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1
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0013408376
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Cortech and ONO collaborate in oral elastase inhibitor development
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174095; March 13; note
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174095 Cortech and ONO collaborate in oral elastase inhibitor development. Cortech Press Release 1995 March 13 Cortech and ONO announce their collaboration in the development of an oral elastase inhibitor. ONO will fund Cortech's research of potential orally bioavailable human elastase inhibitors.
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(1995)
Cortech Press Release
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2
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8944254696
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MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: A double-bind, randomized, placebo-controlled clinical trial
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230053
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230053 MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: A double-bind, randomized, placebo-controlled clinical trial. Luisetti M, Sturani C, Sella D, Madonini E, Galavotti V, Bruno G, Peona V, Kucich U, Dagnino G, Rosenbloom J, Starcher B, Grassi C Eur Respir 1996 9 7 1482-1486
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Rosenbloom, J.10
Starcher, B.11
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3
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Ono amend collaboration with Cortech
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247240
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247240 Ono amend collaboration with Cortech. Scrip 1997 2231 10
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Scrip
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4
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Cortech seeks to establish new company based on its protease inhibitor technology
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296641; September 01
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296641 Cortech seeks to establish new company based on its protease inhibitor technology. Cortech Inc Press Release 1998 September 01
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(1998)
Cortech Inc Press Release
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5
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Cortech makes announcement
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317583; March 08
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317583 Cortech makes announcement. Cortech Inc Press Release 1999 March 08
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(1999)
Cortech Inc Press Release
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6
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Ono's new drugs R&D pipeline
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366431
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366431 Ono's new drugs R&D pipeline. Pharma Jpn 1999 1675 16
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(1999)
Pharma Jpn
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7
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Drug development pipeline: ONO-6818, ONO-8815
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368565; May 30
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368565 Drug development pipeline: ONO-6818, ONO-8815. Ono Pharmaceutical Co Ltd Company Communication 2000 May 30
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(2000)
Ono Pharmaceutical Co Ltd Company Communication
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8
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Structural and inflammatory changes in COPD: A comparison with asthma
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381286
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381286 Structural and inflammatory changes in COPD: A comparison with asthma. Jeffery PK Thorax 1998 53 2 129-136
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Thorax
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Jeffery, P.K.1
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9
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Ono: Aims at overseas business development through tie-ups
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391542
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391542 Ono: Aims at overseas business development through tie-ups. Pharma Jpn 2000 1723 13
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Development of orally active nonpeptidic inhibitors of human neutrophil elastase
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404465
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404465 Development of orally active nonpeptidic inhibitors of human neutrophil elastase. Ohmoto K, Yamamoto T, Okuma M, Horiuchi T, Imanishi H, Odagaki Y, Kawabata K, Sekioka T, Hirota Y, Matsuoka S, Nakai H et al J Med Chem 2001 44 8 1268-1285
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J Med Chem
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11
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0035105397
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The crystal structure of the complex of on-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase
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407193; note
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195 hydroxyl group in the active site of elastase.
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(2001)
Bioorg Med Chem
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Odagaki, Y.1
Ohmoto, K.2
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Industry - Healthcare (pharmaceuticals): Wait-&-see stance retained; Valuations more attractive
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422782 Industry - Healthcare (pharmaceuticals): Wait-&-see stance retained; Valuations more attractive. Mita M Morgan Stanley Dean Witter 2001 September 11
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Morgan Stanley Dean Witter
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Mita, M.1
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13
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In vivo effects of ONO-6818, an orally active neutrophil elastase inhibitor
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423688; W19/03
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423688 In vivo effects of ONO-6818, an orally active neutrophil elastase inhibitor. Sekikoa T, Kitagawa K, Nakao S, Hagio T, Tanaka K, Kawabata K, Obata T Inflamm Res 2001 50 Suppl 3 W19/03
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Inflamm Res
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Sekikoa, T.1
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16
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Design and synthesis of new orally active ihibitors of human neutrophil elastase
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448417 Design and synthesis of new orally active ihibitors of human neutrophil elastase. Ohmoto K, Okuma M, Yamamoto T, Kijima H, Sekioka T, Kitagawa K, Yamamoto S, Tanaka K, Kawabata K, Sakata A, Imawaka H et al Bioorg Med Chem 2001 9 5 1307-1323
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Bioorg Med Chem
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Ohmoto, K.1
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Kitagawa, K.6
Yamamoto, S.7
Tanaka, K.8
Kawabata, K.9
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17
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0035125164
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Improved synthesis of a new nonpeptidic inhibitor of human neutrophil elastase
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448419
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448419 Improved synthesis of a new nonpeptidic inhibitor of human neutrophil elastase. Ohmoto K, Yamamoto T, Horiuchi T, Kojima T, Hachiya K, Hashimoto S, Kawamura M, Nakai H, Toda M Synlett 2001 2 299-301
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Synlett
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Ohmoto, K.1
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Nakai, H.8
Toda, M.9
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18
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0035721724
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Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells
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448420
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448420 Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells. Terui T, Sano K, Okada M, Shirota H, Honda M, Ozawa M, Hirasawa N, Tamura G, Tagami H J Invest Dermatol 2001 117 2 236-243
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J Invest Dermatol
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Terui, T.1
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19
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0001502564
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Pharmacological profile of a novel orally active neutrophil elastase inhibitor, ONO-6818
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453940
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453940 Pharmacological profile of a novel orally active neutrophil elastase inhibitor, ONO-6818. Seikioka T, Hirota Y, Nakao S, Sato W, Omoto K, Tanaka T, Kawabata K, Obata T Am J Respir Crit Care Med 2001 163 A597
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Am J Respir Crit Care Med
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Seikioka, T.1
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Omoto, K.5
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Obata, T.8
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21
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Healthcare: Slowing momentum
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456597; June 18
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456597 Healthcare: Slowing momentum. Mita M Morgan Stanley Dean Witter 2002 June 18
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(2002)
Morgan Stanley Dean Witter
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Mita, M.1
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22
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0142125569
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Annual flash report (unaudited): Year ended March 31 2002
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456761; May 17
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456761 Annual flash report (unaudited): Year ended March 31 2002. Ono Pharmaceutical Co Ltd Company Publication 2002 May 17
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(2002)
Ono Pharmaceutical Co Ltd Company Publication
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