EPO-dependent activation of PI3K/Akt/FoxO3a signalling mediates neuroprotection in in vitro and in vivo models of Parkinson's disease

Journal of Molecular Neuroscience

Volumn 53, Issue 1, 2014, Pages 117-124

  Jia, Yu ^a,b   Mo, Shi Jing ^c   Feng, Qi Qi ^b   Zhan, Ma Li ^b   OuYang, Li Si ^b   Chen, Jia Chang ^b   Ma, Yu Xin ^d   Wu, Jia Jia ^b   Lei, Wan Long ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Erythropoietin; Parkinson's disease; PI3K Akt FoxO3a

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; ERYTHROPOIETIN; OXIDOPAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; FORKHEAD TRANSCRIPTION FACTOR; FOXO3A PROTEIN, RAT; MORPHOLINE DERIVATIVE; NEUROPROTECTIVE AGENT; PROTEIN KINASE INHIBITOR;

ADULT; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MULTIGENE FAMILY; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PC12 CELL LINE; PROTEIN EXPRESSION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; LOCOMOTION; METABOLISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TOXICITY;

RATTUS;

ANIMALS; APOPTOSIS; CHROMONES; ERYTHROPOIETIN; FORKHEAD TRANSCRIPTION FACTORS; LOCOMOTION; MALE; MORPHOLINES; NEURONS; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PARKINSON DISEASE; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84899938968     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-0208-0     Document Type: Article

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