A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression

Haematologica

Volumn 99, Issue 4, 2014, Pages

  Storti, Federica ^a   Santambrogio, Sara ^a   Crowther, Lisa M ^a   Otto, Teresa ^b   Abreu Rodríguez, Irene ^a   Kaufmann, Muriel ^a   Hu, Cheng Jun ^c   Dame, Christof ^d   Fandrey, Joachim ^b   Wenger, Roland H ^a   Hoogewijs, David ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c UNIVERSITY OF COLORADO   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Erythropoietin; HIF; Hypoxia; Oxygen sensing; Red cells

Indexed keywords

ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR; MESSENGER RNA; 5' UNTRANSLATED REGION; OXYGEN;

CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA FLANKING REGION; DNA RESPONSIVE ELEMENT; ERYTHROPOIESIS; GENE CONSTRUCT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; KIDNEY; LETTER; LIVER; LUCIFERASE ASSAY; PROMOTER REGION; 5' UNTRANSLATED REGION; ANOXIA; GENETICS; METABOLISM;

5' UNTRANSLATED REGIONS; ANOXIA; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; HUMANS; OXYGEN; RESPONSE ELEMENTS;

EID: 84897451173     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2013.102707     Document Type: Letter

References (15)

1. Maxwell PH, Osmond MK, Pugh CW, Heryet A, Nicholls LG, Tan CC, et al. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int. 1993;44(5):1149-62.
2. Obara N, Suzuki N, Kim K, Nagasawa T, Imagawa S, Yamamoto M. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. Blood. 2008;111(10):5223-32.
3. Wenger RH, Hoogewijs D. Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells. Am J Physiol Renal Physiol. 2010;298(6):F1287-F96.
4. Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, et al. Plasticity of renal erythropoietin-producing cells governs fibrosis. J Am Soc Nephrol. 2013;24(10):1599-616.
5. Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, et al. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood. 2010;116(16):3039-48.
6. Köchling J, Curtin PT, Madan A. Regulation of human erythropoietin gene induction by upstream flanking sequences in transgenic mice. Br J Haematol. 1998;103(4):960-8.
7. Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements. Mol Cell Biol. 1990;10(3):930-8.
8. Blanchard KL, Acquaviva AM, Galson DL, Bunn HF. Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol Cell Biol. 1992;12(12):5373-85.
9. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 1992;12(12):5447-54.
10. Suzuki N, Obara N, Pan X, Watanabe M, Jishage K-I, Minegishi N, et al. Specific contribution of the erythropoietin gene 3′ enhancer to hepatic erythropoiesis after late embryonic stages. Mol Cell Biol. 2011;31(18):3896-905.
11. Schödel J, Oikonomopoulos S, Ragoussis J, Pugh CW, Ratcliffe PJ, Mole DR. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood. 2011;117(23):e207-e17.
12. Warnecke C, Zaborowska Z, Kurreck J, Erdmann VA, Frei U, Wiesener M, et al. Differentiating the functional role of hypoxiainducible factor (HIF)-1ffand HIF-2aa(EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2iitarget gene in Hep3B and Kelly cells. FASEB J. 2004;18(12):1415-7.
13. Wollenick K, Hu J, Kristiansen G, Schraml P, Rehrauer H, Berchner-Pfannschmidt U, et al. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res. 2012;40(5):1928-43.
14. Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, et al. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem. 2004;279(37):38458-65.
15. Yamazaki S, Souma T, Hirano I, Pan X, Minegishi N, Suzuki N, et al. A mouse model of adult-onset anaemia due to erythropoietin deficiency. Nat Commun. 2013;4:1950.