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Volumn 5, Issue JUN, 2015, Pages

Harnessing pandemonium: The clinical implications of tumor heterogeneity in ovarian cancer

Author keywords

Chemotherapy resistance; Clonal evolution; Diversity; Heterogeneity; HGSOC; ITH; Ovarian cancer; Tumor evolution

Indexed keywords


EID: 84934295552     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2015.00149     Document Type: Review
Times cited : (56)

References (56)
  • 1
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: causes and consequences
    • Marusyk A, Polyak K. Tumor heterogeneity: causes and consequences. Biochim Biophys Acta (2010) 1805:105-17. doi: 10.1016/j.bbcan.2009.11.002.
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 105-117
    • Marusyk, A.1    Polyak, K.2
  • 2
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science (1976) 194:23-8. doi:10.1126/science.959840.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 3
    • 0014983638 scopus 로고
    • Colony formation by normal and leukemic human marrow cells in culture: effect of conditioned medium from human leukocytes
    • Iscove NN, Senn JS, Till JE, McCulloch EA. Colony formation by normal and leukemic human marrow cells in culture: effect of conditioned medium from human leukocytes. Blood (1971) 37:1-5.
    • (1971) Blood , vol.37 , pp. 1-5
    • Iscove, N.N.1    Senn, J.S.2    Till, J.E.3    McCulloch, E.A.4
  • 4
    • 65349131893 scopus 로고    scopus 로고
    • Cancer stem cells: a guide for skeptics
    • Tomasson MH. Cancer stem cells: a guide for skeptics. J Cell Biochem (2009) 105:745-9. doi:10.1002/jcb.22050.
    • (2009) J Cell Biochem , vol.105 , pp. 745-749
    • Tomasson, M.H.1
  • 5
    • 84897503799 scopus 로고    scopus 로고
    • Cancer: clonal cooperation
    • Polyak K, Marusyk A. Cancer: clonal cooperation. Nature (2014) 508:52-3. doi:10.1038/508052a.
    • (2014) Nature , vol.508 , pp. 52-53
    • Polyak, K.1    Marusyk, A.2
  • 6
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso A, Dick JE. Evolution of the cancer stem cell model. Cell Stem Cell (2014) 14:275-91. doi:10.1016/j.stem.2014.02.006.
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 7
    • 84862757952 scopus 로고    scopus 로고
    • Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
    • Gillies RJ, Verduzco D, Gatenby RA. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer (2012) 12:487-93. doi:10.1038/nrc3298.
    • (2012) Nat Rev Cancer , vol.12 , pp. 487-493
    • Gillies, R.J.1    Verduzco, D.2    Gatenby, R.A.3
  • 8
    • 0018075053 scopus 로고
    • Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor
    • Heppner GH, Dexter DL, DeNucci T, Miller FR, Calabresi P. Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor. Cancer Res (1978) 38:3758-63.
    • (1978) Cancer Res , vol.38 , pp. 3758-3763
    • Heppner, G.H.1    Dexter, D.L.2    DeNucci, T.3    Miller, F.R.4    Calabresi, P.5
  • 9
    • 0020404981 scopus 로고
    • Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change
    • Taparowsky E, Suard Y, Fasano O, Shimizu K, Goldfarb M, Wigler M. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature (1982) 300:762-5. doi:10.1038/300762a0.
    • (1982) Nature , vol.300 , pp. 762-765
    • Taparowsky, E.1    Suard, Y.2    Fasano, O.3    Shimizu, K.4    Goldfarb, M.5    Wigler, M.6
  • 10
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature (2001) 409:860-921. doi:10.1038/35057062.
    • (2001) Nature , vol.409 , pp. 860-921
  • 12
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature (2004) 431:931-45. doi:10.1038/nature03001.
    • (2004) Nature , vol.431 , pp. 931-945
  • 14
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, et al. The genomic landscapes of human breast and colorectal cancers. Science (2007) 318:1108-13. doi:10.1126/science.1145720.
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3    Lin, J.4    Sjöblom, T.5    Leary, R.J.6
  • 15
    • 84880063629 scopus 로고    scopus 로고
    • From human genome to cancer genome: the first decade
    • Wheeler DA, Wang L. From human genome to cancer genome: the first decade. Genome Res (2013) 23:1054-62. doi:10.1101/gr.157602.113.
    • (2013) Genome Res , vol.23 , pp. 1054-1062
    • Wheeler, D.A.1    Wang, L.2
  • 17
    • 79952041937 scopus 로고    scopus 로고
    • Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial
    • Gianni L, Dafni U, Gelber RD, Azambuja E, Muehlbauer S, Goldhirsch A, et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial. Lancet Oncol (2011) 12:236-44. doi:10.1016/S1470-2045(11)70033-X.
    • (2011) Lancet Oncol , vol.12 , pp. 236-244
    • Gianni, L.1    Dafni, U.2    Gelber, R.D.3    Azambuja, E.4    Muehlbauer, S.5    Goldhirsch, A.6
  • 18
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature (2010) 467:596-9. doi:10.1038/nature09454.
    • (2010) Nature , vol.467 , pp. 596-599
    • Bollag, G.1    Hirth, P.2    Tsai, J.3    Zhang, J.4    Ibrahim, P.N.5    Cho, H.6
  • 19
    • 36549055697 scopus 로고    scopus 로고
    • Will targeted therapy hold its promise? An evidence-based review
    • Murdoch D, Sager J. Will targeted therapy hold its promise? An evidence-based review. Curr Opin Oncol (2008) 20:104-11. doi:10.1097/CCO.0b013e3282f44b12.
    • (2008) Curr Opin Oncol , vol.20 , pp. 104-111
    • Murdoch, D.1    Sager, J.2
  • 20
    • 84913621210 scopus 로고    scopus 로고
    • Targeting HER2 in ovarian and uterine cancers: challenges and future directions
    • Teplinsky E, Muggia F. Targeting HER2 in ovarian and uterine cancers: challenges and future directions. Gynecol Oncol (2014) 135:364-70. doi:10.1016/j.ygyno.2014.09.003.
    • (2014) Gynecol Oncol , vol.135 , pp. 364-370
    • Teplinsky, E.1    Muggia, F.2
  • 21
    • 84964240053 scopus 로고    scopus 로고
    • Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
    • McGranahan N, Swanton C. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell (2015) 27:15-26. doi:10.1016/j.ccell.2014.12.001.
    • (2015) Cancer Cell , vol.27 , pp. 15-26
    • McGranahan, N.1    Swanton, C.2
  • 23
    • 77649219639 scopus 로고    scopus 로고
    • The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory
    • Kurman RJ, Shih IeM. The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol (2010) 34:433-43. doi:10.1097/PAS.0b013e3181cf3d79.
    • (2010) Am J Surg Pathol , vol.34 , pp. 433-443
    • Kurman, R.J.1    Shih, IeM.2
  • 25
    • 84879674095 scopus 로고    scopus 로고
    • Precursors and pathogenesis of ovarian carcinoma
    • Lim D, Oliva E. Precursors and pathogenesis of ovarian carcinoma. Pathology (2013) 45:229-42. doi:10.1097/PAT.0b013e32835f2264.
    • (2013) Pathology , vol.45 , pp. 229-242
    • Lim, D.1    Oliva, E.2
  • 26
    • 55549147904 scopus 로고    scopus 로고
    • Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests: a study of 120 tumors
    • Seidman JD, Khedmati F. Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests: a study of 120 tumors. Arch Pathol Lab Med (2008) 132:1753-60. doi:10.1043/1543-2165-132.11.1753.
    • (2008) Arch Pathol Lab Med , vol.132 , pp. 1753-1760
    • Seidman, J.D.1    Khedmati, F.2
  • 27
    • 34548525798 scopus 로고    scopus 로고
    • Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction
    • Callahan MJ, Crum CP, Medeiros F, Kindelberger DW, Elvin JA, Garber JE, et al. Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction. J Clin Oncol (2007) 25:3985-90. doi:10.1200/JCO.2007.12.2622.
    • (2007) J Clin Oncol , vol.25 , pp. 3985-3990
    • Callahan, M.J.1    Crum, C.P.2    Medeiros, F.3    Kindelberger, D.W.4    Elvin, J.A.5    Garber, J.E.6
  • 28
    • 33846624310 scopus 로고    scopus 로고
    • Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship
    • Kindelberger DW, Lee Y, Miron A, Hirsch MS, Feltmate C, Medeiros F, et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol (2007) 31:161-9. doi:10.1097/01.pas.0000213335.40358.47.
    • (2007) Am J Surg Pathol , vol.31 , pp. 161-169
    • Kindelberger, D.W.1    Lee, Y.2    Miron, A.3    Hirsch, M.S.4    Feltmate, C.5    Medeiros, F.6
  • 30
    • 84920854704 scopus 로고    scopus 로고
    • Precursors of ovarian cancer in the fallopian tube: serous tubal intraepithelial carcinoma-an update
    • Zeppernick F, Meinhold-Heerlein I, Shih IeM. Precursors of ovarian cancer in the fallopian tube: serous tubal intraepithelial carcinoma-an update. J Obstet Gynaecol Res (2015) 41:6-11. doi:10.1111/jog.12550.
    • (2015) J Obstet Gynaecol Res , vol.41 , pp. 6-11
    • Zeppernick, F.1    Meinhold-Heerlein, I.2    Shih, IeM.3
  • 31
    • 42949138321 scopus 로고    scopus 로고
    • A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations
    • Folkins AK, Jarboe EA, Saleemuddin A, Lee Y, Callahan MJ, Drapkin R, et al. A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations. Gynecol Oncol (2008) 108:168-73. doi:10.1016/j.ygyno.2008.01.012.
    • (2008) Gynecol Oncol , vol.108 , pp. 168-173
    • Folkins, A.K.1    Jarboe, E.A.2    Saleemuddin, A.3    Lee, Y.4    Callahan, M.J.5    Drapkin, R.6
  • 32
    • 0018358230 scopus 로고
    • An approach to the problem of heterogeneity of human tumour-cell populations
    • Sirachỳ J. An approach to the problem of heterogeneity of human tumour-cell populations. Br J Cancer (1979) 39:570-7. doi:10.1038/bjc.1979.103.
    • (1979) Br J Cancer , vol.39 , pp. 570-577
    • Sirachỳ, J.1
  • 33
    • 0025212711 scopus 로고
    • Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas
    • Ehlen T, Dubeau L. Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas. Oncogene (1990) 5:219-23.
    • (1990) Oncogene , vol.5 , pp. 219-223
    • Ehlen, T.1    Dubeau, L.2
  • 34
    • 0025321563 scopus 로고
    • Frequent loss of heterozygosity on chromosomes 6q, 11, and 17 in human ovarian carcinomas
    • Lee JH, Kavanagh JJ, Wildrick DM, Wharton JT, Blick M. Frequent loss of heterozygosity on chromosomes 6q, 11, and 17 in human ovarian carcinomas. Cancer Res (1990) 50:2724-8.
    • (1990) Cancer Res , vol.50 , pp. 2724-2728
    • Lee, J.H.1    Kavanagh, J.J.2    Wildrick, D.M.3    Wharton, J.T.4    Blick, M.5
  • 35
    • 9144274358 scopus 로고    scopus 로고
    • Identification of clinically relevant genes on chromosome 11 in a functional model of ovarian cancer tumor suppression
    • Stronach EA, Sellar GC, Blenkiron C, Rabiasz GJ, Taylor KJ, Miller EP, et al. Identification of clinically relevant genes on chromosome 11 in a functional model of ovarian cancer tumor suppression. Cancer Res (2003) 63:8648-55.
    • (2003) Cancer Res , vol.63 , pp. 8648-8655
    • Stronach, E.A.1    Sellar, G.C.2    Blenkiron, C.3    Rabiasz, G.J.4    Taylor, K.J.5    Miller, E.P.6
  • 36
    • 0032145440 scopus 로고    scopus 로고
    • Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers
    • Rhei E, Bogomolniy F, Federici MG, Maresco DL, Offit K, Robson ME, et al. Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers. Cancer Res (1998) 58:3193-6.
    • (1998) Cancer Res , vol.58 , pp. 3193-3196
    • Rhei, E.1    Bogomolniy, F.2    Federici, M.G.3    Maresco, D.L.4    Offit, K.5    Robson, M.E.6
  • 37
    • 0026005828 scopus 로고
    • Frequent allelic losses and mutations of the p53 gene in human ovarian cancer
    • Okamoto A, Sameshima Y, Yokoyama S, Terashima Y, Sugimura T, Terada M, et al. Frequent allelic losses and mutations of the p53 gene in human ovarian cancer. Cancer Res (1991) 51(19):5171-6.
    • (1991) Cancer Res , vol.51 , Issue.19 , pp. 5171-5176
    • Okamoto, A.1    Sameshima, Y.2    Yokoyama, S.3    Terashima, Y.4    Sugimura, T.5    Terada, M.6
  • 38
    • 33846591472 scopus 로고    scopus 로고
    • Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours
    • Khalique L, Ayhan A, Weale ME, Jacobs IJ, Ramus SJ, Gayther SA. Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours. J Pathol (2007) 211:286-95. doi:10.1002/path.2112.
    • (2007) J Pathol , vol.211 , pp. 286-295
    • Khalique, L.1    Ayhan, A.2    Weale, M.E.3    Jacobs, I.J.4    Ramus, S.J.5    Gayther, S.A.6
  • 39
    • 84885735554 scopus 로고    scopus 로고
    • Mutational landscape and significance across 12 major cancer types
    • Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C. Mutational landscape and significance across 12 major cancer types. Nature (2013) 502:333-9. doi:10.1038/nature12634.
    • (2013) Nature , vol.502 , pp. 333-339
    • Kandoth, C.1    McLellan, M.D.2    Vandin, F.3    Ye, K.4    Niu, B.5    Lu, C.6
  • 40
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature (2011) 474:609-15. doi:10.1038/nature10166.
    • (2011) Nature , vol.474 , pp. 609-615
  • 41
    • 83355168010 scopus 로고    scopus 로고
    • Copy number variation analysis of matched ovarian primary tumors and peritoneal metastasis
    • Malek JA, Mery E, Mahmoud YA, Al-Azwani EK, Roger L, Huang R, et al. Copy number variation analysis of matched ovarian primary tumors and peritoneal metastasis. PLoS One (2011) 6:e28561. doi:10.1371/journal.pone.0028561.
    • (2011) PLoS One , vol.6
    • Malek, J.A.1    Mery, E.2    Mahmoud, Y.A.3    Al-Azwani, E.K.4    Roger, L.5    Huang, R.6
  • 42
    • 84863725818 scopus 로고    scopus 로고
    • Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes
    • McBride DJ, Etemadmoghadam D, Cooke SL, Alsop K, George J, Butler A, et al. Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes. J Pathol (2012) 227:446-55. doi:10.1002/path.4042.
    • (2012) J Pathol , vol.227 , pp. 446-455
    • McBride, D.J.1    Etemadmoghadam, D.2    Cooke, S.L.3    Alsop, K.4    George, J.5    Butler, A.6
  • 43
    • 84934313840 scopus 로고    scopus 로고
    • Results of ARIEL2: a phase 2 trial to prospectively identify ovarian cancer patients likely to respond to rucaparib using tumor genetic analysis
    • McNeish IA, Oza AM, Coleman RL, Scott CL, Konecny GE, Tinker A, et al. Results of ARIEL2: a phase 2 trial to prospectively identify ovarian cancer patients likely to respond to rucaparib using tumor genetic analysis. J Clin Oncol (2015) 33(Suppl):abstr5508.
    • (2015) J Clin Oncol , vol.33
    • McNeish, I.A.1    Oza, A.M.2    Coleman, R.L.3    Scott, C.L.4    Konecny, G.E.5    Tinker, A.6
  • 44
    • 52649085237 scopus 로고    scopus 로고
    • Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
    • Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S, et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res (2008) 14:5198-208. doi:10.1158/1078-0432.CCR-08-0196.
    • (2008) Clin Cancer Res , vol.14 , pp. 5198-5208
    • Tothill, R.W.1    Tinker, A.V.2    George, J.3    Brown, R.4    Fox, S.B.5    Lade, S.6
  • 46
    • 84887511784 scopus 로고    scopus 로고
    • Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas
    • Gerlinger M, Quezada SA, Peggs KS, Furness AJ, Fisher R, Marafioti T, et al. Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas. J Pathol (2013) 231:424-32. doi:10.1002/path.4284.
    • (2013) J Pathol , vol.231 , pp. 424-432
    • Gerlinger, M.1    Quezada, S.A.2    Peggs, K.S.3    Furness, A.J.4    Fisher, R.5    Marafioti, T.6
  • 47
    • 84887167328 scopus 로고    scopus 로고
    • High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer
    • Emerson RO, Sherwood AM, Rieder MJ, Guenthoer J, Williamson DW, Carlson CS, et al. High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer. J Pathol (2013) 231:433-40. doi:10.1002/path.4260.
    • (2013) J Pathol , vol.231 , pp. 433-440
    • Emerson, R.O.1    Sherwood, A.M.2    Rieder, M.J.3    Guenthoer, J.4    Williamson, D.W.5    Carlson, C.S.6
  • 49
    • 78049380554 scopus 로고    scopus 로고
    • The patterns and dynamics of genomic instability in metastatic pancreatic cancer
    • Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings LA, et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature (2010) 467:1109-13. doi:10.1038/nature09460.
    • (2010) Nature , vol.467 , pp. 1109-1113
    • Campbell, P.J.1    Yachida, S.2    Mudie, L.J.3    Stephens, P.J.4    Pleasance, E.D.5    Stebbings, L.A.6
  • 50
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med (2012) 366:883-92. doi:10.1056/NEJMoa1113205.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5    Gronroos, E.6
  • 51
    • 84885092663 scopus 로고    scopus 로고
    • Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling
    • Bashashati A, Ha G, Tone A, Ding J, Prentice LM, Roth A, et al. Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling. J Pathol (2013) 231:21-34. doi:10.1002/path.4230.
    • (2013) J Pathol , vol.231 , pp. 21-34
    • Bashashati, A.1    Ha, G.2    Tone, A.3    Ding, J.4    Prentice, L.M.5    Roth, A.6
  • 52
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: evolution through space and time
    • Swanton C. Intratumor heterogeneity: evolution through space and time. Cancer Res (2012) 72:4875-82. doi:10.1158/0008-5472.CAN-12-2217.
    • (2012) Cancer Res , vol.72 , pp. 4875-4882
    • Swanton, C.1
  • 53
    • 84924359778 scopus 로고    scopus 로고
    • Phylogenetic quantification of intra-tumor heterogeneity predicts time to relapse in high-grade serous ovarian cancer
    • Schwarz RF, Ng CK, Cooke SL, Newman S, Temple J, Piskorz AM, et al. Phylogenetic quantification of intra-tumor heterogeneity predicts time to relapse in high-grade serous ovarian cancer. PLoS Med (2015) 12:e1001789. doi:10.1371/journal.pmed.1001789.
    • (2015) PLoS Med , vol.12
    • Schwarz, R.F.1    Ng, C.K.2    Cooke, S.L.3    Newman, S.4    Temple, J.5    Piskorz, A.M.6
  • 54
    • 84880378159 scopus 로고    scopus 로고
    • Circulating tumour cells: insights into tumour heterogeneity
    • Hayes DF, Paoletti C. Circulating tumour cells: insights into tumour heterogeneity. J Intern Med (2013) 274(2):137-43. doi:10.1111/joim.12047.
    • (2013) J Intern Med , vol.274 , Issue.2 , pp. 137-143
    • Hayes, D.F.1    Paoletti, C.2
  • 55
    • 84877579861 scopus 로고    scopus 로고
    • Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
    • Murtaza M, Dawson SJ, Tsui DW, Gale D, Forshew T, Piskorz AM, et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature (2013) 497:108-12. doi:10.1038/nature12065.
    • (2013) Nature , vol.497 , pp. 108-112
    • Murtaza, M.1    Dawson, S.J.2    Tsui, D.W.3    Gale, D.4    Forshew, T.5    Piskorz, A.M.6
  • 56
    • 84907855592 scopus 로고    scopus 로고
    • Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
    • de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC, Yates L, et al. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science (2014) 346:251-6. doi:10.1126/science.1253462.
    • (2014) Science , vol.346 , pp. 251-256
    • de Bruin, E.C.1    McGranahan, N.2    Mitter, R.3    Salm, M.4    Wedge, D.C.5    Yates, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.