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Volumn 36, Issue 1, 2016, Pages 108-118

Clinicopathological indices to predict hepatocellular carcinoma molecular classification

Author keywords

Clinical diagnostic; Gene expression; Histopathology; Molecular subclass; Predictive index

Indexed keywords

ALPHA FETOPROTEIN; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 4; CATENIN BETA 1; CHEMOKINE RECEPTOR CXCR4; COLLAGEN TYPE 1; COLLAGEN TYPE 1A2; COLLAGEN TYPE 3; COLLAGEN TYPE 3A1; COLLAGEN TYPE 6A2; CYTOKERATIN 19; DECARBOXYPROTHROMBIN; EPITHELIAL CELL ADHESION MOLECULE; GLUTAMATE AMMONIA LIGASE; GLYPICAN 3; K RAS PROTEIN; LYVE1 PROTEIN; MOLECULAR MARKER; MYC PROTEIN; ONCOPROTEIN; RAF PROTEIN; STROMAL CELL DERIVED FACTOR 1; SURVIVIN; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; TUMOR MARKER; UNCLASSIFIED DRUG; WNT PROTEIN; YAP PROTEIN; BMP4 PROTEIN, HUMAN; CELL ADHESION MOLECULE; EPCAM PROTEIN, HUMAN; TUMOR ANTIGEN;

EID: 84933557723     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12889     Document Type: Article
Times cited : (74)

References (59)
  • 1
    • 84913530344 scopus 로고    scopus 로고
    • Pathogenesis and prevention of hepatitis C virusinduced hepatocellular carcinoma
    • Hoshida Y, Fuchs BC, Bardeesy N, Baumert TF, Chung RT. Pathogenesis and prevention of hepatitis C virusinduced hepatocellular carcinoma. J Hepatol 2014; 60: S79–90.
    • (2014) J Hepatol , vol.60 , pp. S79-S90
    • Hoshida, Y.1    Fuchs, B.C.2    Bardeesy, N.3    Baumert, T.F.4    Chung, R.T.5
  • 2
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378–90.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 3
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised,double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised,double-blind, placebo-controlled trial. Lancet Oncol 2009; 10: 25–34.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 4
    • 84898989382 scopus 로고    scopus 로고
    • Hepatocellular carcinoma:Reasons for phase III failure and novel perspectives on trial design
    • Llovet JM, Hernandez-Gea V. Hepatocellular carcinoma:reasons for phase III failure and novel perspectives on trial design. Clin Cancer Res 2014; 20: 2072–9.
    • (2014) Clin Cancer Res , vol.20 , pp. 2072-2079
    • Llovet, J.M.1    Hernandez-Gea, V.2
  • 5
    • 70349739285 scopus 로고    scopus 로고
    • Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
    • Hoshida Y, Nijman SM, Kobayashi M, et al. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res 2009; 69: 7385–92.
    • (2009) Cancer Res , vol.69 , pp. 7385-7392
    • Hoshida, Y.1    Nijman, S.M.2    Kobayashi, M.3
  • 6
    • 84883718528 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
    • Kan Z, Zheng H, Liu X, et al. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res 2013; 23: 1422–33.
    • (2013) Genome Res , vol.23 , pp. 1422-1433
    • Kan, Z.1    Zheng, H.2    Liu, X.3
  • 7
    • 84901617583 scopus 로고    scopus 로고
    • SERPINB3 is associated with TGF-beta1 and cytoplasmic beta-catenin expression in hepatocellular carcinomas with poor prognosis
    • Turato C, Vitale A, Fasolato S, et al. SERPINB3 is associated with TGF-beta1 and cytoplasmic beta-catenin expression in hepatocellular carcinomas with poor prognosis. Br J Cancer 2014; 110: 2708–15.
    • (2014) Br J Cancer , vol.110 , pp. 2708-2715
    • Turato, C.1    Vitale, A.2    Fasolato, S.3
  • 8
    • 85004183063 scopus 로고    scopus 로고
    • Molecular classification of hepatocellular carcinoma: Potential therapeutic implications
    • Goossens N, Sun X, Hoshida Y. Molecular classification of hepatocellular carcinoma: potential therapeutic implications. Hepat Oncol 2015; 60: S79–90.
    • (2015) Hepat Oncol , vol.60 , pp. S79-S90
    • Goossens, N.1    Sun, X.2    Hoshida, Y.3
  • 9
    • 84897450600 scopus 로고    scopus 로고
    • Transforming growth factorbeta as a therapeutic target in hepatocellular carcinoma
    • Giannelli G, Villa E, Lahn M. Transforming growth factorbeta as a therapeutic target in hepatocellular carcinoma. Cancer Res 2014; 74: 1890–4.
    • (2014) Cancer Res , vol.74 , pp. 1890-1894
    • Giannelli, G.1    Villa, E.2    Lahn, M.3
  • 10
    • 84874040548 scopus 로고    scopus 로고
    • First-in-man phase I study of GC33, a novel recombinant humanized antibody against glypican-3, in patients with advanced hepatocellular carcinoma
    • Zhu AX, Gold PJ, El-Khoueiry AB, et al. First-in-man phase I study of GC33, a novel recombinant humanized antibody against glypican-3, in patients with advanced hepatocellular carcinoma. Clin Cancer Res 2013; 19: 920–8.
    • (2013) Clin Cancer Res , vol.19 , pp. 920-928
    • Zhu, A.X.1    Gold, P.J.2    El-Khoueiry, A.B.3
  • 11
    • 84871721240 scopus 로고    scopus 로고
    • Tivantinib for second-line treatment of advanced hepatocellular carcinoma:A randomised, placebo-controlled phase 2 study
    • Santoro A, Rimassa L, Borbath I, et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma:a randomised, placebo-controlled phase 2 study. Lancet Oncol 2013; 14: 55–63.
    • (2013) Lancet Oncol , vol.14 , pp. 55-63
    • Santoro, A.1    Rimassa, L.2    Borbath, I.3
  • 12
    • 84896493342 scopus 로고    scopus 로고
    • Epitope-optimized alphafetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma
    • Hong Y, Peng Y, Guo ZS, et al. Epitope-optimized alphafetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma. Hepatology 2014; 59: 1448–58.
    • (2014) Hepatology , vol.59 , pp. 1448-1458
    • Hong, Y.1    Peng, Y.2    Guo, Z.S.3
  • 13
    • 84876734918 scopus 로고    scopus 로고
    • Molecular subtype and response to dasatinib, an Src/Abl small molecule kinase inhibitor, in hepatocellular carcinoma cell lines in vitro
    • Finn RS, Aleshin A, Dering J, et al. Molecular subtype and response to dasatinib, an Src/Abl small molecule kinase inhibitor, in hepatocellular carcinoma cell lines in vitro. Hepatology 2013; 57: 1838–46.
    • (2013) Hepatology , vol.57 , pp. 1838-1846
    • Finn, R.S.1    Aleshin, A.2    Dering, J.3
  • 14
    • 84888294592 scopus 로고    scopus 로고
    • Genomic profiling of cell lines for personalized targeted therapy for hepatocellular carcinoma
    • Deshmukh M, Hoshida Y. Genomic profiling of cell lines for personalized targeted therapy for hepatocellular carcinoma. Hepatology 2013; 58: 2207.
    • (2013) Hepatology , vol.58 , pp. 2207
    • Deshmukh, M.1    Hoshida, Y.2
  • 15
    • 84925103805 scopus 로고    scopus 로고
    • YAP inhibition restores hepatocyte differentiation in advanced HCC leading to tumor regression
    • Fitamant J, Kottakis F, Benhamouche S, et al. YAP inhibition restores hepatocyte differentiation in advanced HCC leading to tumor regression. Cell Rep 2015; 10: S2211–1247.
    • (2015) Cell Rep , vol.10 , pp. S1247-S2211
    • Fitamant, J.1    Kottakis, F.2    Benhamouche, S.3
  • 16
    • 84858658381 scopus 로고    scopus 로고
    • EASL-EORTC clinical practice guidelines:Management of hepatocellular carcinoma
    • Easl-Eortc. EASL-EORTC clinical practice guidelines:management of hepatocellular carcinoma. J Hepatol 2012; 56: 908–43.
    • (2012) J Hepatol , vol.56 , pp. 908-943
  • 17
    • 84900450842 scopus 로고    scopus 로고
    • Transcriptome profiling of archived sectioned formalin-fixed paraffin-embedded (AS-FFPE) tissue for disease classification
    • Kojima K, April C, Canasto-Chibuque C, et al. Transcriptome profiling of archived sectioned formalin-fixed paraffin-embedded (AS-FFPE) tissue for disease classification. PLoS ONE 2014; 9: e86961.
    • (2014) Plos ONE , vol.9
    • Kojima, K.1    April, C.2    Canasto-Chibuque, C.3
  • 18
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association,American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association,American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012; 142: 1592–609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 19
    • 34248327856 scopus 로고    scopus 로고
    • Neoplasms of the liver
    • Goodman ZD. Neoplasms of the liver. Mod Pathol 2007; 20(Suppl 1): S49–60.
    • (2007) Mod Pathol , vol.20 , Issue.1 , pp. S49-S60
    • Goodman, Z.D.1
  • 20
    • 85049416767 scopus 로고    scopus 로고
    • Sciencedirect (Online Service). MacSween’s Pathology of the Liver, 6th edn
    • online resource (1 v.)
    • Macsween RNM, Burt AD, Portmann B, Ferrell LD,Sciencedirect (Online Service). MacSween’s Pathology of the Liver, 6th edn. Edinburgh: Churchill Livingstone, 2011; 1 online resource (1 v.).
    • (2011) Edinburgh: Churchill Livingstone , vol.1
    • Macsween, R.1    Burt, A.D.2    Portmann, B.3    Ferrell, L.D.4
  • 22
    • 0020614127 scopus 로고
    • Clear cell carcinoma of liver. An ultrastructural study
    • Wu PC, Lai CL, Lam KC, Lok AS, Lin HJ. Clear cell carcinoma of liver. An ultrastructural study. Cancer 1983; 52: 504–7.
    • (1983) Cancer , vol.52 , pp. 504-507
    • Wu, P.C.1    Lai, C.L.2    Lam, K.C.3    Lok, A.S.4    Lin, H.J.5
  • 23
    • 0023669342 scopus 로고
    • A clinico-pathologic study of clear-cell hepatocellular carcinoma
    • Audisio RA, Bombelli L, Lombardi L, Andreola S. A clinico-pathologic study of clear-cell hepatocellular carcinoma. Tumori 1987; 73: 389–95.
    • (1987) Tumori , vol.73 , pp. 389-395
    • Audisio, R.A.1    Bombelli, L.2    Lombardi, L.3    Reola, S.4
  • 24
    • 9544226398 scopus 로고    scopus 로고
    • Clinicopathologic study on clear cell hepatocellular carcinoma
    • Yang SH, Watanabe J, Nakashima O, Kojiro M. Clinicopathologic study on clear cell hepatocellular carcinoma. Pathol Int 1996; 46: 503–9.
    • (1996) Pathol Int , vol.46 , pp. 503-509
    • Yang, S.H.1    Watanabe, J.2    Nakashima, O.3    Kojiro, M.4
  • 25
    • 78049529652 scopus 로고    scopus 로고
    • Steatohepatitic hepatocellular carcinoma (SH-HCC): A distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASH
    • Salomao M, Yu WM, Brown RS Jr, Emond JC, Lefkowitch JH. Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASH. Am J Surg Pathol 2010; 34: 1630–6.
    • (2010) Am J Surg Pathol , vol.34 , pp. 1630-1636
    • Salomao, M.1    Yu, W.M.2    Brown, R.S.3    Emond, J.C.4    Lefkowitch, J.H.5
  • 26
    • 84879625497 scopus 로고    scopus 로고
    • Steatohepatitic hepatocellular carcinoma, a morphologic indicator of associated metabolic risk factors: A study from India
    • Jain D, Nayak NC, Kumaran V, Saigal S. Steatohepatitic hepatocellular carcinoma, a morphologic indicator of associated metabolic risk factors: a study from India. Arch Pathol Lab Med 2013; 137: 961–6.
    • (2013) Arch Pathol Lab Med , vol.137 , pp. 961-966
    • Jain, D.1    Nayak, N.C.2    Kumaran, V.3    Saigal, S.4
  • 27
    • 84899916295 scopus 로고    scopus 로고
    • Hepatocellular carcinoma with steatohepatitic features:A clinicopathological study of Japanese patients
    • Shibahara J, Ando S, Sakamoto Y, Kokudo N, Fukayama M. Hepatocellular carcinoma with steatohepatitic features:a clinicopathological study of Japanese patients. Histopathology 2014; 64: 951–62.
    • (2014) Histopathology , vol.64 , pp. 951-962
    • Shibahara, J.1    Ando, S.2    Sakamoto, Y.3    Kokudo, N.4    Fukayama, M.5
  • 28
    • 78651053628 scopus 로고
    • Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies
    • Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7: 462–503.
    • (1954) Cancer , vol.7 , pp. 462-503
    • Edmondson, H.A.1    Steiner, P.E.2
  • 29
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313–21.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 30
    • 33745685014 scopus 로고    scopus 로고
    • Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation
    • Unitt E, Marshall A, Gelson W, et al. Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation. J Hepatol 2006; 45: 246–53.
    • (2006) J Hepatol , vol.45 , pp. 246-253
    • Unitt, E.1    Marshall, A.2    Gelson, W.3
  • 31
    • 84889095314 scopus 로고    scopus 로고
    • Chromophobe hepatocellular carcinoma with abrupt anaplasia: A proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features
    • Wood LD, Heaphy CM, Daniel HD, et al. Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features. Mod Pathol 2013; 26: 1586–93.
    • (2013) Mod Pathol , vol.26 , pp. 1586-1593
    • Wood, L.D.1    Heaphy, C.M.2    Daniel, H.D.3
  • 32
    • 0041731798 scopus 로고    scopus 로고
    • Hepatocellular carcinoma with osteoclast-like giant cells: Possibility of osteoclastogenesis by hepatocyte-derived cells
    • Ikeda T, Seki S, Maki M, et al. Hepatocellular carcinoma with osteoclast-like giant cells: possibility of osteoclastogenesis by hepatocyte-derived cells. Pathol Int 2003; 53: 450–6.
    • (2003) Pathol Int , vol.53 , pp. 450-456
    • Ikeda, T.1    Seki, S.2    Maki, M.3
  • 33
    • 77349092851 scopus 로고    scopus 로고
    • Molecular classification and novel targets in hepatocellular carcinoma:Recent advancements
    • Hoshida Y, Toffanin S, Lachenmayer A, et al. Molecular classification and novel targets in hepatocellular carcinoma:recent advancements. Semin Liver Dis 2010; 30: 35–51.
    • (2010) Semin Liver Dis , vol.30 , pp. 35-51
    • Hoshida, Y.1    Toffanin, S.2    Lachenmayer, A.3
  • 34
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005; 102: 15545–50.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 35
    • 84876907931 scopus 로고    scopus 로고
    • Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease
    • Zhang B, Gaiteri C, Bodea LG, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Cell 2013; 153: 707–20.
    • (2013) Cell , vol.153 , pp. 707-720
    • Zhang, B.1    Gaiteri, C.2    Bodea, L.G.3
  • 38
    • 79960888804 scopus 로고    scopus 로고
    • Inferring causal genomic alterations in breast cancer using gene expression data
    • Tran LM, Zhang B, Zhang Z, et al. Inferring causal genomic alterations in breast cancer using gene expression data. BMC Syst Biol 2011; 5: 121.
    • (2011) BMC Syst Biol , vol.5 , pp. 121
    • Tran, L.M.1    Zhang, B.2    Zhang, Z.3
  • 39
    • 84919385796 scopus 로고    scopus 로고
    • Recent advances in the treatment of non-small cell and small cell lung cancer
    • Stinchcombe TE. Recent advances in the treatment of non-small cell and small cell lung cancer. F1000prime Rep 2014; 6: 117.
    • (2014) F1000prime Rep , vol.6 , pp. 117
    • Stinchcombe, T.E.1
  • 40
    • 84859888123 scopus 로고    scopus 로고
    • The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis
    • Salomao M, Remotti H, Vaughan R, et al. The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis. Hum Pathol 2012; 43: 737–46.
    • (2012) Hum Pathol , vol.43 , pp. 737-746
    • Salomao, M.1    Remotti, H.2    Vaughan, R.3
  • 41
    • 4544273428 scopus 로고    scopus 로고
    • Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
    • Lee JS, Chu IS, Heo J, et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 2004; 40: 667–76.
    • (2004) Hepatology , vol.40 , pp. 667-676
    • Lee, J.S.1    Chu, I.S.2    Heo, J.3
  • 42
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault S, Rickman DS, De Reynies A, et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 2007; 45: 42–52.
    • (2007) Hepatology , vol.45 , pp. 42-52
    • Boyault, S.1    Rickman, D.S.2    De Reynies, A.3
  • 43
    • 53049086329 scopus 로고    scopus 로고
    • Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
    • Chiang DY, Villanueva A, Hoshida Y, et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res 2008; 68: 6779–88.
    • (2008) Cancer Res , vol.68 , pp. 6779-6788
    • Chiang, D.Y.1    Villanueva, A.2    Hoshida, Y.3
  • 44
    • 84930204654 scopus 로고    scopus 로고
    • YAP activation is an early event and a potential therapeutic target in liver cancer development
    • Perra A, Kowalik MA, Ghiso E, et al. YAP activation is an early event and a potential therapeutic target in liver cancer development. J Hepatol 2014; 61: 1088–96.
    • (2014) J Hepatol , vol.61 , pp. 1088-1096
    • Perra, A.1    Kowalik, M.A.2    Ghiso, E.3
  • 45
    • 17544373837 scopus 로고    scopus 로고
    • Survivin promotes cell proliferation in human hepatocellular carcinoma
    • Ito T, Shiraki K, Sugimoto K, et al. Survivin promotes cell proliferation in human hepatocellular carcinoma. Hepatology 2000; 31: 1080–5.
    • (2000) Hepatology , vol.31 , pp. 1080-1085
    • Ito, T.1    Shiraki, K.2    Sugimoto, K.3
  • 46
    • 47749093561 scopus 로고    scopus 로고
    • Molecular signaling pathways that regulate prostate gland development
    • Prins GS, Putz O. Molecular signaling pathways that regulate prostate gland development. Differentiation 2008; 76: 641–59.
    • (2008) Differentiation , vol.76 , pp. 641-659
    • Prins, G.S.1    Putz, O.2
  • 47
    • 84875055629 scopus 로고    scopus 로고
    • Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning
    • Mehta V, Schmitz CT, Keil KP, et al. Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning. Dev Biol 2013; 376: 125–35.
    • (2013) Dev Biol , vol.376 , pp. 125-135
    • Mehta, V.1    Schmitz, C.T.2    Keil, K.P.3
  • 48
    • 84892370936 scopus 로고    scopus 로고
    • Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
    • Ding BS, Cao Z, Lis R, et al. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature 2014; 505: 97–102.
    • (2014) Nature , vol.505 , pp. 97-102
    • Ding, B.S.1    Cao, Z.2    Lis, R.3
  • 49
    • 68949122522 scopus 로고    scopus 로고
    • Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor-1alpha-mediated stellate cell activation
    • Hong F, Tuyama A, Lee TF, et al. Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation. Hepatology 2009; 49: 2055–67.
    • (2009) Hepatology , vol.49 , pp. 2055-2067
    • Hong, F.1    Tuyama, A.2    Lee, T.F.3
  • 50
    • 84896492282 scopus 로고    scopus 로고
    • Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice
    • Chen Y, Huang Y, Reiberger T, et al. Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. Hepatology 2014; 59: 1435–47.
    • (2014) Hepatology , vol.59 , pp. 1435-1447
    • Chen, Y.1    Huang, Y.2    Reiberger, T.3
  • 51
    • 33845790499 scopus 로고    scopus 로고
    • A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis
    • Llovet JM, Chen Y, Wurmbach E, et al. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 2006; 131: 1758–67.
    • (2006) Gastroenterology , vol.131 , pp. 1758-1767
    • Llovet, J.M.1    Chen, Y.2    Wurmbach, E.3
  • 52
    • 33947396135 scopus 로고    scopus 로고
    • Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis
    • Di Tommaso L, Franchi G, Park YN, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 2007; 45: 725–34.
    • (2007) Hepatology , vol.45 , pp. 725-734
    • Di Tommaso, L.1    Franchi, G.2    Park, Y.N.3
  • 53
    • 84858658381 scopus 로고    scopus 로고
    • EASLEORTC clinical practice guidelines: Management of hepatocellular carcinoma
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver. EASLEORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 2012; 56: 908–43.
    • (2012) J Hepatol , vol.56 , pp. 908-943
  • 54
    • 57349090407 scopus 로고    scopus 로고
    • Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    • Hoshida Y, Villanueva A, Kobayashi M, et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 2008; 359: 1995–2004.
    • (2008) N Engl J Med , vol.359 , pp. 1995-2004
    • Hoshida, Y.1    Villanueva, A.2    Kobayashi, M.3
  • 55
    • 77953004083 scopus 로고    scopus 로고
    • Why most gene expression signatures of tumors have not been useful in the clinic
    • Koscielny S. Why most gene expression signatures of tumors have not been useful in the clinic. Sci Transl Med 2010; 2: 14 ps2.
    • (2010) Sci Transl Med , vol.2 , pp. 14
    • Koscielny, S.1
  • 56
    • 62749123476 scopus 로고    scopus 로고
    • Prognostic indicators in hepatocellular carcinoma: A systematic review of 72 studies
    • Tandon P, Garcia-Tsao G. Prognostic indicators in hepatocellular carcinoma: a systematic review of 72 studies. Liver Int 2009; 29: 502–10.
    • (2009) Liver Int , vol.29 , pp. 502-510
    • Tandon, P.1    Garcia-Tsao, G.2
  • 57
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma:An update
    • Bruix J, Sherman M. Management of hepatocellular carcinoma:an update. Hepatology 2011; 53: 1020–2.
    • (2011) Hepatology , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 58
    • 84880245463 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease in the United States: The Third National Health and Nutrition Examination Survey, 1988–1994
    • Lazo M, Hernaez R, Eberhardt MS, et al. Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988–1994. Am J Epidemiol 2013; 178: 38–45.
    • (2013) Am J Epidemiol , vol.178 , pp. 38-45
    • Lazo, M.1    Hernaez, R.2    Eberhardt, M.S.3


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