메뉴 건너뛰기




Volumn 24, Issue 14, 2015, Pages 1635-1647

Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis in Vitro

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A1; CYCLIN D2; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; NERVE GROWTH FACTOR; PROTEIN KINASE B; SCATTER FACTOR; SOMATOMEDIN C; STAT3 PROTEIN; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN; CXCL12 PROTEIN, HUMAN; HGF PROTEIN, HUMAN; IGF1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; NGF PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

EID: 84934297053     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2014.0316     Document Type: Article
Times cited : (554)

References (76)
  • 2
    • 33745492981 scopus 로고    scopus 로고
    • Chronic wound pathogenesis and current treatment strategies: A unifying hypothesis
    • Mustoe TA, K O'Shaughnessy and O Kloeters. (2006). Chronic wound pathogenesis and current treatment strategies: A unifying hypothesis. Plast Reconstr Surg 117: 35S-41S.
    • (2006) Plast Reconstr Surg , vol.117 , pp. 35S-41S
    • Mustoe, T.A.1    O'shaughnessy, K.2    Kloeters, O.3
  • 3
    • 70449659580 scopus 로고    scopus 로고
    • The wound healing process: An overview of the cellular and molecular mechanisms
    • Velnar T, T Bailey and V Smrkolj. (2009). The wound healing process: An overview of the cellular and molecular mechanisms. J Int Med Res 37:1528-1542.
    • (2009) J Int Med Res , vol.37 , pp. 1528-1542
    • Velnar, T.1    Bailey, T.2    Smrkolj, V.3
  • 4
    • 85046909189 scopus 로고    scopus 로고
    • Wound healing: Biologic features and approaches to maximize healing trajectories
    • Robson MC, DL Steed and MG Franz. (2001). Wound healing: biologic features and approaches to maximize healing trajectories. Curr Probl Surg 38:72-140.
    • (2001) Curr Probl Surg , vol.38 , pp. 72-140
    • Robson, M.C.1    Steed, D.L.2    Franz, M.G.3
  • 5
    • 22844434968 scopus 로고    scopus 로고
    • Normal cutaneous wound healing: Clinical correlation with cellular and molecular events
    • discussion 686
    • Baum CL and CJ Arpey. (2005). Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg 31:674-686; discussion 686.
    • (2005) Dermatol Surg , vol.31 , pp. 674-686
    • Baum, C.L.1    Arpey, C.J.2
  • 6
    • 2442717879 scopus 로고    scopus 로고
    • Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrowderived cells
    • Galiano RD, OM Tepper, CR Pelo, KA Bhatt, M Callaghan, N Bastidas, S Bunting, HG Steinmetz and GC Gurtner. (2004). Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrowderived cells. Am J Pathol 164:1935-1947.
    • (2004) Am J Pathol , vol.164 , pp. 1935-1947
    • Galiano, R.D.1    Tepper, O.M.2    Pelo, C.R.3    Bhatt, K.A.4    Callaghan, M.5    Bastidas, N.6    Bunting, S.7    Steinmetz, H.G.8    Gurtner, G.C.9
  • 7
    • 34248225758 scopus 로고    scopus 로고
    • Cellular and molecular basis of wound healing in diabetes
    • Brem H and M Tomic-Canic. (2007). Cellular and molecular basis of wound healing in diabetes. J Clin Invest 117: 1219-1222.
    • (2007) J Clin Invest , vol.117 , pp. 1219-1222
    • Brem, H.1    Tomic-Canic, M.2
  • 8
    • 0037220689 scopus 로고    scopus 로고
    • Cellular dysfunction in the diabetic fibroblast: Impairment in migration, vascular endothelial growth factor production, and response to hypoxia
    • Lerman OZ, RD Galiano, M Armour, JP Levine and GC Gurtner. (2003). Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J Pathol 162:303-312.
    • (2003) Am J Pathol , vol.162 , pp. 303-312
    • Lerman, O.Z.1    Galiano, R.D.2    Armour, M.3    Levine, J.P.4    Gurtner, G.C.5
  • 9
    • 0033012820 scopus 로고    scopus 로고
    • Cultured fibroblasts from chronic diabetic wounds on the lower extremity (non-insulin-dependent diabetes mellitus) show disturbed proliferation
    • Loots MA, EN Lamme, JR Mekkes, JD Bos and E Middelkoop. (1999). Cultured fibroblasts from chronic diabetic wounds on the lower extremity (non-insulin-dependent diabetes mellitus) show disturbed proliferation. Arch Dermatol Res 291:93-99.
    • (1999) Arch Dermatol Res , vol.291 , pp. 93-99
    • Loots, M.A.1    Lamme, E.N.2    Mekkes, J.R.3    Bos, J.D.4    Middelkoop, E.5
  • 11
    • 0030889354 scopus 로고    scopus 로고
    • Marrow stromal cells as stem cells for nonhematopoietic tissues
    • Prockop DJ. (1997). Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71-74.
    • (1997) Science , vol.276 , pp. 71-74
    • Prockop, D.J.1
  • 12
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • Uccelli A, L Moretta and V Pistoia. (2008). Mesenchymal stem cells in health and disease. Nat Rev Immunol 8:726-736.
    • (2008) Nat Rev Immunol , vol.8 , pp. 726-736
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 13
    • 84872023663 scopus 로고    scopus 로고
    • Concise review: Clinical translation of wound healing therapies based on mesenchymal stem cells
    • Jackson WM, LJ Nesti and RS Tuan. (2012). Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem Cells Transl Med 1: 44-50.
    • (2012) Stem Cells Transl Med , vol.1 , pp. 44-50
    • Jackson, W.M.1    Nesti, L.J.2    Tuan, R.S.3
  • 14
    • 76949083500 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy for nonhealing cutaneous wounds
    • Hanson SE, ML Bentz and P Hematti. (2010). Mesenchymal stem cell therapy for nonhealing cutaneous wounds. Plast Reconstr Surg 125:510-516.
    • (2010) Plast Reconstr Surg , vol.125 , pp. 510-516
    • Hanson, S.E.1    Bentz, M.L.2    Hematti, P.3
  • 15
    • 67649576912 scopus 로고    scopus 로고
    • Muscular dystrophy therapy by nonautologous mesenchymal stem cells: Muscle regeneration without immunosuppression and inflammation
    • Shabbir A, D Zisa, M Leiker, C Johnston, H Lin and T Lee. (2009). Muscular dystrophy therapy by nonautologous mesenchymal stem cells: muscle regeneration without immunosuppression and inflammation. Transplantation 87: 1275-1282.
    • (2009) Transplantation , vol.87 , pp. 1275-1282
    • Shabbir, A.1    Zisa, D.2    Leiker, M.3    Johnston, C.4    Lin, H.5    Lee, T.6
  • 16
    • 78249278186 scopus 로고    scopus 로고
    • Activation of host tissue trophic factors through JAK-STAT3 signaling: A mechanism of mesenchymal stem cell-mediated cardiac repair
    • Shabbir A, D Zisa, H Lin, M Mastri, G Roloff, G Suzuki and T Lee. (2010). Activation of host tissue trophic factors through JAK-STAT3 signaling: A mechanism of mesenchymal stem cell-mediated cardiac repair. Am J Physiol Heart Circ Physiol 299:H1428-H1438.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. H1428-H1438
    • Shabbir, A.1    Zisa, D.2    Lin, H.3    Mastri, M.4    Roloff, G.5    Suzuki, G.6    Lee, T.7
  • 17
    • 66949176268 scopus 로고    scopus 로고
    • Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: A noninvasive therapeutic regimen
    • Shabbir A, D Zisa, G Suzuki and T Lee. (2009). Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: A noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol 296:H1888-H1897.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296 , pp. H1888-H1897
    • Shabbir, A.1    Zisa, D.2    Suzuki, G.3    Lee, T.4
  • 18
    • 44849121129 scopus 로고    scopus 로고
    • Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    • Chen L, EE Tredget, PY Wu and Y Wu. (2008). Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 3:e1886.
    • (2008) PLoS One , vol.3 , pp. e1886
    • Chen, L.1    Tredget, E.E.2    Wu, P.Y.3    Wu, Y.4
  • 19
    • 84872105612 scopus 로고    scopus 로고
    • Stimulation of skin and wound fibroblast migration by mesenchymal stem cells derived from normal donors and chronic wound patients
    • Rodriguez-Menocal L, M Salgado, D Ford and E Van Badiavas. (2012). Stimulation of skin and wound fibroblast migration by mesenchymal stem cells derived from normal donors and chronic wound patients. Stem Cells Transl Med 1:221-229.
    • (2012) Stem Cells Transl Med , vol.1 , pp. 221-229
    • Rodriguez-Menocal, L.1    Salgado, M.2    Ford, D.3    Van Badiavas, E.4
  • 20
    • 84860858416 scopus 로고    scopus 로고
    • Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials
    • Vlassov AV, S Magdaleno, R Setterquist and R Conrad. (2012). Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta 1820:940-948.
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 940-948
    • Vlassov, A.V.1    Magdaleno, S.2    Setterquist, R.3    Conrad, R.4
  • 22
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, K Ekstrom, A Bossios, M Sjostrand, JJ Lee and JO Lotvall. (2007). Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654-659.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 25
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Unit 3 22
    • Théry C, S Amigorena, G Raposo and A Clayton. (2006). Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol Chapter 3:Unit 3 22.
    • (2006) Curr Protoc Cell Biol Chapter , vol.3
    • Théry, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 26
    • 84867117645 scopus 로고    scopus 로고
    • Exosomes as biomarker enriched microvesicles: Characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes
    • Hosseini-Beheshti E, S Pham, H Adomat, N Li and ES Tomlinson Guns. (2012). Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. Mol Cell Proteomics 11:863-885.
    • (2012) Mol Cell Proteomics , vol.11 , pp. 863-885
    • Hosseini-Beheshti, E.1    Pham, S.2    Adomat, H.3    Li, N.4    Tomlinson Guns, E.S.5
  • 27
    • 79955863801 scopus 로고    scopus 로고
    • Microvesicle-mediated release of soluble LH/hCG receptor (LHCGR) from transfected cells and placenta explants
    • Chambers AE, PF Stanley, H Randeva and S Banerjee. (2011). Microvesicle-mediated release of soluble LH/hCG receptor (LHCGR) from transfected cells and placenta explants. Reprod Biol Endocrinol 9:64.
    • (2011) Reprod Biol Endocrinol , vol.9 , pp. 64
    • Chambers, A.E.1    Stanley, P.F.2    Randeva, H.3    Banerjee, S.4
  • 28
    • 84883412245 scopus 로고    scopus 로고
    • Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro
    • Yang L, XH Wu, D Wang, CL Luo and LX Chen. (2013). Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro. Mol Med Rep 8:1272-1278.
    • (2013) Mol Med Rep , vol.8 , pp. 1272-1278
    • Yang, L.1    Wang, D.2    Luo, C.L.3    Chen, L.X.4
  • 29
    • 84877153402 scopus 로고    scopus 로고
    • Extracellular vesicles: Communication, coercion, and conditioning
    • Shifrin DA, Jr., M Demory Beckler, RJ Coffey and MJ Tyska. (2013). Extracellular vesicles: communication, coercion, and conditioning. Mol Biol Cell 24:1253-1259.
    • (2013) Mol Biol Cell , vol.24 , pp. 1253-1259
    • Shifrin, D.A.1    Demory Beckler, M.2    Coffey, R.J.3    Tyska, M.J.4
  • 30
    • 0141887410 scopus 로고    scopus 로고
    • STRO-1, HOP-26 (CD63), CD49a and SB-10 (CD166) as markers of primitive human marrow stromal cells and their more differentiated progeny: A comparative investigation in vitro
    • Stewart K, P Monk, S Walsh, CM Jefferiss, J Letchford and JN Beresford. (2003). STRO-1, HOP-26 (CD63), CD49a and SB-10 (CD166) as markers of primitive human marrow stromal cells and their more differentiated progeny: A comparative investigation in vitro. Cell Tissue Res 313: 281-290.
    • (2003) Cell Tissue Res , vol.313 , pp. 281-290
    • Stewart, K.1    Monk, P.2    Walsh, S.3    Jefferiss, C.M.4    Letchford, J.5    Beresford, J.N.6
  • 32
    • 84884171136 scopus 로고    scopus 로고
    • Micro-RNA and protein profiling of brain metastasis competent cell-derived exosomes
    • Camacho L, P Guerrero and D Marchetti. (2013). Micro-RNA and protein profiling of brain metastasis competent cell-derived exosomes. PLoS One 8:e73790.
    • (2013) PLoS One , vol.8 , pp. e73790
    • Camacho, L.1    Guerrero, P.2    Marchetti, D.3
  • 35
    • 34347218991 scopus 로고    scopus 로고
    • In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro
    • Liang CC, AY Park and JL Guan. (2007). In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2:329-333.
    • (2007) Nat Protoc , vol.2 , pp. 329-333
    • Liang, C.C.1    Park, A.Y.2    Guan, J.L.3
  • 36
    • 77956283576 scopus 로고    scopus 로고
    • Accelerated wound healing by mTOR activation in genetically defined mouse models
    • Squarize CH, RM Castilho, TH Bugge and JS Gutkind. (2010). Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One 5:e10643.
    • (2010) PLoS One , vol.5 , pp. e10643
    • Squarize, C.H.1    Castilho, R.M.2    Bugge, T.H.3    Gutkind, J.S.4
  • 37
    • 39149102509 scopus 로고    scopus 로고
    • Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases
    • Sano S, KS Chan and J DiGiovanni. (2008). Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases. J Dermatol Sci 50:1-14.
    • (2008) J Dermatol Sci , vol.50 , pp. 1-14
    • Sano, S.1    Chan, K.S.2    Digiovanni, J.3
  • 38
    • 0037821639 scopus 로고    scopus 로고
    • P38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: Evidence of cross-talk activation between MAP kinase cascades
    • Sharma GD, J He and HE Bazan. (2003). p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades. J Biol Chem 278:21989-21997.
    • (2003) J Biol Chem , vol.278 , pp. 21989-21997
    • Sharma, G.D.1    He, J.2    Bazan, H.E.3
  • 40
    • 0034616028 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes
    • Funamoto M, Y Fujio, K Kunisada, S Negoro, E Tone, T Osugi, H Hirota, M Izumi, K Yoshizaki, et al. (2000). Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes. J Biol Chem 275:10561-10566.
    • (2000) J Biol Chem , vol.275 , pp. 10561-10566
    • Funamoto, M.1    Fujio, Y.2    Kunisada, K.3    Negoro, S.4    Tone, E.5    Osugi, T.6    Hirota, H.7    Izumi, M.8    Yoshizaki, K.9
  • 42
    • 78649622426 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: A biochemical and genetic study of es-tablished cancer cell lines and clinical isolated human cancer cells
    • Huang WL, HH Yeh, CC Lin, WW Lai, JY Chang, WT Chang and WC Su. (2010). Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: A biochemical and genetic study of es-tablished cancer cell lines and clinical isolated human cancer cells. Mol Cancer 9:309.
    • (2010) Mol Cancer , vol.9 , pp. 309
    • Huang, W.L.1    Yeh, H.H.2    Lin, C.C.3    Lai, W.W.4    Chang, J.Y.5    Chang, W.T.6    Su, W.C.7
  • 43
    • 0037390253 scopus 로고    scopus 로고
    • Treatment of chronic wounds with bone marrow-derived cells
    • Badiavas EV and V Falanga. (2003). Treatment of chronic wounds with bone marrow-derived cells. Arch Dermatol 139:510-516.
    • (2003) Arch Dermatol , vol.139 , pp. 510-516
    • Badiavas, E.V.1    Falanga, V.2
  • 44
    • 80053630148 scopus 로고    scopus 로고
    • Potential benefits of allogeneic bone marrow mesenchymal stem cells for wound healing
    • Badiavas AR and EV Badiavas. (2011). Potential benefits of allogeneic bone marrow mesenchymal stem cells for wound healing. Expert Opin Biol Ther 11:1447-1454.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1447-1454
    • Badiavas, A.R.1    Badiavas, E.V.2
  • 45
    • 0742289577 scopus 로고    scopus 로고
    • The potential of bone marrow cells to orchestrate homeostasis and healing in skin
    • Badiavas EV. (2004). The potential of bone marrow cells to orchestrate homeostasis and healing in skin. Blood Cells Mol Dis 32:21-23.
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 21-23
    • Badiavas, E.V.1
  • 48
    • 84884274645 scopus 로고    scopus 로고
    • MSCs: Delivery routes and engraftment, cell-targeting strategies, and immune modulation
    • Kean TJ, P Lin, AI Caplan and JE Dennis. (2013). MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation. Stem Cells Int 2013: 732742.
    • (2013) Stem Cells Int , vol.2013 , pp. 732742
    • Kean, T.J.1    Lin, P.2    Caplan, A.I.3    Dennis, J.E.4
  • 49
    • 84891795530 scopus 로고    scopus 로고
    • Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-beta/SMAD2 and PI3K/Akt pathways
    • Jun EK, Q Zhang, BS Yoon, JH Moon, G Lee, G Park, PJ Kang, JH Lee, A Kim and S You. (2014). Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-beta/SMAD2 and PI3K/Akt pathways. Int J Mol Sci 15:605-628.
    • (2014) Int J Mol Sci , vol.15 , pp. 605-628
    • Jun, E.K.1    Zhang, Q.2    Yoon, B.S.3    Moon, J.H.4    Lee, G.5    Park, G.6    Kang, P.J.7    Lee, J.H.8    Kim, A.9    You, S.10
  • 50
    • 84871831849 scopus 로고    scopus 로고
    • Acceleration of wound healing by multiple growth factors and cytokines secreted from multipotential stromal cells/mesenchymal stem cells
    • Tamama K and SS Kerpedjieva. (2012). Acceleration of wound healing by multiple growth factors and cytokines secreted from multipotential stromal cells/mesenchymal stem cells. Adv Wound Care (New Rochelle) 1:177-182.
    • (2012) Adv Wound Care (New Rochelle) , vol.1 , pp. 177-182
    • Tamama, K.1    Kerpedjieva, S.S.2
  • 52
    • 77950628997 scopus 로고    scopus 로고
    • Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays
    • Walter MN, KT Wright, HR Fuller, S MacNeil and WE Johnson. (2010). Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res 316:1271-1281.
    • (2010) Exp Cell Res , vol.316 , pp. 1271-1281
    • Walter, M.N.1    Wright, K.T.2    Fuller, H.R.3    Macneil, S.4    Johnson, W.E.5
  • 53
    • 1142286348 scopus 로고    scopus 로고
    • Nanotubular highways for intercellular organelle transport
    • Rustom A, R Saffrich, I Markovic, P Walther and HH Gerdes. (2004). Nanotubular highways for intercellular organelle transport. Science 303:1007-1010.
    • (2004) Science , vol.303 , pp. 1007-1010
    • Rustom, A.1    Saffrich, R.2    Markovic, I.3    Walther, P.4    Gerdes, H.H.5
  • 56
    • 84887117028 scopus 로고    scopus 로고
    • Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats
    • Xin H, Y Li, Y Cui, JJ Yang, ZG Zhang and M Chopp. (2013). Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 33:1711-1715.
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1711-1715
    • Xin, H.1    Cui, Y.2    Yang, J.J.3    Zhang, Z.G.4    Chopp, M.5
  • 57
    • 84891819825 scopus 로고    scopus 로고
    • Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice
    • Zhu YG, XM Feng, J Abbott, XH Fang, Q Hao, A Monsel, JM Qu, MA Matthay and JW Lee. (2014). Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells 32:116-125.
    • (2014) Stem Cells , vol.32 , pp. 116-125
    • Zhu, Y.G.1    Feng, X.M.2    Abbott, J.3    Fang, X.H.4    Hao, Q.5    Monsel, A.6    Matthay, M.A.7    Lee, J.W.8
  • 58
    • 58249126860 scopus 로고    scopus 로고
    • Primary cultured fibroblasts derived from patients with chronic wounds: A methodology to produce human cell lines and test putative growth factor therapy such as GMCSF
    • Brem H, MS Golinko, O Stojadinovic, A Kodra, RF Diegelmann, S Vukelic, H Entero, DL Coppock and M Tomic-Canic. (2008). Primary cultured fibroblasts derived from patients with chronic wounds: A methodology to produce human cell lines and test putative growth factor therapy such as GMCSF. J Transl Med 6:75.
    • (2008) J Transl Med , vol.6 , pp. 75
    • Brem, H.1    Golinko, M.S.2    Stojadinovic, O.3    Kodra, A.4    Diegelmann, R.F.5    Vukelic, S.6    Entero, H.7    Coppock, D.L.8    Tomic-Canic, M.9
  • 62
    • 80053560934 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro
    • Guiducci S, M Manetti, E Romano, B Mazzanti, C Ceccarelli, S Dal Pozzo, AF Milia, S Bellando-Randone, G Fiori, et al. (2011). Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro. Ann Rheum Dis 70:2011-2021.
    • (2011) Ann Rheum Dis , vol.70 , pp. 2011-2021
    • Guiducci, S.1    Manetti, M.2    Romano, E.3    Mazzanti, B.4    Ceccarelli, C.5    Dal Pozzo, S.6    Milia, A.F.7    Bellando-Randone, S.8    Fiori, G.9
  • 63
    • 79954988933 scopus 로고    scopus 로고
    • Serum-deprived human multipotent mesenchymal stromal cells (MSCs) are highly angiogenic
    • Oskowitz A, H McFerrin, M Gutschow, ML Carter and R Pochampally. (2011). Serum-deprived human multipotent mesenchymal stromal cells (MSCs) are highly angiogenic. Stem Cell Res 6:215-225.
    • (2011) Stem Cell Res , vol.6 , pp. 215-225
    • Oskowitz, A.1    McFerrin, H.2    Gutschow, M.3    Carter, M.L.4    Pochampally, R.5
  • 64
    • 84898461927 scopus 로고    scopus 로고
    • Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
    • Bian S, L Zhang, L Duan, X Wang, Y Min and H Yu. (2014). Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berl) 92:387-397.
    • (2014) J Mol Med (Berl) , vol.92 , pp. 387-397
    • Bian, S.1    Zhang, L.2    Duan, L.3    Wang, X.4    Min, Y.5    Yu, H.6
  • 65
    • 1642373909 scopus 로고    scopus 로고
    • Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    • Kinnaird T, E Stabile, MS Burnett, CW Lee, S Barr, S Fuchs and SE Epstein. (2004). Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 94: 678-685.
    • (2004) Circ Res , vol.94 , pp. 678-685
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3    Lee, C.W.4    Barr, S.5    Fuchs, S.6    Epstein, S.E.7
  • 66
    • 67650531456 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance the viability and proliferation of human fetal intestinal epithelial cells following hypoxic injury via paracrine mechanisms
    • Weil BR, TA Markel, JL Herrmann, AM Abarbanell and DR Meldrum. (2009). Mesenchymal stem cells enhance the viability and proliferation of human fetal intestinal epithelial cells following hypoxic injury via paracrine mechanisms. Surgery 146:190-197.
    • (2009) Surgery , vol.146 , pp. 190-197
    • Weil, B.R.1    Markel, T.A.2    Herrmann, J.L.3    Abarbanell, A.M.4    Meldrum, D.R.5
  • 67
    • 70449705826 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) as a key therapeutic trophic factor in bone marrow mesenchymal stem cellmediated cardiac repair
    • Zisa D, A Shabbir, G Suzuki and T Lee. (2009). Vascular endothelial growth factor (VEGF) as a key therapeutic trophic factor in bone marrow mesenchymal stem cellmediated cardiac repair. Biochem Biophys Res Commun 390:834-838.
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 834-838
    • Zisa, D.1    Shabbir, A.2    Suzuki, G.3    Lee, T.4
  • 68
    • 0002955655 scopus 로고    scopus 로고
    • The role of growth factors in the healing of chronic wounds
    • Robson MC. (1997). The role of growth factors in the healing of chronic wounds. Wound Repair Regen 5: 12-17.
    • (1997) Wound Repair Regen , vol.5 , pp. 12-17
    • Robson, M.C.1
  • 70
    • 0032943898 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: Importance of oxygen and age
    • Wu L, YP Xia, SI Roth, E Gruskin and TA Mustoe. (1999). Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: importance of oxygen and age. Am J Pathol 154:301-309.
    • (1999) Am J Pathol , vol.154 , pp. 301-309
    • Wu, L.1    Xia, Y.P.2    Roth, S.I.3    Gruskin, E.4    Mustoe, T.A.5
  • 71
    • 84856468503 scopus 로고    scopus 로고
    • Microvesicles as novel biomarkers and therapeutic targets in transplantation medicine
    • Fleissner F, Y Goerzig, A Haverich and T Thum. (2012). Microvesicles as novel biomarkers and therapeutic targets in transplantation medicine. Am J Transplant 12:289-297.
    • (2012) Am J Transplant , vol.12 , pp. 289-297
    • Fleissner, F.1    Goerzig, Y.2    Haverich, A.3    Thum, T.4
  • 74
    • 84903536644 scopus 로고    scopus 로고
    • 14-3-3 and beta-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway
    • Dovrat S, M Caspi, A Zilberberg, L Lahav, A Firsow, H Gur and R Rosin-Arbesfeld. (2014). 14-3-3 and beta-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway. Mol Oncol 8:894-911.
    • (2014) Mol Oncol , vol.8 , pp. 894-911
    • Dovrat, S.1    Caspi, M.2    Zilberberg, A.3    Lahav, L.4    Firsow, A.5    Gur, H.6    Rosin-Arbesfeld, R.7
  • 76
    • 84870297256 scopus 로고    scopus 로고
    • Insights into bone marrow-derived mesenchymal stem cells safety for cutaneous repair and regeneration
    • Wu Y, S Huang, J Enhe and X Fu. (2012). Insights into bone marrow-derived mesenchymal stem cells safety for cutaneous repair and regeneration. Int Wound J 9:586-594.
    • (2012) Int Wound J , vol.9 , pp. 586-594
    • Wu, Y.1    Huang, S.2    Enhe, J.3    Fu, X.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.