Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 4, 2015, Pages 804-816

  Yin, Ying ^a   Li, Xinyuan ^a   Sha, Xiaojin ^a   Xi, Hang ^a   Li, Ya Feng ^a   Shao, Ying ^a   Mai, Jietang ^a   Virtue, Anthony ^a   Lopez Pastrana, Jahaira ^a   Meng, Shu ^a   Tilley, Douglas G ^b   Monroy, M Alexandra ^c   Choi, Eric T ^c   Thomas, Craig J ^c   Jiang, Xiaohua ^a   Wang, Hong ^a   Yang, Xiao Feng ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Pharmacology   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

atherosclerosis; caspase 1; inflammation

Indexed keywords

APOLIPOPROTEIN E; CELL ADHESION MOLECULE; GENOMIC DNA; INTERLEUKIN 1BETA CONVERTING ENZYME; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; TRANSCRIPTION FACTOR AP 1; AUTACOID; CASPASE INHIBITOR; CYTOKINE; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HYPERLIPIDEMIA; LIPID OXIDATION; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; AORTIC DISEASES; ATHEROSCLEROSIS; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TIME;

ANIMALS; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BONE MARROW TRANSPLANTATION; CASPASE 1; CASPASE INHIBITORS; CELL ADHESION MOLECULES; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; HYPERLIPIDEMIAS; INFLAMMATION MEDIATORS; LIPOPROTEINS, LDL; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SIRTUIN 1; TIME FACTORS; TRANSCRIPTION FACTOR AP-1;

EID: 84933513721     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.305282     Document Type: Article

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