Systemic anti-inflammatory effect induced by counter-irritation through a local release of somatostatin from nociceptors

British Journal of Pharmacology

Volumn 125, Issue 4, 1998, Pages 916-922

  Szolcsányi, János ^a   Pintér, Erika ^a   Helyes, Zsuzsanna ^a   Oroszi, Gábor ^b   Németh, Jôzsef ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b Military Hospital   (Hungary)

Author keywords

Anti inflammatory effect; Capsaicin sensitive primary afferent neurone; Cysteamine; Dextran oedema; Mustard oil; Neurogenic inflammation; Somatostatin; Somatostatin antiserum

Indexed keywords

ALLYL ISOTHIOCYANATE; CAPSAICIN; DEXTRAN; LIQUID PARAFFIN; MERCAPTAMINE; SOMATOSTATIN; SOMATOSTATIN ANTIBODY;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; DENERVATION; EXCITATION; EXTRAVASATION; FEMALE; HINDLIMB; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; NEUROGENIC INFLAMMATION; NOCICEPTIVE RECEPTOR; NONHUMAN; PAW EDEMA; PLASMA; PRIORITY JOURNAL; RAT; SENSORY RECEPTOR; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CAPSAICIN; DEXTRANS; EDEMA; FEMALE; INFLAMMATION; RATS; RATS, WISTAR; RECEPTORS, SENSORY; SOMATOSTATIN;

EID: 0031728130     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702144     Document Type: Article

References (34)

1. ATKINSON, D.C. & HICKS, R. (1974). Possible role of adrenergic mechanism in the systemic anti-inflammatory activity of acetic acid in rats. Eur. J. Pharmacol., 26, 158-165.
2. BARTHÓ, L. & SZOLCSÁNYI, J. (1981). Opiate agonists inhibit neurogenic plasma extravasation in the rat. Eur. J. Pharmacol., 73, 101-104.
3. BONTA, I.L. (1978). Endogenous modulators of the inflammatory response. In Handbook of Experimental Pharmacology, Inflammation. eds. Vane, J.R. & Ferreira, S.H., Vol 50/1, 523-567, Berlin: Springer-Verlag.
4. CATERINA, M.J., SCHUMACHER, M.A., TOMINAGA, M., ROSEN, T.A., LEVINE, J.D. & JULIUS, D. (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 389, 816-824.
5. CHAHL, L.A. (1991). Antidromic vasodilatation and neurogenic inflammation. In Novel Peripheral Neurotransmitters. ed. Beli, C., 161-191. New York: Pergamon Press.
6. FIORAVANTI, A., GOVONI, M., LA MONTAGNA, G., PERPIGNANO, G., TIRRI, G., TROTTA, F., BOGLIOLO, A., CIOCCI, A., TAUCERI, M.T. & MARCOLONGO, R. (1995). Somatostatin-14 and joint inflammation: evidence for intra-articular efficacy of prolonged administration in rheumatoid arthritis. Drugs Exp. Clin. Res., 21, 97-103.
7. GAMSE, R., LEEMAN, S.E., HOLZER, P. & LEMBECK, L. (1981). Differential effect of capsaicin on the content of somatostatin, substance P and neurotensin in the nervous system of the rat. Naunyn-Schmiedeberg's Arch. Pharmacol., 317, 140-148.
8. GEPPETTI, P. & HOLZER, P. (eds.) (1996). Neurogenic Inflammation. Boca Raton, U.S.A.: CRC Press.
9. GILLIES, C.H. (1895). The theory of practice of counter-irritation. London: MacMillan and Co.
10. GOLDSTEIN, S., SHEMANO, I., DEMEO, R. & BEILER, J.M. (1967). Anti-inflammatory activity of several irritants in three models of experimental inflammation in rats. Arch. Int. Pharmacodyn., 167, 39-53.
11. GREEN, P.G., JÄNIG, W. & LEVINE, J.D. (1997). Negative feed-back neuroendocrine control of the inflammatory response in rat is dependent on the sympathetic postganglionic neuron. J. Neurosci., 17, 3234-3238.
12. HANDWERKER, H.O., ANTON, F., FOCHER, L. & REEH, P.W. (1987). Nociceptor functions in intact skin and neurogenic or non-neurogenic inflammation. Acta Physiol. Hung., 69, 333-342.
13. JANCSÓ, N., JANCSÓ-GÁBOR, A. & SZOLCSÁNYI, J. (1967). Direct evidence for neurogenic inflammation and its prevention by denervation and by pre-treatment with capsaicin. Br. J. Pharmacol., 31, 138-151.
14. KARALIS, K., MASTOKAROS, G., CHROUSOS, G.P. & TOLIS, G. (1994). Somatostatin analogues suppress the inflammatory reaction in vivo. J. Clin. Invest., 93, 2000-2006.
15. 5)enkephalinamide. Eur. J. Pharmacol., 85, 171-176.
16. LEWITH, G.T. & WATKINS, A.D. (1996). Unconventional therapies in asthma: an overview. Allergy, 51, 761-769.
17. LUNDBERG, J.M. (1996). Pharmacology of cotransmission in the autonomic nervous system: Integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide. Pharmacological Reviews, 48, 113-178.
18. LYNN, B. (1996). Efferent function of nociceptors. In Neurobiology of Nociceptors. eds. Belmonte, C & Cervero, F. 418-438. U.S.A., New York: Oxford University Press.
19. MAGGI, C.A. (1995). Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog. Neurobiol., 45, 1-98.
20. MCLEOD, K.R., HARMON, D.L., SCHILLO, K.K., HILEMAN, S.M. & MITCELL, Jr, G.E. (1995). Effects of cysteamine on pulsatile growth hormone release and plasma insulin concentrations in sheep. Comp. Biochem. Physiol., 112B, 523-533.
21. NÉMETH, J., HELYES, Z.S., PINTÉR, E. & SZOLCSÁNYI, J. (1996). Development of somatostatin radioimmunoassay for the measurement of plasma and tissue contents of hormone. Acta Physiol. Hung., 84, 221-223.
22. NICHOLAS, J.J. (1994). Physical modalities in rheumatological rehabilitation. Arch. Phys. Med. Rehabil., 75, 994-1001.
23. PALKOVITS, M., BROWNSTEIN, M.J., EIDEN, L.E., BEINFELD, M.C., RUSSEL, J., ARIMURA, A. & SZABÓ, S. (1982). Selective depletion of somatostatin in rat brain by cysteamine. Brain Res., 240, 178-180.
24. (1-14)-like immunoreactivity: evidence for the importance of the disulfide bond for cysteamine action. Endocrinology, 116, 1699-1702.
25. PINTER, E. & SZOLCSÁNYI, J. (1995). Plasma extravasation in the skin and pelvic organs evoked by antidromic stimulation of the lumbosacral dorsal roots of the rat. Neuroscience, 68, 603-614.
26. PINTÉR, E. & SZOLCSÁNYI, J. (1996). Systemic anti-inflammatory effect induced by antidromic stimulation of the dorsal roots in the rat. Neurosci. Lett., 212, 33-36.
27. SELYE, H. (1965). The must cells. Washington: Butterworths.
28. SZOLCSÁNYI, J. (1987). Selective responsiveness of polymodal nociceptors of the rabbit ear to capsaicin, bradykinin and ultraviolet irradiation. J. Physiol (London), 388, 9-23.
29. SZOLCSÁNYI, J. (1988). Antidromic vasodilatation and neurogenic inflammation. Agents Actions, 23, 4-11.
30. SZOLCSÁNYI, J. (1993). Actions of capsaicin on sensory receptors. In Capsaicin in the study of pain. ed. Wood, J.N., 1-26. London: Academic Press.
31. SZOLCSÁNYI, J. (1996a). Neurogenic inflammation: reevaluation of axon reflex theory. In Neurogenic Inflammation. eds. Geppetti, G. & Holzer, P. 33-42. Boca Raton, U.S.A.: CRC Press.
32. SZOLCSÁNYI, J. (1996b). Capsaicin-sensitive sensory nerve terminals with local and systemic efferent functions: facts and scopes of an unorthodox neuroregulatory mechanism. In Progress in Brain Research. eds. Kumazawa, T., Kruger, L. & Mizumura, K., Vol. 113, 343-359. Amsterdam: Elsevier.
33. SZOLCSÁNYI, J., HELYES, Z.S., OROSZI, G., NÉMETH, J. & PINTÉR, E. (1998). Release of somatostatin and its role in mediation of the anti-inflammatory effect induced by antidromic stimulation of sensory fibres of the rat's sciatic nerve. Br. J. Pharmacol., 123, 936-942.
34. XU, X.J., HAO, J.X., WIESENFELD-HALLIN, Z.S., HAKANSON, R., FOLKERS, K. & HÖKFELT, T. (1991). Spantide II,s a novel tachykinin antagonist, and galanin inhibit plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw. Neuroscience, 42, 731-737.