Growth hormone increases the proliferation of existing cardiac myocytes and the total number of cardiac myocytes in the rat heart

Cardiovascular Research

Volumn 76, Issue 3, 2007, Pages 400-408

  Brüel, Annemarie ^a,c   Christoffersen, Tue E H ^b   Nyengaard, Jens R ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Rigshospitalet   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Growth factors; Histo(patho)logy; Hormones; Hypertrophy; Myocyte

Indexed keywords

CASPASE 3; GROWTH HORMONE; KI 67 ANTIGEN; SODIUM CHLORIDE; SOMATOMEDIN C; STEM CELL FACTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE REGULATION; CELL DIVISION; CELL NUCLEUS; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HEART; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART PERFUSION; HEMODYNAMIC PARAMETERS; HORMONAL REGULATION; HORMONE DETERMINATION; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; SEXUAL MATURATION; STEM CELL; STEREOLOGY; TISSUE SECTION; WISTAR RAT;

ANIMALS; BODY WEIGHT; CASPASE 3; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GROWTH HORMONE; HEART VENTRICLES; HYPERPLASIA; INSULIN-LIKE GROWTH FACTOR I; KI-67 ANTIGEN; MYOCYTES, CARDIAC; ORGAN SIZE; PROTO-ONCOGENE PROTEINS C-KIT; RATS; RATS, WISTAR;

EID: 35548967049     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2007.06.026     Document Type: Article

References (46)

1. Isgaard J. Cardiovascular disease and risk factors: the role of growth hormone. Horm Res 62 Suppl 4 (2004) 31-38
2. Thuesen L., Christiansen J.S., Sorensen K.E., Jørgensen J.O.L., Ørskov H., and Henningsen P. Increased myocardial contractility following growth hormone administration in normal man. An echocardiographic study. Dan Med Bull 35 (1988) 193-196
3. Cittadini A., Strömer H., Katz S.E., Clark R., Moses A.C., Morgan J.P., et al. Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat - a combined in vivo and in vitro evaluation. Circulation 93 (1996) 800-809
4. Isgaard J., Kujacic V., Jennische E., Holmang A., Sun X.Y., Hedner T., et al. Growth hormone improves cardiac function in rats with experimental myocardial infarction. Eur J Clin Invest 27 (1997) 517-525
5. Yang R., Bunting S., Gillett N., Clark R., and Jin H. Growth hormone improves cardiac performance in experimental heart failure. Circulation 92 (1995) 262-267
6. Cittadini A., Isgaard J., Monti M.G., Casaburi C., Di Gianni A., Serpico R., et al. Growth hormone prolongs survival in experimental postinfarction heart failure. J Am Coll Cardiol 41 (2003) 2154-2163
7. Fazio S., Sabatini D., Capaldo B., Vigorito C., Giordano A., Guida R., et al. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy [see comments]. N Engl J Med 334 (1996) 809-814
8. Osterziel K.J., Strohm O., Schuler J., Friedrich M., Hanlein D., Willenbrock R., et al. Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy. Lancet 351 (1998) 1233-1237
9. Genth-Zotz S., Zotz R., Geil S., Voigtlander T., Meyer J., and Darius H. Recombinant growth hormone therapy in patients with ischemic cardiomyopathy: effects on hemodynamics, left ventricular function, and cardiopulmonary exercise capacity. Circulation 99 (1999) 18-21
10. Spallarossa P., Rossettin P., Minuto F., Caruso D., Cordera R., Battistini M., et al. Evaluation of growth hormone administration in patients with chronic heart failure secondary to coronary artery disease. Am J Cardiol 84 (1999) 430-433
11. Isgaard J., Bergh C.H., Caidahl K., Lomsky M., Hjalmarson A., and Bengtsson B.A. A placebo-controlled study of growth hormone in patients with congestive heart failure. Eur Heart J 19 (1998) 1704-1711
12. LeCorvosier P., Hittinger L., Chanson P., Montagne O., Macquin-Mavier I., and Maison P. Cardiac effects of growth hormone treatment in chronic heart failure. a meta-analysis. J Clin Endocrinol Metab 92 (2007) 180-185
13. Anker S.D., Volterrani M., Pflaum C.D., Strasburger C.J., Osterziel K.J., Doehner W., et al. Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone. J Am Coll Cardiol 38 (2001) 443-452
14. Imanishi R., Ashizawa N., Ohtsuru A., Seto S., Akiyama-Uchida Y., Kawano H., et al. GH suppresses TGF-beta-mediated fibrosis and retains cardiac diastolic function. Mol Cell Endocrinol 218 (2004) 137-146
15. Brüel A., and Oxlund H. The effect of growth hormone on rat myocardial collagen. Growth Horm IGF Res 9 (1999) 123-130
16. Brüel A., Nyengaard J.R., and Danielsen C.C. MMP-2 in the left rat ventricle is increased by growth hormone. Growth Horm IGF Res 16 (2006) 193-201
17. Brüel A., Oxlund H., and Nyengaard J.R. Growth hormone increases the total number of myocyte nuclei in the left ventricle of adult rats. Growth Horm IGF Res 12 (2002) 106-115
18. Brüel A., Oxlund H., and Nyengaard J.R. Growth hormone increases the total number of cardiac myocyte nuclei in young rats but not in old rats. Mech Ageing Dev 123 (2002) 1353-1362
19. Brüel A., Oxlund H., and Nyengaard J.R. The total length of myocytes and capillaries, and total number of myocyte nuclei in the rat heart are time-dependently increased by growth hormone. Growth Horm IGF Res 15 (2005) 256-264
20. Brüel A., and Nyengaard J.R. Design-based stereological estimation of the total number of cardiac myocytes in histological sections. Basic Res Cardiol 100 (2005) 311-319
21. Gundersen H.J.G. The smooth fractionator. J Microsc 207 (2002) 191-210
22. Nyengaard J.R., and Gundersen H.J.G. The isector: a simple and direct method for generating isotropic, uniform random sections from small specimens. J Microsc 165 (1992) 427-431
23. Gundersen H.J.G. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of Wiliam R. Thompson. J Microsc 143 (1986) 3-45
24. Kroustrup J.P., and Gundersen H.J.G. Sampling problems in an heterogeneous organ: Quantitation of relative and total volume of pancreatic islets by light microscopy. J Microsc 132 (1983) 43-55
25. Flyvbjerg A., Frystyk J., Osterby R., and Orskov H. Kidney IGF-I and renal hypertrophy in GH-deficient diabetic dwarf rats. Am J Physiol 262 (1992) E956-E962
26. Sjogren K., Liu J.L., Blad K., Skrtic S., Vidal O., Wallenius V., et al. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci U S A 96 (1999) 7088-7092
27. Isgaard J., Nilsson A., Vikman K., and Isaksson O.G.P. Growth hormone regulates the level of insulin-like growth factor-I mRNA in rat skeletal muscle. J Endocrinol 120 (1989) 107-112
28. Clark R.G., Carlsson L.M.S., and Robinson I.C.A.F. Growth hormone secretory profiles in conscious female rats. J Endocrinol 114 (1987) 399-407
29. Jørgensen P.H., Bang C., Andreassen T.T., Flyvbjerg A., and Ørskov H. Dose-response study of the effect of growth hormone on mechanical properties of skin graft wounds. J Surg Res 58 (1995) 295-301
30. Schluter C., Duchrow M., Wohlenberg C., Becker M.H., Key G., Flad H.D., et al. The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol 123 (1993) 513-522
31. Lopez F., Belloc F., Lacombe F., Dumain P., Reiffers J., Bernard P., et al. Modalities of synthesis of Ki67 antigen during the stimulation of lymphocytes. Cytometry 12 (1991) 42-49
32. Reiss K., Cheng W., Ferber A., Kajstura J., Li P., Li B., et al. Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc Natl Acad Sci U S A 93 (1996) 8630-8635
33. Anversa P., Leri A., and Kajstura J. Cardiac regeneration. J Am Coll Cardiol 47 (2006) 1769-1776
34. Urbanek K., Cesselli D., Rota M., Nascimbene A., De Angelis A., Hosoda T., et al. Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A 103 (2006) 9226-9231
35. Moretti A., Caron L., Nakano A., Lam J.T., Bernshausen A., Chen Y., et al. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127 (2006) 1151-1165
36. Buerke M., Murohara T., Skurk C., Nuss C., Tomaselli K., and Lefer A.M. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci U S A 92 (1995) 8031-8035
37. Tanaka N., Ryoke T., Hongo M., Mao L., Rockman H.A., Clark R.G., et al. Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice. Am J Physiol 275 (1998) H393-H399
38. Bollano E., Omerovic E., Bohlooly M., Kujacic V., Madhu B., Tornell J., et al. Impairment of cardiac function and bioenergetics in adult transgenic mice overexpressing the bovine growth hormone gene. Endocrinology 141 (2000) 2229-2235
39. Richey P.A., and Brown S.P. Pathological versus physiological left ventricular hypertrophy: a review. J Sports Sci 16 (1998) 129-141
40. Weber K.T. Fibrosis and hypertensive heart disease. Curr Opin Cardiol 15 (2000) 264-272
41. DeBosch B., Treskov I., Lupu T.S., Weinheimer C., Kovacs A., Courtois M., et al. Akt1 is required for physiological cardiac growth. Circulation 113 (2006) 2097-2104
42. McMullen J.R., Shioi T., Huang W.Y., Zhang L., Tarnavski O., Bisping E., et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J Biol Chem 279 (2004) 4782-4793
43. Jenkins P.J., Mukherjee A., and Shalet S.M. Does growth hormone cause cancer?. Clin Endocrinol (Oxf) 64 (2006) 115-121
44. Wu Y., Cui K., Miyoshi K., Hennighausen L., Green J.E., Setser J., et al. Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res 63 (2003) 4384-4388
45. Wu Y., Yakar S., Zhao L., Hennighausen L., and LeRoith D. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 62 (2002) 1030-1035
46. Jenkins P.J., and Besser M. Clinical perspective: acromegaly and cancer: a problem. J Clin Endocrinol Metab 86 (2001) 2935-2941