Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats

Journal of Gene Medicine

Volumn 10, Issue 4, 2008, Pages 368-374

  Nonaka Sarukawa, Mutsuko ^a   Okada, Takashi ^a   Ito, Takayuki ^a   Yamamoto, Keiji ^a   Yoshioka, Toru ^b   Nomoto, Tatsuya ^a   Hojo, Yukihiro ^a   Shimpo, Masahisa ^a   Urabe, Masashi ^a   Mizukami, Hiroaki ^a   Kume, Akihiro ^a   Ikeda, Uichi ^b   Shimada, Kazuyuki ^a   Ozawa, Keiya ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

AAV vector; Gene therapy; Hypertension; Inflammation; Interleukin 10

Indexed keywords

ATRIAL NATRIURETIC FACTOR; ENHANCED GREEN FLUORESCENT PROTEIN; INTERLEUKIN 10; PARVOVIRUS VECTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL INFILTRATION; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; ECHOCARDIOGRAPHY; FIBROSIS; GLOMERULUS FILTRATION RATE; HEART DISEASE; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART WEIGHT; HIGH SODIUM INTAKE; HISTOPATHOLOGY; HYPERTENSION; INFLAMMATION; INFLAMMATORY CELL; KIDNEY DYSFUNCTION; NONHUMAN; ORGAN INJURY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; SYSTOLIC BLOOD PRESSURE;

ANIMALS; DEPENDOVIRUS; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; INTERLEUKIN-10; MALE; RATS; RATS, INBRED DAHL; VENTRICULAR REMODELING;

ADENO-ASSOCIATED VIRUS; ANIMALIA; RATTUS;

EID: 42049114321     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1166     Document Type: Article

References (31)

1. Levine B, Kalman J, Mayer L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990; 323: 236-241.
2. Vasan RS, Sullivan LM, Roubenoff R, et al. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation 2003; 107: 1486-1491.
3. Mattson DL, James L, Berdan EA, et al. Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension 2006; 48: 149-156.
4. Tian N, Gu JW, Jordan S, et al. Immune suppression prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension. Am J Physiol Heart Circ Physiol 2007; 292: H1018-H1025.
5. Chung ES, Packer M, Lo KH, et al. Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial. Circulation 2003; 107: 3133-3140.
6. Mann DL, McMurray JJ, Packer M, et al. Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL). Circulation 2004; 109: 1594-1602.
7. Elenkov IJ, Chrousos GP. Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann NY Acad Sci 2002; 966: 290-303.
8. Cattaruzza M, Slodowski W, Stojakovic M, et al. Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells. J Biol Chem 2003; 278: 37874-37880.
9. Selzman CH, McIntyre RC, Jr., Shames BD, et al. Interleukin-10 inhibits human vascular smooth muscle proliferation. J Mol Cell Cardiol 1998; 30: 889-896.
10. Ito T, Okada T, Miyashita H, et al. Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats. Circ Res 2007; 101: 734-741.
11. Nishio R, Matsumori A, Shioi T, et al. Treatment of experimental viral myocarditis with interleukin-10. Circulation 1999; 100: 1102-1108.
12. Palaniyandi SS, Watanabe K, Ma M, et al. Inhibition of mast cells by interleukin-10 gene transfer contributes to protection against acute myocarditis in rats. Eur J Immunol 2004; 34: 3508-3515.
13. Kihara Y, Sasayama S. Transition from compensatory hypertrophy to dilated failing left ventricle in Dahl-lwai salt-sensitive rats. Am J Hypertens 1997; 10: 78S-82S.
14. Okada T, Shimazaki K, Nomoto T, et al. Adeno-associated viral vector-mediated gene therapy of ischemia-induced neuronal death. Methods Enzymol 2002; 346: 378-393.
15. Matsushita T, Elliger S, Elliger C, et al. Adeno-associated virus vectors can be efficiently produced without helper virus. Gene Ther 1998; 5: 938-945.
16. Okada T, Nomoto T, Yoshioka T, et al. Large-scale production of recombinant viruses by use of a large culture vessel with active gassing. Hum Gene Ther 2005; 16: 1212-1218.
17. Nakahara T, Hashimoto K, Hirano M, et al. Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression. Am J Physiol Endocrinol Metab 2003; 285: E1273-1281.
18. Ueno S, Ohki R, Hashimoto T, et al. DNA microarray analysis of in vivo progression mechanism of heart failure. Biochem Biophys Res Commun 2003; 307: 771-777.
19. Stumpf C, Lehner C, Yilmaz A, et al. Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure. Clin Sci (Lond) 2003; 105: 45-50.
20. Ito T, Ikeda U. Inflammatory cytokines and cardiovascular disease. Curr Drug Targets Inflamm Allergy 2003; 2: 257-265.
21. Yoshioka T, Okada T, Maeda Y, et al. Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice. Gene Ther 2004; 11: 1772-1779.
22. Hauck B, Chen L, Xiao W. Generation and characterization of chimeric recombinant AAV vectors. Mol Ther 2003; 7: 419-425.
23. Ito T, Okada T, Mimuro J, et al. Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. Hypertension 2007; 50: 531-536.
24. Mu W, Ouyang X, Agarwal A, et al. IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J Am Soc Nephrol 2005; 16: 3651-3660.
25. Saito Y, Nakao K, Arai H, et al. Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart. J Clin Invest 1989; 83: 298-305.
26. de Boer RA, Henning RH, Suurmeijer AJ, et al. Early expression of natriuretic peptides and SERCA in mild heart failure: association with severity of the disease. Int J Cardiol 2001; 78: 5-12.
27. Ichihara S, Obata K, Yamada Y, et al. Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors. J Mol Cell Cardiol 2006; 41: 318-329.
28. Kuwahara F Kai H, Tokuda K, et al. Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation? Hypertension 2004; 43: 739-745.
29. Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994; 331: 1286-1292.
30. Kuwahara F, Kai H, Tokuda K, et al. Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction, in pressure-overloaded rats. Circulation 2002; 106: 130-135.
31. Chrysohoou C, Pitsavos C, Panagiotakos DB, et al. Association between prehypertension status and inflammatory markers related to atherosclerotic disease: the ATTICA Study. Am J Hypertens 2004; 17: 568-573.