Regulation of thick ascending limb transport: role of nitric oxide. Am J Physiol Renal Physiol 2006; 290: F1279-F84.
138. Ying WZ, Sanders PW. Dietary salt enhances glomerular endothelial nitric oxide synthase through TGF-á1. Am J Physiol Renal Physiol 1998; 275: F18-F24.
139. Matavelli LC, Kadowitz PJ, Navar LG, Majid DS. Renal hemodynamic and excretory responses to intra-arterial infusion of peroxynitrite in anesthetized rats. Am J Physiol Renal Physiol 2009; 296: F170-F6.
140. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitriteinduced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys 1991; 288: 481-7.
141. Dutta UK, Lane J, Roberts LJ, 2nd, Majid DS. Superoxide formation and interaction with nitric oxide modulate systemic arterial pressure and renal function in salt-depleted dogs. Exp Biol Med 2006; 231: 269-76.
142. Reckelhoff JF, Romero JC. Role of oxidative stress in angiotensininduced hypertension. Am J Physiol Regul Integr Comp Physiol 2003; 284: R893-R912.
143. Kobori H, Nishiyama A. Effects of tempol on renal angiotensinogen production in Dahl salt-sensitive rats. Biochem Biophys Res Commun 2004; 315: 746-50.
144. Miyata K, Ohashi N, Suzaki Y, Katsurada A, Kobori H. Sequential activation of the reactive oxygen species/angiotensinogen/reninangiotensin system axis in renal injury of type 2 diabetic rats. Clin Exp Pharmacol Physiol 2008; 35: 922-7.
145. Saeed A, Dibona GF, Marcussen N, Guron G. High-NaCl intake impairs dynamic autoregulation of renal blood flow in ANG IIinfused rats. Am J Physiol Regul Integr Comp Physiol 2010; 299: R1142-9.
146. Semprun-Prieto LC, Sukhanov S, Yoshida T, et al. Angiotensin II induced catabolic effect and muscle atrophy are redox dependent. Biochem Biophys Res Commun 2011; 409: 217-21.
147. Ortiz RM, Kobori H, Conte D, Navar LG. Angiotensin II-induced reduction in body mass is Ang II receptor mediated in association with elevated corticosterone. Growth Horm IGF Res 2010; 20: 282-8.
148. Mitchell KD, Bagatell SJ, Miller CS, Mouton CR, Seth DM, Mullins JJ. Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats. J Renin Angiotensin Aldosterone Syst 2006; 7: 74-86.
149. Huskova Z, Vanourkova Z, Erbanova M, et al. Inappropriately high circulating and intrarenal angiotensin II levels during dietary salt loading exacerbate hypertension in Cyp1a1-Ren-2 transgenic rats. J Hypertens 2010; 28: 495-509.
150. Das UN. Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period. J Assoc Physicians India 2006; 54: 133-42.
151. Singh P, Bahrami L, Castillo A, Majid DS. TNF-alpha type 2 receptor mediates renal inflammatory response to chronic angiotensin II administration with high salt intake in mice. Am J Physiol Renal Physiol 2013; 304: F991-F9.
152. Kreydiyyeh SI, Markossian S. Tumor necrosis factor alpha downregulates the Na+-K+ ATPase and the Na+-K+2Cl-cotransporter in the kidney cortex and medulla. Cytokine 2006; 33: 138-44.
153. Shahid M, Francis J, Majid DS. Tumor necrosis factor-alpha induces renal vasoconstriction as well as natriuresis in mice. Am J Physiol Renal Physiol 2008; 295: F1836-F44.
154. Al-Lamki RS, Mayadas TN. TNF receptors: signaling pathways and contribution to renal dysfunction. Kidney Int 2015; 87(2): 281-96.
155. Chen CC, Pedraza PL, Hao S, Stier CT, Ferreri NR. TNFR1-deficient mice display altered blood pressure and renal responses to ANG II infusion. Am J Physiol Renal Physiol 2010; 299: F1141-F50.
156. Singh P, Castillo A, Majid DS. Decrease in IL-10 and increase in TNF-alpha levels in renal tissues during systemic inhibition of nitric oxide in anesthetized mice. Physiol Rep 2014; 2: e00228.