A two-step model of T cell subset commitment: Antigen-independent commitment of T cells before encountering nominal antigen during pathogenic infections

International Immunology

Volumn 14, Issue 6, 2002, Pages 567-575

  Kanoh, Makoto ^a   Uetani, Teruyoshi ^a   Sakan, Hirokazu ^a   Maruyama, Saho ^a   Liu, Fengzhi ^a   Sumita, Kohsuke ^a   Asano, Yoshihiro ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antigen presenting cell; GATA 3; Pathogen infection; T cell commitment; T bet

Indexed keywords

ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 4; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; CHEMOKINE; CHEMOKINE RECEPTOR; DNA BINDING PROTEIN; GAMMA INTERFERON; GATA3 PROTEIN, MOUSE; OVALBUMIN; T BOX TRANSCRIPTION FACTOR TBX21; T-BOX TRANSCRIPTION FACTOR TBX21; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL INTERACTION; CONTROLLED STUDY; DENDRITIC CELL; IMMUNITY; IMMUNOSTIMULATION; LISTERIA MONOCYTOGENES; LISTERIOSIS; LYMPHOCYTE FUNCTION; MACROPHAGE; MODEL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; ANTIGEN PRESENTING CELL; BAGG ALBINO MOUSE; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL DIFFERENTIATION; GENE EXPRESSION; GENETICS; IMMUNOLOGY; MOUSE MUTANT; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS; CELL DIFFERENTIATION; CHEMOKINES; DNA-BINDING PROTEINS; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; KILLER CELLS, NATURAL; LISTERIA INFECTIONS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; OVALBUMIN; RECEPTORS, CHEMOKINE; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTE SUBSETS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0035988224     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxf024     Document Type: Article

References (39)

1. The role of T-cell subsets and cytokines in the regulation of infection
2. Immunity to intracellular bacteria
3. Studies in listeriosis show the strong symbiosis between the innate cellular system and the T-cell response
4. Innate immunity: Impact on the adaptive immune response
5. h2 cells: Different patterns of lymphokines secretion lead to different functional properties
6. h2 and more
7. Generation of Interleukin 4-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL4-producing cells
8. h2-like helper effectors
9. + T cells through IL-12 produced by Listeria-induced macrophages
10. IL-12: Initiation cytokine for cell-mediated immunity
11. IL-12-deficient mice are defective in IFN-γ production and type I cytokine responses
12. h2 cell response
13. + T cells
14. Functional diversity of helper T lymphocytes
15. Cytokines induce the development of functionally heterogeneous T helper cell subsets
16. h1-type immune responses by the transcription factor IRF
17. An alternative pathway for type 1 T cell differentiation
18. Primary and secondary immune responses to Listeria monocytogenes
19. Measles: Immunosuppression, interleukin-12, and complement receptors
20. Selective suppression of interleukin-12 induction after macrophage receptor ligation
21. h2 development and commitment
22. h2 cytokine gene expression in CD4 T cells
23. h2-specific expression of the interleukin-5 gene
24. h1 lineage commitment
25. h2 polarization
26. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4, or 5, using modified cDNA expression vectors
27. h1 helper T cells
28. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
29. Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1
30. lo thymocytes in vivo
31. + thymocytes
32. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
33. Role of the major histocompatibility complex in T cell activation of B cell subpopulations. Major histocompatibility complex-restricted and -unrestricted B cell responses are mediated by distinct B cell subpopulations
34. Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated
35. h2-mediated responses
36. IL-12 is not required for induction of type 1 cytokine responses in viral infections
37. Requirement for IRF-1 in the microenvironment supporting development of natural killer cells
38. Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis
39. Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice