Oligomeric TTR V30M aggregates compromise cell viability, erythropoietin gene expression and promoter activity in the human hepatoma cell line Hep3B

Amyloid

Volumn 22, Issue 2, 2015, Pages 93-99

  Moreira, Luciana ^a,b   Beiraõ, Joaõ Melo ^b,c   Beiraõ, Idalina ^b,c   Costa, Paulo Pinhoe E ^a,b  

^a NATIONAL INSTITUTE OF HEALTH   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c HOSPITAL DE SANTO ANTÓNIO   (Portugal)

Author keywords

Anemia; EPO expression; EPO promoter; Familial amyloid polyneuropathy; Transthyretin

Indexed keywords

CASPASE 3; CASPASE 7; ERYTHROPOIETIN; MESSENGER RNA;

CELL SURVIVAL; FAMILIAL AMYLOID POLYNEUROPATHY; GENETICS; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PHOTON CORRELATION SPECTROSCOPY; PHYSIOLOGY; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

AMYLOID NEUROPATHIES, FAMILIAL; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL SURVIVAL; DYNAMIC LIGHT SCATTERING; ERYTHROPOIETIN; HUMANS; LIVER NEOPLASMS; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84934296766     PISSN: 13506129     EISSN: 17442818     Source Type: Journal    
DOI: 10.3109/13506129.2015.1007497     Document Type: Article

References (49)

1. Benson MD. Liver transplantation and transthyretin amyloidosis. Muscle Nerve 2013;47:157-62.
2. Benson MD, Kincaid JC. The molecular biology and clinical features of amyloid neuropathy. Muscle Nerve 2007;36:411-23.
3. Reixach N, Deechongkit S, Jiang X, Kelly JW, Buxbaum JN. Tissue damage in the amyloidoses: transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proc Natl Acad Sci USA 2004;101:2817-22.
4. Sousa MM, Cardoso I, Fernandes R, Guimarães A, Saraiva MJ. Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates. Am J Pathol 2001;159:1993-2000.
5. Sousa MM, Du Yan S, Fernandes R, Guimaraes A, Stern D, Saraiva MJ. Familial amyloid polyneuropathy: receptor for advanced glycation end products-dependent triggering of neuronal inflammatory and apoptotic pathways. J Neurosci 2001;21:7576-86.
6. Sousa MM, Yan SD, Stern D, Saraiva MJ. Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation. Lab Invest 2000;80:1101-10.
7. Monteiro FA, Sousa MM, Cardoso I, do Amaral JB, Guimarães A, Saraiva MJ. Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy. J Neurochem 2006;97:151-61.
8. Planté-Bordeneuve V, Said G. Familial amyloid polyneuropathy. Lancet Neurol 2011;10:1086-97.
9. Beiraõ I, Lobato L, Costa PM, Fonseca I, Mendes P, Silva M, Bravo F, et al. Kidney and anemia in familial amyloidosis type I. Kidney Int 2004;66:2004-9.
10. Beiraõ I, Lobato L, Costa PM, Fonseca I, Silva M, Bravo F, Cabrita A, et al. Liver transplantation and anemia in familial amyloidosis ATTR V30M. Amyloid 2007;14:33-7.
11. Beiraõ I, Moreira L, Porto G, Lobato L, Fonseca I, Cabrita A, Costa PM. Low erythropoietin production in familial amyloidosis TTR V30M is not related with renal congophilic amyloid deposition. A clinicopathologic study of twelve cases. Nephron Clin Pract 2008; 109:c95-9.
12. Burlington H, Cronkite EP, Reincke U, Zanjani ED. Erythropoietin production in cultures of goat renal glomeruli. Proc Natl Acad Sci USA 1972;69:3547-50.
13. Lacombe C, Da Silva JL, Bruneval P, Fournier JG, Wendling F, Casadevall N, Camilleri JP, et al. Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest 1988;81:620-3.
14. Fisher JW, Koury S, Ducey T, Mendel S. Erythropoietin production by interstitial cells of hypoxic monkey kidneys. Br J Haematol 1996;95:27-32.
15. Loya F, Yang Y, Lin H, Goldwasser E, Albitar M. Transgenic mice carrying the erythropoietin gene promoter linked to lacZ express the rEPOrter in proximal convoluted tubule cells after hypoxia. Blood 1994;84:1831-6.
16. Horiguchi H, Oguma E, Kayama F. Cadmium and cisplatin damage erythropoietin-producing proximal renal tubular cells. Arch Toxicol 2006;80:680-6.
17. Beiraõ I, Moreira L, Barandela T, Lobato L, Silva P, Gouveia CM, Carneiro F, et al. Erythropoietin production by distal nephron in normal and familial amyloidotic adult human kidneys. Clin Nephrol 2010;74:327-35.
18. Nagai T, Yasuoka Y, Izumi Y, Horikawa K, Kimura M, Nakayama Y, Uematsu T, et al. Reevaluation of erythropoietin production by the nephron. Biochem Biophys Res Commun 2014;449:222-8.
19. Jelkmann W. Regulation of erythropoietin production. J Physiol 2011;589:1251-8.
20. Storti F, Santambrogio S, Crowther LM, Otto T, Abreu-Rodŕguez I, Kaufmann M, Hu CJ, et al. A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression. Haematologica 2014;99:e45-8.
21. Barbosa C, Romaõ L. Translation of the human erythropoietin transcript is regulated by an upstream open reading frame in response to hypoxia. RNA 2014;20:594-608.
22. Stockmann C, Fandrey J. Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression. Clin Exp Pharmacol Physiol 2006;33:968-79.
23. Imagawa S, Yamamoto M, Miura Y. Negative regulation of the erythropoietin gene expression by the GATA transcription factors. Blood 1997;89:1430-9.
24. La Ferla K, Reimann C, Jelkmann W, Hellwig-Bürgel T. Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB. FASEB J 2002;16:1811-13.
25. Goldberg MA, Glass GA, Cunningham JM, Bunn HF. The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci USA 1987;84:7972-6.
26. Moore SD, Prevelige Jr PE. Structural transformations accompanying the assembly of bacteriophage P22 portal protein rings in vitro. J Biol Chem 2001;276:6779-88.
27. Miroy GJ, Lai Z, Lashuel HA, Peterson SA, Strang C, Kelly JW. Inhibiting transthyretin amyloid fibril formation via protein stabilization. Proc Natl Acad Sci USA 1996;93:15051-6.
28. Kusser W. Use of self-quenched, fluorogenic LUX primers for gene expression profiling. Methods Mol Biol 2006;335:115-33.
29. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
30. Pires RH, Karsai á , Saraiva MJ, Damas AM, Kellermayer MS. Distinct annular oligomers captured along the assembly and disassembly pathways of transthyretin amyloid protofibrils. PLoS One 2012;7:e44992.
31. Sörgjerd K, Klingstedt T, Lindgren M, Kagedal K, Hammarström P. Prefibrillar transthyretin oligomers and cold stored native tetrameric transthyretin are cytotoxic in cell culture. Biochem Biophys Res Commun 2008;377:1072-8.
32. Andersson K, Olofsson A, Nielsen EH, Svehag SE, Lundgren E. Only amyloidogenic intermediates of transthyretin induce apoptosis. Biochem Biophys Res Commun 2002;294:309-14.
33. Hou X. Transthyretin oligomers induce calcium influx via voltagegated calcium channels. J Neurochem 2007;100:446-57.
34. Nunes RJ, de Oliveira P, Lages A, Becker JD, Marcelino P, Barroso E, Perdigoto R, et al. Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. J Biol Chem 2013;288:31752-60.
35. Beck I, Ramirez S, Weinmann R, Caro J. Enhancer element at the 30-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem 1991;266:15563-6.
36. Metzen E, Ratcliffe PJ. HIF hydroxylation and cellular oxygen sensing. Biol Chem 2004;385:223-30.
37. Takino J, Yamagishi S, Takeuchi M. Glycer-AGEs-RAGE signaling enhances the angiogenic potential of hepatocellular carcinoma by upregulating VEGF expression. World J Gastroenterol 2012;18: 1781-8.
38. Liepnieks JJ, Zhang LQ, Benson MD. Progression of transthyretin amyloid neuropathy after liver transplantation. Neurology 2010;75: 324-7.
39. Oshima T, Kawahara S, Ueda M, Kawakami Y, Tanaka R, Okazaki T, Misumi Y, et al. Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation. J Neurol Neurosurg Psychiatry 2014;85:740-6.
40. Beiraõ JM, Moreira LM, Oliveira JC, Menéres MJ, Pessoa BB, Matos ME, Costa PP, et al. Aqueous humor erythropoietin levels in open-angle glaucoma patients with and without TTR V30M familial amyloid polyneuropathy. Mol Vis 2014;20:970-6.
41. Chong ZZ, Shang YC, Mu Y, Cui S, Yao Q, Maiese K. Targeting erythropoietin for chronic neurodegenerative diseases. Expert Opin Ther Targets 2013;17:707-20.
42. Arabpoor Z, Hamidi G, Rashidi B, Shabrang M, Alaei H, Sharifi MR, Salami M, et al. Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease. Adv Biomed Res 2012;1:50.
43. Jia Y, Mo SJ, Feng QQ, Zhan ML, Ouyang LS, Chen JC, Ma YX, et al. EPO-dependent activation of PI3K/Akt/FoxO3a signalling mediates neuroprotection in in vitro and in vivo models of Parkinson's disease. J Mol Neurosci 2014;53:117-24.
44. Bahçekapl N, Akgün-Dar K, Albeniz I, Kapucu A, Kandil A, Yag z O, Uzüm G. Erythropoietin pretreatment suppresses seizures and prevents the increase in inflammatory mediators during pentylenetetrazole-induced generalized seizures. Int J Neurosci 2014;124:762-70.
45. Najmi Varzaneh F, Najmi Varzaneh F, Azimi AR, Rezaei N, Sahraian MA. Efficacy of combination therapy with erythropoietin and methylprednisolone in clinical recovery of severe relapse in multiple sclerosis. Acta Neurol Belg 2014;114:273-8.
46. Nagańska E, Taraszewska A, Matyja E, Grieb P, Rafaowska J. Neuroprotective effect of erythropoietin in amyotrophic lateral sclerosis (ALS) model in vitro. Ultrastructural study. Folia Neuropathol 2010;48:35-44.
47. Ma R, Huang C, Hu J, Wang M, Xiang J, Li G. JAK2/STAT5/BclxL signaling is essential for erythropoietin-mediated protection against PC12 cells apoptosis induced by Ab25-35. Br J Pharmacol 2014;171:3234-5.
48. Ma R, Xiong N, Huang C, Tang Q, Hu B, Xiang J, Li G. Erythropoietin protects PC12 cells from beta-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Neuropharmacology 2009;56:1027-34.
49. Wenker SD, Chamorro ME, Vittori DC, Nesse AB. Protective action of erythropoietin on neuronal damage induced by activated microglia. FEBS J 2013;280:1630-42.