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Volumn 796, Issue , 2014, Pages 3-13

The GPCR crystallography boom: Providing an invaluable source of structural information and expanding the scope of homology modeling

Author keywords

3D models; Crystal structures; Docking; Homology; Rhodopsin

Indexed keywords

ADENOSINE A2A RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CHEMOKINE RECEPTOR CXCR4; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; G PROTEIN COUPLED RECEPTOR; RHODOPSIN; SEROTONIN UPTAKE INHIBITOR; SERPENTINE; BACTERIORHODOPSIN; BETA ADRENERGIC RECEPTOR;

EID: 84934435689     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-7-7423-0_1     Document Type: Article
Times cited : (18)

References (74)
  • 1
    • 84871286519 scopus 로고    scopus 로고
    • Restructuring G-proteincoupled receptor activation
    • Audet M, Bouvier M (2012) Restructuring G-proteincoupled receptor activation. Cell 151:14-23
    • (2012) Cell , vol.151 , pp. 14-23
    • Audet, M.1    Bouvier, M.2
  • 2
    • 0027506471 scopus 로고
    • The probable arrangement of the helices in G protein-coupled receptors
    • Baldwin J (1993) The probable arrangement of the helices in G protein-coupled receptors. EMBO J 12:1693-1703
    • (1993) EMBO J , vol.12 , pp. 1693-1703
    • Baldwin, J.1
  • 3
    • 0026755609 scopus 로고
    • Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains
    • Ballesteros JA, Weinstein H (1992) Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains. Biophys J 62:107-109
    • (1992) Biophys J , vol.62 , pp. 107-109
    • Ballesteros, J.A.1    Weinstein, H.2
  • 5
    • 79960009157 scopus 로고    scopus 로고
    • Homology models in docking and high-throughput docking
    • Cavasotto CN (2011) Homology models in docking and high-throughput docking. Curr Top Med Chem 11:1528-1534
    • (2011) Curr Top Med Chem , vol.11 , pp. 1528-1534
    • Cavasotto, C.N.1
  • 10
    • 77949370572 scopus 로고    scopus 로고
    • The impact of GPCR structures on pharmacology and structure-based drug design
    • Congreve M, Marshall F (2009) The impact of GPCR structures on pharmacology and structure-based drug design. Br J Pharmacol 159:986-996
    • (2009) Br J Pharmacol , vol.159 , pp. 986-996
    • Congreve, M.1    Marshall, F.2
  • 11
    • 79960176452 scopus 로고    scopus 로고
    • Progress in structure based drug design for G protein-coupled receptors
    • Congreve M, Langmead CJ, Mason JS, Marshall FH (2011) Progress in structure based drug design for G protein-coupled receptors. J Med Chem 54:4283-4311
    • (2011) J Med Chem , vol.54 , pp. 4283-4311
    • Congreve, M.1    Langmead, C.J.2    Mason, J.S.3    Marshall, F.H.4
  • 12
    • 43949095157 scopus 로고    scopus 로고
    • On the applicability of GPCR homology models to computer-aided drug discovery: A comparison between in silico and crystal structures of the beta2-adrenergic receptor
    • Costanzi S (2008) On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor. J Med Chem 51: 2907-2914
    • (2008) J Med Chem , vol.51 , pp. 2907-2914
    • Costanzi, S.1
  • 13
    • 77955113796 scopus 로고    scopus 로고
    • Modeling G protein-coupled receptors: A concrete possibility
    • Costanzi S (2010) Modeling G protein-coupled receptors: a concrete possibility. Chim Oggi 28:26-31
    • (2010) Chim Oggi , vol.28 , pp. 26-31
    • Costanzi, S.1
  • 14
    • 84865248665 scopus 로고    scopus 로고
    • Chapter 18. Structure-based virtual screening for ligands of G protein-coupled receptors
    • Giraldo J, Pin J-P (eds), The Royal Society of Chemistry, London and Cambridge
    • Costanzi S (2011) Chapter 18. Structure-based virtual screening for ligands of G protein-coupled receptors. In: Giraldo J, Pin J-P (eds) G protein-coupled receptors: from structure to function. The Royal Society of Chemistry, London and Cambridge, pp 359-374
    • (2011) G Protein-coupled Receptors: From Structure to Function , pp. 359-374
    • Costanzi, S.1
  • 15
    • 84858110277 scopus 로고    scopus 로고
    • Homology modeling of class a G protein-coupled receptors
    • Costanzi S (2012) Homology modeling of class a G protein-coupled receptors. Methods Mol Biol 857:259-279
    • (2012) Methods Mol Biol , vol.857 , pp. 259-279
    • Costanzi, S.1
  • 16
    • 71749083052 scopus 로고    scopus 로고
    • Rhodopsin and the others: A historical perspective on structural studies of G protein-coupled receptors
    • Costanzi S, Siegel J, Tikhonova I, Jacobson K (2009) Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors. Curr Pharm Des 15:3994-4002
    • (2009) Curr Pharm des , vol.15 , pp. 3994-4002
    • Costanzi, S.1    Siegel, J.2    Tikhonova, I.3    Jacobson, K.4
  • 19
    • 0023656534 scopus 로고
    • The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis
    • Dohlman H, Bouvier M, Benovic J, Caron M, Lefkowitz R (1987) The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. J Biol Chem 262:14282-14288
    • (1987) J Biol Chem , vol.262 , pp. 14282-14288
    • Dohlman, H.1    Bouvier, M.2    Benovic, J.3    Caron, M.4    Lefkowitz, R.5
  • 20
    • 0037462168 scopus 로고    scopus 로고
    • G protein signaling and the molecular basis of antidepressant action
    • Donati RJ, Rasenick MM (2003) G protein signaling and the molecular basis of antidepressant action. Life Sci 73:1-17
    • (2003) Life Sci , vol.73 , pp. 1-17
    • Donati, R.J.1    Rasenick, M.M.2
  • 21
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson R, Lagerström M, Lundin L, Schiöth H (2003) The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 63:1256-1272
    • (2003) Mol Pharmacol , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerström, M.2    Lundin, L.3    Schiöth, H.4
  • 22
    • 36949011636 scopus 로고    scopus 로고
    • The G protein-coupled receptor subset of the rat genome
    • Gloriam D, Fredriksson R, Schiöth H (2007) The G protein-coupled receptor subset of the rat genome. BMC Genomics 8:338
    • (2007) BMC Genomics , vol.8 , pp. 338
    • Gloriam, D.1    Fredriksson, R.2    Schiöth, H.3
  • 23
    • 79957756393 scopus 로고    scopus 로고
    • Successful prediction of the intra- and extracellular loops of four G-protein-coupled receptors
    • Goldfeld DA, Zhu K, Beuming T, Friesner RA (2011) Successful prediction of the intra- and extracellular loops of four G-protein-coupled receptors. Proc Natl Acad Sci U S A 108:8275-8280
    • (2011) Proc Natl Acad Sci U S a , vol.108 , pp. 8275-8280
    • Goldfeld, D.A.1    Zhu, K.2    Beuming, T.3    Friesner, R.A.4
  • 24
    • 84872602272 scopus 로고    scopus 로고
    • Loop prediction for a GPCR homology model: Algorithms and results
    • Goldfeld DA, Zhu K, Beuming T, Friesner RA (2012) Loop prediction for a GPCR homology model: algorithms and results. Proteins 81:214-228
    • (2012) Proteins , vol.81 , pp. 214-228
    • Goldfeld, D.A.1    Zhu, K.2    Beuming, T.3    Friesner, R.A.4
  • 26
    • 58149203324 scopus 로고    scopus 로고
    • Discovery of new GPCR biology: One receptor structure at a time
    • Hanson MA, Stevens RC (2009) Discovery of new GPCR biology: one receptor structure at a time. Structure 17:8-14
    • (2009) Structure , vol.17 , pp. 8-14
    • Hanson, M.A.1    Stevens, R.C.2
  • 27
    • 0035171024 scopus 로고    scopus 로고
    • Rhodopsin structure, function, and topography the Friedenwald lecture
    • Hargrave PA (2001) Rhodopsin structure, function, and topography the Friedenwald lecture. Invest Ophthalmol Vis Sci 42:3-9
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 3-9
    • Hargrave, P.A.1
  • 29
    • 0016842810 scopus 로고
    • Three-dimensional model of purple membrane obtained by electron microscopy
    • Henderson R, Unwin PN (1975) Three-dimensional model of purple membrane obtained by electron microscopy. Nature 257:28-32
    • (1975) Nature , vol.257 , pp. 28-32
    • Henderson, R.1    Unwin, P.N.2
  • 30
    • 0026451988 scopus 로고
    • Molecular modeling of adenosine receptors. I. The ligand binding site on the A1 receptor
    • IJzerman A, Van Galen P, Jacobson K (1992) Molecular modeling of adenosine receptors. I. The ligand binding site on the A1 receptor. Drug Des Discov 9:49-67
    • (1992) Drug des Discov , vol.9 , pp. 49-67
    • Ijzerman, A.1    Van Galen, P.2    Jacobson, K.3
  • 31
    • 0028773638 scopus 로고
    • Molecular modeling of adenosine receptors. The ligand binding site on the rat adenosine A2A receptor
    • IJzerman AP, van der Wenden EM, Van Galen PJ, Jacobson KA (1994) Molecular modeling of adenosine receptors. The ligand binding site on the rat adenosine A2A receptor. Eur J Pharmacol 268:95-104
    • (1994) Eur J Pharmacol , vol.268 , pp. 95-104
    • Ijzerman, A.P.1    Van Der Wenden, E.M.2    Van Galen, P.J.3    Jacobson, K.A.4
  • 33
    • 84865228105 scopus 로고    scopus 로고
    • New insights for drug design from the x-ray crystallographic structures of g-protein-coupled receptors
    • Jacobson KA, Costanzi S (2012) New insights for drug design from the x-ray crystallographic structures of g-protein-coupled receptors. Mol Pharmacol 82: 361-371
    • (2012) Mol Pharmacol , vol.82 , pp. 361-371
    • Jacobson, K.A.1    Costanzi, S.2
  • 35
    • 77649196223 scopus 로고    scopus 로고
    • GPCR 3D homology models for ligand screening: Lessons learned from blind predictions of adenosine A2a receptor complex
    • Katritch V, Rueda M, Lam P, Yeager M, Abagyan R (2010) GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex. Proteins 78:197-211
    • (2010) Proteins , vol.78 , pp. 197-211
    • Katritch, V.1    Rueda, M.2    Lam, P.3    Yeager, M.4    Abagyan, R.5
  • 36
    • 80051521545 scopus 로고    scopus 로고
    • Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment
    • Kufareva I, Rueda M, Katritch V, Stevens RC, Abagyan R (2011) Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure 19:1108-1126
    • (2011) Structure , vol.19 , pp. 1108-1126
    • Kufareva, I.1    Rueda, M.2    Katritch, V.3    Stevens, R.C.4    Abagyan, R.5
  • 37
    • 33947420477 scopus 로고    scopus 로고
    • Seven transmembrane receptors: A brief personal retrospective
    • Lefkowitz RJ (2007a) Seven transmembrane receptors: a brief personal retrospective. Biochim Biophys Acta 1768:748-755
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 748-755
    • Lefkowitz, R.J.1
  • 38
    • 34147137118 scopus 로고    scopus 로고
    • Seven transmembrane receptors: Something old, something new
    • Lefkowitz RJ (2007b) Seven transmembrane receptors: something old, something new. Acta Physiol (Oxf) 190:9-19
    • (2007) Acta Physiol (Oxf) , vol.190 , pp. 9-19
    • Lefkowitz, R.J.1
  • 40
    • 84860505658 scopus 로고    scopus 로고
    • New insights from structural biology into the druggability of G protein-coupled receptors
    • Mason JS, Bortolato A, Congreve M, Marshall FH (2012) New insights from structural biology into the druggability of G protein-coupled receptors. Trends Pharmacol Sci 33:249-260
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 249-260
    • Mason, J.S.1    Bortolato, A.2    Congreve, M.3    Marshall, F.H.4
  • 42
    • 69049108756 scopus 로고    scopus 로고
    • Modern homology modeling of G-protein coupled receptors: Which structural template to use?
    • Mobarec J, Sanchez R, Filizola M (2009) Modern homology modeling of G-protein coupled receptors: which structural template to use? J Med Chem 52:5207-5216
    • (2009) J Med Chem , vol.52 , pp. 5207-5216
    • Mobarec, J.1    Sanchez, R.2    Filizola, M.3
  • 44
    • 0035423908 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin: Implications for vision and beyond
    • Okada T, Palczewski K (2001) Crystal structure of rhodopsin: implications for vision and beyond. Curr Opin Struct Biol 11:420-426
    • (2001) Curr Opin Struct Biol , vol.11 , pp. 420-426
    • Okada, T.1    Palczewski, K.2
  • 45
    • 0001228323 scopus 로고
    • A common motif in G-protein-coupled 7 transmembrane helix receptors
    • Oliveira L, Paiva ACM, Vriend G (1993) A common motif in G-protein-coupled 7 transmembrane helix receptors. J Comput Aided Mol Des 7:649-658
    • (1993) J Comput Aided Mol des , vol.7 , pp. 649-658
    • Oliveira, L.1    Paiva, A.C.2    Vriend, G.3
  • 49
    • 0026517309 scopus 로고
    • On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the threedimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors
    • Pardo L, Ballesteros JA, Osman R, Weinstein H (1992) On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the threedimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors. Proc Natl Acad Sci U S A 89:4009-4012
    • (1992) Proc Natl Acad Sci U S a , vol.89 , pp. 4009-4012
    • Pardo, L.1    Ballesteros, J.A.2    Osman, R.3    Weinstein, H.4
  • 50
    • 47049130668 scopus 로고    scopus 로고
    • Crystal structure of the ligand-free G-proteincoupled receptor opsin
    • Park JH, Scheerer P, Hofmann KP, Choe HW, Ernst OP (2008) Crystal structure of the ligand-free G-proteincoupled receptor opsin. Nature 454:183-187
    • (2008) Nature , vol.454 , pp. 183-187
    • Park, J.H.1    Scheerer, P.2    Hofmann, K.P.3    Choe, H.W.4    Ernst, O.P.5
  • 52
    • 78650701635 scopus 로고    scopus 로고
    • Ligandsteered modeling and docking: A benchmarking study in class a G-protein-coupled receptors
    • Phatak SS, Gatica EA, Cavasotto CN (2010) Ligandsteered modeling and docking: a benchmarking study in class a G-protein-coupled receptors. J Chem Inf Model 50:2119-2128
    • (2010) J Chem Inf Model , vol.50 , pp. 2119-2128
    • Phatak, S.S.1    Gatica, E.A.2    Cavasotto, C.N.3
  • 58
    • 58149091781 scopus 로고    scopus 로고
    • Pharmacogenomics of G protein-coupled receptor ligands in cardiovascular medicine
    • Rosskopf D, Michel MC (2008) Pharmacogenomics of G protein-coupled receptor ligands in cardiovascular medicine. Pharmacol Rev 60:513-535
    • (2008) Pharmacol Rev , vol.60 , pp. 513-535
    • Rosskopf, D.1    Michel, M.C.2
  • 59
    • 80053615320 scopus 로고    scopus 로고
    • The significance of G protein-coupled receptor crystallography for drug discovery
    • Salon JA, Lodowski DT, Palczewski K (2011) The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev 63:901-937
    • (2011) Pharmacol Rev , vol.63 , pp. 901-937
    • Salon, J.A.1    Lodowski, D.T.2    Palczewski, K.3
  • 61
    • 0027190359 scopus 로고
    • Projection structure of rhodopsin
    • Schertler G, Villa C, Henderson R (1993) Projection structure of rhodopsin. Nature 362:770-772
    • (1993) Nature , vol.362 , pp. 770-772
    • Schertler, G.1    Villa, C.2    Henderson, R.3
  • 62
    • 84860669844 scopus 로고    scopus 로고
    • Recent advances in the development of 14-alkoxy substituted morphinans as potent and safer opioid analgesics
    • Spetea M, Schmidhammer H (2012) Recent advances in the development of 14-alkoxy substituted morphinans as potent and safer opioid analgesics. Curr Med Chem 19:2442-2457
    • (2012) Curr Med Chem , vol.19 , pp. 2442-2457
    • Spetea, M.1    Schmidhammer, H.2
  • 64
    • 80052083563 scopus 로고    scopus 로고
    • Nanobody stabilization of G protein-coupled receptor conformational states
    • Steyaert J, Kobilka BK (2011) Nanobody stabilization of G protein-coupled receptor conformational states. Curr Opin Struct Biol 21:567-572
    • (2011) Curr Opin Struct Biol , vol.21 , pp. 567-572
    • Steyaert, J.1    Kobilka, B.K.2
  • 65
    • 84865436871 scopus 로고    scopus 로고
    • A crystal clear solution for determining Gprotein-coupled receptor structures
    • Tate CG (2012) A crystal clear solution for determining Gprotein-coupled receptor structures. Trends Biochem Sci 37:343-352
    • (2012) Trends Biochem Sci , vol.37 , pp. 343-352
    • Tate, C.G.1
  • 67
    • 79953284222 scopus 로고    scopus 로고
    • Docking-based virtual screening for ligands of G protein-coupled receptors: Not only crystal structures but also in silico models
    • doi:10.1016/j.jmgm.2010.1011.1005
    • Vilar S, Ferino G, Phatak SS, Berk B, Cavasotto CN, Costanzi S (2010) Docking-based virtual screening for ligands of G protein-coupled receptors: Not only crystal structures but also in silico models. J Mol Graph Model. doi:10.1016/j.jmgm.2010.1011.1005
    • (2010) J Mol Graph Model
    • Vilar, S.1    Ferino, G.2    Phatak, S.S.3    Berk, B.4    Cavasotto, C.N.5    Costanzi, S.6
  • 68
    • 79953274843 scopus 로고    scopus 로고
    • In silico analysis of the binding of agonists and blockers to the beta2-adrenergic receptor
    • Vilar S, Karpiak J, Berk B, Costanzi S (2011) In silico analysis of the binding of agonists and blockers to the beta2-adrenergic receptor. J Mol Graph Model 29:809-817
    • (2011) J Mol Graph Model , vol.29 , pp. 809-817
    • Vilar, S.1    Karpiak, J.2    Berk, B.3    Costanzi, S.4
  • 70
    • 70349513038 scopus 로고    scopus 로고
    • Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models
    • Worth C, Kleinau G, Krause G (2009) Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One 4:e7011
    • (2009) PLoS One , vol.4
    • Worth, C.1    Kleinau, G.2    Krause, G.3


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