Hepatocellular carcinoma with steatohepatitic features: A clinicopathological study of Japanese patients

Histopathology

Volumn 64, Issue 7, 2014, Pages 951-962

  Shibahara, Junji ^a   Ando, Sumiyo ^a   Sakamoto, Yoshihiro ^a   Kokudo, Norihiro ^a   Fukayama, Masashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Alcohol; Diabetes mellitus; Hepatitis C virus; Hepatocellular carcinoma; Metabolic syndrome; Non alcoholic fatty liver disease; Steatohepatitis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; TRIACYLGLYCEROL;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT; BILIRUBIN BLOOD LEVEL; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CHEMOEMBOLIZATION; CHOLESTEROL BLOOD LEVEL; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN TISSUE; HYPERLIPIDEMIA; HYPERTENSION; INFLAMMATORY INFILTRATE; JAPANESE (PEOPLE); LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OVERALL SURVIVAL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STEATOSIS; TRIACYLGLYCEROL BLOOD LEVEL; COHORT ANALYSIS; FATTY LIVER; JAPAN; LIVER; LIVER TUMOR; MIDDLE AGED; PATHOLOGY; PROGNOSIS; VERY ELDERLY; YOUNG ADULT;

HEPATITIS C VIRUS;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; COHORT STUDIES; FATTY LIVER; FEMALE; HUMANS; JAPAN; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84899916295     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/his.12343     Document Type: Article

References (20)

1. Ferlay J, Shin HR, Bray F et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 2010; 127; 2893-2917.
2. Theise ND, Curado MP, Franceschi S et al. Hepatocellular carcinoma. In Bosman FT, Carneiro F, Hruban RH, Theise ND eds. WHO classification of tumours of the digestive system. Lyon: IARC, 2010; 205-216.
3. Hoshida Y, Moeini A, Alsinet C et al. Gene signatures in the management of hepatocellular carcinoma. Semin. Oncol. 2012; 39; 473-485.
4. Salomao M, Yu WM, Brown RS et al. Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASH. Am. J. Surg. Pathol. 2010; 34; 1630-1636.
5. Salomao M, Remotti H, Vaughan R et al. The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis. Hum. Pathol. 2012; 43; 737-746.
6. Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996; 24; 289-293.
7. Kleiner DE, Brunt EM, Van Natta M et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41; 1313-1321.
8. Busler JF, Geevarghese SK, Kelly BS et al. The steatohepatitic variant of hepatocellular carcinoma is associated with non-alcoholic steatohepatitis. Mod. Pathol. 2012; 25 (Suppl. S1); 411A.
9. Alexander J, Torbenson M, Wu TT et al. Steatohepatitic hepatocellular carcinoma did not increase in the last decade: metabolic syndrome may not be the only contributing factor. Mod. Pathol. 2013; 26 (Suppl. S1); 397A.
10. Ishak KG. Pathologic features of chronic hepatitis. A review and update. Am. J. Clin. Pathol. 2000; 113; 40-55.
11. Caldwell SH, Lee VD, Kleiner DE et al. NASH and cryptogenic cirrhosis: a histological analysis. Ann. Hepatol. 2009; 8; 346-352.
12. Fartoux L, Poujol-Robert A, Guéchot J et al. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut 2005; 54; 1003-1008.
13. Hézode C, Roudot-Thoraval F, Zafrani ES et al. Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3 infections. J. Viral Hepatol. 2004; 11; 455-458.
14. Kumar D, Farrell GC, Fung C et al. Hepatitis C virus genotype 3 is cytopathic to hepatocytes: reversal of hepatic steatosis after sustained therapeutic response. Hepatology 2002; 36; 1266-1272.
15. Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011; 141; 1572-1585.
16. Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001; 121; 91-100.
17. Dunn W, Sanyal AJ, Brunt EM et al. Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD). J. Hepatol. 2012; 57; 384-391.
18. Gunji T, Sato H, Iijima K et al. Modest alcohol consumption has an inverse association with liver fat content. Hepatogastroenterology 2012; 59; 2552-2556.
19. Rodríguez-Perálvarez M, Luong TV, Andreana L et al. A systematic review of microvascular invasion in hepatocellular carcinoma: diagnostic and prognostic variability. Ann. Surg. Oncol. 2013; 20; 325-339.
20. Shindoh J, Andreou A, Aloia TA et al. Microvascular invasion does not predict long-term survival in hepatocellular carcinoma up to 2 cm: reappraisal of the staging system for solitary tumors. Ann. Surg. Oncol. 2013; 20; 1223-1229.