Efficacy of combination therapy with erythropoietin and methylprednisolone in clinical recovery of severe relapse in multiple sclerosis

Acta Neurologica Belgica

Volumn 114, Issue 4, 2014, Pages 273-278

  Najmi Varzaneh, Fatemeh ^a   Najmi Varzaneh, Farnaz ^a,b   Azimi, Amir Reza ^a   Rezaei, Nima ^b,c   Sahraian, Mohammad Ali ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Erythropoietin; Methylprednisolone; Multiple sclerosis; Treatment

Indexed keywords

ERYTHROPOIETIN; METHYLPREDNISOLONE; PLACEBO;

ADULT; AMBULATORY MONITORING; ARTICLE; BLOOD ANALYSIS; BLOOD PRESSURE MONITORING; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ERYTHROCYTE COUNT; EXPANDED DISABILITY STATUS SCALE; FEMALE; HEADACHE; HUMAN; HYPERTENSION; MALE; MOTOR PERFORMANCE; MULTIPLE SCLEROSIS; NAUSEA; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYCYTHEMIA; RANDOMIZED CONTROLLED TRIAL; WALKING;

EID: 84911999600     PISSN: 03009009     EISSN: 22402993     Source Type: Journal    
DOI: 10.1007/s13760-014-0286-y     Document Type: Article

References (36)

1. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L (1998) Axonal transection in the lesions of multiple sclerosis. New Eng J Med 338(5):278–285 (Epub 1998/01/29)
2. Losseff NA, Wang L, Lai HM, Yoo DS, Gawne-Cain ML, McDonald WI et al (1996) Progressive cerebral atrophy in multiple sclerosis. A serial MRI study. Brain J Neurol 119(Pt 6):2009–2019 (Epub 1996/12/01)
3. Peterson JW, Bo L, Mork S, Chang A, Trapp BD (2001) Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 50(3):389–400 (Epub 2001/09/18)
4. Smith T, Groom A, Zhu B, Turski L (2000) Autoimmune encephalomyelitis ameliorated by AMPA antagonists. Nat Med 6(1):62–66 (Epub 1999/12/29)
5. Meyer R, Weissert R, Diem R, Storch MK, de Graaf KL, Kramer B et al (2001) Acute neuronal apoptosis in a rat model of multiple sclerosis. J Neurosci Off J Soc Neurosci 21(16):6214–6220 (Epub 2001/08/07)
6. Brusaferri F, Candelise L (2000) Steroids for multiple sclerosis and optic neuritis: a meta-analysis of randomized controlled clinical trials. J Neurol 247(6):435–442 (Epub 2000/08/10)
7. Diem R, Hobom M, Maier K, Weissert R, Storch MK, Meyer R et al (2003) Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway. J Neurosci Off J Soc Neurosci 23(18):6993–7000 PEpub 2003/08/09
8. Noseworthy JH, Gold R, Hartung HP (1999) Treatment of multiple sclerosis: recent trials and future perspectives. Curr Opin Neurol 12(3):279–293 (Epub 1999/09/28)
9. Parry A, Corkill R, Blamire AM, Palace J, Narayanan S, Arnold D et al (2003) Beta-interferon treatment does not always slow the progression of axonal injury in multiple sclerosis. J Neurol 250(2):171–178 (Epub 2003/02/08)
10. Ehrenreich H, Fischer B, Norra C, Schellenberger F, Stender N, Stiefel M et al (2007) Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis. Brain J Neurol 130(Pt 10):2577–2588 (Epub 2007/08/31)
11. Ehrenreich H, Aust C, Krampe H, Jahn H, Jacob S, Herrmann M et al (2004) Erythropoietin: novel approaches to neuroprotection in human brain disease. Metab Brain Dis 19(3–4):195–206 (Epub 2004/11/24)
12. Juul S (2004) Recombinant erythropoietin as a neuroprotective treatment: in vitro and in vivo models. Clin Perinatol 31(1):129–142 (Epub 2004/06/09)
13. Brines ML, Ghezzi P, Keenan S, Agnello D, de Lanerolle NC, Cerami C et al (2000) Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 97(19):10526–10531 (Epub 2000/09/14)
14. Jelkmann W (1992) Erythropoietin: structure, control of production, and function. Physiol Rev 72(2):449–489 (Epub 1992/04/01)
15. Hasselblatt M, Ehrenreich H, Siren AL (2006) The brain erythropoietin system and its potential for therapeutic exploitation in brain disease. J Neurosurg Anesthesiol 18(2):132–138 (Epub 2006/04/22)
16. Konishi Y, Chui DH, Hirose H, Kunishita T, Tabira T (1993) Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo. Brain Res 609(1–2):29–35 (Epub 1993/04/23)
17. Campana WM, Myers RR (2001) Erythropoietin and erythropoietin receptors in the peripheral nervous system: changes after nerve injury. FASEB J Off Publ Federation Am Soc Exp Biol 15(10):1804–1806 (Epub 2001/08/02)
18. Shingo T, Sorokan ST, Shimazaki T, Weiss S (2001) Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci Off J Soc Neurosci 21(24):9733–9743 (Epub 2001/12/12)
19. Siren AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P et al (2001) Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98(7):4044–4049 (Epub 2001/03/22)
20. Celik M, Gokmen N, Erbayraktar S, Akhisaroglu M, Konakc S, Ulukus C et al (2002) Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci USA 99(4):2258–2263 (Epub 2002/02/21)
21. Keswani SC, Buldanlioglu U, Fischer A, Reed N, Polley M, Liang H et al (2004) A novel endogenous erythropoietin mediated pathway prevents axonal degeneration. Ann Neurol 56(6):815–826 (Epub 2004/10/08)
22. Li W, Maeda Y, Yuan RR, Elkabes S, Cook S, Dowling P (2004) Beneficial effect of erythropoietin on experimental allergic encephalomyelitis. Ann Neurol 56(6):767–777 (Epub 2004/11/25)
23. Savino C, Pedotti R, Baggi F, Ubiali F, Gallo B, Nava S et al (2006) Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis. J Neuroimmunol 172(1–2):27–37 (Epub 2005/12/13)
24. Agnello D, Bigini P, Villa P, Mennini T, Cerami A, Brines ML et al (2002) Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis. Brain Res 952(1):128–134 (Epub 2002/10/05)
25. Avasarala JR, Konduru SS (2005) Recombinant erythropoietin down-regulates IL-6 and CXCR4 genes in TNF-alpha-treated primary cultures of human microvascular endothelial cells: implications for multiple sclerosis. J Mol Neurosci MN 25(2):183–189 (Epub 2005/03/24)
26. Genc K, Genc S, Baskin H, Semin I (2006) Erythropoietin decreases cytotoxicity and nitric oxide formation induced by inflammatory stimuli in rat oligodendrocytes. Physiol Res Acad Scientiarum Bohemoslovaca 55(1):33–38 (Epub 2005/04/29)
27. Zhang J, Li Y, Cui Y, Chen J, Lu M, Elias SB et al (2005) Erythropoietin treatment improves neurological functional recovery in EAE mice. Brain Res 1034(1–2):34–39 (Epub 2005/02/17)
28. Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33(11):1444–1452 (Epub 1983/11/01)
29. Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M et al (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69(2):292–302 (Epub 2011/03/10)
30. Sattler MB, Merkler D, Maier K, Stadelmann C, Ehrenreich H, Bahr M et al (2004) Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis. Cell Death Differ 11(Suppl 2):S181–S192 (Epub 2004/10/02)
31. Sinnecker T, Mittelstaedt P, Dorr J, Pfueller CF, Harms L, Niendorf T et al (2012) Multiple sclerosis lesions and irreversible brain tissue damage: a comparative ultrahigh-field strength magnetic resonance imaging study. Arch Neurol 69(6):739–745 (Epub 2012/02/22)
32. Diem R, Sattler MB, Merkler D, Demmer I, Maier K, Stadelmann C et al (2005) Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis. Brain J Neurol 128(Pt 2):375–385 (Epub 2004/12/17)
33. Campbell Z, Sahm D, Donohue K, Jamison J, Davis M, Pellicano C et al (2012) Characterizing contrast-enhancing and re-enhancing lesions in multiple sclerosis. Neurology 78(19):1493–1499 (Epub 2012/04/28)
34. Gorio A, Madaschi L, Di Stefano B, Carelli S, Di Giulio AM, De Biasi S et al (2005) Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury. Proc Natl Acad Sci USA 102(45):16379–16384 (Epub 2005/11/02)
35. Naismith RT, Xu J, Tutlam NT, Scully PT, Trinkaus K, Snyder AZ et al (2010) Increased diffusivity in acute multiple sclerosis lesions predicts risk of black hole. Neurology 74(21):1694–1701 (Epub 2010/05/26)
36. Sloka JS, Stefanelli M (2005) The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler 11(4):425–432 (Epub 2005/07/27)