Cannabinoid receptor 1 is a major mediator of renal fibrosis

Kidney International

Volumn 88, Issue 1, 2015, Pages 72-84

  Lecru, Lola ^a   Desterke, Christophe ^a   Grassin Delyle, Stanislas ^b   Chatziantoniou, Christos ^c   Vandermeersch, Sophie ^c   Devocelle, Aurore ^a   Vernochet, Amelia ^a   Ivanovski, Ninoslav ^a   Ledent, Catherine ^d   Ferlicot, Sophie ^e   Dalia, Meriem ^a   Saïd, Myriam ^a   Beaudreuil, Séverine ^a,e   Charpentier, Bernard ^a,e   Vazquez, Aimé ^a   Giron Michel, Julien ^a   Azzarone, Bruno ^f   Durrbach, Antoine ^a,e,g   François, Hélène ^a,e,g  

^a HÔPITAL PAUL BROUSSE   (France)

^b LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^c HÔPITAL TENON   (France)

^d UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^e BICÊTRE HOSPITAL   (France)

^f G GASLINI INSTITUTE   (Italy)

^g Institut Francilien de Recherche en Néphrologie et Transplantation   (France)

Author keywords

Cannabinoid; Chronic kidney disease; Fibrosis; Myofibroblast

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; AM 6545; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; COLLAGEN TYPE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; RIMONABANT; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; ARACHIDONIC ACID DERIVATIVE; CCL2 PROTEIN, MOUSE; COLLAGEN; ENDOCANNABINOID; LIGAND; MESSENGER RNA; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC EFFECT; ARTICLE; CB1 GENE; CELL ACTIVATION; CELL COUNT; CELL DIFFERENTIATION; CELL INFILTRATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG EFFECT; DRUG MECHANISM; FIBROGENESIS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; IN VITRO STUDY; INFLAMMATION; INTERSTITIAL NEPHRITIS; KIDNEY BIOPSY; KIDNEY FIBROSIS; MACROPHAGE; MICROARRAY ANALYSIS; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; TISSUE DISTRIBUTION; UPREGULATION; URETER OBSTRUCTION; ACUTE DISEASE; ANIMAL; CELL CULTURE; COMPLICATION; DIABETES MELLITUS; DISEASE MODEL; DNA MICROARRAY; DRUG EFFECTS; FIBROSIS; GENE EXPRESSION PROFILING; GENETICS; KIDNEY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ACUTE DISEASE; ANIMALS; ARACHIDONIC ACIDS; CELLS, CULTURED; CHEMOKINE CCL2; COLLAGEN; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; ENDOCANNABINOIDS; FIBROSIS; GENE EXPRESSION PROFILING; GLOMERULONEPHRITIS, IGA; GLYCERIDES; HUMANS; KIDNEY; LIGANDS; MACROPHAGES; MICE; MICE, KNOCKOUT; MYOFIBROBLASTS; NEPHRITIS, INTERSTITIAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PIPERIDINES; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; URETERAL OBSTRUCTION;

EID: 84934435290     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2015.63     Document Type: Article

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