메뉴 건너뛰기




Volumn 35, Issue 25, 2015, Pages 9491-9507

ERK2 alone drives inflammatory pain but cooperates with ERK1 in sensory neuron survival

Author keywords

ERK; MAP kinase; MEK; Nociception; Pain; Sensory neuron

Indexed keywords

CRE RECOMBINASE; FREUND ADJUVANT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SODIUM CHANNEL NAV1.8;

EID: 84933544769     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4404-14.2015     Document Type: Article
Times cited : (32)

References (69)
  • 1
    • 33644769222 scopus 로고    scopus 로고
    • 2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8
    • CrossRef Medline
    • 2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8. Neurosci Lett 397:140-144. CrossRef Medline
    • (2006) Neurosci Lett , vol.397 , pp. 140-144
    • Abe, J.1    Hosokawa, H.2    Sawada, Y.3    Matsumura, K.4    Kobayashi, S.5
  • 3
    • 1942423228 scopus 로고    scopus 로고
    • Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia
    • CrossRef Medline
    • Agarwal N, Offermanns S, Kuner R (2004) Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia. Genesis 38:122-129. CrossRef Medline
    • (2004) Genesis , vol.38 , pp. 122-129
    • Agarwal, N.1    Offermanns, S.2    Kuner, R.3
  • 4
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • CrossRef Medline
    • Airaksinen MS, Saarma M (2002) The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3:383-394. CrossRef Medline
    • (2002) Nat Rev Neurosci , vol.3 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 5
    • 77956108186 scopus 로고    scopus 로고
    • Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models
    • CrossRef Medline
    • Alter BJ, Zhao C, Karim F, Landreth GE, Gereau RW 4th (2010) Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models. J Neurosci 30:11537-11547. CrossRef Medline
    • (2010) J Neurosci , vol.30 , pp. 11537-11547
    • Alter, B.J.1    Zhao, C.2    Karim, F.3    Landreth, G.E.4    Gereau, R.W.5
  • 6
    • 0031848282 scopus 로고    scopus 로고
    • Endogenous nerve growth factor regulates the sensitivity of nociceptors in the adult rat
    • CrossRef Medline
    • Bennett DL, Koltzenburg M, Priestley JV, Shelton DL, McMahon SB (1998) Endogenous nerve growth factor regulates the sensitivity of nociceptors in the adult rat. Eur J Neurosci 10:1282-1291. CrossRef Medline
    • (1998) Eur J Neurosci , vol.10 , pp. 1282-1291
    • Bennett, D.L.1    Koltzenburg, M.2    Priestley, J.V.3    Shelton, D.L.4    McMahon, S.B.5
  • 7
    • 0026165752 scopus 로고
    • Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies
    • Medline
    • Boulton TG, Cobb MH (1991) Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul 2:357-371. Medline
    • (1991) Cell Regul , vol.2 , pp. 357-371
    • Boulton, T.G.1    Cobb, M.H.2
  • 9
    • 84862666906 scopus 로고    scopus 로고
    • A novel behavioral assay for measuring cold sensation in mice
    • CrossRef Medline
    • Brenner DS, Golden JP, GereauRW4th (2012) A novel behavioral assay for measuring cold sensation in mice. PLoS One 7:e39765. CrossRef Medline
    • (2012) PLoS One , vol.7
    • Brenner, D.S.1    Golden, J.P.2    Gereau, R.W.3
  • 10
    • 84908086272 scopus 로고    scopus 로고
    • A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo
    • CrossRef Medline
    • Brenner DS, Golden JP, Vogt SK, Dhaka A, Story GM, Gereau RW IV (2014a) A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain 155:2124-2133. CrossRef Medline
    • (2014) Pain , vol.155 , pp. 2124-2133
    • Brenner, D.S.1    Golden, J.P.2    Vogt, S.K.3    Dhaka, A.4    Story, G.M.5    Gereau IV, R.W.6
  • 11
    • 84906849345 scopus 로고    scopus 로고
    • A technique to measure cold adaptation in freely behaving mice
    • CrossRef Medline
    • Brenner DS, Vogt SK, Gereau RW (2014b) A technique to measure cold adaptation in freely behaving mice. J Neurosci Methods 236C:86-91. CrossRef Medline
    • (2014) J Neurosci Methods , vol.236 C , pp. 86-91
    • Brenner, D.S.1    Vogt, S.K.2    Gereau, R.W.3
  • 12
    • 33847145480 scopus 로고    scopus 로고
    • Activation of the extracellular signalregulated kinase in the amygdala modulates pain oerception
    • CrossRef Medline
    • Carrasquillo Y, GereauRW4th (2007) Activation of the extracellular signalregulated kinase in the amygdala modulates pain oerception. J Neurosci 27:1543-1551. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 1543-1551
    • Carrasquillo, Y.1    Gereau IV, R.W.2
  • 13
    • 66749156637 scopus 로고    scopus 로고
    • Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
    • CrossRef Medline
    • Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ (2009) Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A 106:9075-9080. CrossRef Medline
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9075-9080
    • Cavanaugh, D.J.1    Lee, H.2    Lo, L.3    Shields, S.D.4    Zylka, M.J.5    Basbaum, A.I.6    Anderson, D.J.7
  • 14
    • 33847271109 scopus 로고    scopus 로고
    • Roles of capsaicin-sensitive primary afferents in differential rat models of inflammatory pain: A systematic comparative study in conscious rats
    • CrossRef Medline
    • Chen HS, He X, Wang Y, WenWW,You HJ, Arendt-Nielsen L (2007) Roles of capsaicin-sensitive primary afferents in differential rat models of inflammatory pain: a systematic comparative study in conscious rats. Exp Neurol 204:244-251. CrossRef Medline
    • (2007) Exp Neurol , vol.204 , pp. 244-251
    • Chen, H.S.1    He, X.2    Wang, Y.3    Wen, W.W.4    You, H.J.5    Arendt-Nielsen, L.6
  • 15
    • 0028091616 scopus 로고
    • Dorsal root ganglion cell death and surviving cell numbers in relation to the development of sensory innervation in the rat hindlimb
    • CrossRef Medline
    • Coggeshall RE, Pover CM, Fitzgerald M (1994) Dorsal root ganglion cell death and surviving cell numbers in relation to the development of sensory innervation in the rat hindlimb. Dev Brain Res 82:193-212. CrossRef Medline
    • (1994) Dev Brain Res , vol.82 , pp. 193-212
    • Coggeshall, R.E.1    Pover, C.M.2    Fitzgerald, M.3
  • 16
    • 0036758662 scopus 로고    scopus 로고
    • Phosphorylation of extracellular signalregulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization
    • Medline
    • Dai Y, Iwata K, Fukuoka T, Kondo E, Tokunaga A, Yamanaka H, Tachibana T, Liu Y, Noguchi K (2002) Phosphorylation of extracellular signalregulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization. J Neurosci 22:7737-7745. Medline
    • (2002) J Neurosci , vol.22 , pp. 7737-7745
    • Dai, Y.1    Iwata, K.2    Fukuoka, T.3    Kondo, E.4    Tokunaga, A.5    Yamanaka, H.6    Tachibana, T.7    Liu, Y.8    Noguchi, K.9
  • 18
    • 33748188892 scopus 로고    scopus 로고
    • Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold
    • CrossRef Medline
    • Elitt CM, McIlwrath SL, Lawson JJ, Malin SA, Molliver DC, Cornuet PK, Koerber HR, Davis BM, Albers KM (2006) Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold. J Neurosci 26:8578-8587. CrossRef Medline
    • (2006) J Neurosci , vol.26 , pp. 8578-8587
    • Elitt, C.M.1    McIlwrath, S.L.2    Lawson, J.J.3    Malin, S.A.4    Molliver, D.C.5    Cornuet, P.K.6    Koerber, H.R.7    Davis, B.M.8    Albers, K.M.9
  • 19
    • 78751509692 scopus 로고    scopus 로고
    • The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation
    • CrossRef Medline
    • Fyffe-Maricich SL, Karlo JC, Landreth GE, Miller RH (2011) The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation. J Neurosci 31:843-850. CrossRef Medline
    • (2011) J Neurosci , vol.31 , pp. 843-850
    • Fyffe-Maricich, S.L.1    Karlo, J.C.2    Landreth, G.E.3    Miller, R.H.4
  • 20
    • 43049176430 scopus 로고    scopus 로고
    • Activation of JNK pathway in persistent pain
    • CrossRef Medline
    • Gao YJ, Ji RR (2008) Activation of JNK pathway in persistent pain. Neurosci Lett 437:180-183. CrossRef Medline
    • (2008) Neurosci Lett , vol.437 , pp. 180-183
    • Gao, Y.J.1    Ji, R.R.2
  • 22
    • 84862900786 scopus 로고    scopus 로고
    • ERK1/ ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination
    • CrossRef Medline
    • Ishii A, Fyffe-Maricich SL, Furusho M, Miller RH, Bansal R (2012) ERK1/ ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination. J Neurosci 32:8855-8864. CrossRef Medline
    • (2012) J Neurosci , vol.32 , pp. 8855-8864
    • Ishii, A.1    Fyffe-Maricich, S.L.2    Furusho, M.3    Miller, R.H.4    Bansal, R.5
  • 23
    • 84871781182 scopus 로고    scopus 로고
    • Sustained activation of ERK1/2 MAPK in oligodendrocytes and Schwann cells enhances myelin growth and stimulates oligodendrocyte progenitor expansion
    • CrossRef Medline
    • Ishii A, Furusho M, Bansal R (2013) Sustained activation of ERK1/2 MAPK in oligodendrocytes and Schwann cells enhances myelin growth and stimulates oligodendrocyte progenitor expansion. J Neurosci 33:175-186. CrossRef Medline
    • (2013) J Neurosci , vol.33 , pp. 175-186
    • Ishii, A.1    Furusho, M.2    Bansal, R.3
  • 24
    • 0033971253 scopus 로고    scopus 로고
    • Development of peripheral hindlimb and central spinal cord innervation by subpopulations of dorsal root ganglion cells in the embryonic rat
    • CrossRef Medline
    • Jackman A, Fitzgerald M (2000) Development of peripheral hindlimb and central spinal cord innervation by subpopulations of dorsal root ganglion cells in the embryonic rat. JCompNeurol 418:281-298. CrossRef Medline
    • (2000) JCompNeurol , vol.418 , pp. 281-298
    • Jackman, A.1    Fitzgerald, M.2
  • 25
    • 0033490464 scopus 로고    scopus 로고
    • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    • CrossRef Medline
    • Ji RR, Baba H, Brenner GJ, Woolf CJ (1999) Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 2:1114-1119. CrossRef Medline
    • (1999) Nat Neurosci , vol.2 , pp. 1114-1119
    • Ji, R.R.1    Baba, H.2    Brenner, G.J.3    Woolf, C.J.4
  • 26
    • 0037080003 scopus 로고    scopus 로고
    • ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    • Medline
    • Ji RR, Befort K, Brenner GJ, Woolf CJ (2002) ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci 22:478-485. Medline
    • (2002) J Neurosci , vol.22 , pp. 478-485
    • Ji, R.R.1    Befort, K.2    Brenner, G.J.3    Woolf, C.J.4
  • 27
    • 33645325812 scopus 로고    scopus 로고
    • Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuronspecific dominant negative mitogen activated protein kinase kinase (MEK)
    • CrossRef Medline
    • Karim F, Hu HJ, Adwanikar H, Kaplan D, Gereau RW 4th (2006) Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuronspecific dominant negative mitogen activated protein kinase kinase (MEK). Mol Pain 2:2. CrossRef Medline
    • (2006) Mol Pain , vol.2 , pp. 2
    • Karim, F.1    Hu, H.J.2    Adwanikar, H.3    Kaplan, D.4    Gereau IV, R.W.5
  • 28
    • 0020955460 scopus 로고
    • Interactions between the sympathetic and sensory innervation of the iris
    • Medline
    • Kessler JA, Bell WO, Black IB (1983) Interactions between the sympathetic and sensory innervation of the iris. J Neurosci 3:1301-1307. Medline
    • (1983) J Neurosci , vol.3 , pp. 1301-1307
    • Kessler, J.A.1    Bell, W.O.2    Black, I.B.3
  • 29
    • 0025775101 scopus 로고
    • Soma neurofilament immunoreactivity is related to cell size and fibre conduction velocity in rat primary sensory neurons
    • CrossRef Medline
    • Lawson SN, Waddell PJ (1991) Soma neurofilament immunoreactivity is related to cell size and fibre conduction velocity in rat primary sensory neurons. J Physiol 435:41-63. CrossRef Medline
    • (1991) J Physiol , vol.435 , pp. 41-63
    • Lawson, S.N.1    Waddell, P.J.2
  • 30
    • 37549016809 scopus 로고    scopus 로고
    • Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels
    • CrossRef Medline
    • Lefloch R, Pouysségur J, Lenormand P (2008) Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol 28:511-527. CrossRef Medline
    • (2008) Mol Cell Biol , vol.28 , pp. 511-527
    • Lefloch, R.1    Pouysségur, J.2    Lenormand, P.3
  • 31
    • 0028207288 scopus 로고
    • Regulation of cutaneous C-fiber heat nociceptors by nerve growth factor in the developing rat
    • Medline
    • Lewin GR, Mendell LM (1994) Regulation of cutaneous C-fiber heat nociceptors by nerve growth factor in the developing rat. J Neurophysiol 71:941-949. Medline
    • (1994) J Neurophysiol , vol.71 , pp. 941-949
    • Lewin, G.R.1    Mendell, L.M.2
  • 32
    • 21844470486 scopus 로고    scopus 로고
    • Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia
    • CrossRef Medline
    • Malik-Hall M, Dina OA, Levine JD (2005) Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia. Eur J Neurosci 21:3387-3394. CrossRef Medline
    • (2005) Eur J Neurosci , vol.21 , pp. 3387-3394
    • Malik-Hall, M.1    Dina, O.A.2    Levine, J.D.3
  • 35
    • 84876090616 scopus 로고    scopus 로고
    • Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold
    • CrossRef Medline
    • McCoy ES, Taylor-Blake B, Street SE, Pribisko AL, Zheng J, Zylka MJ (2013) Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold. Neuron 78:138-151. CrossRef Medline
    • (2013) Neuron , vol.78 , pp. 138-151
    • McCoy, E.S.1    Taylor-Blake, B.2    Street, S.E.3    Pribisko, A.L.4    Zheng, J.5    Zylka, M.J.6
  • 36
    • 78149479471 scopus 로고    scopus 로고
    • IL-6-and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex
    • CrossRef Medline
    • Melemedjian OK, Asiedu MN, Tillu DV, Peebles KA, Yan J, Ertz N, Dussor GO, Price TJ (2010) IL-6-and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. J Neurosci 30:15113-15123. CrossRef Medline
    • (2010) J Neurosci , vol.30 , pp. 15113-15123
    • Melemedjian, O.K.1    Asiedu, M.N.2    Tillu, D.V.3    Peebles, K.A.4    Yan, J.5    Ertz, N.6    Dussor, G.O.7    Price, T.J.8
  • 37
    • 33745233509 scopus 로고    scopus 로고
    • Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1-and TRPM8-containing small sensory neurons
    • CrossRef Medline
    • Mizushima T, Obata K, Katsura H, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Tokunaga A, Mashimo T, Noguchi K (2006) Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1-and TRPM8-containing small sensory neurons. Neuroscience 140:1337-1348. CrossRef Medline
    • (2006) Neuroscience , vol.140 , pp. 1337-1348
    • Mizushima, T.1    Obata, K.2    Katsura, H.3    Yamanaka, H.4    Kobayashi, K.5    Dai, Y.6    Fukuoka, T.7    Tokunaga, A.8    Mashimo, T.9    Noguchi, K.10
  • 38
    • 23444444748 scopus 로고    scopus 로고
    • ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis
    • CrossRef Medline
    • Nekrasova T, Shive C, Gao Y, Kawamura K, Guardia R, Landreth G, Forsthuber TG (2005) ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. J Immunol 175:2374-2380. CrossRef Medline
    • (2005) J Immunol , vol.175 , pp. 2374-2380
    • Nekrasova, T.1    Shive, C.2    Gao, Y.3    Kawamura, K.4    Guardia, R.5    Landreth, G.6    Forsthuber, T.G.7
  • 41
    • 0037704450 scopus 로고    scopus 로고
    • Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury
    • Medline
    • Obata K, Yamanaka H, Dai Y, Tachibana T, Fukuoka T, Tokunaga A, Yoshikawa H, Noguchi K (2003) Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci 23:4117-4126. Medline
    • (2003) J Neurosci , vol.23 , pp. 4117-4126
    • Obata, K.1    Yamanaka, H.2    Dai, Y.3    Tachibana, T.4    Fukuoka, T.5    Tokunaga, A.6    Yoshikawa, H.7    Noguchi, K.8
  • 42
    • 2942685267 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body
    • CrossRef Medline
    • Obata K, Yamanaka H, Dai Y, Mizushima T, Fukuoka T, Tokunaga A, Noguchi K (2004) Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body. Neuroscience 126:1011-1021. CrossRef Medline
    • (2004) Neuroscience , vol.126 , pp. 1011-1021
    • Obata, K.1    Yamanaka, H.2    Dai, Y.3    Mizushima, T.4    Fukuoka, T.5    Tokunaga, A.6    Noguchi, K.7
  • 43
    • 84933561787 scopus 로고    scopus 로고
    • Animal models of experimental neuropathic pain
    • Ed 6 (McMahon SB, Koltzenburg M, Tracey I, Turk DC, eds), Philadelphia: Elsevier
    • Ossipov MH, Porreca F (2013) Animal models of experimental neuropathic pain. In: Wall and Melzack's textbook of pain, Ed 6 (McMahon SB, Koltzenburg M, Tracey I, Turk DC, eds), pp 889-900. Philadelphia: Elsevier.
    • (2013) Wall and Melzack's textbook of pain , pp. 889-900
    • Ossipov, M.H.1    Porreca, F.2
  • 44
    • 84867571253 scopus 로고    scopus 로고
    • Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system
    • CrossRef Medline
    • Otsubo Y, Satoh Y, Kodama M, Araki Y, Satomoto M, Sakamoto E, Pagès G, Pouysségur J, Endo S, Kazama T (2012) Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system. Pain 153:2241-2252. CrossRef Medline
    • (2012) Pain , vol.153 , pp. 2241-2252
    • Otsubo, Y.1    Satoh, Y.2    Kodama, M.3    Araki, Y.4    Satomoto, M.5    Sakamoto, E.6    Pagès, G.7    Pouysségur, J.8    Endo, S.9    Kazama, T.10
  • 46
    • 0033757828 scopus 로고    scopus 로고
    • Development of sensory neurons in the absence of NGF/TrkA signaling in vivo
    • CrossRef Medline
    • Patel TD, Jackman A, Rice FL, Kucera J, SniderWD (2000) Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. Neuron 25:345-357. CrossRef Medline
    • (2000) Neuron , vol.25 , pp. 345-357
    • Patel, T.D.1    Jackman, A.2    Rice, F.L.3    Kucera, J.4    Snider, W.D.5
  • 47
    • 0030932645 scopus 로고    scopus 로고
    • The differential contribution of capsaicin-sensitive afferents to behavioral and cardiovascular measures of brief and persistent nociception and to Fos expression in the formalin test
    • CrossRef Medline
    • Peterson MA, Basbaum AI, Abbadie C, Rohde DS, McKay WR, Taylor BK (1997) The differential contribution of capsaicin-sensitive afferents to behavioral and cardiovascular measures of brief and persistent nociception and to Fos expression in the formalin test. Brain Res 755:9-16. CrossRef Medline
    • (1997) Brain Res , vol.755 , pp. 9-16
    • Peterson, M.A.1    Basbaum, A.I.2    Abbadie, C.3    Rohde, D.S.4    McKay, W.R.5    Taylor, B.K.6
  • 48
    • 30544438062 scopus 로고    scopus 로고
    • Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation
    • CrossRef Medline
    • Premkumar LS, Raisinghani M, Pingle SC, Long C, Pimentel F (2005) Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation. J Neurosci 25:11322-11329. CrossRef Medline
    • (2005) J Neurosci , vol.25 , pp. 11322-11329
    • Premkumar, L.S.1    Raisinghani, M.2    Pingle, S.C.3    Long, C.4    Pimentel, F.5
  • 49
    • 67449115950 scopus 로고    scopus 로고
    • Translating nociceptor sensitivity: The role of axonal protein synthesis in nociceptor physiology
    • CrossRef Medline
    • Price TJ, Géranton SM (2009) Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology. Eur J Neurosci 29: 2253-2263. CrossRef Medline
    • (2009) Eur J Neurosci , vol.29 , pp. 2253-2263
    • Price, T.J.1    Géranton, S.M.2
  • 50
    • 0029923562 scopus 로고    scopus 로고
    • Formalin-evoked activity in identified primary afferent fibers: Systemic lidocaine suppresses phase-2 activity
    • CrossRef Medline
    • Puig S, Sorkin LS (1996) Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity. Pain 64: 345-355. CrossRef Medline
    • (1996) Pain , vol.64 , pp. 345-355
    • Puig, S.1    Sorkin, L.S.2
  • 51
    • 84862294189 scopus 로고    scopus 로고
    • ERK1/2 MAP kinases: Structure, function, and regulation
    • CrossRef Medline
    • Roskoski R Jr (2012) ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol Res 66:105-143. CrossRef Medline
    • (2012) Pharmacol Res , vol.66 , pp. 105-143
    • Roskoski, R.1
  • 52
    • 0242607637 scopus 로고    scopus 로고
    • An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
    • CrossRef Medline
    • Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche S (2003) An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep 4:964-968. CrossRef Medline
    • (2003) EMBO Rep , vol.4 , pp. 964-968
    • Saba-El-Leil, M.K.1    Vella, F.D.2    Vernay, B.3    Voisin, L.4    Chen, L.5    Labrecque, N.6    Ang, S.L.7    Meloche, S.8
  • 53
    • 0037794324 scopus 로고    scopus 로고
    • Neurotrophic factors as novel therapeutics for neuropathic pain
    • CrossRef Medline
    • Sah DW, Ossipo MH, Porreca F (2003) Neurotrophic factors as novel therapeutics for neuropathic pain. Nat Rev Drug Discov 2:460-472. CrossRef Medline
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 460-472
    • Sah, D.W.1    Ossipo, M.H.2    Porreca, F.3
  • 54
    • 49049085537 scopus 로고    scopus 로고
    • Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function
    • CrossRef Medline
    • Samuels IS, Karlo JC, Faruzzi AN, Pickering K, Herrup K, Sweatt JD, Saitta SC, Landreth GE (2008) Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci 28:6983-6995. CrossRef Medline
    • (2008) J Neurosci , vol.28 , pp. 6983-6995
    • Samuels, I.S.1    Karlo, J.C.2    Faruzzi, A.N.3    Pickering, K.4    Herrup, K.5    Sweatt, J.D.6    Saitta, S.C.7    Landreth, G.E.8
  • 55
    • 35148894535 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory: ERK2 has a specific function in learning and memory
    • CrossRef Medline
    • Satoh Y, Endo S, Ikeda T, Yamada K, Ito M, Kuroki M, Hiramoto T, Imamura O, Kobayashi Y, Watanabe Y, Itohara S, Takishima K (2007) Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory: ERK2 has a specific function in learning and memory. J Neurosci 27:10765-10776. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 10765-10776
    • Satoh, Y.1    Endo, S.2    Ikeda, T.3    Yamada, K.4    Ito, M.5    Kuroki, M.6    Hiramoto, T.7    Imamura, O.8    Kobayashi, Y.9    Watanabe, Y.10    Itohara, S.11    Takishima, K.12
  • 57
    • 78751493171 scopus 로고    scopus 로고
    • Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice
    • CrossRef Medline
    • Satoh Y, Kobayashi Y, Takeuchi A, Pagès G, Pouysségur J, Kazama T (2011b) Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice. J Neurosci 31:1149-1155. CrossRef Medline
    • (2011) J Neurosci , vol.31 , pp. 1149-1155
    • Satoh, Y.1    Kobayashi, Y.2    Takeuchi, A.3    Pagès, G.4    Pouysségur, J.5    Kazama, T.6
  • 58
    • 84866429193 scopus 로고    scopus 로고
    • Nav1. 8 expression is not restricted to nociceptors in mouse peripheral nervous system
    • CrossRef Medline
    • Shields SD, Ahn HS, Yang Y, Han C, Seal RP, Wood JN, Waxman SG, Dib-Hajj SD (2012) Nav1. 8 expression is not restricted to nociceptors in mouse peripheral nervous system. Pain 153:2017-2030. CrossRef Medline
    • (2012) Pain , vol.153 , pp. 2017-2030
    • Shields, S.D.1    Ahn, H.S.2    Yang, Y.3    Han, C.4    Seal, R.P.5    Wood, J.N.6    Waxman, S.G.7    Dib-Hajj, S.D.8
  • 59
    • 76149104939 scopus 로고    scopus 로고
    • ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1. 7 and alters its gating properties
    • CrossRef Medline
    • Stamboulian S, Choi JS, Ahn HS, Chang YW, Tyrrell L, Black JA, Waxman SG, Dib-Hajj SD (2010) ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1. 7 and alters its gating properties. J Neurosci 30:1637-1647. CrossRef Medline
    • (2010) J Neurosci , vol.30 , pp. 1637-1647
    • Stamboulian, S.1    Choi, J.S.2    Ahn, H.S.3    Chang, Y.W.4    Tyrrell, L.5    Black, J.A.6    Waxman, S.G.7    Dib-Hajj, S.D.8
  • 60
    • 0026674117 scopus 로고
    • The formalin test: An evaluation of the method
    • CrossRef Medline
    • Tjølsen A, Berge OG, Hundskaar S, Rosland JH, Hole K (1992) The formalin test: an evaluation of the method. Pain 51:5-17. CrossRef Medline
    • (1992) Pain , vol.51 , pp. 5-17
    • Tjølsen, A.1    Berge, O.G.2    Hundskaar, S.3    Rosland, J.H.4    Hole, K.5
  • 61
    • 76949102275 scopus 로고    scopus 로고
    • BDNF is essentially required for the early postnatal survival of nociceptors
    • CrossRef Medline
    • Valdés-Sánchez T, Kirstein M, Pérez-Villalba A, Vega JA, Fariñas I (2010) BDNF is essentially required for the early postnatal survival of nociceptors. Dev Biol 339:465-476. CrossRef Medline
    • (2010) Dev Biol , vol.339 , pp. 465-476
    • Valdés-Sánchez, T.1    Kirstein, M.2    Pérez-Villalba, A.3    Vega, J.A.4    Fariñas, I.5
  • 62
    • 33845904217 scopus 로고    scopus 로고
    • ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially
    • CrossRef Medline
    • Vantaggiato C, Formentini I, Bondanza A, Naldini L, Brambilla R (2006) ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially. J Biol 5:1-15. CrossRef Medline
    • (2006) J Biol , vol.5 , pp. 1-15
    • Vantaggiato, C.1    Formentini, I.2    Bondanza, A.3    Naldini, L.4    Brambilla, R.5
  • 63
    • 58149391339 scopus 로고    scopus 로고
    • Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity
    • CrossRef Medline
    • Xu Q, Garraway SM, Weyerbacher AR, Shin SJ, Inturrisi CE (2008) Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity. J Neurosci 28:14087-14096. CrossRef Medline
    • (2008) J Neurosci , vol.28 , pp. 14087-14096
    • Xu, Q.1    Garraway, S.M.2    Weyerbacher, A.R.3    Shin, S.J.4    Inturrisi, C.E.5
  • 64
    • 79955014406 scopus 로고    scopus 로고
    • ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation
    • ra25 CrossRef Medline
    • Yasuda T, Kometani K, Takahashi N, Imai Y, Aiba Y, Kurosaki T (2011) ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation. Sci Signal 4:ra25. CrossRef Medline
    • (2011) Sci Signal , vol.4
    • Yasuda, T.1    Kometani, K.2    Takahashi, N.3    Imai, Y.4    Aiba, Y.5    Kurosaki, T.6
  • 65
    • 34247517890 scopus 로고    scopus 로고
    • Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo
    • CrossRef Medline
    • Zhong J, Li X, McNamee C, Chen AP, Baccarini M, Snider WD (2007) Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci 10:598-607. CrossRef Medline
    • (2007) Nat Neurosci , vol.10 , pp. 598-607
    • Zhong, J.1    Li, X.2    McNamee, C.3    Chen, A.P.4    Baccarini, M.5    Snider, W.D.6
  • 66
    • 4644250844 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization
    • CrossRef Medline
    • Zhuang ZY, Xu H, Clapham DE, Ji RR (2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci 24:8300-8309. CrossRef Medline
    • (2004) J Neurosci , vol.24 , pp. 8300-8309
    • Zhuang, Z.Y.1    Xu, H.2    Clapham, D.E.3    Ji, R.R.4
  • 67
    • 0037095747 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse
    • Medline
    • Zwick M, Davis BM, Woodbury CJ, Burkett JN, Koerber HR, Simpson JF, Albers KM (2002) Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse. J Neurosci 22:4057-4065. Medline
    • (2002) J Neurosci , vol.22 , pp. 4057-4065
    • Zwick, M.1    Davis, B.M.2    Woodbury, C.J.3    Burkett, J.N.4    Koerber, H.R.5    Simpson, J.F.6    Albers, K.M.7
  • 68
    • 11344251617 scopus 로고    scopus 로고
    • Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd
    • CrossRef Medline
    • Zylka MJ, Rice FL, Anderson DJ (2005) Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 45:17-25. CrossRef Medline
    • (2005) Neuron , vol.45 , pp. 17-25
    • Zylka, M.J.1    Rice, F.L.2    Anderson, D.J.3
  • 69
    • 53049093740 scopus 로고    scopus 로고
    • Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine
    • CrossRef Medline
    • Zylka MJ, Sowa NA, Taylor-Blake B, Twomey MA, Herrala A, Voikar V, Vihko P (2008) Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine. Neuron 60:111-122. CrossRef Medline
    • (2008) Neuron , vol.60 , pp. 111-122
    • Zylka, M.J.1    Sowa, N.A.2    Taylor-Blake, B.3    Twomey, M.A.4    Herrala, A.5    Voikar, V.6    Vihko, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.