The interaction of heparin tetrasaccharides with chemokine CCL5 is modulated by sulfation pattern and pH

Journal of Biological Chemistry

Volumn 290, Issue 25, 2015, Pages 15421-15436

  Singh, Arunima ^a   Kett, Warren C ^b   Severin, India C ^c   Agyekum, Isaac ^a   Duan, Jiana ^a   Amster, I Jonathan ^a   Proudfoot, Amanda E I ^c   Coombe, Deirdre R ^b   Woods, Robert J ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b CURTIN UNIVERSITY   (Australia)

^c MERCK SERONO S A   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARBOXYLATION; OLIGOSACCHARIDES; SULFUR COMPOUNDS;

CARBOXYLATE GROUPS; CHEMOKINES; GLYCOSAMINOGLYCANS; HEPARAN SULFATES; HOMODIMERS; PHYSIOLOGICAL CONDITION; STRONG DEPENDENCES; TETRASACCHARIDES;

POLYSACCHARIDES;

CARBOXYLIC ACID; CHEMOKINE RECEPTOR CCR1; GLYCOSAMINOGLYCAN; HEPARIN; HEPARIN FRAGMENT; HEPARIN TETRASACCHARIDE; HISTIDINE; HOMODIMER; RANTES; SULFATE; TETRASACCHARIDE; UNCLASSIFIED DRUG; CCL5 PROTEIN, HUMAN; CCR1 PROTEIN, HUMAN; OLIGOSACCHARIDE; PROTEIN BINDING;

ARTICLE; COMPLEX FORMATION; IC50; MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PH; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SULFATION; SURFACE CHARGE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PROTEIN MOTIF;

AMINO ACID MOTIFS; CHEMOKINE CCL5; HEPARIN; HUMANS; HYDROGEN-ION CONCENTRATION; OLIGOSACCHARIDES; PROTEIN BINDING; RECEPTORS, CCR1;

EID: 84934317380     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.655845     Document Type: Article

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