Improved clearance of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene

Journal of Immunology

Volumn 162, Issue 11, 1999, Pages 6734-6739

  Gomes, M Salomé ^a   Flórido, Manuela ^a   Pais, Teresa F ^a   Appelberg, Rui ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE MUTATION; GRANULOMA; GRANULOMATOUS INFLAMMATION; INFECTION; MACROPHAGE; MOUSE; MYCOBACTERIUM AVIUM; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; FEMALE; INTERFERON TYPE II; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MYCOBACTERIUM AVIUM; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; SPECIES SPECIFICITY; TUBERCULOSIS;

EID: 0345593709     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Inderlied, C. B., C. A. Kemper, and L. E. M. Bermudez. 1993. The Mycobacterium avium complex. Clin. Microbiol. Rev. 6:266.
2. Holland, S. M. 1996. Host defense against nontuberculous mycobacterial infections. Semin. Respir. Infect. 11:217.
3. Appelberg, R., and Orme, I. M. 1993. Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages. Immunology 80:352.
4. Appelberg, R., A. G. Castro, J. Pedrosa, R. A. Silva, I. M. Orme, and P. Minóprio. 1994. Role of γ interferon and tumor necrosis factor α during T-cell-independent and -dependent phases of Mycobacterium avium infection. Infect. Immun. 62: 3962.
5. Sarmento, A. M., and R. Appelberg. 1996. Involvement of reactive oxygen intermediates in the tumor necrosis factor-dependent bacteriostasis of Mycobacterium avium. Infect. Immun. 64:3224.
6. Schaible, U. E., S. Sturgill-Koszycki, P. H. Schlesinger, and D. G. Russell. 1998. Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages. J. Immunol. 160: 1290.
7. Stuehr, D. J., and M. A. Marletta. 1985. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. USA 82:7738.
8. Stuehr, D. J., and M. A. Marletta. 1987. Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-γ. J. Immunol. 139:518.
9. Nathan, C. F., and J. B. Hibbs. 1991. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 3:65.
10. Fang, F. C. 1997. Mechanisms of nitric oxide-related antimicrobial activity. J. Clin. Invest. 99:2818.
11. Chan, J., Y. Xing, R. S. Magiozzo, and B. R. Bloom. 1992. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. Exp. Med. 175:1111.
12. Chan, J., K. Tanaka, D. Carroll, J. Flynn, and B. R. Bloom. 1995. Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect. Immun. 63:736.
13. MacMicking, J. D., R. J. North, R. La Course, J. S. Mudgett, S. K. Shah, and C. F. Nathan. 1997. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl. Acad. Sci. USA 94:5243.
14. Flesch, I. E. A., and S. H. E. Kaufmann. 1991. Mechanisms involved in mycobacterial growth inhibition by interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates. Infect. Immun. 59:3213.
15. Bermudez, L. E. 1993. Differential mechanisms of intracellular killing of Mycobacterium avium and Listeria monocytogenes by activated human and murine macrophages: the role of nitric oxide. Clin. Exp. Immunol. 91:277.
16. Doi, T., M. Ando, T. Akaike, M. Suga, K. Sato, and H. Maeda. 1993. Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis. Infect. Immun. 61:1980.
17. Sato, K., H. Tomioka, and H. Saito. 1992. Differential susceptibilities of Mycobacterium avium and Mycobacterium intracellulare to sodium nitrite. J. Clin. Microbiol. 30:2994.
18. Doherty, T. M., and A. Sher. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J. Immunol. 158:4822.
19. Karupiah, G., J. Chen, S. Mahalingam, C. F. Nathan, and J. D. MacMicking. 1998. Rapid interferon-γ-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. J. Exp. Med. 188:1541.
20. MacMicking, J. D., C. Nathan, G. Hom, N. Chartrain, D. S. Fletcher, M. Trumbauer, K. Stevens, Q. Xie, K. Sokol, N. Hutchinson, H. Chen, and J. S. Mudgett. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641.
21. Medina, E., B. J. Rogerson, and R. J. North. 1996. The Nramp1 antimicrobial resistance gene segregates independently of resistance to virulent Mycobacterium tuberculosis. Immunology 88:479.
22. Silva, R. A., T. F. Pais, and R. Appelberg. 1998. Evaluation of interleukin 12 in immunotherapy and vaccine design in experimental Mycobacterium avium infections. J. Immunol. 161:5578.
23. Castro, A. G., P. Minóprio, and R. Appelberg 1995. The relative impact of bacterial virulence and host genetic background on cytokine expression during Mycobacterium avium infection of mice. Immunology 85:556.
24. Taylor-Robinson, A. W., F. Y. Liew, A. Severn, D. Xu, S. J. McSorley, P. Garside, J. Padron, and R. S. Phillips. 1994. Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur. J. Immunol. 24:980.
25. Al-Ramadi, B. K., J. J. Meissler, D. Huang, and T. K. Eisenstein. 1992. Immunosuppression induced by nitric oxide and its inhibition by interleukin-4. Eur. J. Immunol. 22:2249.
26. Denham, S., and I. J. Rowland. 1992. Inhibition of the reactive proliferation of lymphocytes by activated macrophages: the role of nitric oxide. Clin. Exp. Immunol. 87:157.
27. Albina, J. E., J. A. Abate, and W. L. Henry. 1991. Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation: role of IFN-γ in the induction of the nitric oxide-synthesizing pathway. J. Immunol. 147:144.
28. Yamamoto, Y., T. W. Klein, and H. Friedman. 1996. Immunoregulatory role of nitric oxide in Legionella pneumophila-infected macrophages. Cell. Immunol. 171:213.
29. Gregory, S. H., E. J. Wing, R. A. Hoffman, and R. L. Simmons. 1993. Reactive nitrogen intermediates suppress the primary immunologic response to Listeria. J. Immunol. 150:2901.
30. Boockvar, K. S., D. L. Granger, R. M. Ponston, M. Maybodi, M. K. Washington, J. B. Hibbs, and R. L. Kurlander. 1994. Nitric oxide produced during murine listeriosis is protective. Infect. Immun. 62:1089.
31. Beckerman, K. P., H. W. Rogers, J. A. Corbett, R. D. Schreiber, M. L. McDaniel, and E. R. Unanue. 1993. Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J. Immunol. 150:888.
32. Samson, J. N., J. A. M. Langermans, P. H. P. Groeneveld, and R. van Furth. 1996. Acquired resistance against a secondary infection with Listeria monocytogenes in mice is not dependent on reactive nitrogen intermediates. Infect. Immun. 64:1197.
33. Appelberg, R., R. Soares, P. Ferreira, and M. T. Silva. 1989. Induction of non-specific immunosuppression in mice by mycobacterial infections and its relation to macrophage activation. Scand. J. Immunol. 30:165.
34. Hogaboam, C. M., S. W. Chensue, M. L. Steinhauser, G. B. Huffnagle, N. W. Lukacs, R. M. Strieter, and S. L. Kunkel. 1997. Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide. J. Immunol. 159:5585.