Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Tan, Xing Lin ^a   Xue, Yue Qiang ^a   Ma, Tao ^a,b   Wang, Xiaofang ^a,c   Li, Jing Jing ^a   Lan, Lubin ^a   Malik, Kafait U ^a   McDonald, Michael P ^a   Dopico, Alejandro M ^a   Liao, Francesca Fang ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b WUXI NO 2 PEOPLE S HOSPITAL   (China)

^c ZHENGZHOU UNIVERSITY   (China)

Author keywords

Cerebral amyloid angiopathy (CAA); Cerebral chronic hypoperfusion; Cerebral dysfunction; Cerebral microinfarction; Endothelial nitric oxide synthase (eNOS); Microvessel occlusion; Thrombosis; Vascular dementia

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; NERVE PROTEIN; NOS3 PROTEIN, MOUSE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL OCCLUSION; BRAIN ANGIOGRAPHY; BRAIN CORTEX; BRAIN INFARCTION; BRAIN PERFUSION; CAPILLARY DENSITY; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME DEFICIENCY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PROTEIN EXPRESSION; RETROSPLENIAL GRANULAR CORTEX; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPOROPARIETAL CORTEX; THROMBOTIC CEREBRAL INFARCTION; VASCULAR AMYLOIDOSIS; WESTERN BLOTTING; AGING; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; BRAIN CIRCULATION; DEFICIENCY; DISEASE COURSE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HETEROZYGOTE; MAZE TEST; MEMORY DISORDER; MOUSE MUTANT; PARIETAL LOBE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; TEMPORAL LOBE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

MUS;

AGING; ANIMALS; BLOOD-BRAIN BARRIER; CEREBRAL AMYLOID ANGIOPATHY; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HETEROZYGOTE; HIPPOCAMPUS; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, NEUROLOGIC MUTANTS; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE TYPE III; ORGAN SPECIFICITY; PARIETAL LOBE; RNA, MESSENGER; TEMPORAL LOBE;

EID: 84933526095     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0020-0     Document Type: Article

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