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Volumn 70, Issue 22, 2010, Pages 9473-9482

MicroRNA miR-302 inhibits the tumorigenecity of human pluripotent stem cells by coordinate suppression of the CDK2 and CDK4/6 cell cycle pathways

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN E; MICRORNA; PROTEIN P14; PROTEIN P19;

EID: 78549288558     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-2746     Document Type: Article
Times cited : (159)

References (21)
  • 1
    • 52949125268 scopus 로고    scopus 로고
    • Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state
    • Lin SL, Chang D, Chang-Lin S, et al. Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA 2008;14:2115-24.
    • (2008) RNA , vol.14 , pp. 2115-2124
    • Lin, S.L.1    Chang, D.2    Chang-Lin, S.3
  • 2
    • 78549296558 scopus 로고    scopus 로고
    • Role of mir-302 microRNA family in stem cell pluripotency and renewal
    • Ying SY, editor. New York: Springer Publishers
    • Lin SL, Ying SY. Role of mir-302 microRNA family in stem cell pluripotency and renewal. In: Ying SY, editor. Current perspectives in microRNAs. New York: Springer Publishers; 2008, p. 167-85.
    • (2008) Current Perspectives in MicroRNAs , pp. 167-185
    • Lin, S.L.1    Ying, S.Y.2
  • 3
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 4
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20.
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 5
    • 34249908901 scopus 로고    scopus 로고
    • In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
    • Wernig M, Meissner A, Foreman R, et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007;448:318-24.
    • (2007) Nature , vol.448 , pp. 318-324
    • Wernig, M.1    Meissner, A.2    Foreman, R.3
  • 6
    • 53549133376 scopus 로고    scopus 로고
    • Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells
    • Card DA, Hebbar PB, Li L, et al. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol 2008;28:6426-38.
    • (2008) Mol Cell Biol , vol.28 , pp. 6426-6438
    • Card, D.A.1    Hebbar, P.B.2    Li, L.3
  • 9
    • 34547103279 scopus 로고    scopus 로고
    • Lats2 is an essential mitotic regulator required for the coordination of cell division
    • Yabuta N, Okada N, Ito A, et al. Lats2 is an essential mitotic regulator required for the coordination of cell division. J Biol Chem 2007;282:19259-71.
    • (2007) J Biol Chem , vol.282 , pp. 19259-19271
    • Yabuta, N.1    Okada, N.2    Ito, A.3
  • 10
    • 78549236669 scopus 로고    scopus 로고
    • [homepage on the Internet]. Cambridge (MA): Whitehead Institute for Biomedical Research; [updated 2009 April;cited 2010 July 27]. Available from
    • TargetScanHuman release 5.1 [homepage on the Internet]. Cambridge (MA): Whitehead Institute for Biomedical Research; c2006-2009 [updated 2009 April;cited 2010 July 27]. Available from: http://www.targetscan.org/.
    • (2006) TargetScanHuman Release 5.1
  • 11
    • 78549263913 scopus 로고    scopus 로고
    • [homepage on the Internet]. New York: Center for Comparative Functional Genomics; [updated 2007 March 26; cited 2010 July 27]. Avaliable from
    • PICTAR-VERT [homepage on the Internet]. New York: Center for Comparative Functional Genomics; c2005-2007 [updated 2007 March 26; cited 2010 July 27]. Avaliable from: http://pictar.mdc-berlin.de/cgi-bin/PicTar-vertebrate.cgi/.
    • (2005) PICTAR-VERT
  • 12
    • 2942534403 scopus 로고    scopus 로고
    • Human embryonic stem cells express a unique set of microRNAs
    • Suh MR, Lee Y, Kim JY, et al. Human embryonic stem cells express a unique set of microRNAs. Dev Biol 2004;270:488-98.
    • (2004) Dev Biol , vol.270 , pp. 488-498
    • Suh, M.R.1    Lee, Y.2    Kim, J.Y.3
  • 13
    • 33847333362 scopus 로고    scopus 로고
    • Hyaluronan stimulates transformation of androgen-independent prostate cancer
    • Lin SL, Chang D, Ying SY. Hyaluronan stimulates transformation of androgen-independent prostate cancer. Carcinogenesis 2007;28:310-20.
    • (2007) Carcinogenesis , vol.28 , pp. 310-320
    • Lin, S.L.1    Chang, D.2    Ying, S.Y.3
  • 14
    • 33646528191 scopus 로고    scopus 로고
    • Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation
    • Berthet C, Klarmann KD, Hilton MB, et al. Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell 2006;10:563-73.
    • (2006) Dev Cell , vol.10 , pp. 563-573
    • Berthet, C.1    Klarmann, K.D.2    Hilton, M.B.3
  • 15
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999;397:164-8.
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    Van Lohuizen, M.5
  • 16
    • 0028869884 scopus 로고
    • Lack of cyclin D-Cdk complexes in Rb-negative cells correlated with high levels of p16INK4/MTS1 tumor suppressor gene product
    • Parry D, Bates S, Mann DJ, Peters G. Lack of cyclin D-Cdk complexes in Rb-negative cells correlated with high levels of p16INK4/MTS1 tumor suppressor gene product. EMBO J 1995;14:503-11.
    • (1995) EMBO J , vol.14 , pp. 503-511
    • Parry, D.1    Bates, S.2    Mann, D.J.3    Peters, G.4
  • 17
    • 0029587551 scopus 로고
    • Alternative reading frames of the NK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of the NK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995;83:993-1000.
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 18
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
    • Kamijo T, Zindy F, Roussel MF, et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 1997;91:649-59.
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3
  • 19
    • 58149352816 scopus 로고    scopus 로고
    • 1to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cell
    • 1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cell. Oncogene 2009;28:20-30.
    • (2009) Oncogene , vol.28 , pp. 20-30
    • Neganova, I.1    Zhang, X.2    Atkinson, S.3    Lako, M.4
  • 20
    • 0021321996 scopus 로고
    • Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro
    • Andrews PW, Damjanov I, Simon D, et al. Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Lab Invest 1984;50:147-62.
    • (1984) Lab Invest , vol.50 , pp. 147-162
    • Andrews, P.W.1    Damjanov, I.2    Simon, D.3
  • 21
    • 66149160608 scopus 로고    scopus 로고
    • Embryonic stem cell-specific microRNAs promote induced pluripotency
    • Judson RL, Babiarz JE, Venere M, Blelloch R. Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol 2009;27:459-61.
    • (2009) Nat Biotechnol , vol.27 , pp. 459-461
    • Judson, R.L.1    Babiarz, J.E.2    Venere, M.3    Blelloch, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.