-
1
-
-
0030434509
-
Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for Prostaglandin H Synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate
-
Arlen RR, Wells PG. 1996. Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for Prostaglandin H Synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate. J Pharm and Exp Thera (JPET) 277:1649-1658.
-
(1996)
J Pharm and Exp Thera (JPET)
, vol.277
, pp. 1649-1658
-
-
Arlen, R.R.1
Wells, P.G.2
-
2
-
-
0037164357
-
Thalidomide is not a human mutagen
-
Ashby J, Tinwell H. 2002. Thalidomide is not a human mutagen. Br Med J 325:1245.
-
(2002)
Br Med J
, vol.325
, pp. 1245
-
-
Ashby, J.1
Tinwell, H.2
-
3
-
-
17644432448
-
Thalidomide: lack of mutagenic activity across phyla and genetic endpoints
-
Ashby J, Tinwell H, Callander RD, et al. 1997. Thalidomide: lack of mutagenic activity across phyla and genetic endpoints. Mutation Res 396:45-64.
-
(1997)
Mutation Res
, vol.396
, pp. 45-64
-
-
Ashby, J.1
Tinwell, H.2
Callander, R.D.3
-
4
-
-
0034885038
-
A case of roberts syndrome described in 1737
-
Bates AW. 2001. A case of roberts syndrome described in 1737. J Med Genet 38:565-567.
-
(2001)
J Med Genet
, vol.38
, pp. 565-567
-
-
Bates, A.W.1
-
5
-
-
50549203840
-
Teratogenic effects of thalidomide and related substances
-
Boylen JB, Horne HH, Johnson WJ. 1963. Teratogenic effects of thalidomide and related substances. Lancet 1:552.
-
(1963)
Lancet
, vol.1
, pp. 552
-
-
Boylen, J.B.1
Horne, H.H.2
Johnson, W.J.3
-
6
-
-
0017760210
-
Linear growth of children with limb deformities following exposure to thalidomide in utero
-
Brook CG, Jarvis SN, Newman CG. 1977. Linear growth of children with limb deformities following exposure to thalidomide in utero. Acta Paediatr Scand 66:673-675.
-
(1977)
Acta Paediatr Scand
, vol.66
, pp. 673-675
-
-
Brook, C.G.1
Jarvis, S.N.2
Newman, C.G.3
-
7
-
-
0030299068
-
Thalidomide, a current teratogen in south america
-
Castilla EE, Ashton-Prolla P, Barreda-Mejia E, et al. 1996. Thalidomide, a current teratogen in south america. Teratology 54:273-277.
-
(1996)
Teratology
, vol.54
, pp. 273-277
-
-
Castilla, E.E.1
Ashton-Prolla, P.2
Barreda-Mejia, E.3
-
8
-
-
84916880505
-
Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
-
Chamberlain PP, Lopez-Girona A, Miller K, et al. 2014. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat Struct Mol Biol 21:803-809.
-
(2014)
Nat Struct Mol Biol
, vol.21
, pp. 803-809
-
-
Chamberlain, P.P.1
Lopez-Girona, A.2
Miller, K.3
-
9
-
-
0343583426
-
Ocular defects in thalidomide babies
-
Cullen JF. 1964. Ocular defects in thalidomide babies. Br J Ophthalmol 48:151-153.
-
(1964)
Br J Ophthalmol
, vol.48
, pp. 151-153
-
-
Cullen, J.F.1
-
10
-
-
0344974212
-
Thalidomide induced malformations-a radiological survey
-
Cuthbert R, Speirs AL. 1963. Thalidomide induced malformations-a radiological survey. Clin Radiol 14:163-199.
-
(1963)
Clin Radiol
, vol.14
, pp. 163-199
-
-
Cuthbert, R.1
Speirs, A.L.2
-
12
-
-
73449145248
-
Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide
-
Ema M, Ise R, Kato H, et al. 2010. Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide. Reprod Toxicol 29:49-56.
-
(2010)
Reprod Toxicol
, vol.29
, pp. 49-56
-
-
Ema, M.1
Ise, R.2
Kato, H.3
-
13
-
-
84908226157
-
Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells
-
Feng Q, Tan HH, Ge ZZ, et al. 2014. Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. J Dig Dis 15:85-95.
-
(2014)
J Dig Dis
, vol.15
, pp. 85-95
-
-
Feng, Q.1
Tan, H.H.2
Ge, Z.Z.3
-
14
-
-
84905568369
-
Structure of the DDB1-CRBN e3 ubiquitin ligase in complex with thalidomide
-
Fischer ES, Bohm K, Lydeard JR, et al. 2014. Structure of the DDB1-CRBN e3 ubiquitin ligase in complex with thalidomide. Nature 512:49-53.
-
(2014)
Nature
, vol.512
, pp. 49-53
-
-
Fischer, E.S.1
Bohm, K.2
Lydeard, J.R.3
-
15
-
-
0033985996
-
Evaluation of the developmental toxicity of thalidomide using frog embryo teratogenesis assay-Xenopus (FETAX):biotransformation and detoxification
-
Fort DJ, Stover EL, Bantle JA. et al. 2000. Evaluation of the developmental toxicity of thalidomide using frog embryo teratogenesis assay-Xenopus (FETAX):biotransformation and detoxification. Teratog Carcinog Mutagen 20:35-47.
-
(2000)
Teratog Carcinog Mutagen
, vol.20
, pp. 35-47
-
-
Fort, D.J.1
Stover, E.L.2
Bantle, J.A.3
-
17
-
-
84907432297
-
Embryonic stem cell differentiation and its modulation by developmental toxicants
-
Gao X, Yourick JJ, Sprando RL. 2014. Embryonic stem cell differentiation and its modulation by developmental toxicants. PLoS One 9:e108510.
-
(2014)
PLoS One
, vol.9
, pp. e108510
-
-
Gao, X.1
Yourick, J.J.2
Sprando, R.L.3
-
18
-
-
80052913982
-
Racemates revisited: heterochiral assemblies and the example of DL-thalidomide
-
Hague DE, Idle JR, Mitchell SC, et al. 2011. Racemates revisited: heterochiral assemblies and the example of DL-thalidomide. Xenobiotica 41:837-843.
-
(2011)
Xenobiotica
, vol.41
, pp. 837-843
-
-
Hague, D.E.1
Idle, J.R.2
Mitchell, S.C.3
-
19
-
-
33748455819
-
Prenatal exposure to thalidomide, altered vasculogenesis, and CNS malformations
-
Hallene KL, Oby E, Lee BJ, et al. 2006. Prenatal exposure to thalidomide, altered vasculogenesis, and CNS malformations. Neuroscience 142:267-283.
-
(2006)
Neuroscience
, vol.142
, pp. 267-283
-
-
Hallene, K.L.1
Oby, E.2
Lee, B.J.3
-
20
-
-
0018871925
-
Congenital short femur: clinical, genetic and epidemiological comparison of the naturally occurring condition with that caused by thalidomide
-
Hamanishi C. 1980. Congenital short femur: clinical, genetic and epidemiological comparison of the naturally occurring condition with that caused by thalidomide. J Bone Joint Surg 62-B:307-320.
-
(1980)
J Bone Joint Surg
, vol.62 B
, pp. 307-320
-
-
Hamanishi, C.1
-
21
-
-
0347320849
-
A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway
-
Hansen JM, Harris C. 2004. A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway. Antioxid Redox Signal 6:1-14.
-
(2004)
Antioxid Redox Signal
, vol.6
, pp. 1-14
-
-
Hansen, J.M.1
Harris, C.2
-
22
-
-
84871922476
-
Redox control of teratogenesis
-
Hansen JM, Harris C. 2013. Redox control of teratogenesis. Reprod Toxicol 35:165-179.
-
(2013)
Reprod Toxicol
, vol.35
, pp. 165-179
-
-
Hansen, J.M.1
Harris, C.2
-
23
-
-
0036787835
-
Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide
-
Hansen JM, Gong SG, Philbert M, et al. 2002. Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide. Dev Dyn 225:186-194.
-
(2002)
Dev Dyn
, vol.225
, pp. 186-194
-
-
Hansen, J.M.1
Gong, S.G.2
Philbert, M.3
-
24
-
-
84918578594
-
Thalidomide mimics uridine binding to an aromatic cage in cereblon
-
Hartmann MD, Boichenko I, Coles M, et al. 2014. Thalidomide mimics uridine binding to an aromatic cage in cereblon. J Struct Biol 188:225-232.
-
(2014)
J Struct Biol
, vol.188
, pp. 225-232
-
-
Hartmann, M.D.1
Boichenko, I.2
Coles, M.3
-
25
-
-
8844245412
-
A mutation in a novel ATP-dependent lon protease gene in a kindred with mild mental retardation
-
Higgins JJ, Pucilowska J, Lombardi RQ, et al. 2004. A mutation in a novel ATP-dependent lon protease gene in a kindred with mild mental retardation. Neurology 63:1927-1931.
-
(2004)
Neurology
, vol.63
, pp. 1927-1931
-
-
Higgins, J.J.1
Pucilowska, J.2
Lombardi, R.Q.3
-
27
-
-
77949350034
-
Identification of a primary target of thalidomide teratogenicity
-
Ito T, Ando H, Suzuki T, et al. 2010. Identification of a primary target of thalidomide teratogenicity. Science 327:1345-1350.
-
(2010)
Science
, vol.327
, pp. 1345-1350
-
-
Ito, T.1
Ando, H.2
Suzuki, T.3
-
28
-
-
79958765360
-
Teratogenic effects of thalidomide: molecular mechanisms
-
Ito T, Ando H, Handa H. 2011. Teratogenic effects of thalidomide: molecular mechanisms. Cell Mol Life Sci 68:1569-1579.
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 1569-1579
-
-
Ito, T.1
Ando, H.2
Handa, H.3
-
29
-
-
84965277249
-
Teratogenetic properties of thalidomide
-
James WH. 1965. Teratogenetic properties of thalidomide. Br Med J 2:1064.
-
(1965)
Br Med J
, vol.2
, pp. 1064
-
-
James, W.H.1
-
30
-
-
0015466279
-
Chemical structure and teratogenic properties IV. An outline of a chemical hypothesis for the teratogenic action of thalidomide
-
Jonsson NA. 1972. Chemical structure and teratogenic properties IV. An outline of a chemical hypothesis for the teratogenic action of thalidomide. Acta Pharm Suec 9:543-562.
-
(1972)
Acta Pharm Suec
, vol.9
, pp. 543-562
-
-
Jonsson, N.A.1
-
31
-
-
0015852484
-
The effect of thalidomide intake during 113 human pregnancies
-
Kajii T, Kida M, Takahashi K. 1973. The effect of thalidomide intake during 113 human pregnancies. Teratology 8:163-166.
-
(1973)
Teratology
, vol.8
, pp. 163-166
-
-
Kajii, T.1
Kida, M.2
Takahashi, K.3
-
32
-
-
0023789457
-
Thalidomide update: regulatory aspects
-
Kelsey FO. 1988. Thalidomide update: regulatory aspects. Teratology 38:221-226.
-
(1988)
Teratology
, vol.38
, pp. 221-226
-
-
Kelsey, F.O.1
-
33
-
-
0031171663
-
Effects of thalidomide and related metabolites in a mouse corneal model of neovascularisation
-
Kenyon BM, Browne F, D'Amato RJ. 1997. Effects of thalidomide and related metabolites in a mouse corneal model of neovascularisation. Exp Eye Res 64:971-978.
-
(1997)
Exp Eye Res
, vol.64
, pp. 971-978
-
-
Kenyon, B.M.1
Browne, F.2
D'Amato, R.J.3
-
34
-
-
37849052222
-
Thalidomide induces limb anomalies by PTEN stabilization, akt suppression, and stimulation of caspase-dependent cell death
-
Knobloch J, Schmitz I, Gotz K, et al. 2008. Thalidomide induces limb anomalies by PTEN stabilization, akt suppression, and stimulation of caspase-dependent cell death. Mol Cell Biol 28:529-538.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 529-538
-
-
Knobloch, J.1
Schmitz, I.2
Gotz, K.3
-
35
-
-
78650912364
-
Apoptosis induction by thalidomide: critical for limb teratogenicity but therapeutic potential in idiopathic pulmonary fibrosis?
-
Knobloch J, Jungck D, Koch A. 2011. Apoptosis induction by thalidomide: critical for limb teratogenicity but therapeutic potential in idiopathic pulmonary fibrosis? Curr Mol Pharmacol 4:26-61.
-
(2011)
Curr Mol Pharmacol
, vol.4
, pp. 26-61
-
-
Knobloch, J.1
Jungck, D.2
Koch, A.3
-
36
-
-
34247607671
-
Thalidomide induces limb deformities by perturbing the bmp/dkk1/wnt signaling pathway
-
Knobloch J, Shaughnessy JD Jr, Ruther U. 2007. Thalidomide induces limb deformities by perturbing the bmp/dkk1/wnt signaling pathway. FASEB J 21:1410-1421.
-
(2007)
FASEB J
, vol.21
, pp. 1410-1421
-
-
Knobloch, J.1
Shaughnessy, J.J.2
Ruther, U.3
-
37
-
-
4444246179
-
Mutations in sall4 in malformed father and daughter postulated previously to reflect mutagenesis by thalidomide
-
Kohlhase J, Holmes LB. 2004. Mutations in sall4 in malformed father and daughter postulated previously to reflect mutagenesis by thalidomide. Birth Defects Res A 70:550-551.
-
(2004)
Birth Defects Res A
, vol.70
, pp. 550-551
-
-
Kohlhase, J.1
Holmes, L.B.2
-
38
-
-
0037488242
-
Mutations at the sall4 locus on chromosone 20 result in a range of clinically overlapping phenotypes including okihiro syndrome, Holt-oram sundrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomdie embryopathy
-
Kohlhase J, Schubert L, Liebers M et al. 2003. Mutations at the sall4 locus on chromosone 20 result in a range of clinically overlapping phenotypes including okihiro syndrome, Holt-oram sundrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomdie embryopathy. J Med Genet 40:473-478.
-
(2003)
J Med Genet
, vol.40
, pp. 473-478
-
-
Kohlhase, J.1
Schubert, L.2
Liebers, M.3
-
39
-
-
84892576029
-
Lenalidomide causes selective degradation of ikzf1 and ikzf3 in multiple myeloma cells
-
Kronke J, Udeshi N, Narla A, et al. 2014. Lenalidomide causes selective degradation of ikzf1 and ikzf3 in multiple myeloma cells. Science 343:301-305.
-
(2014)
Science
, vol.343
, pp. 301-305
-
-
Kronke, J.1
Udeshi, N.2
Narla, A.3
-
40
-
-
84897882037
-
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
-
Kusumbe AP, Ramasamy SK, Adams RH. 2014. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 507:323-328.
-
(2014)
Nature
, vol.507
, pp. 323-328
-
-
Kusumbe, A.P.1
Ramasamy, S.K.2
Adams, R.H.3
-
41
-
-
77950538918
-
Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia
-
Lebrin F, Srun S, Raymond K, et al. 2010. Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat Med 16:420-428.
-
(2010)
Nat Med
, vol.16
, pp. 420-428
-
-
Lebrin, F.1
Srun, S.2
Raymond, K.3
-
42
-
-
79960175072
-
Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)-dependent, reactive oxygen species (ROS)-mediated mechanism
-
Lee CJJ, Goncalves LL, Wells PG. 2011. Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)-dependent, reactive oxygen species (ROS)-mediated mechanism. FASEB J 25:2468-2483.
-
(2011)
FASEB J
, vol.25
, pp. 2468-2483
-
-
Lee, C.J.J.1
Goncalves, L.L.2
Wells, P.G.3
-
43
-
-
84878257427
-
Disruption of the cereblon gene enhances hepatic AMPK activity and prevents High-fat Diet-induced obesity and insulin resistance in mice
-
Lee KM, Yang SJ, Kim YD, et al. 2013. Disruption of the cereblon gene enhances hepatic AMPK activity and prevents High-fat Diet-induced obesity and insulin resistance in mice. Diabetes 62:1855-1864.
-
(2013)
Diabetes
, vol.62
, pp. 1855-1864
-
-
Lee, K.M.1
Yang, S.J.2
Kim, Y.D.3
-
44
-
-
49749214015
-
Thalidomide and congenital abnormalities
-
Lenz W. 1962. Thalidomide and congenital abnormalities. Lancet 1:271-272
-
(1962)
Lancet
, vol.1
, pp. 271-272
-
-
Lenz, W.1
-
45
-
-
0023789803
-
A short history of thalidomide embryopathy
-
Lenz W. 1988. A short history of thalidomide embryopathy. Teratology 28:203-215.
-
(1988)
Teratology
, vol.28
, pp. 203-215
-
-
Lenz, W.1
-
46
-
-
0005752567
-
Foetal malformations due to Thalidomide
-
Lenz W, Knapp K. 1962. Foetal malformations due to Thalidomide. German Med. Monthly 7:253-258.
-
(1962)
German Med. Monthly
, vol.7
, pp. 253-258
-
-
Lenz, W.1
Knapp, K.2
-
47
-
-
0026082888
-
Consistent arterial abnormalities associated with a varierty of congenital malformations of the human lower limb
-
Levinsohn EM, Hootnick DR, Packard DSJ. 1991. Consistent arterial abnormalities associated with a varierty of congenital malformations of the human lower limb. Invest Radiol 26:364-373.
-
(1991)
Invest Radiol
, vol.26
, pp. 364-373
-
-
Levinsohn, E.M.1
Hootnick, D.R.2
Packard, D.S.J.3
-
48
-
-
84912573981
-
Inhibition of endothelial Slit2/Robo1 signalling by thalidomide restrains angiogenesis by blocking the PI3K/Akt pathway
-
Li Y, Fu S, Chen H, et al. 2014. Inhibition of endothelial Slit2/Robo1 signalling by thalidomide restrains angiogenesis by blocking the PI3K/Akt pathway. Dig Dis Sci. 59:2958-2966.
-
(2014)
Dig Dis Sci
, vol.59
, pp. 2958-2966
-
-
Li, Y.1
Fu, S.2
Chen, H.3
-
49
-
-
84964166518
-
Congenital ear abnormalities due to thalidomide
-
Livingstone G. 1965. Congenital ear abnormalities due to thalidomide. Proc R Soc Med 58:493-497.
-
(1965)
Proc R Soc Med
, vol.58
, pp. 493-497
-
-
Livingstone, G.1
-
50
-
-
84873410016
-
Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration
-
Love NR, Chen Y, Ishibashi S. et al. 2013. Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration. Nat. Cell Biol. 15:222-228.
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 222-228
-
-
Love, N.R.1
Chen, Y.2
Ishibashi, S.3
-
51
-
-
81055124181
-
Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration
-
Love NR, Chen Y, Bonev B. et al. 2011. Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration. BMC Dev Biol 11:70.
-
(2011)
BMC Dev Biol
, vol.11
, pp. 70
-
-
Love, N.R.1
Chen, Y.2
Bonev, B.3
-
52
-
-
84892593087
-
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of ikaros proteins
-
Lu G, Middleton RE, Sun H, et al. 2014. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of ikaros proteins. Science 343:305-309.
-
(2014)
Science
, vol.343
, pp. 305-309
-
-
Lu, G.1
Middleton, R.E.2
Sun, H.3
-
53
-
-
0017093977
-
Studies of the etiology of thalidomide dysmorphogenesis
-
McBride WG. 1976. Studies of the etiology of thalidomide dysmorphogenesis. Teratology 14:71-87.
-
(1976)
Teratology
, vol.14
, pp. 71-87
-
-
McBride, W.G.1
-
54
-
-
70349787456
-
History, heresy and radiology in scientific discovery
-
McCredie J. 2009. History, heresy and radiology in scientific discovery. J Med Imaging Radiat Oncol 53:433-441.
-
(2009)
J Med Imaging Radiat Oncol
, vol.53
, pp. 433-441
-
-
McCredie, J.1
-
55
-
-
0001465169
-
Thalidomide and congenital malformations
-
McBride W. 1961. Thalidomide and congenital malformations. Lancet 1:358
-
(1961)
Lancet
, vol.1
, pp. 358
-
-
McBride, W.1
-
56
-
-
0015831948
-
Some congenital abnormalities: possibly due to embryonic peripheral neuropathy
-
McCredie J, McBride WG. 1973. Some congenital abnormalities: possibly due to embryonic peripheral neuropathy. Clin Radiol 24:204-211.
-
(1973)
Clin Radiol
, vol.24
, pp. 204-211
-
-
McCredie, J.1
McBride, W.G.2
-
57
-
-
84881091385
-
Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic invitro
-
Mahony C, Erskine L, Niven J, et al. 2013. Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic invitro. Proc Natl Acad Sci USA 110:12703-12708.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 12703-12708
-
-
Mahony, C.1
Erskine, L.2
Niven, J.3
-
58
-
-
84878959215
-
Molecular analysis of regulative events in the developing chick limb
-
Mahony C, Vargesson N. 2013. Molecular analysis of regulative events in the developing chick limb. J Anat 223:1-13.
-
(2013)
J Anat
, vol.223
, pp. 1-13
-
-
Mahony, C.1
Vargesson, N.2
-
59
-
-
71249138154
-
Thalidomide attenuates nitric oxide-driven angiogenesis by interacting with soluble guanylyl cyclase
-
Majumder S, Rajaram M, Muley A, et al. 2009. Thalidomide attenuates nitric oxide-driven angiogenesis by interacting with soluble guanylyl cyclase. Br J Pharmacol 158:1720-1734.
-
(2009)
Br J Pharmacol
, vol.158
, pp. 1720-1734
-
-
Majumder, S.1
Rajaram, M.2
Muley, A.3
-
60
-
-
43749110077
-
Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning
-
Mariani FV, Ahn C, Martin G. 2008. Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature 453:401-405.
-
(2008)
Nature
, vol.453
, pp. 401-405
-
-
Mariani, F.V.1
Ahn, C.2
Martin, G.3
-
61
-
-
84865506513
-
Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells
-
Meganathan K, Jagtap S, Wagh V, et al. 2012. Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells. PLoS One 7:e44228.
-
(2012)
PLoS One
, vol.7
, pp. e44228
-
-
Meganathan, K.1
Jagtap, S.2
Wagh, V.3
-
62
-
-
0023832112
-
Embryotoxic effects of thalidomide-derivatives in the non-human primate callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (em12) on skeletal development
-
Merker HJ, Heger W, Sames K, et al. 1988. Embryotoxic effects of thalidomide-derivatives in the non-human primate callithrix jacchus. I. Effects of 3-(1, 3-dihydro-1-oxo-2H-isoindol-2-yl)-2, 6-dioxopiperidine (em12) on skeletal development. Arch Toxicol 61:165-179.
-
(1988)
Arch Toxicol
, vol.61
, pp. 165-179
-
-
Merker, H.J.1
Heger, W.2
Sames, K.3
-
63
-
-
0342313474
-
Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses
-
Miller MT, Stromland K. 1999. Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses. Teratology 60:306-321.
-
(1999)
Teratology
, vol.60
, pp. 306-321
-
-
Miller, M.T.1
Stromland, K.2
-
64
-
-
80051797312
-
What can we learn from the thalidomide experience: an ophthalmologic perspective
-
Miller MT, Stromland K. 2011. What can we learn from the thalidomide experience: an ophthalmologic perspective. Curr Opin Opthalmol 22:356-364.
-
(2011)
Curr Opin Opthalmol
, vol.22
, pp. 356-364
-
-
Miller, M.T.1
Stromland, K.2
-
65
-
-
14644405668
-
Autism associated with conditions characterised by developmental errors in early embryogenesis: a mini-review
-
Miller MT, Stromland K, Ventura L, et al. 2005. Autism associated with conditions characterised by developmental errors in early embryogenesis: a mini-review. Int J Dev Neuro 23:201-219.
-
(2005)
Int J Dev Neuro
, vol.23
, pp. 201-219
-
-
Miller, M.T.1
Stromland, K.2
Ventura, L.3
-
66
-
-
68949114237
-
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected
-
Miller MT., Ventura L., Stromland K. 2009. Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected. Birth Defects Res A Clin Mol Teratol 85:667-676.
-
(2009)
Birth Defects Res A Clin Mol Teratol
, vol.85
, pp. 667-676
-
-
Miller, M.T.1
Ventura, L.2
Stromland, K.3
-
67
-
-
79957542842
-
A zebrafish model of roberts syndrome reveals that esco2 depletion interferes with development by disrupting the cell cycle
-
Article ID 2011.
-
Monnich M, Kuriger Z, Print CG, Horsfeld JA. 2011. A zebrafish model of roberts syndrome reveals that esco2 depletion interferes with development by disrupting the cell cycle. PLoS One 6:e20051. Article ID 2011.
-
(2011)
PLoS One
, vol.6
, pp. e20051
-
-
Monnich, M.1
Kuriger, Z.2
Print, C.G.3
Horsfeld, J.A.4
-
68
-
-
0027230553
-
Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation
-
Moreira AL, Sampaio EP, Zmuidzinas A, et al. 1993. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med 177:1675-1680.
-
(1993)
J Exp Med
, vol.177
, pp. 1675-1680
-
-
Moreira, A.L.1
Sampaio, E.P.2
Zmuidzinas, A.3
-
69
-
-
0017684524
-
Clinical observations on the thalidomide syndrome
-
Newman CG. 1977. Clinical observations on the thalidomide syndrome. Proc R Soc Med 70:225-227.
-
(1977)
Proc R Soc Med
, vol.70
, pp. 225-227
-
-
Newman, C.G.1
-
70
-
-
0021848841
-
Teratogen update: clinical aspects of thalidomide embryopathy-a continuing preoccupation
-
Newman CGH. 1985. Teratogen update: clinical aspects of thalidomide embryopathy-a continuing preoccupation. Teratology 32:133-144.
-
(1985)
Teratology
, vol.32
, pp. 133-144
-
-
Newman, C.G.H.1
-
71
-
-
0022980440
-
The thalidomide syndrome: risks of exposure and spectrum of malformations
-
Newman CGH. 1986. The thalidomide syndrome: risks of exposure and spectrum of malformations. Clin Perinatol 13:555-573.
-
(1986)
Clin Perinatol
, vol.13
, pp. 555-573
-
-
Newman, C.G.H.1
-
72
-
-
0032973733
-
Shoulder joint replacement for osteoarthrosis in association with thalidomide-induced phocomelia
-
Newman RJ. 1999. Shoulder joint replacement for osteoarthrosis in association with thalidomide-induced phocomelia. Clin Rehabil 13:250-252.
-
(1999)
Clin Rehabil
, vol.13
, pp. 250-252
-
-
Newman, R.J.1
-
73
-
-
0037731526
-
Antiangiogenic activity of N-substituted and tetrafluorinated thalidomide analogues
-
Ng SS, Gutschow M, Weiss M, et al. 2003. Antiangiogenic activity of N-substituted and tetrafluorinated thalidomide analogues. Cancer Res 63:3189-3194.
-
(2003)
Cancer Res
, vol.63
, pp. 3189-3194
-
-
Ng, S.S.1
Gutschow, M.2
Weiss, M.3
-
74
-
-
1542314309
-
Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family
-
Niemann S., Zhao C., Pascu F., et al., 2004. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet 74:558-563.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 558-563
-
-
Niemann, S.1
Zhao, C.2
Pascu, F.3
-
75
-
-
0013832139
-
The sensitive phase in thalidomide embryopathy
-
article in German).
-
Nowack E. 1965. The sensitive phase in thalidomide embryopathy. Humangenetik 1:516-536. (article in German).
-
(1965)
Humangenetik
, vol.1
, pp. 516-536
-
-
Nowack, E.1
-
76
-
-
84925400339
-
Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes
-
Ornoy A, Reece EA, Pavlinkova G., et al. 2015. Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes. Birth Defects Res C Embryo Today 105:53-72.
-
(2015)
Birth Defects Res C Embryo Today
, vol.105
, pp. 53-72
-
-
Ornoy, A.1
Reece, E.A.2
Pavlinkova, G.3
-
77
-
-
0343583487
-
Teratological implications of soft tissue abnormalities found in human lower limbs with bony defects
-
In: Feinberg RN, Sherer DK, Auerbach R, editors. . New York. Karger.
-
Packard DS Jr, Levinsohn EM, Hootnick DR. 1991 Teratological implications of soft tissue abnormalities found in human lower limbs with bony defects. In: Feinberg RN, Sherer DK, Auerbach R, editors. Development of the Vascular System. Issues in Biomedicine. New York. Karger. pp. 157-169.
-
(1991)
Development of the Vascular System. Issues in Biomedicine
, pp. 157-169
-
-
Packard, D.S.1
Levinsohn, E.M.2
Hootnick, D.R.3
-
78
-
-
0032920883
-
Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity
-
Parman T, Wiley MJ, Wells PG. 1999. Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity. Nat Med 5:582-585.
-
(1999)
Nat Med
, vol.5
, pp. 582-585
-
-
Parman, T.1
Wiley, M.J.2
Wells, P.G.3
-
79
-
-
0036007215
-
5'-OH-thalidomide, a metabolite of thalidomide, inhibits angiogenesis
-
Price DK, Ando Y, Kruger EA, Weiss M, Figg WD. 2002. 5'-OH-thalidomide, a metabolite of thalidomide, inhibits angiogenesis. Ther Drug Monit 24:104-110.
-
(2002)
Ther Drug Monit
, vol.24
, pp. 104-110
-
-
Price, D.K.1
Ando, Y.2
Kruger, E.A.3
Weiss, M.4
Figg, W.D.5
-
80
-
-
84897830319
-
Endothelial notch activity promotes angiogenesis and osteogenesis in bone
-
Ramasamy SK, Kusumbe AP, Wang L, Adams RH. 2014. Endothelial notch activity promotes angiogenesis and osteogenesis in bone. Nature 507:376-380.
-
(2014)
Nature
, vol.507
, pp. 376-380
-
-
Ramasamy, S.K.1
Kusumbe, A.P.2
Wang, L.3
Adams, R.H.4
-
81
-
-
84926067379
-
Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes microtubule network by binding at vinblastine binding site on tubulin
-
Rashid A, Kuppa A, Kunwar A, et al. 2015. Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes microtubule network by binding at vinblastine binding site on tubulin. Biochemistry 54:2149-2159.
-
(2015)
Biochemistry
, vol.54
, pp. 2149-2159
-
-
Rashid, A.1
Kuppa, A.2
Kunwar, A.3
-
82
-
-
0017367152
-
Evalulation of thalidomide children
-
Ruffing L. 1977. Evalulation of thalidomide children. Birth Defects Orig Artic Ser 13:287-300.
-
(1977)
Birth Defects Orig Artic Ser
, vol.13
, pp. 287-300
-
-
Ruffing, L.1
-
84
-
-
0020957120
-
Clinical studies on teenage brazilian victims of thalidomide. Brazilian
-
Schmidt M, Salzano FM. 1983. Clinical studies on teenage brazilian victims of thalidomide. Brazilian. J Med Biol Res 16:105-109.
-
(1983)
J Med Biol Res
, vol.16
, pp. 105-109
-
-
Schmidt, M.1
Salzano, F.M.2
-
85
-
-
28144464283
-
Inactivating mutations in esco2 causes SC phocomelia and roberts syndrome: no phenotype-genotype correlation
-
Schule A, Oviedo A, Johnston K, Pai S, Francker U. 2005. Inactivating mutations in esco2 causes SC phocomelia and roberts syndrome: no phenotype-genotype correlation. Am J Hum Genet 77:1117-1128.
-
(2005)
Am J Hum Genet
, vol.77
, pp. 1117-1128
-
-
Schule, A.1
Oviedo, A.2
Johnston, K.3
Pai, S.4
Francker, U.5
-
87
-
-
84883833410
-
Thalidomide in the treatment of lepra reactions
-
Sheskin J. 1965. Thalidomide in the treatment of lepra reactions. Clin Pharmacol Ther 6:303-306.
-
(1965)
Clin Pharmacol Ther
, vol.6
, pp. 303-306
-
-
Sheskin, J.1
-
88
-
-
84867013214
-
Nitric oxide rescues thalidomide mediated teratogenicity
-
article
-
Siamwala JH, Veeriah V, Priya MK, et al. 2012. Nitric oxide rescues thalidomide mediated teratogenicity. Sci Rep 2:679. article
-
(2012)
Sci Rep
, vol.2
, pp. 679
-
-
Siamwala, J.H.1
Veeriah, V.2
Priya, M.K.3
-
89
-
-
84890252109
-
Studies on the relationship between the chemical structure and embryotoxic activity of thalidomide and related compounds
-
In: Robson JM, Sullivan, F, Smith, RL, editors. . London: Churchill Ltd.
-
Smith RL, Fabro S, Schumacher H, et al. 1965. Studies on the relationship between the chemical structure and embryotoxic activity of thalidomide and related compounds. In: Robson JM, Sullivan, F, Smith, RL, editors. Embryopathic activity of drugs. London: Churchill Ltd. pp. 194-209.
-
(1965)
Embryopathic activity of drugs
, pp. 194-209
-
-
Smith, R.L.1
Fabro, S.2
Schumacher, H.3
-
90
-
-
0001145253
-
Thalidomide and malformations in liverpool
-
Smithells RW. 1962. Thalidomide and malformations in liverpool. Lancet 1:1270-1273.
-
(1962)
Lancet
, vol.1
, pp. 1270-1273
-
-
Smithells, R.W.1
-
91
-
-
0015912824
-
Defects and disabilities of thalidomide children
-
Smithells RW. 1973. Defects and disabilities of thalidomide children. Br Med J 1:269-272.
-
(1973)
Br Med J
, vol.1
, pp. 269-272
-
-
Smithells, R.W.1
-
92
-
-
0344341695
-
The incidence of limb and ear defects since the withdrawal of thalidomide
-
Smithells RW, Leck I. 1963. The incidence of limb and ear defects since the withdrawal of thalidomide. Lancet 1:1095-1097.
-
(1963)
Lancet
, vol.1
, pp. 1095-1097
-
-
Smithells, R.W.1
Leck, I.2
-
93
-
-
0026761072
-
Recognition of thalidomide defects
-
Smithells RW, Newman CGH. 1992. Recognition of thalidomide defects. J Med Genet 29:716-723.
-
(1992)
J Med Genet
, vol.29
, pp. 716-723
-
-
Smithells, R.W.1
Newman, C.G.H.2
-
94
-
-
0003163821
-
Thalidomide and congenital abnormalities
-
Somers GS. 1962. Thalidomide and congenital abnormalities. Lancet 1:912-913.
-
(1962)
Lancet
, vol.1
, pp. 912-913
-
-
Somers, G.S.1
-
95
-
-
0013993082
-
Thalidomide victims in a rehabilitation centre
-
Soules BJ. 1966. Thalidomide victims in a rehabilitation centre. Ha-Ahot be-Yisrael 12:43-45.
-
(1966)
Ha-Ahot be-Yisrael
, vol.12
, pp. 43-45
-
-
Soules, B.J.1
-
96
-
-
0344111641
-
Thalidomide and congenital abnormalities
-
Spiers AL. 1962. Thalidomide and congenital abnormalities. Lancet 1:303-305.
-
(1962)
Lancet
, vol.1
, pp. 303-305
-
-
Spiers, A.L.1
-
97
-
-
0023729816
-
Proposed mechanisms of action in thalidomide embryopathy
-
Stephens TD. 1988. Proposed mechanisms of action in thalidomide embryopathy. Teratology 38:229-239.
-
(1988)
Teratology
, vol.38
, pp. 229-239
-
-
Stephens, T.D.1
-
98
-
-
68949090176
-
The effect of thalidomide in chicken embryos
-
Stephens TD. 2009. The effect of thalidomide in chicken embryos. Birth Defects Res A 85:725-731.
-
(2009)
Birth Defects Res A
, vol.85
, pp. 725-731
-
-
Stephens, T.D.1
-
99
-
-
0034058818
-
Hypothesis: thalidomide embryopathy-proposed mechanism of action
-
Stephens TD, Fillmore BJ. 2000. Hypothesis: thalidomide embryopathy-proposed mechanism of action. Teratology 61:189-195.
-
(2000)
Teratology
, vol.61
, pp. 189-195
-
-
Stephens, T.D.1
Fillmore, B.J.2
-
101
-
-
0036708517
-
Offspring of male and female parents with thalidomide embryopathy: birth defects and functional anomalies
-
Stromland K, Philipson E, Andersson Gronlund M. 2002. Offspring of male and female parents with thalidomide embryopathy: birth defects and functional anomalies. Teratology 66:115-121.
-
(2002)
Teratology
, vol.66
, pp. 115-121
-
-
Stromland, K.1
Philipson, E.2
Andersson Gronlund, M.3
-
103
-
-
33646260913
-
Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells
-
Tamilarasan KP, Kolluru GK, Rajaram M, et al. 2006. Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells. BMC Cell Biol 7:17.
-
(2006)
BMC Cell Biol
, vol.7
, pp. 17
-
-
Tamilarasan, K.P.1
Kolluru, G.K.2
Rajaram, M.3
-
104
-
-
73849164353
-
A study of the german outbreak of phocomelia. The thalidomide syndrome
-
Taussig HB. 1962. A study of the german outbreak of phocomelia. The thalidomide syndrome. JAMA 180:1106-1114.
-
(1962)
JAMA
, vol.180
, pp. 1106-1114
-
-
Taussig, H.B.1
-
105
-
-
66649093493
-
Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation
-
Therapontos C, Erskine L, Gardner E, et al. 2009. Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation. Proc Natl Acad Sci USA 106:8573-8578.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 8573-8578
-
-
Therapontos, C.1
Erskine, L.2
Gardner, E.3
-
106
-
-
33645469813
-
Thalidomide use in the US: experience with pregnancy testing in the STEPS prrogramme
-
Uhl K, Cox E, Rogan R, et al. 2006. Thalidomide use in the US: experience with pregnancy testing in the STEPS prrogramme. Drug Safety 29:321-329.
-
(2006)
Drug Safety
, vol.29
, pp. 321-329
-
-
Uhl, K.1
Cox, E.2
Rogan, R.3
-
108
-
-
0037272253
-
Vascularization of the developing chick limb bud: role of the TGFbeta signalling pathway
-
Vargesson N. 2003. Vascularization of the developing chick limb bud: role of the TGFbeta signalling pathway. J Anat 202:93-103.
-
(2003)
J Anat
, vol.202
, pp. 93-103
-
-
Vargesson, N.1
-
109
-
-
73149091643
-
Thalidomide-induced limb defects: resolving a 50-year-old puzzle
-
Vargesson N. 2009. Thalidomide-induced limb defects: resolving a 50-year-old puzzle. BioEssays 31:1327-1336.
-
(2009)
BioEssays
, vol.31
, pp. 1327-1336
-
-
Vargesson, N.1
-
110
-
-
84916238331
-
Thalidomide embryopathy: an enigmatic challenge
-
Vargesson N. 2013. Thalidomide embryopathy: an enigmatic challenge. ISRN Dev Biol 2013:1-18. doi:10.1155/2013/241016
-
(2013)
ISRN Dev Biol
, vol.2013
, pp. 1-18
-
-
Vargesson, N.1
-
111
-
-
0035894535
-
smad7 misexpression during embryonic angiogenesis causes vascular dilation and malformations independently of vascular smooth muscle cell function
-
Vargesson N, Laufer E. 2001. smad7 misexpression during embryonic angiogenesis causes vascular dilation and malformations independently of vascular smooth muscle cell function. Dev Biol 240:499-516.
-
(2001)
Dev Biol
, vol.240
, pp. 499-516
-
-
Vargesson, N.1
Laufer, E.2
-
112
-
-
20944444999
-
Roberts syndrome is caused by mutations in esco2, a human homolog of yeast eco1 that is essential for the establishment of sister chromatid cohesion
-
Vega H, Waisfisz Q, Gordillo M, et al. 2005. Roberts syndrome is caused by mutations in esco2, a human homolog of yeast eco1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37:468-470.
-
(2005)
Nat Genet
, vol.37
, pp. 468-470
-
-
Vega, H.1
Waisfisz, Q.2
Gordillo, M.3
-
113
-
-
84874854011
-
Recognition of the phenotype of thalidomide embryopathy in countries endemic for leprosy: new cases and review of the main dysmorphological findings
-
Vianna FS, Schuler-Faccini L, Leite JC, et al. 2013. Recognition of the phenotype of thalidomide embryopathy in countries endemic for leprosy: new cases and review of the main dysmorphological findings. Clin Dysmorphol 22:59-63.
-
(2013)
Clin Dysmorphol
, vol.22
, pp. 59-63
-
-
Vianna, F.S.1
Schuler-Faccini, L.2
Leite, J.C.3
-
114
-
-
61349091797
-
Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer
-
Wells PG., McCallum GP., Chen CS et al., Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer. 2009. Toxicological Sciences 108:4-18.
-
(2009)
Toxicological Sciences
, vol.108
, pp. 4-18
-
-
Wells, P.G.1
McCallum, G.P.2
Chen, C.S.3
-
115
-
-
84863848262
-
The non-redundant function of cohesin acetyle transferase esco2: some answers and new questions
-
Whelan G, Kreidl E, Peters JM, Eichele G. 2012. The non-redundant function of cohesin acetyle transferase esco2: some answers and new questions. Nucleus 3:330-334.
-
(2012)
Nucleus
, vol.3
, pp. 330-334
-
-
Whelan, G.1
Kreidl, E.2
Peters, J.M.3
Eichele, G.4
-
116
-
-
0036388898
-
An in ovo chicken model to study the systemic and localized teratogenic effects of valproic acid
-
Whitsel AI, Johnson CB, Forehand CJ. 2002. An in ovo chicken model to study the systemic and localized teratogenic effects of valproic acid. Teratology 66:153-163.
-
(2002)
Teratology
, vol.66
, pp. 153-163
-
-
Whitsel, A.I.1
Johnson, C.B.2
Forehand, C.J.3
-
117
-
-
22044444554
-
Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate
-
Yabu T, Tomimoto H, Taguchi Y, et al. 2005. Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. Blood 106:125-134.
-
(2005)
Blood
, vol.106
, pp. 125-134
-
-
Yabu, T.1
Tomimoto, H.2
Taguchi, Y.3
-
118
-
-
0032922147
-
STEPS: a comprehensive program for controlling amnd monitoring access to thalidomide
-
Zeldis JB, Williams BA, Thomas SD, et al. 1999. STEPS: a comprehensive program for controlling amnd monitoring access to thalidomide. Clin Thera 21:319-330.
-
(1999)
Clin Thera
, vol.21
, pp. 319-330
-
-
Zeldis, J.B.1
Williams, B.A.2
Thomas, S.D.3
-
119
-
-
84922450940
-
Zebrafish cul4a, but not cul4b, modulatescardiac and forelimb development by upregulating tbx5a expression
-
Zhao X, Jiang B, Hu H, et al. 2015. Zebrafish cul4a, but not cul4b, modulatescardiac and forelimb development by upregulating tbx5a expression. Hum Mol Gen 24:853-864.
-
(2015)
Hum Mol Gen
, vol.24
, pp. 853-864
-
-
Zhao, X.1
Jiang, B.2
Hu, H.3
|