Genomic profiling of cell lines for personalized targeted therapy for hepatocellular carcinoma

Hepatology

Volumn 58, Issue 6, 2013, Pages 2207-2207

  Deshmukh, Manjeet ^a   Hoshida, Yujin ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; BIOLOGICAL MARKER; DASATINIB; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; AFP PROTEIN, HUMAN; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

APOPTOSIS; CANCER CELL CULTURE; CELL CYCLE ARREST; DRUG SENSITIVITY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LETTER; LIVER CELL CARCINOMA; MOLECULARLY TARGETED THERAPY; PHENOTYPE; PRIORITY JOURNAL; CARCINOMA, HEPATOCELLULAR; GENETICS; LIVER NEOPLASMS; PERSONALIZED MEDICINE; TUMOR CELL LINE;

ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; HUMANS; INDIVIDUALIZED MEDICINE; LIVER NEOPLASMS; MOLECULAR TARGETED THERAPY; PYRIMIDINES; THIAZOLES;

EID: 84888294592     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26407     Document Type: Letter

References (6)

1. Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012;483:603-607.
2. Finn RS, Aleshin A, Dering J, Yang P, Ginther C, Desai A, et al. Molecular subtype and response to dasatinib, a src/abl small molecule kinase inhibitor, in hepatocellular carcinoma cell lines in vitro. Hepatology 2013;57:1838-1846.
3. Kawai HF, Kaneko S, Honda M, Shirota Y, Kobayashi K. alpha-fetoprotein-producing hepatoma cell lines share common expression profiles of genes in various categories demonstrated by cDNA microarray analysis. Hepatology 2001;33:676-691.
4. Lee JS, Thorgeirsson SS. Functional and genomic implications of global gene expression profiles in cell lines from human hepatocellular cancer. Hepatology 2002;35:1134-1143.
5. Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, Chiang DY, et al. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res 2009;69:7385-7392.
6. Hoshida Y, Toffanin S, Lachenmayer A, Villanueva A, Minguez B, Llovet JM. Molecular classification and novel targets in hepatocellular carcinoma: recent advancements. Semin Liver Dis 2010;30:35-51.