The role of growth factors in the healing of chronic wounds

Wound Repair and Regeneration

Volumn 5, Issue 1, 1997, Pages 12-17

  Robson, Martin C ^a  

^a Bay Pines VA Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002955655     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.1997.50106.x     Document Type: Review

References (24)

1. Robson MC. Growth factors as wound healing agents. Curr Opinion Biotech 1991;2:863-7.
2. Robson MC, Stonberg BD, Heggers JP. Wound healing alterations caused by infection. Clin Plast Surg 1990;17:485-92.
3. Bennett NT, Schultz GS. Growth factors and wound healing: part II. Role in normal and chronic wound healing. Am J Surg 1993;166:74-81.
4. Cooper DM, Yu EZ, Hennessey P, Ko F, Robson MC. Determination of endogenous cytokines in chronic wounds. Ann Surg 1994;219:688-92.
5. Herrick SE, McCollum CI, Ferguson MWJ. Chronic ischaemia/ reperfusion: a cause of venous ulcer formation and delayed healing [abstract]. Wound Rep Reg 1994;2:213.
6. Hayward PG, Hokanson J, Heggers JP, Fiddes J, Klingbeil C, Goeger M, Robson MC. Fibroblast growth factor reverses the bacterial retardation of wound contraction. Am J Surg 1992;163: 288-93.
7. Pauolakkainen PA, Twardzik DR, Ranchalis JE, Pankay SC, Reed MJ, Gombotz WR. The enhancement in wound healing by transforming growth factor-β1 (TGF-β1) depends on the topical delivery system. J Surg Res 1995;58:321-9.
8. Robson MC, Phillips LG, Thomason A, Altrock BW, Anthony MS, Robson LE, Odom LL, Yanagihara D, Pierce GF. Recombinant human platelet-derived growth factor-BB for the treatment of chronic pressure ulcers. Ann Plast Surg 1992;29: 193-201.
9. Robson MC, Phillips LG, Lawrence WT, Bishop JB, Youngerman JS, Hayward PG, Broemeling LD, Heggers JP. The safety and effect of topically applied recombinant basic fibroblast growth factor on healing of chronic pressure sores. Ann Surg 1992;216: 401-8.
10. Robson MC, Phillips LG, Thomason A, Robson LE, Pierce GL. Platelet-derived growth factor-BB for the treatment of chronic pressure ulcers. Lancet 1992;339:23-5.
11. Stenberg BD, Phillips LG, Hokanson JA, Heggers JP, Robson MC. Effect of bFGF on the inhibition of contraction caused by bacteria. J Surg Res, 1991;50:47-50.
12. Kucukcelebei A, Hui PS, Sahara K, Ko F, Robson MC. The effect of interleukin-1β on the inhibition of contraction of excisional wounds caused by bacterial contamination. Surg Forum 1992;43: 715-6.
13. Robson MC, Abdulla A, Burns BF, Phillips LG, Garrison L, Cowan W, Hill D, Vandeberg J, Robson LE, Scheeler S. Safety and effect of topical recombinant human interleukin-1β in the management of pressure sores. Wound Rep Reg 1994;2:177-81.
14. Vandeberg JS, Robson MC, Mikhail RS. Extension of life span of pressure ulcer fibroblasts with recombinant human interleukin-1 beta (rhuIL-1B). Am J Pathol. In press.
15. Falanga V, Eaglstein WH, Bucalo B, Katz MH, Harris B, Carson P. Topical use of human recombinant epidermal growth factor (h-EGF) in venous ulcers. J Dermatol Surg Oncol 1992;16:604-6.
16. Robson MC, Phillips LG, Cooper DM, Lyle WG, Robson LE, Odom L, Hill DP, Hanham AF, Ksander GA. The safety and effect of transforming growth factor-β2 for the treatment of venous stasis ulcers. Wound Rep Reg 1995;3:157-67.
17. Bishop JB, Phillips LG, Mustoe TA, VanderZee AJ, Wiersma L, Roach DE, Heggers JP, Hill DP, Taylor EL, Robson MC. A prospective randomized evaluator-blinded trial of two potential wound healing agents for the treatment of venous stasis ulcers. J Vasc Surg 1992;16:251-7.
18. Mustoe TA, Cutler NR, Allman RM, Goode P, Deuel TF, Prose JA, Bear M, Serdar CM, Pierce GF. Phase II study to evaluate recombinant PDGF-BB in the treatment of pressure sores. Arch Surg 1994;129:213-9.
19. Steed DL, Webster MW, Ricotta JJ, Luterman A, Commerotta AJ, Brown S, Walsh DB, Bergamini TM, Baker WH, Donohoe DJ. Topical recombinant human platelet-derived growth factor (rhPDGF-B) accelerates healing of diabetic neurotropic foot ulcers. J Vasc Surg In press.
20. Richard J-L, Purer-Richard C, Daures J-P, Clouet S, Vannereau D, Bringer J, Rodier M, Jacob C, Comte-Bardonnet M. Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot. Diabetes Care 1995;18:64-9.
21. Brown GL, Curtsinger L, Jurkiewicz MJ, Nahai F, Schultz G. Stimulation of healing chronic wounds by epidermal growth factor. Plast Reconstr Surg 1991;88:189-94.
22. Robson MC. Discussion. Plast Reconstr Surg 1991;88:195-6.
23. Slama J, Andree C, Winkler T, Swain WF, Eriksson E. Gene transfer. Ann Plast Surg 1995;35:429-39.
24. Andree C, Swain W, Page C, Macklin MD, Slama J, Hatzsis D, Eriksson E. In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc Natl Acad Sci U S A 1994;91:12188-92.