MicroRNA-302/367 cluster governs hESC self-renewal by dually regulating cell cycle and apoptosis pathways

Stem Cell Reports

Volumn 4, Issue 4, 2015, Pages 645-657

  Zhang, Zhonghui ^a,b,c   Hong, Yuanfan ^a   Xiang, Di ^a,b   Zhu, Pei ^a,b   Wu, Elise ^a   Li, Wen ^a   Mosenson, Jeffrey ^a   Wu, Wen Shu ^a,b,c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^c Berkeley   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 302; MICRORNA 367; PROTEIN BCL XL; UNCLASSIFIED DRUG; BNIP3L PROTEIN, HUMAN; BUTYRIC ACID DERIVATIVE; MEMBRANE PROTEIN; MIRN302 MICRORNA, HUMAN; MIRN367 MICRORNA, HUMAN; ONCOPROTEIN; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL REGENERATION; CELL RENEWAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYONIC STEM CELL; GENE CLUSTER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; BIOLOGICAL MODEL; CELL CYCLE; CELL CYCLE CHECKPOINT; CELL SELF-RENEWAL; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN EMBRYONIC STEM CELL; METABOLISM; MULTIGENE FAMILY; RNA INTERFERENCE;

APOPTOSIS; BUTYRATES; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL SELF RENEWAL; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMAN EMBRYONIC STEM CELLS; HUMANS; MEMBRANE PROTEINS; MICRORNAS; MODELS, BIOLOGICAL; MULTIGENE FAMILY; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEINS;

EID: 84933671352     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2015.02.009     Document Type: Article

References (33)

1. Abdelalim, E.M. (2013). Molecular mechanisms controlling the cell cycle in embryonic stem cells. Stem Cell Rev. 9, 764-773.
2. Alenzi, F.Q. (2004). Links between apoptosis, proliferation and the cell cycle. Br. J. Biomed. Sci. 61, 99-102.
3. Ambros, V. (2004). The functions of animal microRNAs. Nature 431, 350-355.
4. Amit, M., Carpenter, M.K., Inokuma, M.S., Chiu, C.P., Harris, C.P., Waknitz, M.A., Itskovitz-Eldor, J., and Thomson, J.A. (2000). Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev. Biol. 227, 271-278.
5. Anokye-Danso, F., Trivedi, C.M., Juhr, D., Gupta, M., Cui, Z., Tian, Y., Zhang, Y., Yang, W., Gruber, P.J., Epstein, J.A., and Morrisey, E.E. (2011). Highly efficientmiRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.Cell Stem Cell 8, 376-388.
6. Bajpai, R., Lesperance, J., Kim, M., and Terskikh, A.V. (2008). Efficient propagation of single cells Accutase-dißociated human embryonic stem cells. Mol. Reprod. Dev. 75, 818-827.
7. Bartel, D.P. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
8. Cai, N., Wang, Y.D., and Zheng, P.S. (2013). The microRNA-302- 367 cluster suppreßes the proliferation of cervical carcinoma cells through the novel target AKT1. RNA 19, 85-95.
9. Chen, Y., Lewis, W., Diwan, A., Cheng, E.H., Matkovich, S.J., and Dorn, G.W. 2nd. (2010). Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. Proc. Natl. Acad. Sci. USA 107, 9035-9042.
10. Cheng, S., Hsia, C.Y., Leone, G., and Liou, H.C. (2003). Cyclin E and Bcl-xL cooperatively induce cell cycle progreßion in c-Rel-/- B cells. Oncogene 22, 8472-8486.
11. Emre, N., Vidal, J.G., Elia, J., O'Connor, E.D., Paramban, R.I., Hefferan, M.P., Navarro, R., Goldberg, D.S., Varki, N.M., Marsala, M., and Carson, C.T. (2010). The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers. PLoS ONE 5, e12148.
12. Fareh, M., Turchi, L., Virolle, V., Debruyne, D., Almairac, F., de-la- Forest Divonne, S., Paquis, P., Preynat-Seauve, O., Krause, K.H., Chneiweiß, H., and Virolle, T. (2012). The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma- initiating cells through CXCR4 repreßion and consequent disruption of the SHH-GLI-NANOG network. Cell Death Differ. 19, 232-244.
13. Janumyan, Y.M., Sansam, C.G., Chattopadhyay, A., Cheng, N., Soucie, E.L., Penn, L.Z., Andrews, D., Knudson, C.M., and Yang, E. (2003). Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry. EMBO J. 22, 5459-5470.
14. Kuo, C.H., Deng, J.H., Deng, Q., and Ying, S.Y. (2012). A novel role of miR-302/367 in reprogramming. Biochem. Biophys. Res. Commun. 417, 11-16.
15. Lee, K.Y., and Bae, S.C. (2002). TGF-beta-dependent cell growth arrest and apoptosis. J. Biochem. Mol. Biol. 35, 47-53.
16. Lin, S.L., Chang, D.C., Ying, S.Y., Leu, D., and Wu, D.T. (2010). MicroRNA miR-302 inhibits the tumorigenecity of human pluripotent stem cells by coordinate suppreßion of the CDK2 and CDK4/6 cell cycle pathways. Cancer Res. 70, 9473-9482.
17. Lin, S.L., Chang, D.C., Lin, C.H., Ying, S.Y., Leu, D., and Wu, D.T. (2011). Regulation of somatic cell reprogramming through inducible mir-302 expreßion. Nucleic Acids Res. 39, 1054-1065.
18. Lipchina, I., Elkabetz, Y., Hafner, M., Sheridan, R., Mihailovic, A., Tuschl, T., Sander, C., Studer, L., and Betel, D. (2011). Genomewide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. Genes Dev. 25, 2173-2186.
19. Miyoshi, N., Ishii, H., Nagano, H., Haraguchi, N., Dewi, D.L., Kano, Y., Nishikawa, S., Tanemura, M., Mimori, K., Tanaka, F., et al. (2011). Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 8, 633-638.
20. Pernaute, B., Spruce, T., Smith, K.M., Sánchez-Nieto, J.M., Manzanares, M., Cobb, B., and Rodríguez, T.A. (2014). MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM. Genes Dev. 28, 1873-1878.
21. Pyle, A.D., Lock, L.F., and Donovan, P.J. (2006). Neurotrophins mediate human embryonic stem cell survival. Nat. Biotechnol. 24, 344-350.
22. Scheel, A.H., Beyer, U., Agami, R., and Dobbelstein, M. (2009). Immunofluorescence-based screening identifies germ cell aßociated microRNA 302 as an antagonist to p63 expreßion. Cell Cycle 8, 1426-1432.
23. Schuster, N., and Krieglstein, K. (2002). Mechanisms of TGF-betamediated apoptosis. Cell Tißue Res. 307, 1-14.
24. Shu, J., Xia, Z., Li, L., Liang, E.T., Slipek, N., Shen, D., Foo, J., Subramanian, S., and Steer, C.J. (2012). Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs. RNA Biol. 9, 1275-1287.
25. Suh, M.R., Lee, Y., Kim, J.Y., Kim, S.K., Moon, S.H., Lee, J.Y., Cha, K.Y., Chung, H.M., Yoon, H.S., Moon, S.Y., et al. (2004). Human embryonic stem cells expreß a unique set of microRNAs. Dev. Biol. 270, 488-498.
26. Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S., and Jones, J.M. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147.
27. Wang, Y., Baskerville, S., Shenoy, A., Babiarz, J.E., Baehner, L., and Blelloch, R. (2008). Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat. Genet. 40, 1478-1483.
28. Wang, J., Park, J.W., Drißi, H., Wang, X., and Xu, R.H. (2014). Epigenetic regulation of miR-302 by JMJD1C inhibits neural differentiation of human embryonic stem cells. J. Biol. Chem. 289, 2384-2395.
29. Ware, C.B., Wang, L., Mecham, B.H., Shen, L., Nelson, A.M., Bar, M., Lamba, D.A., Dauphin, D.S., Buckingham, B., Askari, B., et al. (2009). Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell 4, 359-369.
30. Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J.B., Nishikawa, S., Nishikawa, S., Muguruma, K., and Sasai, Y. (2007). A ROCK inhibitor permits survival of dißociated human embryonic stem cells. Nat. Biotechnol. 25, 681-686.
31. Xu, N., Papagiannakopoulos, T., Pan, G., Thomson, J.A., and Kosik, K.S. (2009). MicroRNA-145 regulates OCT4, SOX2, and KLF4 and repreßes pluripotency in human embryonic stem cells. Cell 137, 647-658.
32. Zhang, Z., and Wu, W.S. (2013). Sodium butyrate promotes generation of human induced pluripotent stem cells through induction of the miR302/367 cluster. Stem Cells Dev. 22, 2268-2277.
33. Zhang, Z., Xiang, D., Heriyanto, F., Gao, Y., Qian, Z., and Wu, W.S. (2013). Dißecting the roles of miR-302/367 cluster in cellular reprogramming using TALE-based repreßor and TALEN. Stem Cell Rep. 1, 218-225.