The number of cardiac myocytes in the hypertrophic and hypotrophic left ventricle of the obese and calorie-restricted mouse heart

Journal of Anatomy

Volumn 225, Issue 5, 2014, Pages 539-547

  Schipke, Julia ^a   Banmann, Ewgenija ^a   Nikam, Sandeep ^b   Voswinckel, Robert ^b   Kohlstedt, Karin ^c   Loot, Annemarieke E ^c   Fleming, Ingrid ^c   Mühlfeld, Christian ^a,d,e,f  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)   (Germany)

^e German Center for Lung Research   (Germany)

^f Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy)   (Germany)

Author keywords

Calorie restriction; Cell death; Design based stereology; Myocardium; Obesity

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CALORIC RESTRICTION; CELL SIZE; CONTROL GROUP; CONTROLLED STUDY; ELECTRON MICROSCOPY; HEART DISEASE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART VENTRICLE HYPOTROPHY; LIGHT; LIPID DIET; MALE; MITOCHONDRION; MOUSE; MUSCLE CELL; MUSCLE FIBRIL; NONHUMAN; OBESITY; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; COMPLICATION; HEART VENTRICLE; HYPERTROPHY, LEFT VENTRICULAR; PATHOLOGY; RANDOMIZATION;

MUS;

ANIMALS; CALORIC RESTRICTION; HEART VENTRICLES; HYPERTROPHY, LEFT VENTRICULAR; MALE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; OBESITY; RANDOM ALLOCATION;

EID: 84933516547     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/joa.12236     Document Type: Article

References (55)

1. Ahn J, Kim J (2013) Nutritional status and cardiac autophagy. Diabetes Metab J 37, 30-35.
2. Alpert MA (2001) Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome. Am J Med Sci 321, 225-236.
3. Anversa P, Kajstura J (1998) Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ Res 83, 1-14.
4. Anversa P, Leri A, Kajstura J, et al. (2002) Myocyte growth and cardiac repair. J Mol Cell Cardiol 34, 91-105.
5. Brinks H, Tevaearai H, Mühlfeld C, et al. (2009) Contractile function is preserved in unloaded hearts despite atrophic remodeling. J Thorac Cardiovasc Surg 137, 742-746.
6. Brüel A, Nyengaard JR (2005) Design-based stereological estimation of the total number of cardiac myocytes in histological sections. Basic Res Cardiol 100, 1-9.
7. Brüel A, Christoffersen TE, Nyengaard JR (2007) Growth hormone increases the proliferation of existing cardiac myocytes and the total number of cardiac myocytes in the rat heart. Cardiovasc Res 76, 400-408.
8. Buja LM, Vela D (2008) Cardiomyocyte death and renewal in the normal and diseased heart. Cardiovasc Pathol 17, 349-374.
9. Clubb FJ Jr, Bishop SP (1984) Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy. Lab Invest 50, 571-577.
10. Eisele JC, Schaefer IM, Nyengaard JR, et al. (2008) Effect of voluntary exercise on number and volume of cardiomyocytes and their mitochondria in the mouse left ventricle. Basic Res Cardiol 103, 12-21.
11. Ghosh S, Sulistyoningrum DC, Glier MB, et al. (2011) Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice. J Biol Chem 286, 42483-42493.
12. Gruber C, Kohlstedt K, Loot AE, et al. (2012a) Stereological characterization of left ventricular cardiomyocytes, capillaries, and innervation in the nondiabetic, obese mouse. Cardiovasc Pathol 21, 346-354.
13. Gruber C, Nink N, Nikam S, et al. (2012b) Myocardial remodelling in left ventricular atrophy induced by caloric restriction. J Anat 220, 179-185.
14. Gürtl B, Kratky D, Guelly C, et al. (2009) Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy. Int J Exp Pathol 90, 338-346.
15. Harmancey R, Wilson CR, Taegtmeyer H (2008) Adaptation and maladaptation of the heart in obesity. Hypertension 52, 181-187.
16. Kajstura J, Bolli R, Sonnenblick EH, et al. (2006) Cause of death: suicide. J Mol Cell Cardiol 40, 425-437.
17. Kajstura J, Rota M, Cappetta D, et al. (2012) Cardiomyogenesis in the aging and failing human heart. Circulation 126, 1869-1881.
18. Kenchaiah S, Evans JC, Levy D, et al. (2002) Obesity and the risk of heart failure. N Engl J Med 347, 305-313.
19. Lamounier-Zepter V, Look C, Alvarez J, et al. (2009) Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction. Circ Res 105, 326-334.
20. Li F, Wang X, Capasso JM, et al. (1996) Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 28, 1737-1746.
21. Linzbach AJ (1952) The number of heart muscle nuclei in normal, overworked, atrophic and corhorman-treated heart chambers. Z Kreislaufforsch 41, 641-658.
22. Look C, Morano I, Ehrhart-Bornstein M, et al. (2011) Adipocyte-derived factors suppress heart contraction. Int J Obes (Lond) 35, 84-90.
23. Majno G, Joris I (1995) Apoptosis, oncosis and necrosis. An overview of cell death. Am J Pathol 146, 3-15.
24. Mattfeldt T, Mall G, Gharehbaghi H, et al. (1990) Estimation of surface area and length with the orientator. J Microsc 159, 301-317.
25. Mayhew TM (2008) Taking tissue samples from the placenta: an illustration of principles and strategies. Placenta 29, 1-14.
26. Mayhew TM, Pharaoh A, Austin A, et al. (1997) Stereological estimates of nuclear number in human ventricular cardiomyocytes before and after birth obtained using physical dissectors. J Anat 191, 107-115.
27. Mendez J, Keys A (1961) Density and composition of mammalian muscle. Metabolism 9, 184-188.
28. Messerli FH, Nunez BD, Ventura HO, et al. (1987) Overweight and sudden death. Increased ventricular ectopy in cardiomyopathy of obesity. Arch Intern Med 147, 1725-1728.
29. Michalakis K, Goulis DG, Vazaiou A, et al. (2013) Obesity in the ageing man. Metabolism 62, 1341-1349.
30. Mollova M, Bersell K, Walsh S, et al. (2013) Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci USA 110, 1446-1451.
31. Mühlfeld C, Das SK, Heinzel FR, et al. (2011) Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart. PLoS One 6, e20424.
32. Noorman M, van der Heyden MA, van Veen TA, et al. (2009) Cardiac cell-cell junctions in health and disease: electrical versus mechanical coupling. J Mol Cell Cardiol 47, 23-31.
33. Nyengaard JR, Gundersen HJ (1992) The isector: a simple and direct method for generating isotropic, uniform random sections from small specimens. J Microsc 165, 427-431.
34. Olivetti G, Cigola E, Maestri R, et al. (1996) Aging, cardiac hypertrophy and ischemic cardiomyopathy do not affect the proportion of mononucleated and multinucleated myocytes in the human heart. J Mol Cell Cardiol 28, 1463-1477.
35. Oparil S, Bishop SP, Clubb FJ Jr (1984) Myocardial cell hypertrophy or hyperplasia. Hypertension 6, III38-III43.
36. Ouwens DM, Sell H, Greulich S, et al. (2010) The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease. J Cell Mol Med 14, 2223-2234.
37. Puente BN, Kimura W, Muralidhar SA, et al. (2014) The oxygen-rich postnatal environment induce cardiomyocyte cell-cycle arrest through DNA damage response. Cell 157, 565-579.
38. Samarel AM, Parmacek MS, Magid NM, et al. (1987) Protein synthesis and degradation during starvation-induced cardiac atrophy in rabbits. Circ Res 60, 933-941.
39. Schocken DD, Holloway JD, Powers PS (1989) Weight loss and the heart: effects of anorexia nervosa and starvation. Arch Intern Med 149, 877-881.
40. Schünemann M, Anker SD, Rauchhaus M (2008) Cancer fatigue syndrome reflects clinically non-overt heart failure: an approach towards onco-cardiology. Nat Clin Pract Oncol 5, 632-633.
41. Sharov VG, Sabbah HN, Shimoyama H, et al. (1996) Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. Am J Pathol 148, 141-149.
42. Shimomura H, Terasaki F, Hayashi T, et al. (2001) Autophagic degeneration as a possible mechanism of myocardial cell death in dilated cardiomyopathy. Jpn Circ J 65, 965-968.
43. de Simone G, Scalfi L, Galderisi M, et al. (1994) Cardiac abnormalities in young women with anorexia nervosa. Br Heart J 71, 287-292.
44. Sterio DC (1984) The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134, 127-136.
45. Thomas GA, Kraemer WJ, Comstock BA, et al. (2013) Obesity, growth hormone and exercise. Sports Med 43, 839-849.
46. Trivedi PS, Barouch LA (2008) Cardiomyocyte apoptosis in animal models of obesity. Curr Hypertens Rep 10, 454-460.
47. Tschanz SA, Schneider JP, Knudsen L (2014) Design-based stereology: planning, volumetry and sampling are crucial steps for a successful study. Ann Anat 196, 3-11.
48. Van Emple VP, De Windt LJ (2004) Myocyte hypertrophy and apoptosis: a balancing act. Cardiovasc Res 63, 487-499.
49. Vandewoude MF, Buyssens N (1992a) Effect of ageing and malnutrition on rat myocardium. I. The myocyte. Virchows Arch A Pathol Anat Histopathol 421, 179-188.
50. Vandewoude MF, Buyssens N (1992b) Effect of ageing and malnutrition on rat myocardium. II. The microvasculature. Virchows Arch A Pathol Anat Histopathol 421, 189-192.
51. Watanabe H, Tanabe N, Watanabe T, et al. (2008) Metabolic syndrome and risk of development of atrial fibrillation: the Niigata preventive medicine study. Circulation 117, 1255-1260.
52. Weibel ER (1979) Stereological Methods. Practical Methods for Biological Morphometry, Vol. 1. London: Academic Press.
53. Wende AR, Abel ED (2010) Lipotoxicity in the heart. Biochim Biophys Acta 1801, 311-319.
54. Wulfsohn D, Nyengaard JR, Tang Y (2004) Postnatal growth of cardiomyocytes in the left ventricle of the rat heart. Anat Rec A Discov Mol Cell Evol Biol 277, 236-247.
55. Zak R, Kizu A, Bugaisky L (1979) Cardiac hypertrophy: its characteristics as a growth process. Am J Cardiol 44, 941-946.