Olive Leaf Extract Elevates Hepatic PPAR α mRNA Expression and Improves Serum Lipid Profiles in Ovariectomized Rats

Journal of Medicinal Food

Volumn 18, Issue 7, 2015, Pages 738-744

  Yoon, Leena ^a   Liu, Ya Nan ^a   Park, Hyunjin ^a,b   Kim, Hyun Sook ^a  

^a Sookmyung Women's University   (South Korea)

^b ICAN Nutrition Education and Research   (South Korea)

Author keywords

dyslipidemia; estrogen deficiency; olive leaf extract; ovariectomy; postmenopause

Indexed keywords

ACYL COENZYME A OXIDASE; ADIPONECTIN; ANTILIPEMIC AGENT; CARNITINE PALMITOYLTRANSFERASE I; ESTRADIOL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; OLIVE EXTRACT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; ESTROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTILIPEMIC ACTIVITY; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MEGADOSE; DYSLIPIDEMIA; ESTRADIOL BLOOD LEVEL; ESTROGEN DEFICIENCY; FAT MASS; FEMALE; FOOD INTAKE; LIPID BLOOD LEVEL; LOW DRUG DOSE; NONHUMAN; OLIVE; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; UTERUS WEIGHT; ADIPOSE TISSUE; ANIMAL; BLOOD; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; DYSLIPIDEMIAS; GENE EXPRESSION; GENETICS; LIVER; OLIVE TREE; PHYTOTHERAPY; PLANT LEAF; POSTMENOPAUSE; SPRAGUE DAWLEY RAT;

RATTUS;

ACYL-COA OXIDASE; ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; DYSLIPIDEMIAS; ESTROGENS; FEMALE; GENE EXPRESSION; LIPIDS; LIVER; OLEA; OVARIECTOMY; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; POSTMENOPAUSE; PPAR ALPHA; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 84933568005     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2014.3287     Document Type: Article

References (33)

1. Sun A, Ren J: Estrogen replacement therapy and cardiac function under metabolic syndrome: A treacherous art. Hypertension 2012;59:552-554.
2. Carr MC: The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 2003;88:2404-2411.
3. Phan BA, Toth PP: Dyslipidemia in women: Etiology and management. Int J Womens Health 2014;6:185-194.
4. Kim JJ, Choi YM: Dyslipidemia in women with polycystic ovary syndrome. Obstet Gynaecol Sci 2013;56:137-142.
5. Shapira N: Women's higher health risks in the obesogenic environment: A gender nutrition approach to metabolic dimorphism with predictive, preventive, and personalised medicine. EPMA J 2013;4:1.
6. Choi JS, Song J: Effect of genistein on insulin resistance, renal lipid metabolism, and antioxidative activities in ovariectomized rats. Nutrition 2009;25:676-685.
7. Prasannarong M, Saengsirisuwan V, Piyachaturawat P, Suksamrarn A: Improvements of insulin resistance in ovariectomized rats by a novel phytoestrogen from Curcuma comosa Roxb. BMC Complement Altern Med 2012;12:28.
8. Wainstein J, Ganz T, Boaz M, et al.: Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food 2012;15:605-610.
9. Wang L, Geng C, Jiang L, et al.: The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis. Eur J Nutr 2008;47:235-243.
10. Jemai H, Fki I, Bouaziz M, et al.: Lipid-lowering and antioxidant effects of hydroxytyrosol and its triacetylated derivative recovered from olive tree leaves in cholesterol-fed rats. J Agric Food Chem 2008;56:2630-2636.
11. Ho YJ, Wang CF, Hsu WY, et al.: Psychoimmunological effects of dioscorea in ovariectomized rats: Role of anxiety level. Ann Gen Psychiatry 2007;6:21.
12. Lee OH, Lee BY, Lee J, et al.: Assessment of phenolics-enriched extract and fractions of olive leaves and their antioxidant activities. Bioresour Technol 2009;100:6107-6113.
13. Herrero M, Temirzoda TN, Segura-Carretero A, Quirantes R, Plaza M, Ibanez E: New possibilities for the valorization of olive oil by-products. J Chromatogr A 2011;1218:7511-7520.
14. Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
15. Kurachi H, Adachi H, Ohtsuka S, et al.: Involvement of epidermal growth factor in inducing obesity in ovariectomized mice. Am J Physiol 1993;265:E323-E331.
16. Bray GA: Genetic, hypothalamic and endocrine features of clinical and experimental obesity. Prog Brain Res 1992;93:333-340.
17. Lorden JF, Caudle A: Behavioral and endocrinological effects of single injections of monosodium glutamate in the mouse. Neurobehav Toxicol Teratol 1986;8:509-519.
18. Wegorzewska IN, Walters K, Weiser MJ, et al.: Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol. Am J Obstet Gynecol 2008;199:67.e1-e5.
19. Lee D, Kim S: Correlation of the bone mineral density and weight reduction therapy in estrogen replaced obese postmenopausal women. Korean J Obes 2001;10:306-313.
20. Clegg DJ: Minireview: The year in review of estrogen regulation of metabolism. Mol Endocrinol 2012;26:1957-1960.
21. Stevenson JC, Crook D, Godsland IF: Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis 1993;98:83-90.
22. Sugden MC, Bulmer K, Gibbons GF, Knight BL, Holness MJ: Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin. Biochem J 2002;364:361-368.
23. Linden D, Alsterholm M, Wennbo H, Oscarsson J: PPARalpha deficiency increases secretion and serum levels of apolipoprotein B-containing lipoproteins. J Lipid Res 2001;42:1831-1840.
24. Costet P, Legendre C, More J, Edgar A, Galtier P, Pineau T: Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J Biol Chem 1998;273:29577-29585.
25. Roglans N, Bellido A, Rodriguez C, et al.: Fibrate treatment does not modify the expression of acyl coenzyme A oxidase in human liver. Clin Pharmacol Ther 2002;72:692-701.
26. Mascaro C, Acosta E, Ortiz JA, Marrero PF, Hegardt FG, Haro D: Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J Biol Chem 1998;273:8560-8563.
27. Brandt JM, Djouadi F, Kelly DP: Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem 1998;273:23786-23792.
28. Louet JF, Chatelain F, Decaux JF, et al.: Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. Biochem J 2001;354:189-197.
29. Lenchik L, Register TC, Hsu FC, et al.: Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone 2003;33:646-651.
30. Arita Y, Kihara S, Ouchi N, et al.: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83.
31. Pannacciulli N, Vettor R, Milan G, et al.: Anorexia nervosa is characterized by increased adiponectin plasma levels and reduced nonoxidative glucose metabolism. J Clin Endocrinol Metab 2003;88:1748-1752.
32. Kunnari A, Santaniemi M, Jokela M, et al.: Estrogen replacement therapy decreases plasma adiponectin but not resistin in postmenopausal women. Metabolism 2008;57:1509-1515.
33. Combs TP, Berg AH, Rajala MW, et al.: Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003;52:268-276.