A novel function of interferon regulatory factor-1: Inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection

International Immunology

Volumn 27, Issue 3, 2015, Pages 143-152

  Maruyama, Saho ^a   Kanoh, Makoto ^a   Matsumoto, Akira ^a   Kuwahara, Makoto ^a,b   Yamashita, Masakatsu ^a   Asano, Yoshihiro ^a,c  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b EHIME UNIVERSITY HOSPITAL   (Japan)

^c RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

IL 1; Interferon regulatory factor 1; Listeria monocytogenes; Silencer; Th subset

Indexed keywords

INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 4; 3' UNTRANSLATED REGION; INTERLEUKIN 1 RECEPTOR;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL STRAIN; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GROWTH INHIBITION; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LISTERIA; LISTERIOSIS; MEDIATOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH2 CELL; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; DOWN REGULATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LISTERIA MONOCYTOGENES; METABOLISM; MICROBIOLOGY; PROTEIN TRANSPORT; TH1 CELL; TH1 TH2 BALANCE;

3' UNTRANSLATED REGIONS; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; DOWN-REGULATION; INTERFERON REGULATORY FACTOR-1; INTERLEUKIN-1; INTERLEUKIN-4; LISTERIA MONOCYTOGENES; LISTERIOSIS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN TRANSPORT; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TH1 CELLS; TH1-TH2 BALANCE; TH2 CELLS;

EID: 84933502816     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxu092     Document Type: Article

References (44)

1. Mosmann, T. R. and Coffman, R. L. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
2. Kaufman, S. H. E. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:129.
3. Mosmann, T. R. and Sad, S. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
4. Korn, T., Bettelli, E., Oukka, M. and Kuchroo, V. K. 2009. IL-17 and Th17 cells. Annu. Rev. Immunol. 27:485.
5. Zhu, J., Yamane, H. and Paul W. 2010. Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol. 28:445.
6. Abbas, A. K., Murphy, K. M. and Sher, A. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
7. Hsieh, C. S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A. and Murphy, K. M. 1993. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
8. Medzhitov, R. and Janeway, C. A., Jr. 1997. Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:4.
9. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275.
10. Maruyama, S., Sumita, K., Shen, H. et al. 2003. Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoter. J. Immunol. 170:997.
11. Taki, S., Sato, T., Ogasawara, K. et al. 1997. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 6:673.
12. Lohoff, M., Ferrick, D., Mittrucker, H. W. et al. 1997. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity 6:681.
13. Feng, C., Watanabe, S., Maruyama, S. et al. 1999. An alternate pathway for type 1 T cell differentiation. Int. Immunol. 11:1185.
14. Naoe, Y., Setoguchi, R., Akiyama, K. et al. 2007. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J. Exp. Med. 204:1749.
15. Lee, G. R., Kim, S. T., Spilianakis, C. G., Fields, P. E. and Flavell, R. A. 2006. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity 24:369.
16. Ansel, K. M., Greenwald, R. J., Agarwal, S. et al. 2004. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat. Immunol. 5:1251.
17. Okamoto, M., Van Stry, M., Chung, L. et al. 2009. Mina, an Il4 repressor, controls T helper type 2 bias. Nat. Immunol. 10:872.
18. Kubo, M., Ransom, J., Webb, D., Hashimoto, Y., Tada, T. and Nakayama, T. 1997. T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J. 16:4007.
19. Djuretic, I. M., Levanon, D., Negreanu, V., Groner, Y., Rao, A. and Ansel, K. M. 2007. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat. Immunol. 8:145.
20. Elser, B., Lohoff, M., Kock, S. et al. 2002. IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Immunity 17:703.
21. Taniguchi, T., Ogasawara, K., Takaoka, A. and Tanaka, N. 2001. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19:623.
22. Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. and Bluestone, J. A. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl Acad. Sci. USA 84:1374.
23. Abe, R., Vandenberghe, P., Craighead, N., Smoot, D. S., Lee, K. P. and June, C. H. 1995. Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation. J. Immunol. 154:985.
24. Murphy, K., Heimberger, A. and Loh, D. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250:1720.
25. Matsuyama, T., Kimura, T., Kitagawa, M. et al. 1993. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 75:83.
26. Magram, J. 1996. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 4:471.
27. Kanoh, M., Uetani, T., Sakan, H., Maruyama, S., Liu, F., Sumita, K. and Asano, Y. 2002. A two-step model of T cell subset commitment. Antigen-independent commitment of T cells before encountering nominal antigen during pathogenic infections. Int. Immunol. 6:567.
28. Asano, Y. and Hodes, R. J. 1983. T cell regulation of b cell activation. Cloned Lyt-1+2-T suppressor cells inhibit the major histocompatibility complex-restricted interaction of T helper cells with B cells and/or accessory cells. J. Exp. Med. 158:1178.
29. Sano, K., Fujisawa, I., Abe, R., Asano, Y. and Tada, T. 1987. MHC-restricted minimal regulatory circuit initiated by a class II-autoreactive T cell clone. J. Exp. Med. 165:1284.
30. Kishimoto, H., Kubo, R. T., Yorifuji, H., Nakayama, T., Asano, Y. and Tada, T. 1995. Physical dissociation of the TCR-CD3 complex accompanies receptor ligation. J. Exp. Med. 182:1997.
31. Matsuoka, S., Asano, Y., Sano, K. et al. 1995. A novel type of cell death of lymphocytes induced by a monoclonal antibody without participation of complement. J. Exp. Med. 181:2007.
32. Asano, Y., Shigeta, M., Fathman, C. G., Singer, A. and Hodes, R. J. 1982. Role of the major histocompatibility complex in T cell activation of B cell subpopulations. A single monoclonal T helper cell population activates different B cell subpopulations by distinct pathways. J. Exp. Med. 156:350.
33. Kubo, R. T., Born, W., Kappler, J. W., Marrack, P. and Pigeon, M. 1989. Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors. J. Immunol. 142:2736.
34. Harada, H., Willison, K., Sakakibara, J., Miyamoto, M., Fujita, T. and Taniguchi, T. 1990. Absence of the type I IFN system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated. Cell 63:303.
35. Freudenberg, M. A., Merlin, T., Kalis, C., Chvatchko, Y., Stübig, H. and Galanos, C. 2002. Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by type I IFN and IL-18 signaling. J. Immunol. 169:1665.
36. Honda, K. and Taniguchi, T. 2006. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6:644.
37. McElligot, D. L., Phillips, J. A., Stillman, C. A., Koch, R. J., Mosier, D. E. and Hobbs, M. V. 1997. CD4+ T cells from IRF-1-deficient mice exhibit altered patterns of cytokine expression and cell subset homeostasis. J. Immunol. 159:4180.
38. Blanch, V. J., Piskurich, J. F. and Kaetzel, C. S. 1999. Cutting edge: coordinate regulation of IFN regulatory factor-1 and the polymeric Ig receptor by proinflammatory cytokines. J. Immunol. 162:1232.
39. Geller, D. A., Nguyen, D., Shapiro, R. A. et al. 1993. Cytokine induction of interferon regulatory factor-1 in hepatocytes. Surgery 114:235.
40. Végran, F., Berger, H., Boidot, R. et al. 2014. The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells. Nat. Immunol. 15:758.
41. Yamashita, M., Ukai-Tadenuma, M., Miyamoto, T. et al. 2004. Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279:26983.
42. Wei, G., Abraham, B. J., Yagi, R. et al. 2011. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 35:299.
43. Croft, M. 2009. The role of TNF superfamily members in T-cell function and diseases. Nat. Rev. Immunol. 9:271.
44. Watts, T. H. 2005. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23:23.