-
1
-
-
0037062951
-
RNA interference
-
Hannon GJ (2002) RNA interference. Nature 418:244-251
-
(2002)
Nature
, vol.418
, pp. 244-251
-
-
Hannon, G.J.1
-
2
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-498
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
3
-
-
0035803583
-
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
-
Elbashir SM, Martinez J, Patkaniowska A, Lendeckel W, Tuschl T (2001) Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J 20:6877-6888
-
(2001)
EMBO J
, vol.20
, pp. 6877-6888
-
-
Elbashir, S.M.1
Martinez, J.2
Patkaniowska, A.3
Lendeckel, W.4
Tuschl, T.5
-
5
-
-
77957820261
-
RNAi and small interfering RNAs in human disease therapeutic applications
-
Lares MR, Rossi JJ, Ouellet DL (2010) RNAi and small interfering RNAs in human disease therapeutic applications. Trends Biotechnol 28:570-579
-
(2010)
Trends Biotechnol
, vol.28
, pp. 570-579
-
-
Lares, M.R.1
Rossi, J.J.2
Ouellet, D.L.3
-
6
-
-
34447094733
-
Progress and prospects: RNA-based therapies for treatment of HIV infection
-
Scherer L, Rossi JJ, Weinberg MS (2007) Progress and prospects: RNA-based therapies for treatment of HIV infection. Gene Ther 14:1057-1064
-
(2007)
Gene Ther
, vol.14
, pp. 1057-1064
-
-
Scherer, L.1
Rossi, J.J.2
Weinberg, M.S.3
-
7
-
-
4744373229
-
Noise amidst the silence: Off-target effects of siRNAs?
-
Jackson AL, Linsley PS (2004) Noise amidst the silence: off-target effects of siRNAs? Trends Genet 20:521-524
-
(2004)
Trends Genet
, vol.20
, pp. 521-524
-
-
Jackson, A.L.1
Linsley, P.S.2
-
8
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson AL et al (2003) Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 21:635-637
-
(2003)
Nat Biotechnol
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
-
9
-
-
40249106017
-
Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: Dissection of an off-target effect
-
Clark PR, Pober JS, Kluger MS (2008) Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect. Nucleic Acids Res 36:1081-1097
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 1081-1097
-
-
Clark, P.R.1
Pober, J.S.2
Kluger, M.S.3
-
10
-
-
38049001594
-
Competition potency of siRNA is specified by the 5′-half sequence of the guide strand
-
Yoo JW, Kim S, Lee DK (2007) Competition potency of siRNA is specified by the 5′-half sequence of the guide strand. Biochem Biophys Res Commun 367:78-83
-
(2007)
Biochem Biophys Res Commun
, vol.367
, pp. 78-83
-
-
Yoo, J.W.1
Kim, S.2
Lee, D.K.3
-
11
-
-
33750027210
-
Competition for RISC binding predicts in vitro potency of siRNA
-
Koller E et al (2006) Competition for RISC binding predicts in vitro potency of siRNA. Nucleic Acids Res 34:4467-4476
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 4467-4476
-
-
Koller, E.1
-
12
-
-
36148972467
-
Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells
-
Vickers TA, Lima WF, Nichols JG, Crooke ST (2007) Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells. Nucleic Acids Res 35:6598-6610
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 6598-6610
-
-
Vickers, T.A.1
Lima, W.F.2
Nichols, J.G.3
Crooke, S.T.4
-
13
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grimm D et al (2006) Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441:537-541
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
-
14
-
-
41649115210
-
Sequence- and target- independent angiogenesis suppression by siRNA via TLR3
-
Kleinman ME et al (2008) Sequence- and target- independent angiogenesis suppression by siRNA via TLR3. Nature 452:591-597
-
(2008)
Nature
, vol.452
, pp. 591-597
-
-
Kleinman, M.E.1
-
16
-
-
0041331496
-
SiRNA function in RNAi: A chemical modification analysis
-
Chiu YL, Rana TM (2003) siRNA function in RNAi: a chemical modification analysis. RNA 9:1034-1048
-
(2003)
RNA
, vol.9
, pp. 1034-1048
-
-
Chiu, Y.L.1
Rana, T.M.2
-
17
-
-
63949084982
-
Asymmetric shorterduplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects
-
Chang CI et al (2009) Asymmetric shorterduplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects. Mol Ther 17:725-732
-
(2009)
Mol Ther
, vol.17
, pp. 725-732
-
-
Chang, C.I.1
-
18
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek J et al (2004) Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432:173-178
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
-
19
-
-
33746153768
-
RNAi in moderation
-
Barik S (2006) RNAi in moderation. Nat Biotechnol 24:796-797
-
(2006)
Nat Biotechnol
, vol.24
, pp. 796-797
-
-
Barik, S.1
-
20
-
-
27944459341
-
Activation of the mammalian immune system by siRNAs
-
Marques JT, Williams BR (2005) Activation of the mammalian immune system by siRNAs. Nat Biotechnol 23:1399-1405
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1399-1405
-
-
Marques, J.T.1
Williams, B.R.2
-
21
-
-
33644620908
-
Chemical modification of siRNAs to improve serum stability without loss of efficacy
-
Choung S, Kim YJ, Kim S, Park HO, Choi YC (2006) Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem Biophys Res Commun 342:919-927
-
(2006)
Biochem Biophys Res Commun
, vol.342
, pp. 919-927
-
-
Choung, S.1
Kim, Y.J.2
Kim, S.3
Park, H.O.4
Choi, Y.C.5
-
22
-
-
84859911037
-
Selection and optimization of asymmetric siRNA targeting the human c-MET gene
-
Jo SG, Hong SW, Yoo JW, Lee CH, Kim S, Lee DK (2011) Selection and optimization of asymmetric siRNA targeting the human c-MET gene. Mol Cells 32:543-548
-
(2011)
Mol Cells
, vol.32
, pp. 543-548
-
-
Jo, S.G.1
Hong, S.W.2
Yoo, J.W.3
Lee, C.H.4
Kim, S.5
Lee, D.K.6
-
23
-
-
57049175013
-
Detecting microRNA binding and siRNA off-target effects from expression data
-
van Dongen S, Abreu-Goodger C, Enright AJ (2008) Detecting microRNA binding and siRNA off-target effects from expression data. Nat Methods 5:1023-1025
-
(2008)
Nat Methods
, vol.5
, pp. 1023-1025
-
-
Van Dongen, S.1
Abreu-Goodger, C.2
Enright, A.J.3
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