Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 22, 2014, Pages 8173-8178

  Nonaka, Motohiro ^a   Bao, Xingfeng ^a   Matsumura, Fumiko ^a,b   Götze, Sebastian ^b,c   Kandasamy, Jeyakumar ^b,c   Kononov, Andrew ^b   Broide, David H ^d   Nakayama, Jun ^e   Seeberger, Peter H ^b,c   Fukuda, Minoru ^a  

^a BURNHAM INSTITUTE   (United States)

^b MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Lymphocyte recruitment; Sulfated monosaccharide

Indexed keywords

2,4 O DISULFATED IDURONIC ACID; ANTIASTHMATIC AGENT; DISACCHARIDASE; HEPARAN SULFATE; HEPARIN; IDURONIC ACID; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOSACCHARIDE; OLIGOSACCHARIDE; OVALBUMIN; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CD3+ T LYMPHOCYTE; CELL MIGRATION; CONTROLLED STUDY; DRUG SYNTHESIS; EOSINOPHIL; INFLAMMATION; LUNG LAVAGE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RESPIRATORY TRACT ALLERGY; T LYMPHOCYTE;

LYMPHOCYTE RECRUITMENT; SULFATED MONOSACCHARIDE;

ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CARBOHYDRATE SEQUENCE; CHEMOKINE CCL20; CHEMOTAXIS; DISEASE MODELS, ANIMAL; EOSINOPHILS; HEPARITIN SULFATE; IDURONIC ACID; LUNG; MICE; MICE, KNOCKOUT; N-ACETYLGLUCOSAMINYLTRANSFERASES; OVALBUMIN; POLYSACCHARIDES; RECEPTOR, TIE-2; SULFATES; T-LYMPHOCYTES;

EID: 84901839609     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1319870111     Document Type: Article

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