메뉴 건너뛰기




Volumn 891, Issue , 2012, Pages 85-107

Vector systems for prenatal gene therapy: Principles of retrovirus vector design and production

Author keywords

293T; Concentration; Envelope; Gammaretrovirus; HIV; Lentivirus; MLV; Packaging cell line; Phoenix packaging cell lines; Preparation; Pseudotype; Retrovirus; SIN; Targeting; Titration; WPRE

Indexed keywords

CELL SURFACE PROTEIN; CHLOROQUINE; ENVELOPE PROTEIN; INITIATION FACTOR 1A; LENTIVIRUS VECTOR; MEMBRANE PROTEIN; MICRORNA; RETROVIRUS VECTOR;

EID: 84934437401     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-873-3_5     Document Type: Article
Times cited : (9)

References (60)
  • 1
    • 77953311295 scopus 로고    scopus 로고
    • Self-inactivating alpharetroviral vectors with a split-packaging design
    • Suerth JD, Maetzig T, Galla M et al (2010) Self-inactivating alpharetroviral vectors with a split-packaging design. J Virol 84:6626-6635
    • (2010) J Virol , vol.84 , pp. 6626-6635
    • Suerth, J.D.1    Maetzig, T.2    Galla, M.3
  • 4
    • 0029993858 scopus 로고    scopus 로고
    • Ef fi cient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
    • Naldini L, Blomer U, Gage FH et al (1996) Ef fi cient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A 93:11382-11388
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 11382-11388
    • Naldini, L.1    Blomer, U.2    Gage, F.H.3
  • 5
  • 6
    • 0037129435 scopus 로고    scopus 로고
    • Sustained correction of X-linked severe combined immunode fi ciency by ex vivo gene therapy
    • Hacein-Bey-Abina S, Le DF, Carlier F, Bouneaud C et al (2002) Sustained correction of X-linked severe combined immunode fi ciency by ex vivo gene therapy. N Engl J Med 346: 1185-1193
    • (2002) N Engl J Med , vol.346 , pp. 1185-1193
    • Hacein-Bey-Abina, S.1    Le, D.F.2    Carlier, F.3    Bouneaud, C.4
  • 7
    • 19944421384 scopus 로고    scopus 로고
    • Gene therapy of X-linked severe combined immunode fi ciency by use of a pseudotyped gammaretroviral vector
    • Gaspar HB, Parsley KL, Howe S et al (2004) Gene therapy of X-linked severe combined immunode fi ciency by use of a pseudotyped gammaretroviral vector. Lancet 364:2181-2187
    • (2004) Lancet , vol.364 , pp. 2181-2187
    • Gaspar, H.B.1    Parsley, K.L.2    Howe, S.3
  • 8
    • 59449098985 scopus 로고    scopus 로고
    • Gene therapy for immunode fi ciency due to adenosine deaminase de fi ciency
    • Aiuti A, Cattaneo F, Galimberti S et al (2009) Gene therapy for immunode fi ciency due to adenosine deaminase de fi ciency. N Engl J Med 360:447-458
    • (2009) N Engl J Med , vol.360 , pp. 447-458
    • Aiuti, A.1    Cattaneo, F.2    Galimberti, S.3
  • 9
    • 33645734405 scopus 로고    scopus 로고
    • Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
    • Ott MG, Schmidt M, Schwarzwaelder K et al (2006) Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med 12:401-409
    • (2006) Nat Med , vol.12 , pp. 401-409
    • Ott, M.G.1    Schmidt, M.2    Schwarzwaelder, K.3
  • 10
    • 70449427834 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
    • Cartier N, Hacein-Bey-Abina S, Bartholomae CC et al (2009) Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 326:818-823
    • (2009) Science , vol.326 , pp. 818-823
    • Cartier, N.1    Hacein-Bey-Abina, S.2    Bartholomae, C.C.3
  • 11
    • 0030467991 scopus 로고    scopus 로고
    • Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles
    • Reiser J, Harmison G, Kluepfel-Stahl S et al (1996) Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles. Proc Natl Acad Sci U S A 93: 15266-15271
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 15266-15271
    • Reiser, J.1    Harmison, G.2    Kluepfel-Stahl, S.3
  • 12
    • 0024460181 scopus 로고
    • Improved retroviral vectors for gene transfer and expression
    • 6
    • Miller AD, Rosman GJ (1989) Improved retroviral vectors for gene transfer and expression. Biotechniques 7(980-6):989
    • (1989) Biotechniques , vol.7 , Issue.980 , pp. 989
    • Miller, A.D.1    Rosman, G.J.2
  • 13
    • 0031710033 scopus 로고    scopus 로고
    • A thirdgeneration lentivirus vector with a conditional packaging system
    • Dull T, Zufferey R, Kelly M et al (1998) A thirdgeneration lentivirus vector with a conditional packaging system. J Virol 72:8463-8471
    • (1998) J Virol , vol.72 , pp. 8463-8471
    • Dull, T.1    Zufferey, R.2    Kelly, M.3
  • 14
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L, Blomer U, Gallay P et al (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263-267
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3
  • 15
    • 0034040751 scopus 로고    scopus 로고
    • Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences
    • Follenzi A, Ailles LE, Bakovic S et al (2000) Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat Genet 25:217-222
    • (2000) Nat Genet , vol.25 , pp. 217-222
    • Follenzi, A.1    Ailles, L.E.2    Bakovic, S.3
  • 16
    • 0034646513 scopus 로고    scopus 로고
    • HIV-1 genome nuclear import is mediated by a central DNA fl a. p
    • Zennou V, Petit C, Guetard D et al (2000) HIV-1 genome nuclear import is mediated by a central DNA fl ap. Cell 101:173-185
    • (2000) Cell , vol.101 , pp. 173-185
    • Zennou, V.1    Petit, C.2    Guetard, D.3
  • 17
    • 0036252492 scopus 로고    scopus 로고
    • High-level transduction and gene expression in hematopoietic repopulating cells using a human immunode fi ciency [correction of immunode fi ciency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter
    • Demaison C, Parsley K, Brouns G et al (2002) High-level transduction and gene expression in hematopoietic repopulating cells using a human immunode fi ciency [correction of immunode fi ciency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Hum Gene Ther 13: 803-813
    • (2002) Hum Gene Ther , vol.13 , pp. 803-813
    • Demaison, C.1    Parsley, K.2    Brouns, G.3
  • 18
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves ef fi cient gene delivery in vivo
    • Zufferey R, Nagy D, Mandel RJ et al (1997) Multiply attenuated lentiviral vector achieves ef fi cient gene delivery in vivo. Nat Biotechnol 15:871-875
    • (1997) Nat Biotechnol , vol.15 , pp. 871-875
    • Zufferey, R.1    Nagy, D.2    Mandel, R.J.3
  • 19
    • 12244259252 scopus 로고    scopus 로고
    • Enhancer-deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD
    • Schwickerath O, Brouns G, Thrasher A et al (2004) Enhancer-deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD. J Gene Med 6:603-615
    • (2004) J Gene Med , vol.6 , pp. 603-615
    • Schwickerath, O.1    Brouns, G.2    Thrasher, A.3
  • 20
    • 0022979325 scopus 로고
    • High mutation rate of a spleen necrosis virus-based retrovirus vector
    • Dougherty JP, Temin HM (1986) High mutation rate of a spleen necrosis virus-based retrovirus vector. Mol Cell Biol 6:4387-4395
    • (1986) Mol Cell Biol , vol.6 , pp. 4387-4395
    • Dougherty, J.P.1    Temin, H.M.2
  • 21
    • 15244351083 scopus 로고    scopus 로고
    • Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters
    • Amendola M, Venneri MA, Bif fi A et al (2005) Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters. Nat Biotechnol 23:108-116
    • (2005) Nat Biotechnol , vol.23 , pp. 108-116
    • Amendola, M.1    Venneri, M.A.2    Bif Fi, A.3
  • 22
    • 1842473660 scopus 로고    scopus 로고
    • Newgeneration multicistronic expression platform: PTRIDENT vectors containing size-optimized IRES elements enable homing endonucleasebased cistron swapping into lentiviral expression vectors
    • Fux C, Langer D, Kelm JM (2004) Newgeneration multicistronic expression platform: pTRIDENT vectors containing size-optimized IRES elements enable homing endonucleasebased cistron swapping into lentiviral expression vectors. Biotechnol Bioeng 86:174-187
    • (2004) Biotechnol Bioeng , vol.86 , pp. 174-187
    • Fux, C.1    Langer, D.2    Kelm, J.M.3
  • 23
    • 0031825184 scopus 로고    scopus 로고
    • Production and characterization of a bicistronic Moloney-based retroviral vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for gene therapy of cancer
    • Pizzato M, Franchin E, Calvi P et al (1998) Production and characterization of a bicistronic Moloney-based retroviral vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for gene therapy of cancer. Gene Ther 5:1003-1007
    • (1998) Gene Ther , vol.5 , pp. 1003-1007
    • Pizzato, M.1    Franchin, E.2    Calvi, P.3
  • 24
    • 33646561281 scopus 로고    scopus 로고
    • Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI
    • Chinnasamy D, Milsom MD, Shaffer J et al (2006) Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI. Virol J 3:14
    • (2006) Virol J , vol.3 , pp. 14
    • Chinnasamy, D.1    Milsom, M.D.2    Shaffer, J.3
  • 25
    • 65649098724 scopus 로고    scopus 로고
    • Production of multicistronic HIV-1 based lentiviral vectors
    • Chinnasamy N, Shaffer J, Chinnasamy D (2009) Production of multicistronic HIV-1 based lentiviral vectors. Methods Mol Biol 515:137-150
    • (2009) Methods Mol Biol , vol.515 , pp. 137-150
    • Chinnasamy, N.1    Shaffer, J.2    Chinnasamy, D.3
  • 26
    • 0347003599 scopus 로고    scopus 로고
    • Transduction of bone-marrow-derived mesenchymal stem cells by using lentivirus vectors pseudotyped with modi fi ed RD114 envelope glycoproteins
    • Zhang XY, La RV, Reiser J (2004) Transduction of bone-marrow-derived mesenchymal stem cells by using lentivirus vectors pseudotyped with modi fi ed RD114 envelope glycoproteins. J Virol 78:1219-1229
    • (2004) J Virol , vol.78 , pp. 1219-1229
    • Zhang, X.Y.1    La, R.V.2    Reiser, J.3
  • 27
    • 0031950572 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element
    • Donello JE, Loeb JE, Hope TJ (1998) Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. J Virol 72:5085-5092
    • (1998) J Virol , vol.72 , pp. 5085-5092
    • Donello, J.E.1    Loeb, J.E.2    Hope, T.J.3
  • 28
    • 0015520248 scopus 로고
    • VSV pseudotype produced in cell line derived from human mammary carcinoma
    • Zavada J, Zazadova Z, Malir A, Kocent A (1972) VSV pseudotype produced in cell line derived from human mammary carcinoma. Nat New Biol 240:124-125
    • (1972) Nat New Biol , vol.240 , pp. 124-125
    • Zavada, J.1    Zazadova, Z.2    Malir, A.3    Kocent, A.4
  • 29
    • 0017256419 scopus 로고
    • Viral pseudotypes and phenotypic mixing
    • Zavada J (1976) Viral pseudotypes and phenotypic mixing. Arch Virol 50:1-15
    • (1976) Arch Virol , vol.50 , pp. 1-15
    • Zavada, J.1
  • 30
    • 0026608630 scopus 로고
    • Receptor choice determinants in the envelope glycoproteins of amphotropic, xenotropic, and polytropic murine leukemia viruses
    • Battini JL, Heard JM, Danos O (1992) Receptor choice determinants in the envelope glycoproteins of amphotropic, xenotropic, and polytropic murine leukemia viruses. J Virol 66:1468-1475
    • (1992) J Virol , vol.66 , pp. 1468-1475
    • Battini, J.L.1    Heard, J.M.2    Danos, O.3
  • 31
    • 64549111301 scopus 로고    scopus 로고
    • Ef fi cient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors
    • Rahim AA, Wong AM, Howe SJ et al (2009) Ef fi cient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors. Gene Ther 16:509-520
    • (2009) Gene Ther , vol.16 , pp. 509-520
    • Rahim, A.A.1    Wong, A.M.2    Howe, S.J.3
  • 32
    • 0034781791 scopus 로고    scopus 로고
    • Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery
    • Mazarakis ND, Azzouz M, Rohll JB et al (2001) Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery. Hum Mol Genet 10:2109-2121
    • (2001) Hum Mol Genet , vol.10 , pp. 2109-2121
    • Mazarakis, N.D.1    Azzouz, M.2    Rohll, J.B.3
  • 33
    • 0033182002 scopus 로고    scopus 로고
    • Modifying the host range properties of retroviral vectors
    • Russell SJ, Cosset FL (1999) Modifying the host range properties of retroviral vectors. J Gene Med 1:300-311
    • (1999) J Gene Med , vol.1 , pp. 300-311
    • Russell, S.J.1    Cosset, F.L.2
  • 34
    • 0031582620 scopus 로고    scopus 로고
    • Masking of retroviral envelope functions by oligomerizing polypeptide adaptors
    • Morling FJ, Peng KW, Cosset FL, Russell SJ (1997) Masking of retroviral envelope functions by oligomerizing polypeptide adaptors. Virology 234:51-61
    • (1997) Virology , vol.234 , pp. 51-61
    • Morling, F.J.1    Peng, K.W.2    Cosset, F.L.3    Russell, S.J.4
  • 35
    • 0029094549 scopus 로고
    • Retroviral retargeting by envelopes expressing an N-terminal binding domain
    • Cosset FL, Morling FJ, Takeuchi Y et al (1995) Retroviral retargeting by envelopes expressing an N-terminal binding domain. J Virol 69: 6314-6322
    • (1995) J Virol , vol.69 , pp. 6314-6322
    • Cosset, F.L.1    Morling, F.J.2    Takeuchi, Y.3
  • 36
    • 0030031348 scopus 로고    scopus 로고
    • Improvement of retroviral retargeting by using amino acid spacers between an additional binding domain and the N terminus of Moloney murine leukemia virus S. U
    • Valsesia-Wittmann S, Morling FJ, Nilson BH et al (1996) Improvement of retroviral retargeting by using amino acid spacers between an additional binding domain and the N terminus of Moloney murine leukemia virus SU. J Virol 70:2059-2064
    • (1996) J Virol , vol.70 , pp. 2059-2064
    • Valsesia-Wittmann, S.1    Morling, F.J.2    Nilson, B.H.3
  • 37
    • 0028567517 scopus 로고
    • Tissuespeci fi c targeting of retroviral vectors through ligand-receptor interactions
    • Kasahara N, Dozy AM, Kan YW (1994) Tissuespeci fi c targeting of retroviral vectors through ligand-receptor interactions. Science 266: 1373-1376
    • (1994) Science , vol.266 , pp. 1373-1376
    • Kasahara, N.1    Dozy, A.M.2    Kan, Y.W.3
  • 38
    • 0036889342 scopus 로고    scopus 로고
    • The membrane-proximal domain of vesicular stomatitis virus G protein functions as a membrane fusion potentiator and can induce hemifusion
    • Jeetendra E, Robison CS, Albritton LM, Whitt MA (2002) The membrane-proximal domain of vesicular stomatitis virus G protein functions as a membrane fusion potentiator and can induce hemifusion. J Virol 76:12300-12311
    • (2002) J Virol , vol.76 , pp. 12300-12311
    • Jeetendra, E.1    Robison, C.S.2    Albritton, L.M.3    Whitt, M.A.4
  • 39
    • 76949094417 scopus 로고    scopus 로고
    • Cell-speci fi c targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus
    • Zhang XY, Kutner RH, Bialkowska A et al (2010) Cell-speci fi c targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus. Retrovirology 7:3
    • (2010) Retrovirology , vol.7 , pp. 3
    • Zhang, X.Y.1    Kutner, R.H.2    Bialkowska, A.3
  • 40
    • 16244394824 scopus 로고    scopus 로고
    • Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection
    • Morizono K (2005) Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection. Nat Med 11:346-352
    • (2005) Nat Med , vol.11 , pp. 346-352
    • Morizono, K.1
  • 41
    • 40649094826 scopus 로고    scopus 로고
    • Ef fi cient targeted transduction of primary human endothelial cells with dual-targeted lentiviral vectors
    • Pariente N, Mao SH, Morizono K, Chen IS (2008) Ef fi cient targeted transduction of primary human endothelial cells with dual-targeted lentiviral vectors. J Gene Med 10:242-248
    • (2008) J Gene Med , vol.10 , pp. 242-248
    • Pariente, N.1    Mao, S.H.2    Morizono, K.3    Chen, I.S.4
  • 42
    • 64749102457 scopus 로고    scopus 로고
    • Lentiviral vectors with measles virus glycoproteins-dream team for gene transfer?
    • Buchholz CJ, Muhlebach MD, Cichutek K (2009) Lentiviral vectors with measles virus glycoproteins-dream team for gene transfer? Trends Biotechnol 27:259-265
    • (2009) Trends Biotechnol , vol.27 , pp. 259-265
    • Buchholz, C.J.1    Muhlebach, M.D.2    Cichutek, K.3
  • 43
    • 33748755378 scopus 로고    scopus 로고
    • Targeted retroviral vectors displaying a cleavage site-engineered hemagglutinin (HA) through HA-protease interactions
    • Szecsi J, Drury R, Josserand V et al (2006) Targeted retroviral vectors displaying a cleavage site-engineered hemagglutinin (HA) through HA-protease interactions. Mol Ther 14: 735-744
    • (2006) Mol Ther , vol.14 , pp. 735-744
    • Szecsi, J.1    Drury, R.2    Josserand, V.3
  • 44
    • 0034691083 scopus 로고    scopus 로고
    • Minimal exclusion of plasma membrane proteins during retroviral envelope formation
    • Hammarstedt M, Wallengren K, Pedersen KW et al (2000) Minimal exclusion of plasma membrane proteins during retroviral envelope formation. Proc Natl Acad Sci U S A 97:7527-7532
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7527-7532
    • Hammarstedt, M.1    Wallengren, K.2    Pedersen, K.W.3
  • 45
    • 7244240716 scopus 로고    scopus 로고
    • Targeted retroviral transduction of c-kit + hematopoietic cells using novel ligand display technology
    • Chandrashekran A, Gordon MY, Casimir C (2004) Targeted retroviral transduction of c-kit + hematopoietic cells using novel ligand display technology. Blood 104:2697-2703
    • (2004) Blood , vol.104 , pp. 2697-2703
    • Chandrashekran, A.1    Gordon, M.Y.2    Casimir, C.3
  • 46
    • 39849110286 scopus 로고    scopus 로고
    • Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunode fi ciency
    • Thornhill SI, Schambach A, Howe SJ et al (2008) Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunode fi ciency. Mol Ther 16:590-598
    • (2008) Mol Ther , vol.16 , pp. 590-598
    • Thornhill, S.I.1    Schambach, A.2    Howe, S.J.3
  • 47
    • 33847178027 scopus 로고    scopus 로고
    • Lentiviral vectors targeting WASp expression to hematopoietic cells, ef fi ciently transduce and correct cells from WAS patients
    • Charrier S, Dupre L, Scaramuzza S et al (2007) Lentiviral vectors targeting WASp expression to hematopoietic cells, ef fi ciently transduce and correct cells from WAS patients. Gene Ther 14:415-428
    • (2007) Gene Ther , vol.14 , pp. 415-428
    • Charrier, S.1    Dupre, L.2    Scaramuzza, S.3
  • 48
    • 0029079981 scopus 로고
    • A retroviral vector containing a muscle-speci fi c enhancer drives gene expression only in differentiated muscle fi bers
    • Ferrari G, Salvatori G, Rossi C et al (1995) A retroviral vector containing a muscle-speci fi c enhancer drives gene expression only in differentiated muscle fi bers. Hum Gene Ther 6: 733-742
    • (1995) Hum Gene Ther , vol.6 , pp. 733-742
    • Ferrari, G.1    Salvatori, G.2    Rossi, C.3
  • 49
    • 0027477387 scopus 로고
    • In vitro and in vivo targeting of gene expression to melanoma cells
    • Vile RG, Hart IR (1993) In vitro and in vivo targeting of gene expression to melanoma cells. Cancer Res 53:962-967
    • (1993) Cancer Res , vol.53 , pp. 962-967
    • Vile, R.G.1    Hart, I.R.2
  • 50
    • 0028218329 scopus 로고
    • Targeting of cytokine gene expression to malignant melanoma cells using tissue speci fi c promoter sequences
    • Vile RG, Hart IR (1994) Targeting of cytokine gene expression to malignant melanoma cells using tissue speci fi c promoter sequences. Ann Oncol 5(Suppl 4):59-65
    • (1994) Ann Oncol , vol.5 , Issue.SUPPL. 4 , pp. 59-65
    • Vile, R.G.1    Hart, I.R.2
  • 51
    • 33646564701 scopus 로고    scopus 로고
    • Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer
    • Brown BD, Venneri MA, Zingale A et al (2006) Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer. Nat Med 12:585-591
    • (2006) Nat Med , vol.12 , pp. 585-591
    • Brown, B.D.1    Venneri, M.A.2    Zingale, A.3
  • 52
    • 0028839609 scopus 로고
    • High-titer packaging cells producing recombinant retroviruses resistant to human serum
    • Cosset FL, Takeuchi Y, Battini JL et al (1995) High-titer packaging cells producing recombinant retroviruses resistant to human serum. J Virol 69:7430-7436
    • (1995) J Virol , vol.69 , pp. 7430-7436
    • Cosset, F.L.1    Takeuchi, Y.2    Battini, J.L.3
  • 53
    • 76749155354 scopus 로고    scopus 로고
    • A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating gamma-retroviral vectors using targeted integration
    • Loew R, Meyer Y, Kuehlcke K et al (2010) A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating gamma-retroviral vectors using targeted integration. Gene Ther 17:272-280
    • (2010) Gene Ther , vol.17 , pp. 272-280
    • Loew, R.1    Meyer, Y.2    Kuehlcke, K.3
  • 54
    • 0029833422 scopus 로고    scopus 로고
    • Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
    • Kinsella TM, Nolan GP (1996) Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther 7: 1405-1413
    • (1996) Hum Gene Ther , vol.7 , pp. 1405-1413
    • Kinsella, T.M.1    Nolan, G.P.2
  • 55
    • 58749085714 scopus 로고    scopus 로고
    • Removal of envelope protein-free retroviral vectors by anion-exchange chromatography to improve product quality
    • Rodrigues T, Alves A, Lopes A et al (2008) Removal of envelope protein-free retroviral vectors by anion-exchange chromatography to improve product quality. J Sep Sci 31: 3509-3518
    • (2008) J Sep Sci , vol.31 , pp. 3509-3518
    • Rodrigues, T.1    Alves, A.2    Lopes, A.3
  • 56
    • 30944436658 scopus 로고    scopus 로고
    • Complexation with chondroitin sulfate C and Polybrene rapidly puri fi es retrovirus from inhibitors of transduction and substantially enhances gene transfer
    • Landazuri N, Le Doux JM (2006) Complexation with chondroitin sulfate C and Polybrene rapidly puri fi es retrovirus from inhibitors of transduction and substantially enhances gene transfer. Biotechnol Bioeng 93:146-158
    • (2006) Biotechnol Bioeng , vol.93 , pp. 146-158
    • Landazuri, N.1    Le Doux, J.M.2
  • 57
    • 0036713630 scopus 로고    scopus 로고
    • Titering lentiviral vectors: Comparison of DNA, RNA and marker expression methods
    • Sastry L, Johnson T, Hobson MJ et al (2002) Titering lentiviral vectors: comparison of DNA, RNA and marker expression methods. Gene Ther 9:1155-1162
    • (2002) Gene Ther , vol.9 , pp. 1155-1162
    • Sastry, L.1    Johnson, T.2    Hobson, M.J.3
  • 59
    • 0037431266 scopus 로고    scopus 로고
    • Real-time quantitative reverse transcriptasepolymerase chain reaction as a method for determining lentiviral vector titers and measuring transgene expression
    • Lizee G, Aerts JL, Gonzales MI et al (2003) Real-time quantitative reverse transcriptasepolymerase chain reaction as a method for determining lentiviral vector titers and measuring transgene expression. Hum Gene Ther 14:497-507
    • (2003) Hum Gene Ther , vol.14 , pp. 497-507
    • Lizee, G.1    Aerts, J.L.2    Gonzales, M.I.3
  • 60
    • 4644318481 scopus 로고    scopus 로고
    • Lentiviral vectors: Optimization of packaging, transduction and gene expression
    • Delenda C (2004) Lentiviral vectors: optimization of packaging, transduction and gene expression. J Gene Med 6(Suppl 1):S125-S138
    • (2004) J Gene Med , vol.6 , Issue.SUPPL. 1
    • Delenda, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.